Six weeks phylloquinone supplementation produces undesirable effects on blood lipids with no changes in inflammatory and fibrinolytic markers in postmenopausal women

European Journal of Nutrition

Volumn 47, Issue 7, 2008, Pages 375-379

  Kristensen, Mette ^a   Kudsk, Jane ^a   Bügel, Susanne ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Cardiovascular disease; Fibrinolytic activity; Inflammation; Lipids; Vitamin K

Indexed keywords

BIOLOGICAL MARKER; CHOLESTEROL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LIPID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; OSTEOCALCIN; PHYTOMENADIONE; PLACEBO; TRIACYLGLYCEROL;

ADULT; ARTICLE; ATHEROSCLEROSIS; BODY MASS; CARDIOVASCULAR RISK; CHOLESTEROL BLOOD LEVEL; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG BLOOD LEVEL; FEMALE; FIBRINOLYSIS; HEART PROTECTION; HUMAN; POSTMENOPAUSE; RANDOMIZED CONTROLLED TRIAL; TRIACYLGLYCEROL BLOOD LEVEL; VITAMIN SUPPLEMENTATION;

AGED; ANTIFIBRINOLYTIC AGENTS; BIOLOGICAL MARKERS; CARDIOVASCULAR DISEASES; CROSS-OVER STUDIES; DIETARY SUPPLEMENTS; FEMALE; HUMANS; INFLAMMATION; LIPIDS; MIDDLE AGED; POSTMENOPAUSE; VITAMIN K 1;

EID: 53549100169     PISSN: 14366207     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00394-008-0737-4     Document Type: Article

References (19)

1. SL Booth L Martini JW Peterson E Saltzman GE Dallal RJ Wood 2003 Dietary phylloquinone depletion and repletion in older women J Nutr 133 2565 2569
2. L Braam APG Hoeks F Brouns K Hamulyak MJW Gerichhausen C Vermeer 2004 Beneficial effects of vitamins D and K in the elastic properties of the vessel wall in postmenopausal women: a follow-up study Thromb Haemost 91 373 380
3. S Bugel AD Sorensen O Hels M Kristensen C Vermeer J Jakobsen A Flynn C Molgaard KD Cashman 2007 Effect of phylloquinone supplementation on biochemical markers of vitamin K status and bone turnover in postmenopausal women Br J Nutr 97 373 380
4. FW Eichbaum O Slemer SB Zyngier 1979 Anti-inflammatory effct of warfarin and vitamin k1 Naunyn Schmiedebergs Arch Pharmacol 307 185 190
5. Geleijnse JM, Vermeer C, Schurgers LJ, Grobbee HAP, Witteman, Jacqueline CM (2001) Inverse association of dietary vitamin K2 intake with cardiac events and aortic atherosclerosis: the Rotterdam study. J Thromb Haemost Suppl. Ref type: abstract
6. JM Geleijnse C Vermeer DE Grobbee LJ Schurgers MHJ Knapen IM van der Meer A Hofman JCM Witteman 2004 Dietary intake of menaquinone is associated with a reduced risk of coronary heart disease: the Rotterdam study J Nutr 134 3100 3105
7. TB Harris L Ferrucci RP Tracy MC Corti S Wacholder WH Ettinger Jr H Heimovitz HJ Cohen R Wallace 1999 Associations of elevated Interleukin-6 and C-reactive protein levels with mortality in the elderly Am J Med 106 506 512
8. JE Hokanson MA Austin 1996 Plasma triglyceride level is a risk factor for cardiovascular disease independent of high-density lipoprotein cholesterol level: a meta-analysis of population-based prospective studies J Cardiovasc Risk 3 213 219
9. S Jono Y Ikari C Vermeer P Dissel K Hasegawa A Shioi H Taniwaki A Kizu Y Nishizawa S Saito 2004 Matrix Gla protein is associated with coronary artery calcification as assessed by electron-beam computed tomography Thromb Heamost 91 790 794
10. H Kawashima Y Nakajima Y Matubara J Nakanowatari T Fukata S Mizuno S Tkahashi T Tajima T Nakamura 1997 Effects of vitamin K2 (menatetrenone) on atherosclerosis and blood coagulation in hypercholesterolemic rabbits Jpn J Pharmacol 75 135 143
11. Y Nagasawa M Fujii Y Kajimoto E Imai M Hori 1998 Vitamin K2 and serum cholesterol in patients on continuous ambulatory peritoneal dialysis Lancet 351 724
12. K Reddi B Henderson S Meghji M Wilson S Poole C Hopper M Harris SJ Hodges 1995 Interleukin 6 production by lipopolysaccharide-stimulated human fibroblasts is potently inhibited by Naphthoquinone (vitamin K) compounds Cytokine 7 287 290
13. PM Ridker CH Hennekens JE Buring N Rifai 2000 C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women N Engl J Med 342 836 843
14. PM Ridker N Rifai MJ Stampfer CH Hennekens 2000 Plasma concentration of interleukin-6 and the risk of future myocardial infarction among apparently healthy men Circulation 101 1767 1772
15. Y Seyama M Hayashi H Takegami E Usami 1999 Comparative effects of vitamin K2 and vitamin E on experimental atheriosclerosis Int J Vit Nutr Res 69 23 26
16. MK Shea SL Booth JM Massaro PF Jacques RB D'Agostino Sr B wson-Hughes JM Ordovas CJ O'Donnell S Kathiresan JF Keaney Jr RS Vasan EJ Benjamin 2008 Vitamin K and vitamin D status: associations with inflammatory markers in the Framingham offspring study Am J Epidemiol 167 313 320
17. HMH Spronk BAM Soute LJ Schurgers HHW Thijssen JGR De Mey C Vermeer 2003 Tissue-specific utilization of menaquinone-4 results in the prevention of arterial calcification in warfarin-treated rats J Vasc Res 40 531 537
18. TC Villines C Hatzigeorgiou IM Feuerstein PG O'Malley AJ Taylor 2005 Vitamin K1 intake and coronary calcification Coron Artery Dis 16 199 203
19. JT Willerson PM Ridker 2004 Inflammation as a cardiovascular risk factor Circulation 109 II-2 II-10