Losing the sugar coating: Potential impact of perineuronal net abnormalities on interneurons in schizophrenia

Schizophrenia Research

Volumn 167, Issue 1-3, 2015, Pages 18-27

  Berretta, Sabina ^a,b   Pantazopoulos, Harry ^a,b   Markota, Matej ^a,b   Brown, Christopher ^a   Batzianouli, Eleni T ^a,b  

^a MCLEAN HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Amygdala; Entorhinal cortex; Extracellular matrix; Perineuronal nets; Prefrontal cortex; Schizophrenia

Indexed keywords

MATRIX METALLOPROTEINASE; PROTEOCHONDROITIN SULFATE; 4 AMINOBUTYRIC ACID;

CELL POPULATION; EXTRACELLULAR MATRIX; GABAERGIC TRANSMISSION; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; HUMAN; INTERNEURON; LEARNING; NERVE CELL PLASTICITY; NEUROPATHOLOGY; NONHUMAN; OXIDATIVE STRESS; PERINEURONAL NET; PRIORITY JOURNAL; REGULATORY MECHANISM; REVIEW; SCHIZOPHRENIA; ANIMAL; BRAIN; METABOLISM; PATHOLOGY; PHYSIOLOGY;

ANIMALS; BRAIN; EXTRACELLULAR MATRIX; GAMMA-AMINOBUTYRIC ACID; HUMANS; INTERNEURONS; SCHIZOPHRENIA;

EID: 84936969206     PISSN: 09209964     EISSN: 15732509     Source Type: Journal    
DOI: 10.1016/j.schres.2014.12.040     Document Type: Review

References (186)

1. Abdolmaleky H.M., Cheng K.H., Russo A., Smith C.L., Faraone S.V., Wilcox M., Shafa R., Glatt S.J., Nguyen G., Ponte J.F., Thiagalingam S., Tsuang M.T. Hypermethylation of the reelin (RELN) promoter in the brain of schizophrenic patients: a preliminary report. Am. J. Med. Genet. B Neuropsychiatr. Genet. 2005, 134B(1):60-66.
2. Abdolmaleky H.M., Thiagalingam S., Wilcox M. Genetics and epigenetics in major psychiatric disorders: dilemmas, achievements, applications, and future scope. Am. J. Pharmacogenomics 2005, 5(3):149-160.
3. Adams I., Brauer K., Arelin C., Hartig W., Fine A., Mader M., Arendt T., Bruckner G. Perineuronal nets in the rhesus monkey and human basal forebrain including basal ganglia. Neuroscience 2001, 108(2):285-298.
4. Ajmo J.M., Eakin A.K., Hamel M.G., Gottschall P.E. Discordant localization of WFA reactivity and brevican/ADAMTS-derived fragment in rodent brain. BMC Neurosci. 2008, 9:14.
5. Akbarian S., Huang H.S. Molecular and cellular mechanisms of altered GAD1/GAD67 expression in schizophrenia and related disorders. Brain Res. Rev. 2006, 52(2):293-304.
6. Arion D., Unger T., Lewis D.A., Levitt P., Mirnics K. Molecular evidence for increased expression of genes related to immune and chaperone function in the prefrontal cortex in schizophrenia. Biol. Psychiatry 2007, 62(7):711-721.
7. Balmer T.S., Carels V.M., Frisch J.L., Nick T.A. Modulation of perineuronal nets and parvalbumin with developmental song learning. J. Neurosci. 2009, 29(41):12878-12885.
8. Bandtlow C.E., Zimmermann D.R. Proteoglycans in the developing brain: new conceptual insights for old proteins. Physiol. Rev. 2000, 80(4):1267-1290.
9. Barros C.S., Franco S.J., Muller U. Extracellular matrix: functions in the nervous system. Cold Spring Harb. Perspect. Biol. 2011, 3(1):a005108.
10. Benes F.M., Berretta S. Amygdalo-entorhinal inputs to the hippocampal formation in relation to schizophrenia. Ann. N. Y. Acad. Sci. 2000, 911:293-304.
11. Benes F.M., Berretta S. GABAergic interneurons: implications for understanding schizophrenia and bipolar disorder. Neuropsychopharmacology 2001, 25(1):1-27.
12. Benes F.M., Lim B., Matzilevich D., Walsh J.P., Subburaju S., Minns M. Regulation of the GABA cell phenotype in hippocampus of schizophrenics and bipolars. Proc. Natl. Acad. Sci. U. S. A. 2007, 104(24):10164-10169.
13. Berretta S., Lange N., Bhattacharyya S., Sebro R., Garces J., Benes F.M. Long-term effects of amygdala GABA receptor blockade on specific subpopulations of hippocampal interneurons. Hippocampus 2004, 14(7):876-894.
14. Bertolotto A., Manzardo E., Guglielmone R. Immunohistochemical mapping of perineuronal nets containing chondroitin unsulfated proteoglycan in the rat central nervous system. Cell Tissue Res. 1996, 283(2):283-295.
15. Bespalova I.N., Angelo G.W., Ritter B.P., Hunter J., Reyes-Rabanillo M.L., Siever L.J., Silverman J.M. Genetic variations in the ADAMTS12 gene are associated with schizophrenia in Puerto Rican patients of Spanish descent. Neruomol. Med. 2012, 14(1):53-64.
16. Beurdeley M., Spatazza J., Lee H.H., Sugiyama S., Bernard C., Di Nardo A.A., Hensch T.K., Prochiantz A. Otx2 binding to perineuronal nets persistently regulates plasticity in the mature visual cortex. J. Neurosci. 2012, 32(27):9429-9437.
17. Bitanihirwe B.K., Lim M.P., Kelley J.F., Kaneko T., Woo T.U. Glutamatergic deficits and parvalbumin-containing inhibitory neurons in the prefrontal cortex in schizophrenia. BMC Psychiatr. 2009, 9:71.
18. Brauer K., Hartig W., Bigl V., Bruckner G. Distribution of parvalbumin-containing neurons and lectin-binding perineuronal nets in the rat basal forebrain. Brain Res. 1993, 631(1):167-170.
19. Brauer K., Hartig W., Fritschy J.M., Bruckner G., Bigl V. Co-occurrence of perineuronal nets with GABAA receptor alpha 1 subunit-immunoreactive neurones in the rat septal region. Neuroreport 1995, 6(5):733-736.
20. Brown T.E., Wilson A.R., Cocking D.L., Sorg B.A. Inhibition of matrix metalloproteinase activity disrupts reconsolidation but not consolidation of a fear memory. Neurobiol. Learn. Mem. 2009, 91(1):66-72.
21. Bruckner G., Brauer K., Hartig W., Wolff J.R., Rickmann M.J., Derouiche A., Delpech B., Girard N., Oertel W.H., Reichenbach A. Perineuronal nets provide a polyanionic, glia-associated form of microenvironment around certain neurons in many parts of the rat brain. Glia 1993, 8(3):183-200.
22. Bukalo O., Schachner M., Dityatev A. Modification of extracellular matrix by enzymatic removal of chondroitin sulfate and by lack of tenascin-R differentially affects several forms of synaptic plasticity in the hippocampus. Neuroscience 2001, 104(2):359-369.
23. Buxbaum J.D., Georgieva L., Young J.J., Plescia C., Kajiwara Y., Jiang Y., Moskvina V., Norton N., Peirce T., Williams H., Craddock N.J., Carroll L., Corfas G., Davis K.L., Owen M.J., Harroch S., Sakurai T., O'Donovan M.C. Molecular dissection of NRG1-ERBB4 signaling implicates PTPRZ1 as a potential schizophrenia susceptibility gene. Mol. Psychiatry 2008, 13(2):162-172.
24. Cabungcal J.H., Steullet P., Morishita H., Kraftsik R., Cuenod M., Hensch T.K., Do K.Q. Perineuronal nets protect fast-spiking interneurons against oxidative stress. Proc. Natl. Acad. Sci. U. S. A. 2013, 110(22):9130-9135.
25. Campo C.G., Sinagra M., Verrier D., Manzoni O.J., Chavis P. Reelin secreted by GABAergic neurons regulates glutamate receptor homeostasis. PLoS ONE 2009, 4(5):e5505.
26. Carter C.S., Perlstein W., Ganguli R., Brar J., Mintun M., Cohen J.D. Functional hypofrontality and working memory dysfunction in schizophrenia. Am. J. Psychiatry 1998, 155(9):1285-1287.
27. Carulli D., Rhodes K.E., Fawcett J.W. Upregulation of aggrecan, link protein 1, and hyaluronan synthases during formation of perineuronal nets in the rat cerebellum. J. Comp. Neurol. 2007, 501(1):83-94.
28. Carulli D., Foscarin S., Faralli A., Pajaj E., Rossi F. Modulation of semaphorin3A in perineuronal nets during structural plasticity in the adult cerebellum. Mol. Cell. Neurosci. 2013, 57:10-22.
29. Carulli D., Foscarin S., Faralli A., Pajaj E., Rossi F. Modulation of semaphorin3A in perineuronal nets during structural plasticity in the adult cerebellum. Mol. Cell. Neurosci. 2013, 57C:10-22.
30. Caterson B. Fell-Muir Lecture: chondroitin sulphate glycosaminoglycans: fun for some and confusion for others. Int. J. Exp. Pathol. 2012, 93(1):1-10.
31. Celio M.R., Blumcke I. Perineuronal nets-a specialized form of extracellular matrix in the adult nervous system. Brain Res. Brain Res. Rev. 1994, 19(1):128-145.
32. Celio M.R., Spreafico R., De Biasi S., Vitellaro-Zuccarello L. Perineuronal nets: past and present. Trends Neurosci. 1998, 21(12):510-515.
33. Chang M.C., Park J.M., Pelkey K.A., Grabenstatter H.L., Xu D., Linden D.J., Sutula T.P., McBain C.J., Worley P.F. Narp regulates homeostatic scaling of excitatory synapses on parvalbumin-expressing interneurons. Nat. Neurosci. 2010, 13(9):1090-1097.
34. Chen Y., Beffert U., Ertunc M., Tang T.S., Kavalali E.T., Bezprozvanny I., Herz J. Reelin modulates NMDA receptor activity in cortical neurons. J. Neurosci. 2005, 25(36):8209-8216.
35. Chvatal A., Anderova M., Ziak D., Sykova E. Glial depolarization evokes a larger potassium accumulation around oligodendrocytes than around astrocytes in gray matter of rat spinal cord slices. J. Neurosci. Res. 1999, 56(5):493-505.
36. Cichon S., Muhleisen T.W., Degenhardt F.A., Mattheisen M., Miro X., Strohmaier J., Steffens M., Meesters C., Herms S., Weingarten M., Priebe L., Haenisch B., Alexander M., Vollmer J., Breuer R., Schmal C., Tessmann P., Moebus S., Wichmann H.E., Schreiber S., Muller-Myhsok B., Lucae S., Jamain S., Leboyer M., Bellivier F., Etain B., Henry C., Kahn J.P., Heath S., Hamshere M., O'Donovan M.C., Owen M.J., Craddock N., Schwarz M., Vedder H., Kammerer-Ciernioch J., Reif A., Sasse J., Bauer M., Hautzinger M., Wright A., Mitchell P.B., Schofield P.R., Montgomery G.W., Medland S.E., Gordon S.D., Martin N.G., Gustafsson O., Andreassen O., Djurovic S., Sigurdsson E., Steinberg S., Stefansson H., Stefansson K., Kapur-Pojskic L., Oruc L., Rivas F., Mayoral F., Chuchalin A., Babadjanova G., Tiganov A.S., Pantelejeva G., Abramova L.I., Grigoroiu-Serbanescu M., Diaconu C.C., Czerski P.M., Hauser J., Zimmer A., Lathrop M., Schulze T.G., Wienker T.F., Schumacher J., Maier W., Propping P., Rietschel M., Nothen M.M. Genome-wide association study identifies genetic variation in neurocan as a susceptibility factor for bipolar disorder. Am. J. Hum. Genet. 2011, 88(3):372-381.
37. Cingolani L.A., Thalhammer A., Yu L.M., Catalano M., Ramos T., Colicos M.A., Goda Y. Activity-dependent regulation of synaptic AMPA receptor composition and abundance by beta3 integrins. Neuron 2008, 58(5):749-762.
38. Corvetti L., Rossi F. Degradation of chondroitin sulfate proteoglycans induces sprouting of intact Purkinje axons in the cerebellum of the adult rat. J. Neurosci. 2005, 25(31):7150-7158.
39. Costa E., Davis J., Grayson D.R., Guidotti A., Pappas G.D., Pesold C. Dendritic spine hypoplasticity and downregulation of reelin and GABAergic tone in schizophrenia vulnerability. Neurobiol. Dis. 2001, 8(5):723-742.
40. Curran T., D'Arcangelo G. Role of reelin in the control of brain development. Brain Res. Brain Res. Rev. 1998, 26(2-3):285-294.
41. Deepa S.S., Carulli D., Galtrey C., Rhodes K., Fukuda J., Mikami T., Sugahara K., Fawcett J.W. Composition of perineuronal net extracellular matrix in rat brain: a different disaccharide composition for the net-associated proteoglycans. J. Biol. Chem. 2006, 281(26):17789-17800.
42. Dick G., Tan C.L., Alves J.N., Ehlert E.M., Miller G.M., Hsieh-Wilson L.C., Sugahara K., Oosterhof A., van Kuppevelt T.H., Verhaagen J., Fawcett J.W., Kwok J.C. Semaphorin 3A binds to the perineuronal nets via chondroitin sulfate type E motifs in rodent brains. J. Biol. Chem. 2013, 288(38):27384-27395.
43. Dityatev A., Rusakov D.A. Molecular signals of plasticity at the tetrapartite synapse. Curr. Opin. Neurobiol. 2011, 21(2):353-359.
44. Dityatev A., Schachner M. The extracellular matrix and synapses. Cell Tissue Res. 2006, 326(2):647-654.
45. Dityatev A., Frischknecht R., Seidenbecher C.I. Extracellular matrix and synaptic functions. Results Probl. Cell Differ. 2006, 43:69-97.
46. Dityatev A., Bruckner G., Dityateva G., Grosche J., Kleene R., Schachner M. Activity-dependent formation and functions of chondroitin sulfate-rich extracellular matrix of perineuronal nets. Dev. Neurobiol. 2007, 67(5):570-588.
47. Dityatev A., Schachner M., Sonderegger P. The dual role of the extracellular matrix in synaptic plasticity and homeostasis. Nat. Rev. Neurosci. 2010, 11(11):735-746.
48. Dow D.J., Huxley-Jones J., Hall J.M., Francks C., Maycox P.R., Kew J.N., Gloger I.S., Mehta N.A., Kelly F.M., Muglia P., Breen G., Jugurnauth S., Pederoso I., St Clair D., Rujescu D., Barnes M.R. ADAMTSL3 as a candidate gene for schizophrenia: gene sequencing and ultra-high density association analysis by imputation. Schizophr. Res. 2011, 127(1-3):28-34.
49. Eastwood S.L., Harrison P.J. Cellular basis of reduced cortical reelin expression in schizophrenia. Am. J. Psychiatry 2006, 163(3):540-542.
50. Eastwood S.L., Law A.J., Everall I.P., Harrison P.J. The axonal chemorepellant semaphorin 3A is increased in the cerebellum in schizophrenia and may contribute to its synaptic pathology. Mol. Psychiatry 2003, 8(2):148-155.
51. Faissner A., Pyka M., Geissler M., Sobik T., Frischknecht R., Gundelfinger E.D., Seidenbecher C. Contributions of astrocytes to synapse formation and maturation - potential functions of the perisynaptic extracellular matrix. Brain Res. Rev. 2010, 63(1-2):26-38.
52. Fatemi S.H. Reelin mutations in mouse and man: from reeler mouse to schizophrenia, mood disorders, autism and lissencephaly. Mol. Psychiatry 2001, 6(2):129-133.
53. Fatemi S.H. Reelin glycoprotein in autism and schizophrenia. Int. Rev. Neurobiol. 2005, 71:179-187.
54. Fawcett J. Molecular control of brain plasticity and repair. Prog. Brain Res. 2009, 175:501-509.
55. Fillman S.G., Cloonan N., Miller L.C., Weickert C.S. Markers of inflammation in the prefrontal cortex of individuals with schizophrenia. Mol. Psychiatry 2013, 18(2):133.
56. Fillman S.G., Sinclair D., Fung S.J., Webster M.J., Shannon Weickert C. Markers of inflammation and stress distinguish subsets of individuals with schizophrenia and bipolar disorder. Transl. Psychiatr. 2014, 4:e365.
57. Flashner B.M., Russo M.E., Boileau J.E., Leong D.W., Gallicano G.I. Epigenetic factors and autism spectrum disorders. Neruomol. Med. 2013, 15(2):339-350.
58. Folsom T.D., Fatemi S.H. The involvement of Reelin in neurodevelopmental disorders. Neuropharmacology 2013, 68:122-135.
59. Foster N.L., Mellott J.G., Schofield B.R. Perineuronal nets and GABAergic cells in the inferior colliculus of guinea pigs. Front. Neuroanat. 2014, 7:53.
60. Franco S.J., Muller U. Extracellular matrix functions during neuronal migration and lamination in the mammalian central nervous system. Dev. Neurobiol. 2011, 71(11):889-900.
61. Franklin S.L., Love S., Greene J.R., Betmouni S. Loss of perineuronal net in ME7 prion disease. J. Neuropathol. Exp. Neurol. 2008, 67(3):189-199.
62. Frischknecht R., Gundelfinger E.D. The brain's extracellular matrix and its role in synaptic plasticity. Adv. Exp. Med. Biol. 2012, 970:153-171.
63. Frischknecht R., Heine M., Perrais D., Seidenbecher C.I., Choquet D., Gundelfinger E.D. Brain extracellular matrix affects AMPA receptor lateral mobility and short-term synaptic plasticity. Nat. Neurosci. 2009, 12(7):897-904.
64. Frotscher M. Role for Reelin in stabilizing cortical architecture. Trends Neurosci. 2010, 33(9):407-414.
65. Frotscher M., Chai X., Bock H.H., Haas C.A., Forster E., Zhao S. Role of Reelin in the development and maintenance of cortical lamination. J. Neural Transm. 2009, 116(11):1451-1455.
66. Fung S.J., Fillman S.G., Webster M.J., Shannon Weickert C. Schizophrenia and bipolar disorder show both common and distinct changes in cortical interneuron markers. Schizophr. Res. 2014, 155(1-3):26-30.
67. Galtrey C.M., Fawcett J.W. The role of chondroitin sulfate proteoglycans in regeneration and plasticity in the central nervous system. Brain Res. Rev. 2007, 54(1):1-18.
68. Ganguly K., Rejmak E., Mikosz M., Nikolaev E., Knapska E., Kaczmarek L. Matrix metalloproteinase (MMP) 9 transcription in mouse brain induced by fear learning. J. Biol. Chem. 2013, 288(29):20978-20991.
69. Gati G., Lendvai D. The "dress" makes the neuron - different forms of the extracellular matrix in the central nervous system of vertebrates. Orv. Hetil. 2013, 154(27):1067-1073. (quiz 1078-1069).
70. Gawryluk J.W., Wang J.F., Andreazza A.C., Shao L., Young L.T. Decreased levels of glutathione, the major brain antioxidant, in post-mortem prefrontal cortex from patients with psychiatric disorders. Int. J. Neuropsychopharmacol. 2011, 14(1):123-130.
71. Giamanco K.A., Matthews R.T. Deconstructing the perineuronal net: cellular contributions and molecular composition of the neuronal extracellular matrix. Neuroscience 2012, 218:367-384.
72. Gogolla N., Caroni P., Luthi A., Herry C. Perineuronal nets protect fear memories from erasure. Science 2009, 325(5945):1258-1261.
73. Golgi C. Intorno alla struttura delle cellule nervose. Boll. Soc. Med. Chir. Pavia 1898, 1:1-14.
74. Gray E., Thomas T.L., Betmouni S., Scolding N., Love S. Elevated matrix metalloproteinase-9 and degradation of perineuronal nets in cerebrocortical multiple sclerosis plaques. J. Neuropathol. Exp. Neurol. 2008, 67(9):888-899.
75. Groszewska A., Kapelski P., Skibinska M., Hauser J. Family based association study of MMP-9 gene-1562C>T polymorphism in schizophrenia. Psychiatr. Pol. 2011, 45(3):317-324.
76. Guidotti A., Auta J., Davis J.M., Di-Giorgi-Gerevini V., Dwivedi Y., Grayson D.R., Impagnatiello F., Pandey G., Pesold C., Sharma R., Uzunov D., Costa E. Decrease in reelin and glutamic acid decarboxylase67 (GAD67) expression in schizophrenia and bipolar disorder: a postmortem brain study. Arch. Gen. Psychiatry 2000, 57(11):1061-1069.
77. Guidotti A., Auta J., Chen Y., Davis J.M., Dong E., Gavin D.P., Grayson D.R., Matrisciano F., Pinna G., Satta R., Sharma R.P., Tremolizzo L., Tueting P. Epigenetic GABAergic targets in schizophrenia and bipolar disorder. Neuropharmacology 2011, 60(7-8):1007-1016.
78. Gundelfinger E.D., Frischknecht R., Choquet D., Heine M. Converting juvenile into adult plasticity: a role for the brain's extracellular matrix. Eur. J. Neurosci. 2010, 31(12):2156-2165.
79. Hagihara K., Miura R., Kosaki R., Berglund E., Ranscht B., Yamaguchi Y. Immunohistochemical evidence for the brevican-tenascin-R interaction: colocalization in perineuronal nets suggests a physiological role for the interaction in the adult rat brain. J. Comp. Neurol. 1999, 410(2):256-264.
80. Hartig W., Brauer K., Bigl V., Bruckner G. Chondroitin sulfate proteoglycan-immunoreactivity of lectin-labeled perineuronal nets around parvalbumin-containing neurons. Brain Res. 1994, 635(1-2):307-311.
81. Hartig W., Bruckner G., Brauer K., Schmidt C., Bigl V. Allocation of perineuronal nets and parvalbumin-, calbindin-D28k- and glutamic acid decarboxylase-immunoreactivity in the amygdala of the rhesus monkey. Brain Res. 1995, 698(1-2):265-269.
82. Hartig W., Singer A., Grosche J., Brauer K., Ottersen O.P., Bruckner G. Perineuronal nets in the rat medial nucleus of the trapezoid body surround neurons immunoreactive for various amino acids, calcium-binding proteins and the potassium channel subunit Kv3.1b. Brain Res. 2001, 899(1-2):123-133.
83. Haunso A., Celio M.R., Margolis R.K., Menoud P.A. Phosphacan immunoreactivity is associated with perineuronal nets around parvalbumin-expressing neurones. Brain Res. 1999, 834(1-2):219-222.
84. Hayashi N., Tatsumi K., Okuda H., Yoshikawa M., Ishizaka S., Miyata S., Manabe T., Wanaka A. DACS, novel matrix structure composed of chondroitin sulfate proteoglycan in the brain. Biochem. Biophys. Res. Commun. 2007, 364(2):410-415.
85. Heckers S., Benes F. Hippocampus, III: GABA-containing cell bodies and GAD mRNA. Am. J. Psychiatry 2005, 162(3):450.
86. Heine M., Groc L., Frischknecht R., Beique J.C., Lounis B., Rumbaugh G., Huganir R.L., Cognet L., Choquet D. Surface mobility of postsynaptic AMPARs tunes synaptic transmission. Science 2008, 320(5873):201-205.
87. Hensch T.K. Critical period regulation. Annu. Rev. Neurosci. 2004, 27:549-579.
88. Hobohm C., Gunther A., Grosche J., Rossner S., Schneider D., Bruckner G. Decomposition and long-lasting downregulation of extracellular matrix in perineuronal nets induced by focal cerebral ischemia in rats. J. Neurosci. Res. 2005, 80(4):539-548.
89. Holt D.J., Kunkel L., Weiss A.P., Goff D.C., Wright C.I., Shin L.M., Rauch S.L., Hootnick J., Heckers S. Increased medial temporal lobe activation during the passive viewing of emotional and neutral facial expressions in schizophrenia. Schizophr. Res. 2006, 82(2-3):153-162.
90. Holt D.J., Lebron-Milad K., Milad M.R., Rauch S.L., Pitman R.K., Orr S.P., Cassidy B.S., Walsh J.P., Goff D.C. Extinction memory is impaired in schizophrenia. Biol. Psychiatry 2009, 65(6):455-463.
91. Holt D.J., Coombs G., Zeidan M.A., Goff D.C., Milad M.R. Failure of neural responses to safety cues in schizophrenia. Arch. Gen. Psychiatry 2012, 69(9):893-903.
92. Honda T., Kobayashi K., Mikoshiba K., Nakajima K. Regulation of cortical neuron migration by the Reelin signaling pathway. Neurochem. Res. 2011, 36(7):1270-1279.
93. Horvath S., Mirnics K. Immune system disturbances in schizophrenia. Biol. Psychiatry 2014, 75(4):316-323.
94. Impagnatiello F., Guidotti A.R., Pesold C., Dwivedi Y., Caruncho H., Pisu M.G., Uzunov D.P., Smalheiser N.R., Davis J.M., Pandey G.N., Pappas G.D., Tueting P., Sharma R.P., Costa E. A decrease of reelin expression as a putative vulnerability factor in schizophrenia. Proc. Natl. Acad. Sci. U. S. A. 1998, 95(26):15718-15723.
95. John N., Krugel H., Frischknecht R., Smalla K.H., Schultz C., Kreutz M.R., Gundelfinger E.D., Seidenbecher C.I. Brevican-containing perineuronal nets of extracellular matrix in dissociated hippocampal primary cultures. Mol. Cell. Neurosci. 2006, 31(4):774-784.
