-
1
-
-
0033906634
-
Structure and function of the type 1 insulin-like growth factor receptor
-
T.E. Adams, V.C. Epa, T.P. Garrett, and C.W. Ward Structure and function of the type 1 insulin-like growth factor receptor Cell. Mol. Life Sci. 57 2000 1050 1093
-
(2000)
Cell. Mol. Life Sci.
, vol.57
, pp. 1050-1093
-
-
Adams, T.E.1
Epa, V.C.2
Garrett, T.P.3
Ward, C.W.4
-
2
-
-
14244272868
-
PHENIX: building new software for automated crystallographic structure determination
-
P.D. Adams, R.W. Grosse-Kunstleve, L.W. Hung, T.R. Ioerger, A.J. McCoy, N.W. Moriarty, R.J. Read, J.C. Sacchettini, N.K. Sauter, and T.C. Terwilliger PHENIX: building new software for automated crystallographic structure determination Acta Crystallogr. D Biol. Crystallogr. 58 2002 1948 1954
-
(2002)
Acta Crystallogr. D Biol. Crystallogr.
, vol.58
, pp. 1948-1954
-
-
Adams, P.D.1
Grosse-Kunstleve, R.W.2
Hung, L.W.3
Ioerger, T.R.4
McCoy, A.J.5
Moriarty, N.W.6
Read, R.J.7
Sacchettini, J.C.8
Sauter, N.K.9
Terwilliger, T.C.10
-
3
-
-
70849120946
-
Insulin receptor isoforms and insulin receptor/insulin-like growth factor receptor hybrids in physiology and disease
-
A. Belfiore, F. Frasca, G. Pandini, L. Sciacca, and R. Vigneri Insulin receptor isoforms and insulin receptor/insulin-like growth factor receptor hybrids in physiology and disease Endocr. Rev. 30 2009 586 623
-
(2009)
Endocr. Rev.
, vol.30
, pp. 586-623
-
-
Belfiore, A.1
Frasca, F.2
Pandini, G.3
Sciacca, L.4
Vigneri, R.5
-
4
-
-
14844321328
-
Refinement of severely incomplete structures with maximum likelihood in BUSTER-TNT
-
E. Blanc, P. Roversi, C. Vonrhein, C. Flensburg, S.M. Lea, and G. Bricogne Refinement of severely incomplete structures with maximum likelihood in BUSTER-TNT Acta Crystallogr. D Biol. Crystallogr. 60 2004 2210 2221
-
(2004)
Acta Crystallogr. D Biol. Crystallogr.
, vol.60
, pp. 2210-2221
-
-
Blanc, E.1
Roversi, P.2
Vonrhein, C.3
Flensburg, C.4
Lea, S.M.5
Bricogne, G.6
-
6
-
-
77957946297
-
-
Global Phasing Ltd
-
G. Bricogne, E. Blanc, M. Brandl, C. Flensburg, P. Keller, W. Paciorek, P. Roversi, A. Sharff, O.S. Smart, C. Vonrhein, and T.O. Womack BUSTER Version 2.10 2011 Global Phasing Ltd
-
(2011)
BUSTER Version 2.10
-
-
Bricogne, G.1
Blanc, E.2
Brandl, M.3
Flensburg, C.4
Keller, P.5
Paciorek, W.6
Roversi, P.7
Sharff, A.8
Smart, O.S.9
Vonrhein, C.10
Womack, T.O.11
-
7
-
-
0037199459
-
Structural origins of the functional divergence of human insulin-like growth factor-I and insulin
-
A.M. Brzozowski, E.J. Dodson, G.G. Dodson, G.N. Murshudov, C. Verma, J.P. Turkenburg, F.M. de Bree, and Z. Dauter Structural origins of the functional divergence of human insulin-like growth factor-I and insulin Biochemistry 41 2002 9389 9397
-
(2002)
Biochemistry
, vol.41
, pp. 9389-9397
-
-
Brzozowski, A.M.1
Dodson, E.J.2
Dodson, G.G.3
Murshudov, G.N.4
Verma, C.5
Turkenburg, J.P.6
De Bree, F.M.7
Dauter, Z.8
-
8
-
-
0028146822
-
The structural basis of insulin and insulin-like growth factor-I receptor binding and negative co-operativity, and its relevance to mitogenic versus metabolic signalling
-
P. De Meyts The structural basis of insulin and insulin-like growth factor-I receptor binding and negative co-operativity, and its relevance to mitogenic versus metabolic signalling Diabetologia 37 1994 S135 S148
-
(1994)
Diabetologia
, vol.37
, pp. S135-S148
-
-
De Meyts, P.1
-
9
-
-
5044227353
-
Structural determinants for high-affinity binding of insulin-like growth factor II to insulin receptor (IR)-A, the exon 11 minus isoform of the IR
-
A. Denley, E.R. Bonython, G.W. Booker, L.J. Cosgrove, B.E. Forbes, C.W. Ward, and J.C. Wallace Structural determinants for high-affinity binding of insulin-like growth factor II to insulin receptor (IR)-A, the exon 11 minus isoform of the IR Mol. Endocrinol. 18 2004 2502 2512
-
(2004)
Mol. Endocrinol.
, vol.18
, pp. 2502-2512
-
-
Denley, A.1
Bonython, E.R.2
Booker, G.W.3
Cosgrove, L.J.4
Forbes, B.E.5
Ward, C.W.6
Wallace, J.C.7
-
10
-
-
22544478497
-
Molecular interactions of the IGF system
-
A. Denley, L.J. Cosgrove, G.W. Booker, J.C. Wallace, and B.E. Forbes Molecular interactions of the IGF system Cytokine Growth Factor Rev. 16 2005 421 439
-
(2005)
Cytokine Growth Factor Rev.
, vol.16
, pp. 421-439
-
-
Denley, A.1
Cosgrove, L.J.2
Booker, G.W.3
Wallace, J.C.4
Forbes, B.E.5
-
12
-
-
84861421670
-
Biochemistry. Resolving some old problems in protein crystallography
-
P. Evans Biochemistry. Resolving some old problems in protein crystallography Science 336 2012 986 987
-
(2012)
Science
, vol.336
, pp. 986-987
-
-
Evans, P.1
-
13
-
-
0035890470
-
Hormone-triggered conformational changes within the insulin-receptor ectodomain: requirement for transmembrane anchors
-
R.R. Flörke, K. Schnaith, W. Passlack, M. Wichert, L. Kuehn, M. Fabry, M. Federwisch, and H. Reinauer Hormone-triggered conformational changes within the insulin-receptor ectodomain: requirement for transmembrane anchors Biochem. J. 360 2001 189 198
-
(2001)
Biochem. J.
, vol.360
, pp. 189-198
-
-
Flörke, R.R.1
Schnaith, K.2
Passlack, W.3
Wichert, M.4
Kuehn, L.5
Fabry, M.6
Federwisch, M.7
Reinauer, H.8
-
14
-
-
0032560753
-
Crystal structure of the first three domains of the type-1 insulin-like growth factor receptor
-
T.P. Garrett, N.M. McKern, M. Lou, M.J. Frenkel, J.D. Bentley, G.O. Lovrecz, T.C. Elleman, L.J. Cosgrove, and C.W. Ward Crystal structure of the first three domains of the type-1 insulin-like growth factor receptor Nature 394 1998 395 399
-
(1998)
Nature
, vol.394
, pp. 395-399
-
-
Garrett, T.P.1
McKern, N.M.2
Lou, M.3
Frenkel, M.J.4
Bentley, J.D.5
Lovrecz, G.O.6
Elleman, T.C.7
Cosgrove, L.J.8
Ward, C.W.9
-
15
-
-
84920271615
-
Delineation of the IGF-II C domain elements involved in binding and activation of the IR-A, IR-B and IGF-IR
-
S.T. Henderson, G.V. Brierley, K.H. Surinya, I.K. Priebe, D.E. Catcheside, J.C. Wallace, B.E. Forbes, and L.J. Cosgrove Delineation of the IGF-II C domain elements involved in binding and activation of the IR-A, IR-B and IGF-IR Growth Horm. IGF Res. 25 2014 20 27
-
(2014)
Growth Horm. IGF Res.
, vol.25
, pp. 20-27
-
-
Henderson, S.T.1
Brierley, G.V.2
Surinya, K.H.3
Priebe, I.K.4
Catcheside, D.E.5
Wallace, J.C.6
Forbes, B.E.7
Cosgrove, L.J.8
-
16
-
-
0034598998
-
Properties of an insulin receptor with an IGF-1 receptor loop exchange in the cysteine-rich region
-
P.A. Hoyne, T.C. Elleman, T.E. Adams, K.M. Richards, and C.W. Ward Properties of an insulin receptor with an IGF-1 receptor loop exchange in the cysteine-rich region FEBS Lett. 469 2000 57 60
-
(2000)
FEBS Lett.
, vol.469
, pp. 57-60
-
-
Hoyne, P.A.1
Elleman, T.C.2
Adams, T.E.3
Richards, K.M.4
Ward, C.W.5
-
17
-
-
76449106188
-
Integration, scaling, space-group assignment and post-refinement
-
W. Kabsch Integration, scaling, space-group assignment and post-refinement Acta Crystallogr. D. Biol. Crystallogr. 66 2010 133 144
-
(2010)
Acta Crystallogr. D. Biol. Crystallogr.
, vol.66
, pp. 133-144
-
-
Kabsch, W.1
-
18
-
-
84861425552
-
Linking crystallographic model and data quality
-
P.A. Karplus, and K. Diederichs Linking crystallographic model and data quality Science 336 2012 1030 1033
-
(2012)
Science
, vol.336
, pp. 1030-1033
-
-
Karplus, P.A.1
Diederichs, K.2
-
19
-
-
23844528772
-
Mutation at cleavage site of insulin-like growth factor receptor in a short-stature child born with intrauterine growth retardation
-
Y. Kawashima, S. Kanzaki, F. Yang, T. Kinoshita, K. Hanaki, J. Nagaishi, Y. Ohtsuka, I. Hisatome, H. Ninomoya, and E. Nanba Mutation at cleavage site of insulin-like growth factor receptor in a short-stature child born with intrauterine growth retardation J. Clin. Endocrinol. Metab. 90 2005 4679 4687
-
(2005)
J. Clin. Endocrinol. Metab.
, vol.90
, pp. 4679-4687
-
-
Kawashima, Y.1
Kanzaki, S.2
Yang, F.3
Kinoshita, T.4
Hanaki, K.5
Nagaishi, J.6
Ohtsuka, Y.7
Hisatome, I.8
Ninomoya, H.9
Nanba, E.10
-
21
-
-
0028928843
-
A single-chain insulin-like growth factor I/insulin hybrid binds with high affinity to the insulin receptor
-
C. Kristensen, A.S. Andersen, M. Hach, F.C. Wiberg, L. Schäffer, and T. Kjeldsen A single-chain insulin-like growth factor I/insulin hybrid binds with high affinity to the insulin receptor Biochem. J. 305 1995 981 986
-
(1995)
Biochem. J.
, vol.305
, pp. 981-986
-
-
Kristensen, C.1
Andersen, A.S.2
Hach, M.3
Wiberg, F.C.4
Schäffer, L.5
Kjeldsen, T.6
-
22
-
-
0027960567
-
Cross-linking of a B25 azidophenylalanine insulin derivative to the carboxyl-terminal region of the α-subunit of the insulin receptor. Identification of a new insulin-binding domain in the insulin receptor
-
T. Kurose, M. Pashmforoush, Y. Yoshimasa, R. Carroll, G.P. Schwartz, G.T. Burke, P.G. Katsoyannis, and D.F. Steiner Cross-linking of a B25 azidophenylalanine insulin derivative to the carboxyl-terminal region of the α-subunit of the insulin receptor. Identification of a new insulin-binding domain in the insulin receptor J. Biol. Chem. 269 1994 29190 29197
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 29190-29197
-
-
Kurose, T.1
Pashmforoush, M.2
Yoshimasa, Y.3
Carroll, R.4
Schwartz, G.P.5
Burke, G.T.6
Katsoyannis, P.G.7
Steiner, D.F.8
-
23
-
-
33747584896
-
The first three domains of the insulin receptor differ structurally from the insulin-like growth factor 1 receptor in the regions governing ligand specificity
-
M. Lou, T.P. Garrett, N.M. McKern, P.A. Hoyne, V.C. Epa, J.D. Bentley, G.O. Lovrecz, L.J. Cosgrove, M.J. Frenkel, and C.W. Ward The first three domains of the insulin receptor differ structurally from the insulin-like growth factor 1 receptor in the regions governing ligand specificity Proc. Natl. Acad. Sci. USA 103 2006 12429 12434
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 12429-12434
-
-
Lou, M.1
Garrett, T.P.2
McKern, N.M.3
Hoyne, P.A.4
Epa, V.C.5
Bentley, J.D.6
Lovrecz, G.O.7
Cosgrove, L.J.8
Frenkel, M.J.9
Ward, C.W.10
-
24
-
-
33846426122
-
Solving structures of protein complexes by molecular replacement with Phaser
-
A.J. McCoy Solving structures of protein complexes by molecular replacement with Phaser Acta Crystallogr. D Biol. Crystallogr. 63 2007 32 41
-
(2007)
Acta Crystallogr. D Biol. Crystallogr.
, vol.63
, pp. 32-41
-
-
McCoy, A.J.1
-
25
-
-
33748639228
-
Structure of the insulin receptor ectodomain reveals a folded-over conformation
-
N.M. McKern, M.C. Lawrence, V.A. Streltsov, M.Z. Lou, T.E. Adams, G.O. Lovrecz, T.C. Elleman, K.M. Richards, J.D. Bentley, and P.A. Pilling Structure of the insulin receptor ectodomain reveals a folded-over conformation Nature 443 2006 218 221
-
(2006)
Nature
, vol.443
, pp. 218-221
-
-
McKern, N.M.1
Lawrence, M.C.2
Streltsov, V.A.3
Lou, M.Z.4
Adams, T.E.5
Lovrecz, G.O.6
Elleman, T.C.7
Richards, K.M.8
Bentley, J.D.9
Pilling, P.A.10
-
26
-
-
0036849859
-
Blu-Ice and the Distributed Control System: software for data acquisition and instrument control at macromolecular crystallography beamlines
-
T.M. McPhillips, S.E. McPhillips, H.J. Chiu, A.E. Cohen, A.M. Deacon, P.J. Ellis, E. Garman, A. Gonzalez, N.K. Sauter, and R.P. Phizackerley Blu-Ice and the Distributed Control System: software for data acquisition and instrument control at macromolecular crystallography beamlines J. Synchrotron Radiat. 9 2002 401 406
-
(2002)
J. Synchrotron Radiat.
, vol.9
, pp. 401-406
-
-
McPhillips, T.M.1
McPhillips, S.E.2
Chiu, H.J.3
Cohen, A.E.4
Deacon, A.M.5
Ellis, P.J.6
Garman, E.7
Gonzalez, A.8
Sauter, N.K.9
Phizackerley, R.P.10
-
27
-
-
67049158418
-
A thermodynamic study of ligand binding to the first three domains of the human insulin receptor: relationship between the receptor α-chain C-terminal peptide and the site 1 insulin mimetic peptides
-
J.G. Menting, C.W. Ward, M.B. Margetts, and M.C. Lawrence A thermodynamic study of ligand binding to the first three domains of the human insulin receptor: relationship between the receptor α-chain C-terminal peptide and the site 1 insulin mimetic peptides Biochemistry 48 2009 5492 5500
-
(2009)
Biochemistry
, vol.48
, pp. 5492-5500
-
-
Menting, J.G.1
Ward, C.W.2
Margetts, M.B.3
Lawrence, M.C.4
-
28
-
-
84872162672
-
How insulin engages its primary binding site on the insulin receptor
-
J.G. Menting, J. Whittaker, M.B. Margetts, L.J. Whittaker, G.K.W. Kong, B.J. Smith, C.J. Watson, L. Žáková, E. Kletvíková, and J. Jiráček How insulin engages its primary binding site on the insulin receptor Nature 493 2013 241 245
-
(2013)
Nature
, vol.493
, pp. 241-245
-
-
Menting, J.G.1
Whittaker, J.2
Margetts, M.B.3
Whittaker, L.J.4
Kong, G.K.W.5
Smith, B.J.6
Watson, C.J.7
Žáková, L.8
Kletvíková, E.9
Jiráček, J.10
-
29
-
-
84906306629
-
Protective hinge in insulin opens to enable its receptor engagement
-
J.G. Menting, Y. Yang, S.J. Chan, N.B. Phillips, B.J. Smith, J. Whittaker, N.P. Wickramasinghe, L.J. Whittaker, V. Pandyarajan, and Z.L. Wan Protective hinge in insulin opens to enable its receptor engagement Proc. Natl. Acad. Sci. USA 111 2014 E3395 E3404
-
(2014)
Proc. Natl. Acad. Sci. USA
, vol.111
, pp. E3395-E3404
-
-
Menting, J.G.1
Yang, Y.2
Chan, S.J.3
Phillips, N.B.4
Smith, B.J.5
Whittaker, J.6
Wickramasinghe, N.P.7
Whittaker, L.J.8
Pandyarajan, V.9
Wan, Z.L.10
-
30
-
-
84857640868
-
The insulin and insulin-like growth factor receptor family in neoplasia: an update
-
M. Pollak The insulin and insulin-like growth factor receptor family in neoplasia: an update Nat. Rev. Cancer 12 2012 159 169
-
(2012)
Nat. Rev. Cancer
, vol.12
, pp. 159-169
-
-
Pollak, M.1
-
31
-
-
84855467975
-
The insulin receptor/insulin-like growth factor receptor family as a therapeutic target in oncology
-
M. Pollak The insulin receptor/insulin-like growth factor receptor family as a therapeutic target in oncology Clin. Cancer Res. 18 2012 40 50
-
(2012)
Clin. Cancer Res.
, vol.18
, pp. 40-50
-
-
Pollak, M.1
-
32
-
-
33748744723
-
Hybrid receptors formed by insulin receptor (IR) and insulin-like growth factor I receptor (IGF-IR) have low insulin and high IGF-1 affinity irrespective of the IR splice variant
-
R. Slaaby, L. Schäffer, I. Lautrup-Larsen, A.S. Andersen, A.C. Shaw, I.S. Mathiasen, and J. Brandt Hybrid receptors formed by insulin receptor (IR) and insulin-like growth factor I receptor (IGF-IR) have low insulin and high IGF-1 affinity irrespective of the IR splice variant J. Biol. Chem. 281 2006 25869 25874
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 25869-25874
-
-
Slaaby, R.1
Schäffer, L.2
Lautrup-Larsen, I.3
Andersen, A.S.4
Shaw, A.C.5
Mathiasen, I.S.6
Brandt, J.7
-
33
-
-
77951058594
-
Structural resolution of a tandem hormone-binding element in the insulin receptor and its implications for design of peptide agonists
-
B.J. Smith, K. Huang, G. Kong, S.J. Chan, S. Nakagawa, J.G. Menting, S.-Q. Hu, J. Whittaker, D.F. Steiner, and P.G. Katsoyannis Structural resolution of a tandem hormone-binding element in the insulin receptor and its implications for design of peptide agonists Proc. Natl. Acad. Sci. USA 107 2010 6771 6776
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 6771-6776
-
-
Smith, B.J.1
Huang, K.2
Kong, G.3
Chan, S.J.4
Nakagawa, S.5
Menting, J.G.6
Hu, S.-Q.7
Whittaker, J.8
Steiner, D.F.9
Katsoyannis, P.G.10
-
34
-
-
0022474285
-
Monoclonal antibodies reacting with multiple epitopes on the human insulin receptor
-
M.A. Soos, K. Siddle, M.D. Baron, J.M. Heward, J.P. Luzio, J. Bellatin, and E.S. Lennox Monoclonal antibodies reacting with multiple epitopes on the human insulin receptor Biochem. J. 235 1986 199 208
-
(1986)
Biochem. J.
, vol.235
, pp. 199-208
-
-
Soos, M.A.1
Siddle, K.2
Baron, M.D.3
Heward, J.M.4
Luzio, J.P.5
Bellatin, J.6
Lennox, E.S.7
-
35
-
-
40549117199
-
N-linked glycans of the human insulin receptor and their distribution over the crystal structure
-
L.G. Sparrow, M.C. Lawrence, J.J. Gorman, P.M. Strike, C.P. Robinson, N.M. McKern, and C.W. Ward N-linked glycans of the human insulin receptor and their distribution over the crystal structure Proteins 71 2008 426 439
-
(2008)
Proteins
, vol.71
, pp. 426-439
-
-
Sparrow, L.G.1
Lawrence, M.C.2
Gorman, J.J.3
Strike, P.M.4
Robinson, C.P.5
McKern, N.M.6
Ward, C.W.7
-
36
-
-
15244351255
-
Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease - is this type 3 diabetes?
-
E. Steen, B.M. Terry, E.J. Rivera, J.L. Cannon, T.R. Neely, R. Tavares, X.J. Xu, J.R. Wands, and S.M. de la Monte Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease - is this type 3 diabetes? J. Alzheimers Dis. 7 2005 63 80
-
(2005)
J. Alzheimers Dis.
, vol.7
, pp. 63-80
-
-
Steen, E.1
Terry, B.M.2
Rivera, E.J.3
Cannon, J.L.4
Neely, T.R.5
Tavares, R.6
Xu, X.J.7
Wands, J.R.8
De La Monte, S.M.9
-
37
-
-
0032773139
-
Single-molecule imaging of human insulin receptor ectodomain and its Fab complexes
-
P.A. Tulloch, L.J. Lawrence, N.M. McKern, C.P. Robinson, J.D. Bentley, L. Cosgrove, N. Ivancic, G.O. Lovrecz, K. Siddle, and C.W. Ward Single-molecule imaging of human insulin receptor ectodomain and its Fab complexes J. Struct. Biol. 125 1999 11 18
-
(1999)
J. Struct. Biol.
, vol.125
, pp. 11-18
-
-
Tulloch, P.A.1
Lawrence, L.J.2
McKern, N.M.3
Robinson, C.P.4
Bentley, J.D.5
Cosgrove, L.6
Ivancic, N.7
Lovrecz, G.O.8
Siddle, K.9
Ward, C.W.10
-
38
-
-
0033946267
-
Studies on insulin/IGF-1 hybrid and IGF-1 growth-promoting functional region
-
P. Wang, R.R. Cai, Y.M. Feng, and Y.S. Zhang Studies on insulin/IGF-1 hybrid and IGF-1 growth-promoting functional region IUBMB Life 49 2000 321 325
-
(2000)
IUBMB Life
, vol.49
, pp. 321-325
-
-
Wang, P.1
Cai, R.R.2
Feng, Y.M.3
Zhang, Y.S.4
-
39
-
-
84885378451
-
The insulin receptor changes conformation in unforeseen ways on ligand binding: Sharpening the picture of insulin receptor activation
-
C.W. Ward, J.G. Menting, and M.C. Lawrence The insulin receptor changes conformation in unforeseen ways on ligand binding: Sharpening the picture of insulin receptor activation Bioessays 35 2013 945 954
-
(2013)
Bioessays
, vol.35
, pp. 945-954
-
-
Ward, C.W.1
Menting, J.G.2
Lawrence, M.C.3
-
40
-
-
70449632130
-
Solution structure of ectodomains of the insulin receptor family: the ectodomain of the type 1 insulin-like growth factor receptor displays asymmetry of ligand binding accompanied by limited conformational change
-
A.E. Whitten, B.J. Smith, J.G. Menting, M.B. Margetts, N.M. McKern, G.O. Lovrecz, T.E. Adams, K. Richards, J.D. Bentley, and J. Trewhella Solution structure of ectodomains of the insulin receptor family: the ectodomain of the type 1 insulin-like growth factor receptor displays asymmetry of ligand binding accompanied by limited conformational change J. Mol. Biol. 394 2009 878 892
-
(2009)
J. Mol. Biol.
, vol.394
, pp. 878-892
-
-
Whitten, A.E.1
Smith, B.J.2
Menting, J.G.3
Margetts, M.B.4
McKern, N.M.5
Lovrecz, G.O.6
Adams, T.E.7
Richards, K.8
Bentley, J.D.9
Trewhella, J.10
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