Induction of T-cell development by delta-like 4-expressing fibroblasts

International Immunology

Volumn 25, Issue 10, 2013, Pages 601-611

  Mohtashami, Mahmood ^a   Shah, Divya K ^a   Kianizad, Korosh ^a   Awong, Geneve ^a,b   Zúñiga Pflücker, Juan Carlos ^a  

^a Canada   (Canada)

^b UNIVERSITY HEALTH NETWORK   (Canada)

Author keywords

Delta like 4; Notch; Stromal cells; T cells; Thymus

Indexed keywords

DELTA LIKE 4; PROTEIN; STEM CELL FACTOR RECEPTOR; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR BETA CHAIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CD117+ T LYMPHOCTE; CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD44+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL DIFFERENTIATION; CELL GROWTH; CELL LINE; CELL LINEAGE; COCULTURE; CONTROLLED STUDY; FEMALE; FIBROBLAST; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; LYMPHOCYTOPOIESIS; MOUSE; MYELOPOIESIS; NONHUMAN; PRE T LYMPHOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE; THYMUS;

DELTA-LIKE 4; NOTCH; STROMAL CELLS; T-CELLS; THYMUS;

ADOPTIVE TRANSFER; ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CELL LINE; CLONAL SELECTION, ANTIGEN-MEDIATED; COCULTURE TECHNIQUES; DNA-BINDING PROTEINS; FIBROBLASTS; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE PROTEINS; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; THYMUS GLAND; TRANSGENES;

EID: 84884705663     PISSN: 09538178     EISSN: 14602377     Source Type: Journal    
DOI: 10.1093/intimm/dxt027     Document Type: Article

References (43)

1. Rothenberg, E. V., Moore, J. E. and Yui, M. A. 2008. Launching the T-cell-lineage developmental programme. Nat. Rev. Immunol. 8:9.
2. Hozumi, K., Mailhos, C., Negishi, N. et al. 2008. Delta-like 4 is indispensable in thymic environment specific for T cell development. J. Exp. Med. 205:2507.
3. Koch, U., Fiorini, E., Benedito, R. et al. 2008. Delta-like 4 is the essential, nonredundant ligand for Notch1 during thymic T cell lineage commitment. J. Exp. Med. 205:2515.
4. Radtke, F., Wilson, A., Stark, G., Bauer, M., van Meerwijk, J., MacDonald, H. R. and Aguet, M. 1999. Deficient T cell fate specification in mice with an induced inactivation of Notch1. Immunity 10:547.
5. Ciofani, M. and Zuniga-Pflucker, J. C. 2007. The thymus as an inductive site for T lymphopoiesis. Annu. Rev. Cell Dev. Biol. 23:463.
6. Takahama, Y. 2006. Journey through the thymus: stromal guides for T-cell development and selection. Nat. Rev. Immunol. 6:127.
7. Petrie, H. T. 2002. Role of thymic organ structure and stromal composition in steady-state postnatal T-cell production. Immunol. Rev. 189:8.
8. Godfrey, D. I., Kennedy, J., Suda, T. and Zlotnik, A. 1993. A developmental pathway involving four phenotypically and functionally distinct subsets of CD3-CD4-CD8- triple-negative adult mouse thymocytes defined by CD44 and CD25 expression. J. Immunol. 150:4244.
9. Ceredig, R. and Rolink, T. 2002. A positive look at double-negative thymocytes. Nat. Rev. Immunol. 2:888.
10. Dervovic, D. and Zuniga-Pflucker, J. C. 2010. Positive selection of T cells, an in vitro view. Semin. Immunol. 22:276. 11 Weinreich, M. A. and Hogquist, K. A. 2008. Thymic emigration: when and how T cells leave home. J. Immunol. 181:2265.
11. Weinreich, M. A. and Hogquist, K. A. 2008. Thymic emigration: when and how T cells leave home. J. Immunol. 181:2265.
12. Besseyrias, V., Fiorini, E., Strobl, L. J. et al. 2007. Hierarchy of Notch-Delta interactions promoting T cell lineage commitment and maturation. J. Exp. Med. 204:331.
13. Mohtashami, M., Shah, D. K., Nakase, H., Kianizad, K., Petrie, H. T. and Zuniga-Pflucker, J. C. 2010. Direct comparison of Dll1- and Dll4-mediated Notch activation levels shows differential lymphomyeloid lineage commitment outcomes. J. Immunol. 185:867.
14. Schmitt, T. M. and Zuniga-Pflucker, J. C. 2002. Induction of T cell development from hematopoietic progenitor cells by delta-like-1 in vitro. Immunity 17:749.
15. Griffith, A. V., Fallahi, M., Nakase, H., Gosink, M., Young, B. and Petrie, H. T. 2009. Spatial mapping of thymic stromal microenvironments reveals unique features influencing T lymphoid differentiation. Immunity 31:999.
16. Zuniga-Pflucker, J. C. 2004. T-cell development made simple. Nat. Rev. Immunol. 4:67.
17. Schmitt, T. M. and Zuniga-Pflucker, J. C. 2006. T-cell development, doing it in a dish. Immunol. Rev. 209:95.
18. de Pooter, R. and Zuniga-Pflucker, J. C. 2007. T-cell potential and development in vitro: the OP9-DL1 approach. Curr. Opin. Immunol. 19:163.
19. Jaleco, A. C., Neves, H., Hooijberg, E. et al. 2001. Differential effects of Notch ligands Delta-1 and Jagged-1 in human lymphoid differentiation. J. Exp. Med. 194:991.
20. Armstrong, F., Brunet de la Grange, P., Gerby, B. et al. 2009. NOTCH is a key regulator of human T-cell acute leukemia initiating cell activity. Blood 113:1730.
21. Ikawa, T., Hirose, S., Masuda, K. et al. 2010. An essential developmental checkpoint for production of the T cell lineage. Science 329:93.
22. Abe, N., Hozumi, K., Hirano, K., Yagita, H. and Habu, S. 2010. Notch ligands transduce different magnitudes of signaling critical for determination of T-cell fate. Eur. J. Immunol. 40:2608.
23. Nakano, T., Kodama, H. and Honjo, T. 1994. Generation of lymphohematopoietic cells from embryonic stem cells in culture. Science 265:1098.
24. Zakrzewski, J. L., Kochman, A. A., Lu, S. X. et al. 2006. Adoptive transfer of T-cell precursors enhances T-cell reconstitution after allogeneic hematopoietic stem cell transplantation. Nat. Med. 12:1039.
25. Zakrzewski, J. L., Suh, D., Markley, J. C. et al. 2008. Tumor immunotherapy across MHC barriers using allogeneic T-cell precursors. Nat. Biotechnol. 26:453.
26. Awong, G., Herer, E., Surh, C. D., Dick, J. E., La Motte-Mohs, R. N. and Zuniga-Pflucker, J. C. 2009. Characterization in vitro and engraftment potential in vivo of human progenitor T cells generated from hematopoietic stem cells. Blood 114:972.
27. Bray, S. J. 2006. Notch signalling: a simple pathway becomes complex. Nat. Rev. Mol. Cell Biol. 7:678.
28. Nichols, J. T., Miyamoto, A., Olsen, S. L., D'Souza, B., Yao, C. and Weinmaster, G. 2007. DSL ligand endocytosis physically dissociates Notch1 heterodimers before activating proteolysis can occur. J. Cell Biol. 176:445.
29. + cells mature in the thymus. Blood. 115:261.
30. Varnum-Finney, B., Brashem-Stein, C. and Bernstein, I. D. 2003. Combined effects of Notch signaling and cytokines induce a multiple log increase in precursors with lymphoid and myeloid reconstituting ability Blood. 101:1784.
31. Dallas, M. H., Varnum-Finney, B., Delaney, C., Kato, K. and Bernstein, I. D. 2005. Density of the Notch ligand Delta1 determines generation of B and T cell precursors from hematopoietic stem cells. J. Exp. Med. 201:1361.
32. Mohtashami, M. and Zuniga-Pflucker, J. C. 2006. Threedimensional architecture of the thymus is required to maintain delta-like expression necessary for inducing T cell development. J. Immunol. 176:730.
33. Miyazaki, M., Kawamoto, H., Kato, Y. et al. 2005. Polycomb group gene mel-18 regulates early T progenitor expansion by maintaining the expression of Hes-1, a target of the Notch pathway. J. Immunol. 174:2507.
34. Markowitz, D., Goff, S. and Bank, A. 1988. Construction and use of a safe and efficient amphotropic packaging cell line. Virology 167:400.
35. La Motte-Mohs, R. N., Herer, E. and Zuniga-Pflucker, J. C. 2005. Induction of T-cell development from human cord blood hematopoietic stem cells by Delta-like 1 in vitro. Blood 105:1431.
36. Dervovic, D. D., Ciofani, M., Kianizad, K. and Zuniga-Pflucker, J. C. 2012. Comparative and functional evaluation of in vitro generated to ex vivo CD8 T cells. J. Immunol. 189:3411.
37. McCarthy, S. A., Kruisbeek, A. M., Uppenkamp, I. K., Sharrow, S. O. and Singer, A. 1988. Engagement of the CD4 molecule influences cell surface expression of the T-cell receptor on thymocytes. Nature 336:76.
38. Zuniga-Pflucker, J. C., McCarthy, S. A., Weston, M., Longo, D. L., Singer, A. and Kruisbeek, A. M. 1989. Role of CD4 in thymocyte selection and maturation. J. Exp. Med. 169:2085.
39. + thymocytes by p56lck tyrosine kinase: basis for differential signaling by CD4 and CD8 in immature thymocytes expressing both coreceptor molecules. J. Exp. Med. 178:1701.
40. Shah, D. K., Mohtashami, M. and Zuniga-Pflucker, J. C. 2012. Role of recycling, mindbomb1 association, and exclusion from lipid rafts of Delta-like 4 for effective Notch signaling to drive T cell development. J. Immunol. 189:5797.
41. de Pooter, R. F., Schmitt, T. M., de la Pompa, J. L., Fujiwara, