A highly sensitive assay of IRE1 activity using the small luciferase NanoLuc: Evaluation of ALS-related genetic and pathological factors

Biochemical and Biophysical Research Communications

Volumn 463, Issue 4, 2015, Pages 881-887

  Hikiji, Takahiro ^a   Norisada, Junpei ^a   Hirata, Yoko ^a   Okuda, Kensuke ^b   Nagasawa, Hideko ^b   Ishigaki, Shinsuke ^c   Sobue, Gen ^c   Kiuchi, Kazutoshi ^a   Oh Hashi, Kentaro ^a  

^a GIFU UNIVERSITY   (Japan)

^b GIFU PHARMACEUTICAL UNIVERSITY   (Japan)

^c NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

ER stress; IRE1; NanoLuc; XBP1

Indexed keywords

FIREFLY LUCIFERASE; GREEN FLUORESCENT PROTEIN; HOMOCYSTEINE; MUTANT PROTEIN; PROTEIN IRE1; SAR1 PROTEIN; UNCLASSIFIED DRUG; X BOX BINDING PROTEIN 1; DNA BINDING PROTEIN; ERN1 PROTEIN, HUMAN; PRIMER DNA; PROTEIN SERINE THREONINE KINASE; REGULATORY FACTOR X TRANSCRIPTION FACTORS; RIBONUCLEASE; TRANSCRIPTION FACTOR;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DISEASE COURSE; ENDOPLASMIC RETICULUM; ENZYME ACTIVATION; ENZYME ACTIVITY; EXTRACELLULAR SPACE; GENE OVEREXPRESSION; GOLGI COMPLEX; HEREDITY; HT 29 CELL LINE; HUMAN; HUMAN CELL; HYBRIDOMA CELL LINE; LUCIFERASE ASSAY; MOUSE; NEUROBLASTOMA CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; CELL LINE; GENETICS; METABOLISM; NUCLEOTIDE SEQUENCE; PATHOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

AMYOTROPHIC LATERAL SCLEROSIS; BASE SEQUENCE; CELL LINE; DNA PRIMERS; DNA-BINDING PROTEINS; ENDORIBONUCLEASES; HUMANS; LUCIFERASES, FIREFLY; PROTEIN-SERINE-THREONINE KINASES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSCRIPTION FACTORS;

EID: 84936890798     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2015.05.132     Document Type: Article

References (34)

1. M.J. Gething, and J. Sambrook Protein folding in the cell Nature 355 1992 33 45
2. A. Helenius, T. Marquardt, and I. Braakman The endoplasmic reticulum as a protein-folding compartment Trends Cell. Biol. 2 1992 227 231
3. H.P. Harding, Y. Zhang, and D. Ron Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase Nature 397 1999 271 274
4. M. Calfon, H. Zeng, F. Urano, J.H. Till, S.R. Hubbard, H.P. Harding, S.G. Clark, and D. Ron IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA Nature 415 2002 92 96
5. C. Zhu, F.E. Johansen, and R. Prywes Interaction of ATF6 and serum response factor Mol. Cell. Biol. 17 1997 4957-496
6. K. Haze, H. Yoshida, H. Yanagi, T. Yura, and K. Mori Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress Mol. Biol. Cell. 10 1999 3787 3799
7. M. Wang, R. Ye, E. Barron, P. Baumeister, C. Mao, S. Luo, Y. Fu, B. Luo, L. Dubeau, D.R. Hinton, and A.S. Lee Essential role of the unfolded protein response regulator GRP78/BiP in protection from neuronal apoptosis Cell. Death Differ. 17 2010 488 498
8. S. Oyadomari, and M. Mori Roles of CHOP/GADD153 in endoplasmic reticulum stress Cell. Death Differ. 11 2004 381 389
9. H. Yoshida, T. Matsui, A. Yamamoto, T. Okada, and K. Mori XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor Cell 107 2001 881 891
10. A.H. Lee, N.N. Iwakoshi, and L.H. Glimcher XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response Mol. Cell. Biol. 23 2003 7448 7459
11. A.M. Reimold, N.N. Iwakoshi, J. Manis, P. Vallabhajosyula, E. Szomolanyi-Tsuda, E.M. Gravallese, D. Friend, M.J. Grusby, F. Alt, and L.H. Glimcher Plasma cell differentiation requires the transcription factor XBP-1 Nature 412 2001 300 307
12. A.H. Lee, G.C. Chu, N.N. Iwakoshi, and L.H. Glimcher XBP-1 is required for biogenesis of cellular secretory machinery of exocrine glands EMBO J. 24 2005 4368 4380
13. A.H. Lee, E.F. Scapa, D.E. Cohen, and L.H. Glimcher Regulation of hepatic lipogenesis by the transcription factor XBP1 Science 320 2008 1492 1496
14. T. Iwawaki, and R. Akai Analysis of the XBP1 splicing mechanism using endoplasmic reticulum stress-indicators Biochem. Biophys. Res. Commun. 350 2006 709 715
15. T. Iwawaki, R. Akai, K. Kohno, and M. Miura A transgenic mouse model for monitoring endoplasmic reticulum stress Nat. Med. 10 2004 98 102
16. M.P. Hall, J. Unch, B.F. Binkowski, M.P. Valley, B.L. Butler, M.G. Wood, P. Otto, K. Zimmerman, G. Vidugiris, T. Machleidt, M.B. Robers, H.A. Benink, C.T. Eggers, M.R. Slater, P.L. Meisenheimer, D.H. Klaubert, F. Fan, L.P. Encell, and K.V. Wood Engineered luciferase reporter from a deep sea shrimp utilizing a novel imidazopyrazione substrate ACS Chem. Biol. 7 2012 1848 1857
17. J. Norisada, Y. Hirata, F. Amaya, K. Kiuchi, and K. Oh-hashi A sensitive assay for the biosynthesis and secretion of MANF using NanoLuc activity Biochem. Biophys. Res. Commun. 449 2014 483 489
18. D. Lindholm, H. Wootz, and L. Korhonen ER stress and neurodegenerative diseases Cell. Death Differ. 13 2006 385 392
19. S. Boillee, V.C. Vande, and D.W. Cleveland ALS: A disease of motor neurons and their nonneuronal neighbors Neuron 52 2006 39 59
20. F. Valentino, G. Bivona, D. Butera, P. Paladino, M. Fazzari, T. Piccoli, M. Ciaccio, and V. La Bella Elevated cerebrospinal fluid and plasma homocysteine levels in ALS Eur J. Neurol. 17 2010 84 89
21. H. Nishitoh, H. Kadowaki, A. Nagai, T. Maruyama, T. Yokota, H. Fukutomi, T. Noguchi, A. Matsuzawa, K. Takeda, and H. Ichijo ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1 Genes. Dev. 22 2008 1451 1464
22. Y.J. Zhang, T.F. Gendron, Y.F. Xu, L.W. Ko, S.H. Yen, and L. Petrucelli Phosphorylation regulates proteasomal-mediated degradation and solubility of TAR DNA binding protein-43 C-terminal fragments Mol. Neurodegener. 5 2010 33
23. C. Hetz, P. Thielen, S. Matus, M. Nassif, F. Court, R. Kiffin, G. Martinez, A.M. Cuervo, R.H. Brown, and L.H. Glimcher XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy Genes. Dev. 23 2009 2294 2306
24. M. Aridor, K.N. Fish, S. Bannykh, J. Weissman, T.H. Roberts, J. Lippincott-Schwartz, and W.E. Balch The Sar1 GTPase coordinates biosynthetic cargo selection with endoplasmic reticulum export site assembly J. Cell. Biol. 152 2001 213 229
25. D.J. Dupré, M. Robitaille, N. Éthier, L.R. Villeneuve, A.M. Mamarbachi, and T.E. Hébert Seven transmembrane receptor core signaling complexes are assembled prior to plasma membrane trafficking J. Biol. Chem. 281 2006 34561 34573
26. N.R. Cashman, H.D. Durham, J.K. Blusztajn, K. Oda, T. Tabira, I.T. Shaw, S. Dahrouge, and J.P. Antel Neuroblastoma x spinal cord (NSC) hybrid cell lines resemble developing motor neurons Dev. Dyn. 194 1992 209 221
27. K. Oh-hashi, H. Koga, S. Ikeda, K. Shimada, Y. Hirata, and K. Kiuchi CRELD2 is a novel endoplasmic reticulum stress-inducible gene Biochem. Biophys. Res. Commun. 387 2009 504 510
28. M.P. Mattson, and S.L. Chan Neuronal and glial calcium signaling in Alzheimer's disease Cell. Calcium 34 2003 385 397
29. I.J. Kruman, C. Culmsee, S.L. Chan, Y. Kruman, Z. Guo, L. Penix, and M.P. Mattson Homocysteine elicits a DNA damage response in neurons that promotes apoptosis and hypersensitivity to excitotoxicity J. Neurosci. 20 2000 6920 6926
30. E. Tamagno, G. Robino, A. Obbili, P. Bardini, M. Aragno, M. Parola, and O. Danni H2O2 and 4-hydroxynonenal mediate amyloid beta-induced neuronal apoptosis by activating JNKs and p38MAPK Exp. Neurol. 180 2003 144 155
31. S. Zoccolella, C. Bendotti, E. Beghi, and G. Logroscino Homocysteine levels and amyotrophic lateral sclerosis: A possible link Amyotroph. Lateral Scler. 11 2010 140 147
32. R. Obeid, and W. Herrmann Mechanisms of homocysteine neurotoxicity in neurodegenerative diseases with special reference to dementia FEBS Lett. 580 2006 2994 3005
33. J.D. Atkin, M.A. Farg, K.Y. Soo, A.K. Walker, M. Halloran, B.J. Turner, P. Nagley, and M.K. Horne Mutant SOD1 inhibits ER-Golgi transport in amyotrophic lateral sclerosis J. Neurochem. 129 2014 190 204
34. K. Homma, T. Fujisawa, N. Tsuburaya, N. Yamaguchi, H. Kadowaki, K. Takeda, H. Nishitoh, A. Matsuzawa, I. Naguro, and H. Ichijo SOD1 as a molecular switch for initiating the homeostatic ER stress response under zinc deficiency Mol. Cell. 52 2013 75 86