-
1
-
-
80054025654
-
The role of atg proteins in autophagosome formation
-
Mizushima, N., Yoshimori, T. & Ohsumi, Y. The role of Atg proteins in autophagosome formation. Annu. Rev. Cell Dev. Biol. 27, 107-132 (2011).
-
(2011)
Annu. Rev. Cell Dev. Biol
, vol.27
, pp. 107-132
-
-
Mizushima, N.1
Yoshimori, T.2
Ohsumi, Y.3
-
2
-
-
81055144784
-
Autophagy renovation of cells and tissues
-
Mizushima, N. & Komatsu, M. Autophagy: renovation of cells and tissues. Cell 147, 728-741 (2011).
-
(2011)
Cell
, vol.147
, pp. 728-741
-
-
Mizushima, N.1
Komatsu, M.2
-
3
-
-
39849109338
-
Autophagy fights disease through cellular self-digestion
-
Mizushima, N., Levine, B., Cuervo, A.M. & Klionsky, D.J. Autophagy fights disease through cellular self-digestion. Nature 451, 1069-1075 (2008).
-
(2008)
Nature
, vol.451
, pp. 1069-1075
-
-
Mizushima, N.1
Levine, B.2
Cuervo, A.M.3
Klionsky, D.J.4
-
4
-
-
41749114288
-
Autophagy basic principles and relevance to disease
-
Kundu, M. & Thompson, C.B. Autophagy: basic principles and relevance to disease. Annu. Rev. Pathol. 3, 427-455 (2008).
-
(2008)
Annu. Rev. Pathol
, vol.3
, pp. 427-455
-
-
Kundu, M.1
Thompson, C.B.2
-
5
-
-
67649467294
-
Dynamics and diversity in autophagy mechanisms: Lessons from yeast
-
Nakatogawa, H., Suzuki, K., Kamada, Y. & Ohsumi, Y. Dynamics and diversity in autophagy mechanisms: lessons from yeast. Nat. Rev. Mol. Cell Biol. 10, 458-467 (2009).
-
(2009)
Nat. Rev. Mol. Cell Biol
, vol.10
, pp. 458-467
-
-
Nakatogawa, H.1
Suzuki, K.2
Kamada, Y.3
Ohsumi, Y.4
-
6
-
-
84891747382
-
The machinery of macroautophagy
-
Feng, Y., He, D., Yao, Z. & Klionsky, D.J. The machinery of macroautophagy. Cell Res. 24, 24-41 (2014).
-
(2014)
Cell Res
, vol.24
, pp. 24-41
-
-
Feng, Y.1
He, D.2
Yao, Z.3
Klionsky, D.J.4
-
7
-
-
77951221542
-
The role of the atg1/ulk1 complex in autophagy regulation
-
Mizushima, N. The role of the Atg1/ULK1 complex in autophagy regulation. Curr. Opin. Cell Biol. 22, 132-139 (2010).
-
(2010)
Curr. Opin. Cell Biol
, vol.22
, pp. 132-139
-
-
Mizushima, N.1
-
8
-
-
84871581862
-
Architecture of the atg17 complex as a scaffold for autophagosome biogenesis
-
Ragusa, M.J., Stanley, R.E. & Hurley, J.H. Architecture of the Atg17 complex as a scaffold for autophagosome biogenesis. Cell 151, 1501-1512 (2012).
-
(2012)
Cell
, vol.151
, pp. 1501-1512
-
-
Ragusa, M.J.1
Stanley, R.E.2
Hurley, J.H.3
-
9
-
-
70349644856
-
Atg101, a novel mammalian autophagy protein interacting with atg13
-
Hosokawa, N. et al. Atg101, a novel mammalian autophagy protein interacting with Atg13. Autophagy 5, 973-979 (2009).
-
(2009)
Autophagy
, vol.5
, pp. 973-979
-
-
Hosokawa, N.1
-
10
-
-
67549110195
-
A novel, human atg13 binding protein, atg101, interacts with ulk1 and is essential for macroautophagy
-
Mercer, C.A., Kaliappan, A. & Dennis, P.B. A novel, human Atg13 binding protein, Atg101, interacts with ULK1 and is essential for macroautophagy. Autophagy 5, 649-662 (2009).
-
(2009)
Autophagy
, vol.5
, pp. 649-662
-
-
Mercer, C.A.1
Kaliappan, A.2
Dennis, P.B.3
-
11
-
-
77955884684
-
Characterization of autophagosome formation site by a hierarchical analysis of mammalian atg proteins
-
Itakura, E. & Mizushima, N. Characterization of autophagosome formation site by a hierarchical analysis of mammalian Atg proteins. Autophagy 6, 764-776 (2010).
-
(2010)
Autophagy
, vol.6
, pp. 764-776
-
-
Itakura, E.1
Mizushima, N.2
-
12
-
-
84857850213
-
Structures containing atg9a and the ulk1 complex independently target depolarized mitochondria at initial stages of parkin-mediated mitophagy
-
Itakura, E., Kishi-Itakura, C., Koyama-Honda, I. & Mizushima, N. Structures containing Atg9A and the ULK1 complex independently target depolarized mitochondria at initial stages of Parkin-mediated mitophagy. J. Cell Sci. 125, 1488-1499 (2012).
-
(2012)
J. Cell Sci
, vol.125
, pp. 1488-1499
-
-
Itakura, E.1
Kishi-Itakura, C.2
Koyama-Honda, I.3
Mizushima, N.4
-
13
-
-
33846514235
-
Hierarchy of atg proteins in pre-Autophagosomal structure organization
-
Suzuki, K., Kubota, Y., Sekito, T. & Ohsumi, Y. Hierarchy of Atg proteins in pre-Autophagosomal structure organization. Genes Cells 12, 209-218 (2007).
-
(2007)
Genes Cells
, vol.12
, pp. 209-218
-
-
Suzuki, K.1
Kubota, Y.2
Sekito, T.3
Ohsumi, Y.4
-
14
-
-
43149125546
-
Organization of the pre-Autophagosomal structure responsible for autophagosome formation
-
Kawamata, T., Kamada, Y., Kabeya, Y., Sekito, T. & Ohsumi, Y. Organization of the pre-Autophagosomal structure responsible for autophagosome formation. Mol. Biol. Cell 19, 2039-2050 (2008).
-
(2008)
Mol. Biol. Cell
, vol.19
, pp. 2039-2050
-
-
Kawamata, T.1
Kamada, Y.2
Kabeya, Y.3
Sekito, T.4
Ohsumi, Y.5
-
15
-
-
39449108917
-
The atg1 kinase complex is involved in the regulation of protein recruitment to initiate sequestering vesicle formation for nonspecific autophagy in saccharomyces cerevisiae
-
Cheong, H., Nair, U., Geng, J. & Klionsky, D.J. The Atg1 kinase complex is involved in the regulation of protein recruitment to initiate sequestering vesicle formation for nonspecific autophagy in Saccharomyces cerevisiae. Mol. Biol. Cell 19, 668-681 (2008).
-
(2008)
Mol. Biol. Cell
, vol.19
, pp. 668-681
-
-
Cheong, H.1
Nair, U.2
Geng, J.3
Klionsky, D.J.4
-
16
-
-
84925307913
-
Atg13 horma domain recruits atg9 vesicles during autophagosome formation
-
Suzuki, S.W. et al. Atg13 HORMA domain recruits Atg9 vesicles during autophagosome formation. Proc. Natl. Acad. Sci. USA 112, 3350-3355 (2015).
-
(2015)
Proc. Natl. Acad. Sci. USA
, vol.112
, pp. 3350-3355
-
-
Suzuki, S.W.1
-
17
-
-
84875834380
-
Horma domain in atg13 mediates pi 3-kinase recruitment in autophagy
-
Jao, C.C., Ragusa, M.J., Stanley, R.E. & Hurley, J.H.A. HORMA domain in Atg13 mediates PI 3-kinase recruitment in autophagy. Proc. Natl. Acad. Sci. USA 110, 5486-5491 (2013).
-
(2013)
Proc. Natl. Acad. Sci. USA
, vol.110
, pp. 5486-5491
-
-
Jao, C.C.1
Ragusa, M.J.2
Stanley, R.E.3
Hurley, J.H.A.4
-
18
-
-
84901986623
-
Structural basis of starvation-induced assembly of the autophagy initiation complex
-
Fujioka, Y. et al. Structural basis of starvation-induced assembly of the autophagy initiation complex. Nat. Struct. Mol. Biol. 21, 513-521 (2014).
-
(2014)
Nat. Struct. Mol. Biol
, vol.21
, pp. 513-521
-
-
Fujioka, Y.1
-
19
-
-
84884658187
-
Global analysis of fission yeast mating genes reveals new autophagy factors
-
Sun, L.L. et al. Global analysis of fission yeast mating genes reveals new autophagy factors. PLoS Genet. 9, e1003715 (2013).
-
(2013)
PLoS Genet
, vol.9
, pp. e1003715
-
-
Sun, L.L.1
-
20
-
-
0032134044
-
The horma domain: A common structural denominator in mitotic checkpoints, chromosome synapsis and DNA repair
-
Aravind, L. & Koonin, E.V. The HORMA domain: a common structural denominator in mitotic checkpoints, chromosome synapsis and DNA repair. Trends Biochem. Sci. 23, 284-286 (1998).
-
(1998)
Trends Biochem. Sci
, vol.23
, pp. 284-286
-
-
Aravind, L.1
Koonin, E.V.2
-
21
-
-
84901792768
-
The putative horma domain protein atg101 dimerizes and is required for starvation-induced and selective autophagy in drosophila
-
Hegeduş, K., Nagy, P., Gaspari, Z. & Juhasz, G. The putative HORMA domain protein Atg101 dimerizes and is required for starvation-induced and selective autophagy in Drosophila. Biomed Res. Int. 2014, 470482 (2014).
-
(2014)
Biomed Res. Int
, vol.2014
, pp. 470482
-
-
Hegeduş, K.1
Nagy, P.2
Gaspari, Z.3
Juhasz, G.4
-
22
-
-
56649103902
-
Searching protein structure databases with dalilite v.3
-
Holm, L., Kaariainen, S., Rosenstrom, P. & Schenkel, A. Searching protein structure databases with DaliLite v.3. Bioinformatics 24, 2780-2781 (2008).
-
(2008)
Bioinformatics
, vol.24
, pp. 2780-2781
-
-
Holm, L.1
Kaariainen, S.2
Rosenstrom, P.3
Schenkel, A.4
-
23
-
-
36049044125
-
The mad2 conformational dimer: Structure and implications for the spindle assembly checkpoint
-
Mapelli, M., Massimiliano, L., Santaguida, S. & Musacchio, A. The Mad2 conformational dimer: structure and implications for the spindle assembly checkpoint. Cell 131, 730-743 (2007).
-
(2007)
Cell
, vol.131
, pp. 730-743
-
-
Mapelli, M.1
Massimiliano, L.2
Santaguida, S.3
Musacchio, A.4
-
24
-
-
55249120526
-
Protein metamorphosis: The two-state behavior of mad2
-
Luo, X. & Yu, H. Protein metamorphosis: the two-state behavior of Mad2. Structure 16, 1616-1625 (2008).
-
(2008)
Structure
, vol.16
, pp. 1616-1625
-
-
Luo, X.1
Yu, H.2
-
25
-
-
0343986407
-
Structure of the mad2 spindle assembly checkpoint protein and its interaction with cdc20
-
Luo, X. et al. Structure of the Mad2 spindle assembly checkpoint protein and its interaction with Cdc20. Nat. Struct. Biol. 7, 224-229 (2000).
-
(2000)
Nat. Struct. Biol
, vol.7
, pp. 224-229
-
-
Luo, X.1
-
26
-
-
0036161468
-
The mad2 spindle checkpoint protein undergoes similar major conformational changes upon binding to either mad1 or cdc20
-
Luo, X., Tang, Z., Rizo, J. & Yu, H. The Mad2 spindle checkpoint protein undergoes similar major conformational changes upon binding to either Mad1 or Cdc20. Mol. Cell 9, 59-71 (2002).
-
(2002)
Mol. Cell
, vol.9
, pp. 59-71
-
-
Luo, X.1
Tang, Z.2
Rizo, J.3
Yu, H.4
-
27
-
-
0037093326
-
Crystal structure of the tetrameric mad1-mad2 core complex: Implications of a şafety belt? Binding mechanism for the spindle checkpoint
-
Sironi, L. et al. Crystal structure of the tetrameric Mad1-Mad2 core complex: implications of a şafety belt? binding mechanism for the spindle checkpoint. EMBO J. 21, 2496-2506 (2002).
-
(2002)
EMBO J
, vol.21
, pp. 2496-2506
-
-
Sironi, L.1
-
28
-
-
75749122303
-
Methods in mammalian autophagy research
-
Mizushima, N., Yoshimori, T. & Levine, B. Methods in mammalian autophagy research. Cell 140, 313-326 (2010).
-
(2010)
Cell
, vol.140
, pp. 313-326
-
-
Mizushima, N.1
Yoshimori, T.2
Levine, B.3
-
29
-
-
84924407537
-
Applications of flow cytometry for measurement of autophagy
-
Demishtein, A., Porat, Z., Elazar, Z. & Shvets, E. Applications of flow cytometry for measurement of autophagy. Methods 75, 87-95 (2015).
-
(2015)
Methods
, vol.75
, pp. 87-95
-
-
Demishtein, A.1
Porat, Z.2
Elazar, Z.3
Shvets, E.4
-
30
-
-
43149090064
-
Fip200, a ulk-interacting protein, is required for autophagosome formation in mammalian cells
-
Hara, T. et al. FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells. J. Cell Biol. 181, 497-510 (2008).
-
(2008)
J. Cell Biol
, vol.181
, pp. 497-510
-
-
Hara, T.1
-
31
-
-
78651282673
-
P62 targeting to the autophagosome formation site requires self-oligomerization but not lc3 binding
-
Itakura, E. & Mizushima, N. p62 targeting to the autophagosome formation site requires self-oligomerization but not LC3 binding. J. Cell Biol. 192, 17-27 (2011).
-
(2011)
J. Cell Biol
, vol.192
, pp. 17-27
-
-
Itakura, E.1
Mizushima, N.2
-
32
-
-
0034329418
-
Lc3, a mammalian homologue of yeast apg8p, is localized in autophagosome membranes after processing
-
Kabeya, Y. et al. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J. 19, 5720-5728 (2000).
-
(2000)
EMBO J
, vol.19
, pp. 5720-5728
-
-
Kabeya, Y.1
-
33
-
-
84921366480
-
Wipi proteins: Essential ptdins3p effectors at the nascent autophagosome
-
Proikas-Cezanne, T., Takacs, Z., Donnes, P. & Kohlbacher, O. WIPI proteins: essential PtdIns3P effectors at the nascent autophagosome. J. Cell Sci. 128, 207-217 (2015).
-
(2015)
J. Cell Sci
, vol.128
, pp. 207-217
-
-
Proikas-Cezanne, T.1
Takacs, Z.2
Donnes, P.3
Kohlbacher, O.4
-
34
-
-
50249084987
-
Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum
-
Axe, E.L. et al. Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum. J. Cell Biol. 182, 685-701 (2008).
-
(2008)
J. Cell Biol
, vol.182
, pp. 685-701
-
-
Axe, E.L.1
-
35
-
-
53049102656
-
The atg18-Atg2 complex is recruited to autophagic membranes via phosphatidylinositol 3-phosphate and exerts an essential function
-
Obara, K., Sekito, T., Niimi, K. & Ohsumi, Y. The Atg18-Atg2 complex is recruited to autophagic membranes via phosphatidylinositol 3-phosphate and exerts an essential function. J. Biol. Chem. 283, 23972-23980 (2008).
-
(2008)
J. Biol. Chem
, vol.283
, pp. 23972-23980
-
-
Obara, K.1
Sekito, T.2
Niimi, K.3
Ohsumi, Y.4
-
36
-
-
79953765276
-
Presenting your structures: The ccp4mg molecular-graphics software
-
McNicholas, S., Potterton, E., Wilson, K.S. & Noble, M.E. Presenting your structures: the CCP4mg molecular-graphics software. Acta Crystallogr. D Biol. Crystallogr. 67, 386-394 (2011).
-
(2011)
Acta Crystallogr. D Biol. Crystallogr
, vol.67
, pp. 386-394
-
-
McNicholas, S.1
Potterton, E.2
Wilson, K.S.3
Noble, M.E.4
-
37
-
-
0014432781
-
Solvent content of protein crystals
-
Matthews, B.W. Solvent content of protein crystals. J. Mol. Biol. 33, 491-497 (1968).
-
(1968)
J. Mol. Biol
, vol.33
, pp. 491-497
-
-
Matthews, B.W.1
-
38
-
-
0031059866
-
Processing of x-ray diffraction data collected in oscillation mode
-
Otwinowski, Z. & Minor, W. Processing of X-ray diffraction data collected in oscillation mode. Methods Enzymol. 276, 307-326 (1997).
-
(1997)
Methods Enzymol
, vol.276
, pp. 307-326
-
-
Otwinowski, Z.1
Minor, W.2
-
39
-
-
76449098262
-
Phenix: A comprehensive python-based system for macromolecular structure solution
-
Adams, P.D. et al. PHENIX: a comprehensive Python-based system for macromolecular structure solution. Acta Crystallogr. D Biol. Crystallogr. 66, 213-221 (2010).
-
(2010)
Acta Crystallogr. D Biol. Crystallogr
, vol.66
, pp. 213-221
-
-
Adams, P.D.1
-
41
-
-
0030924992
-
Refinement of macromolecular structures by the maximum-likelihood method
-
Murshudov, G.N., Vagin, A.A. & Dodson, E.J. Refinement of macromolecular structures by the maximum-likelihood method. Acta Crystallogr. D Biol. Crystallogr. 53, 240-255 (1997).
-
(1997)
Acta Crystallogr. D Biol. Crystallogr
, vol.53
, pp. 240-255
-
-
Murshudov, G.N.1
Vagin, A.A.2
Dodson, E.J.3
-
42
-
-
79953737180
-
Overview of the ccp4 suite and current developments
-
Winn, M.D. et al. Overview of the CCP4 suite and current developments. Acta Crystallogr. D Biol. Crystallogr. 67, 235-242 (2011).
-
(2011)
Acta Crystallogr. D Biol. Crystallogr
, vol.67
, pp. 235-242
-
-
Winn, M.D.1
-
43
-
-
3543012707
-
Crystallography & nmr system: A new software suite for macromolecular structure determination
-
Brünger, A.T. et al. Crystallography & NMR system: a new software suite for macromolecular structure determination. Acta Crystallogr. D Biol. Crystallogr. 54, 905-921 (1998).
-
(1998)
Acta Crystallogr. D Biol. Crystallogr
, vol.54
, pp. 905-921
-
-
Brünger, A.T.1
-
44
-
-
0037441653
-
Structure validation by calpha geometry: Phi, psi and cbeta deviation
-
Lovell, S.C. et al. Structure validation by Calpha geometry: phi, psi and Cbeta deviation. Proteins 50, 437-450 (2003).
-
(2003)
Proteins
, vol.50
, pp. 437-450
-
-
Lovell, S.C.1
-
45
-
-
0142227052
-
Retrovirus-mediated gene transfer and expression cloning: Powerful tools in functional genomics
-
Kitamura, T. et al. Retrovirus-mediated gene transfer and expression cloning: powerful tools in functional genomics. Exp. Hematol. 31, 1007-1014 (2003).
-
(2003)
Exp. Hematol
, vol.31
, pp. 1007-1014
-
-
Kitamura, T.1
-
46
-
-
84872345477
-
Proteasome-dependent activation of mammalian target of rapamycin complex 1 (mtorc1) is essential for autophagy suppression and muscle remodeling following denervation
-
Quy, P.N., Kuma, A., Pierre, P. & Mizushima, N. Proteasome-dependent activation of mammalian target of rapamycin complex 1 (mTORC1) is essential for autophagy suppression and muscle remodeling following denervation. J. Biol. Chem. 288, 1125-1134 (2013).
-
(2013)
J. Biol. Chem
, vol.288
, pp. 1125-1134
-
-
Quy, P.N.1
Kuma, A.2
Pierre, P.3
Mizushima, N.4
-
47
-
-
84873734105
-
RNA-guided human genome engineering via cas9
-
Mali, P. et al. RNA-guided human genome engineering via Cas9. Science 339, 823-826 (2013).
-
(2013)
Science
, vol.339
, pp. 823-826
-
-
Mali, P.1
-
48
-
-
65249119430
-
Nutrient-dependent mtorc1 association with the ulk1-Atg13-fip200 complex required for autophagy
-
Hosokawa, N. et al. Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy. Mol. Biol. Cell 20, 1981-1991 (2009).
-
(2009)
Mol. Biol. Cell
, vol.20
, pp. 1981-1991
-
-
Hosokawa, N.1
-
49
-
-
18744400102
-
Lymphotoxin-beta receptor mediates nemo-independent nf-kappab activation
-
Saitoh, T., Nakano, H., Yamamoto, N. & Yamaoka, S. Lymphotoxin-beta receptor mediates NEMO-independent NF-kappaB activation. FEBS Lett. 532, 45-51 (2002).
-
(2002)
FEBS Lett
, vol.532
, pp. 45-51
-
-
Saitoh, T.1
Nakano, H.2
Yamamoto, N.3
Yamaoka, S.4
|