96. Karus M., Samtleben S., Busse C., Tsai T., Dietzel I.D., Faissner A., Wiese S. Normal sulphation levels regulate spinal cord neural precursor cell proliferation and differentiation. Neural Dev. 2012, 7(1):20.
97. Kim J.H., Richardson R. A developmental dissociation of context and GABA effects on extinguished fear in rats. Behav. Neurosci. 2007, 121(1):131-139.
98. Kim S., Webster M.J. Correlation analysis between genome-wide expression profiles and cytoarchitectural abnormalities in the prefrontal cortex of psychiatric disorders. Mol. Psychiatry 2010, 15(3):326-336.
99. Klausmeyer A., Conrad R., Faissner A., Wiese S. Influence of glial-derived matrix molecules, especially chondroitin sulfates, on neurite growth and survival of cultured mouse embryonic motoneurons. J. Neurosci. Res. 2011, 89(2):127-141.
100. Konradi C., Yang C.K., Zimmerman E.I., Lohmann K.M., Gresch P., Pantazopoulos H., Berretta S., Heckers S. Hippocampal interneurons are abnormal in schizophrenia. Schizophr. Res. 2011, 131(1-3):165-173.
101. Kurokawa T., Tsuda M., Sugino Y. Purification and characterization of a lectin from Wistaria floribunda seeds. J. Biol. Chem. 1976, 251(18):5686-5693.
102. Kwok J.C., Dick G., Wang D., Fawcett J.W. Extracellular matrix and perineuronal nets in CNS repair. Dev. Neurobiol. 2011, 71(11):1073-1089.
103. Lakatosova S., Ostatnikova D. Reelin and its complex involvement in brain development and function. Int. J. Biochem. Cell Biol. 2012, 44(9):1501-1504.
104. Lander C., Kind P., Maleski M., Hockfield S. A family of activity-dependent neuronal cell-surface chondroitin sulfate proteoglycans in cat visual cortex. J. Neurosci. 1997, 17(6):1928-1939.
105. Lee H., Leamey C.A., Sawatari A. Perineuronal nets play a role in regulating striatal function in the mouse. PLoS One 2012, 7(3):e32747.
106. Lewis D.A., Gonzalez-Burgos G. Neuroplasticity of neocortical circuits in schizophrenia. Neuropsychopharmacology 2008, 33(1):141-165.
107. Lin L.C., Sibille E. Reduced brain somatostatin in mood disorders: a common pathophysiological substrate and drug target?. Front. Pharmacol. 2013, 4:110.
108. Madinier A., Quattromani M.J., Sjolund C., Ruscher K., Wieloch T. Enriched housing enhances recovery of limb placement ability and reduces aggrecan-containing perineuronal nets in the rat somatosensory cortex after experimental stroke. PLoS One 2014, 9(3):e93121.
109. Maeda N. Structural variation of chondroitin sulfate and its roles in the central nervous system. Cent. Nerv. Syst. Agents Med. Chem. 2010, 10(1):22-31.
110. Manoach D.S., Press D.Z., Thangaraj V., Searl M.M., Goff D.C., Halpern E., Saper C.B., Warach S. Schizophrenic subjects activate dorsolateral prefrontal cortex during a working memory task, as measured by fMRI. Biol. Psychiatry 1999, 45(9):1128-1137.
111. Markota M., Pantazopolous H., Berretta S. Altered expression of TGF-beta1 in the amygdala of schizophrenic subjects. International Congress on Schizophrenia Research, Grand Lakes 2013, (Florida).
112. Matthews R.T., Kelly G.M., Zerillo C.A., Gray G., Tiemeyer M., Hockfield S. Aggrecan glycoforms contribute to the molecular heterogeneity of perineuronal nets. J. Neurosci. 2002, 22(17):7536-7547.
113. Mauney S.A., Athanas K.M., Pantazopoulos H., Shaskan N., Passeri E., Berretta S., Woo T.U. Developmental pattern of perineuronal nets in the human prefrontal cortex and their deficit in schizophrenia. Biol. Psychiatry 2013, 74(6):427-435.
114. McDonald A.J., Mascagni F. Differential expression of Kv3.1b and Kv3.2 potassium channel subunits in interneurons of the basolateral amygdala. Neuroscience 2006, 138(2):537-547.
115. McGrath L.M., Cornelis M.C., Lee P.H., Robinson E.B., Duncan L.E., Barnett J.H., Huang J., Gerber G., Sklar P., Sullivan P., Perlis R.H., Smoller J.W. Genetic predictors of risk and resilience in psychiatric disorders: a cross-disorder genome-wide association study of functional impairment in major depressive disorder, bipolar disorder, and schizophrenia. Am. J. Med. Genet. B Neuropsychiatr. Genet. 2013, 162:779-788.
116. McRae P.A., Porter B.E. The perineuronal net component of the extracellular matrix in plasticity and epilepsy. Neurochem. Int. 2012, 61(7):963-972.
117. McRae P.A., Rocco M.M., Kelly G., Brumberg J.C., Matthews R.T. Sensory deprivation alters aggrecan and perineuronal net expression in the mouse barrel cortex. J. Neurosci. 2007, 27(20):5405-5413.
118. Medina-Flores R., Wang G., Bissel S.J., Murphey-Corb M., Wiley C.A. Destruction of extracellular matrix proteoglycans is pervasive in simian retroviral neuroinfection. Neurobiol. Dis. 2004, 16(3):604-616.
119. Miyata S., Komatsu Y., Yoshimura Y., Taya C., Kitagawa H. Persistent cortical plasticity by upregulation of chondroitin 6-sulfation. Nat. Neurosci. 2012, 15(3):414-422. (S411-412).
120. Morawski M., Bruckner M.K., Riederer P., Bruckner G., Arendt T. Perineuronal nets potentially protect against oxidative stress. Exp. Neurol. 2004, 188(2):309-315.
121. Morris N.P., Henderson Z. Perineuronal nets ensheath fast spiking, parvalbumin-immunoreactive neurons in the medial septum/diagonal band complex. Eur. J. Neurosci. 2000, 12(3):828-838.
122. Muhleisen T.W., Mattheisen M., Strohmaier J., Degenhardt F., Priebe L., Schultz C.C., Breuer R., Meier S., Hoffmann P., Rivandeneira F., Hofman A., Uitterlinden A.G., Moebus S., Gieger C., Emeny R., Ladwig K.H., Wichmann H.E., Schwarz M., Kammerer-Ciernioch J., Schlosser R.G., Nenadic I., Sauer H., Mossner R., Maier W., Rujescu D., Lange C., Ophoff R.A., Schulze T.G., Rietschel M., Nothen M.M., Cichon S. Association between schizophrenia and common variation in neurocan (NCAN), a genetic risk factor for bipolar disorder. Schizophr. Res. 2012, 138(1):69-73.
123. Muir E.M., Adcock K.H., Morgenstern D.A., Clayton R., von Stillfried N., Rhodes K., Ellis C., Fawcett J.W., Rogers J.H. Matrix metalloproteases and their inhibitors are produced by overlapping populations of activated astrocytes. Brain Res. Mol. Brain Res. 2002, 100(1-2):103-117.
124. Nagy V., Bozdagi O., Huntley G.W. The extracellular protease matrix metalloproteinase-9 is activated by inhibitory avoidance learning and required for long-term memory. Learn. Mem. 2007, 14(10):655-664.
125. Nakamura H., Fujii Y., Inoki I., Sugimoto K., Tanzawa K., Matsuki H., Miura R., Yamaguchi Y., Okada Y. Brevican is degraded by matrix metalloproteinases and aggrecanase-1 (ADAMTS4) at different sites. J. Biol. Chem. 2000, 275(49):38885-38890.
126. Nakamura M., Nakano K., Morita S., Nakashima T., Oohira A., Miyata S. Expression of chondroitin sulfate proteoglycans in barrel field of mouse and rat somatosensory cortex. Brain Res. 2009, 1252:117-129.
127. Nowicka D., Soulsby S., Skangiel-Kramska J., Glazewski S. Parvalbumin-containing neurons, perineuronal nets and experience-dependent plasticity in murine barrel cortex. Eur. J. Neurosci. 2009, 30(11):2053-2063.
128. Ojima H., Sakai M., Ohyama J. Molecular heterogeneity of Vicia villosa-recognized perineuronal nets surrounding pyramidal and nonpyramidal neurons in the guinea pig cerebral cortex. Brain Res. 1998, 786(1-2):274-280.
129. Pantazopoulos H., Markota M., Jaquet F., Ghosh D., Wallin A., Santos A., Caterson B., Berretta S. Aggrecan and chondroitin-6-sulfate abnormalities in schizophrenia and bipolar disorder: a postmortem study on the amygdala. Transl. Psychiatr. 2015, (in press).
130. Pantazopoulos H., Lange N., Hassinger L., Berretta S. Subpopulations of neurons expressing parvalbumin in the human amygdala. J. Comp. Neurol. 2006, 496(5):706-722.
131. Pantazopoulos H., Woo T.-U.W., Lim M.P., Lange N., Berretta S. Extracellular matrix-glial abnormalities in the amygdala and entorhinal cortex of subjects diagnosed with schizophrenia. Arch. Gen. Psychiatry 2010, 67(2):155-166.
132. Penn A.A. Early brain wiring: activity-dependent processes. Schizophr. Bull. 2001, 27(3):337-347.
133. Pesold C., Liu W.S., Guidotti A., Costa E., Caruncho H.J. Cortical bitufted, horizontal, and Martinotti cells preferentially express and secrete reelin into perineuronal nets, nonsynaptically modulating gene expression. Proc. Natl. Acad. Sci. U. S. A. 1999, 96(6):3217-3222.
134. Pietersen C.Y., Mauney S.A., Kim S.S., Lim M.P., Rooney R.J., Goldstein J.M., Petryshen T.L., Seidman L.J., Shenton M.E., McCarley R.W., Sonntag K.C., Woo T.U. Molecular profiles of pyramidal neurons in the superior temporal cortex in schizophrenia. J. Neurogenet. 2014, 28(1-2):53-69.
135. Pizzorusso T., Medini P., Berardi N., Chierzi S., Fawcett J.W., Maffei L. Reactivation of ocular dominance plasticity in the adult visual cortex. Science 2002, 298(5596):1248-1251.
136. Porter S., Clark I.M., Kevorkian L., Edwards D.R. The ADAMTS metalloproteinases. Biochem. J. 2005, 386(Pt 1):15-27.
137. Pyka M., Busse C., Seidenbecher C., Gundelfinger E.D., Faissner A. Astrocytes are crucial for survival and maturation of embryonic hippocampal neurons in a neuron-glia cell-insert coculture assay. Synapse 2011, 65(1):41-53.
138. Racz E., Gaal B., Kecskes S., Matesz C. Molecular composition of extracellular matrix in the vestibular nuclei of the rat. Brain Struct. Funct. 2014, 219(4):1385-1403.
139. Rauch A.V., Reker M., Ohrmann P., Pedersen A., Bauer J., Dannlowski U., Harding L., Koelkebeck K., Konrad C., Kugel H., Arolt V., Heindel W., Suslow T. Increased amygdala activation during automatic processing of facial emotion in schizophrenia. Psychiatry Res. 2010, 182(3):200-206.
140. Ripke S., Schizophrenia Working Group of the Psychiatric Genomics, C Biological insights from 108 schizophrenia-associated genetic loci. Nature 2014, 511(7510):421-427.
141. Ripke S., Consortium, T.S.P.G.-W.A.S Genome-wide association study identifies five new schizophrenia loci. Nat. Genet. 2011, 43(10):969-976.
142. Ripke S., O'Dushlaine C., Chambert K., Moran J.L., Kahler A.K., Akterin S., Bergen S.E., Collins A.L., Crowley J.J., Fromer M., Kim Y., Lee S.H., Magnusson P.K., Sanchez N., Stahl E.A., Williams S., Wray N.R., Xia K., Bettella F., Borglum A.D., Bulik-Sullivan B.K., Cormican P., Craddock N., de Leeuw C., Durmishi N., Gill M., Golimbet V., Hamshere M.L., Holmans P., Hougaard D.M., Kendler K.S., Lin K., Morris D.W., Mors O., Mortensen P.B., Neale B.M., O'Neill F.A., Owen M.J., Milovancevic M.P., Posthuma D., Powell J., Richards A.L., Riley B.P., Ruderfer D., Rujescu D., Sigurdsson E., Silagadze T., Smit A.B., Stefansson H., Steinberg S., Suvisaari J., Tosato S., Verhage M., Walters J.T., Levinson D.F., Gejman P.V., Kendler K.S., Laurent C., Mowry B.J., O'Donovan M.C., Owen M.J., Pulver A.E., Riley B.P., Schwab S.G., Wildenauer D.B., Dudbridge F., Holmans P., Shi J., Albus M., Alexander M., Campion D., Cohen D., Dikeos D., Duan J., Eichhammer P., Godard S., Hansen M., Lerer F.B., Liang K.Y., Maier W., Mallet J., Nertney D.A., Nestadt G., Norton N., O'Neill F.A., Papadimitriou G.N., Ribble R., Sanders A.R., Silverman J.M., Walsh D., Williams N.M., Wormley B., Arranz M.J., Bakker S., Bender S., Bramon E., Collier D., Crespo-Facorro B., Hall J., Iyegbe C., Jablensky A., Kahn R.S., Kalaydjieva L., Lawrie S., Lewis C.M., Lin K., Linszen D.H., Mata I., McIntosh A., Murray R.M., Ophoff R.A., Powell J., Rujescu D., Van Os J., Walshe M., Weisbrod M., Wiersma D., Donnelly P., Barroso I., Blackwell J.M., Bramon E., Brown M.A., Casas J.P., Corvin A.P., Deloukas P., Duncanson A., Jankowski J., Markus H.S., Mathew C.G., Palmer C.N., Plomin R., Rautanen A., Sawcer S.J., Trembath R.C., Viswanathan A.C., Wood N.W., Spencer C.C., Band G., Bellenguez C., Freeman C., Hellenthal G., Giannoulatou E., Pirinen M., Pearson R.D., Strange A., Su Z., Vukcevic D., Donnelly P., Langford C., Hunt S.E., Edkins S., Gwilliam R., Blackburn H., Bumpstead S.J., Dronov S., Gillman M., Gray E., Hammond N., Jayakumar A., McCann O.T., Liddle J., Potter S.C., Ravindrarajah R., Ricketts M., Tashakkori-Ghanbaria A., Waller M.J., Weston P., Widaa S., Whittaker P., Barroso I., Deloukas P., Mathew C.G., Blackwell J.M., Brown M.A., Corvin A.P., McCarthy M.I., Spencer C.C., Bramon E., Corvin A.P., O'Donovan M.C., Stefansson K., Scolnick E., Purcell S., McCarroll S.A., Sklar P., Hultman C.M., Sullivan P.F. Genome-wide association analysis identifies 13 new risk loci for schizophrenia. Nat. Genet. 2013, 45:1150-1159.
143. Rivera S., Khrestchatisky M., Kaczmarek L., Rosenberg G.A., Jaworski D.M. Metzincin proteases and their inhibitors: foes or friends in nervous system physiology?. J. Neurosci. 2010, 30(46):15337-15357.
144. Rybakowski J.K., Skibinska M., Leszczynska-Rodziewicz A., Kaczmarek L., Hauser J. Matrix metalloproteinase-9 gene and bipolar mood disorder. Neruomol. Med. 2009, 11(2):128-132.
145. Saetre P., Emilsson L., Axelsson E., Kreuger J., Lindholm E., Jazin E. Inflammation-related genes up-regulated in schizophrenia brains. BMC Psychiatr. 2007, 7:46.
146. Saitoh Y., Matsui F., Chiba Y., Kawamura N., Keino H., Satoh M., Kumagai N., Ishii S., Yoshikawa K., Shimada A., Maeda N., Oohira A., Hosokawa M. Reduced expression of MAb6B4 epitopes on chondroitin sulfate proteoglycan aggrecan in perineuronal nets from cerebral cortices of SAMP10 mice: a model for age-dependent neurodegeneration. J. Neurosci. Res. 2008, 86(6):1316-1323.
147. Seeger G., Brauer K., Hartig W., Bruckner G. Mapping of perineuronal nets in the rat brain stained by colloidal iron hydroxide histochemistry and lectin cytochemistry. Neuroscience 1994, 58(2):371-388.
148. Seeger G., Luth H.J., Winkelmann E., Brauer K. Distribution patterns of Wisteria floribunda agglutinin binding sites and parvalbumin-immunoreactive neurons in the human visual cortex: a double-labelling study. J. Hirnforsch. 1996, 37(3):351-366.
149. Shah A., Lodge D.J. A loss of hippocampal perineuronal nets produces deficits in dopamine system function: relevance to the positive symptoms of schizophrenia. Transl. Psychiatr. 2013, 3:e215.
150. Sinagra M., Verrier D., Frankova D., Korwek K.M., Blahos J., Weeber E.J., Manzoni O.J., Chavis P. Reelin, very-low-density lipoprotein receptor, and apolipoprotein E receptor 2 control somatic NMDA receptor composition during hippocampal maturation in vitro. J. Neurosci. 2005, 25(26):6127-6136.
151. Smith G.M., Strunz C. Growth factor and cytokine regulation of chondroitin sulfate proteoglycans by astrocytes. Glia 2005, 52(3):209-218.
152. Smith S.E., Li J., Garbett K., Mirnics K., Patterson P.H. Maternal immune activation alters fetal brain development through interleukin-6. J. Neurosci. 2007, 27(40):10695-10702.
153. Sorrell J.M., Mahmoodian F., Caterson B. Immunochemical and biochemical comparisons between embryonic chick bone marrow and epiphyseal cartilage chondroitin/dermatan sulphate proteoglycans. J. Cell Sci. 1988, 91(Pt 1):81-90.
154. Spencer K.M. Visual gamma oscillations in schizophrenia: implications for understanding neural circuitry abnormalities. Clin. EEG Neurosci. 2008, 39(2):65-68.
155. Spreafico R., De Biasi S., Vitellaro-Zuccarello L. The perineuronal net: a weapon for a challenge. J. Hist. Neurosci. 1999, 8(2):179-185.
156. Stranahan A.M., Erion J.R., Wosiski-Kuhn M. Reelin signaling in development, maintenance, and plasticity of neural networks. Ageing Res. Rev. 2013, 12(3):815-822.
157. Sturman D.A., Moghaddam B. The neurobiology of adolescence: changes in brain architecture, functional dynamics, and behavioral tendencies. Neurosci. Biobehav. Rev. 2011, 35(8):1704-1712.
158. Suslow T., Lindner C., Dannlowski U., Walhofer K., Rodiger M., Maisch B., Bauer J., Ohrmann P., Lencer R., Zwitserlood P., Kersting A., Heindel W., Arolt V., Kugel H. Automatic amygdala response to facial expression in schizophrenia: initial hyperresponsivity followed by hyporesponsivity. BMC Neurosci. 2013, 14:140.
159. Suttkus A., Rohn S., Weigel S., Glockner P., Arendt T., Morawski M. Aggrecan, link protein and tenascin-R are essential components of the perineuronal net to protect neurons against iron-induced oxidative stress. Cell Death Dis. 2014, 5:e1119.
160. Sykova E., Nicholson C. Diffusion in brain extracellular space. Physiol. Rev. 2008, 88(4):1277-1340.
161. Takesian A.E., Hensch T.K. Balancing plasticity/stability across brain development. Prog. Brain Res. 2013, 207:3-34.
162. Tauchi R., Imagama S., Natori T., Ohgomori T., Muramoto A., Shinjo R., Matsuyama Y., Ishiguro N., Kadomatsu K. The endogenous proteoglycan-degrading enzyme ADAMTS-4 promotes functional recovery after spinal cord injury. J. Neuroinflammation 2012, 9:53.
163. Taylor S.F., Phan K.L., Britton J.C., Liberzon I. Neural response to emotional salience in schizophrenia. Neuropsychopharmacology 2005, 30(5):984-995.
164. Thorne R.G., Nicholson C. In vivo diffusion analysis with quantum dots and dextrans predicts the width of brain extracellular space. Proc. Natl. Acad. Sci. U. S. A. 2006, 103(14):5567-5572.
165. Uhlhaas P.J., Singer W. Abnormal neural oscillations and synchrony in schizophrenia. Nat. Rev. Neurosci. 2010, 11(2):100-113.
166. Van Hove I., Lemmens K., Van de Velde S., Verslegers M., Moons L. Matrix metalloproteinase-3 in the central nervous system: a look on the bright side. J. Neurochem. 2012, 123(2):203-216.
167. Vitellaro-Zuccarello L., De Biasi S., Spreafico R. One hundred years of Golgi's "perineuronal net": history of a denied structure. Ital. J. Neurol. Sci. 1998, 19(4):249-253.
168. Vo T., Carulli D., Ehlert E.M., Kwok J.C., Dick G., Mecollari V., Moloney E.B., Neufeld G., de Winter F., Fawcett J.W., Verhaagen J. The chemorepulsive axon guidance protein semaphorin3A is a constituent of perineuronal nets in the adult rodent brain. Mol. Cell. Neurosci. 2013, 56C:186-200.
169. Vo T., Carulli D., Ehlert E.M., Kwok J.C., Dick G., Mecollari V., Moloney E.B., Neufeld G., de Winter F., Fawcett J.W., Verhaagen J. The chemorepulsive axon guidance protein semaphorin3A is a constituent of perineuronal nets in the adult rodent brain. Mol. Cell. Neurosci. 2013, 56:186-200.
170. Volk D.W., Lewis D.A. Early developmental disturbances of cortical inhibitory neurons: contribution to cognitive deficits in schizophrenia. Schizophr. Bull. 2014, 40:1053-1061.
171. Volk D.W., Matsubara T., Li S., Sengupta E.J., Georgiev D., Minabe Y., Sampson A., Hashimoto T., Lewis D.A. Deficits in transcriptional regulators of cortical parvalbumin neurons in schizophrenia. Am. J. Psychiatry 2012, 169(10):1082-1091.
172. Wang H., Katagiri Y., McCann T.E., Unsworth E., Goldsmith P., Yu Z.X., Tan F., Santiago L., Mills E.M., Wang Y., Symes A.J., Geller H.M. Chondroitin-4-sulfation negatively regulates axonal guidance and growth. J. Cell Sci. 2008, 121(Pt 18):3083-3091.
173. Wang A.Y., Lohmann K.M., Yang C.K., Zimmerman E.I., Pantazopoulos H., Herring N., Berretta S., Heckers S., Konradi C. Bipolar disorder type 1 and schizophrenia are accompanied by decreased density of parvalbumin- and somatostatin-positive interneurons in the parahippocampal region. Acta Neuropathol. 2011, 122(5):615-626.
174. Wegner F., Hartig W., Bringmann A., Grosche J., Wohlfarth K., Zuschratter W., Bruckner G. Diffuse perineuronal nets and modified pyramidal cells immunoreactive for glutamate and the GABA(A) receptor alpha1 subunit form a unique entity in rat cerebral cortex. Exp. Neurol. 2003, 184(2):705-714.
175. Wiese S., Karus M., Faissner A. Astrocytes as a source for extracellular matrix molecules and cytokines. Front. Pharmacol. 2012, 3:120.
176. Wintergerst E.S., Faissner A., Celio M.R. The proteoglycan DSD-1-PG occurs in perineuronal nets around parvalbumin-immunoreactive interneurons of the rat cerebral cortex. Int. J. Dev. Neurosci. 1996, 14(3):249-255.
177. Woo T.U., Spencer K., McCarley R.W. Gamma oscillation deficits and the onset and early progression of schizophrenia. Harv. Rev. Psychiatr. 2010, 18(3):173-189.
178. Wright J.W., Harding J.W. Contributions of matrix metalloproteinases to neural plasticity, habituation, associative learning and drug addiction. Neural Plast. 2009, 2009:579382.
179. Wright J.W., Brown T.E., Harding J.W. Inhibition of hippocampal matrix metalloproteinase-3 and -9 disrupts spatial memory. Neural Plast. 2007, 2007:73813.
180. Xue Y.X., Xue L.F., Liu J.F., He J., Deng J.H., Sun S.C., Han H.B., Luo Y.X., Xu L.Z., Wu P., Lu L. Depletion of perineuronal nets in the amygdala to enhance the erasure of drug memories. J. Neurosci. 2014, 34(19):6647-6658.
181. Yamada J., Jinno S. Spatio-temporal differences in perineuronal net expression in the mouse hippocampus, with reference to parvalbumin. Neuroscience 2013, 253:368-379.
182. Yamaguchi Y. Lecticans: organizers of the brain extracellular matrix. Cell. Mol. Life Sci. 2000, 57(2):276-289.
183. Ye Q., Miao Q.L. Experience-dependent development of perineuronal nets and chondroitin sulfate proteoglycan receptors in mouse visual cortex. Matrix Biol. 2013, 32(6):352-363.
184. Yin Z.Q., Crewther S.G., Wang C., Crewther D.P. Pre- and post-critical period induced reduction of Cat-301 immunoreactivity in the lateral geniculate nucleus and visual cortex of cats Y-blocked as adults or made strabismic as kittens. Mol. Vis. 2006, 12:858-866.
185. Young N.M., Williams R.E. Assignment of lectins specific for d-galactose or N-acetyl-d-galactosamine to two groups, based on their circular dichroism. Can. J. Biochem. Cell Biol. 1985, 63(4):268-271.
186. Zuber B., Nikonenko I., Klauser P., Muller D., Dubochet J. The mammalian central nervous synaptic cleft contains a high density of periodically organized complexes. Proc. Natl. Acad. Sci. U. S. A. 2005, 102(52):19192-19197.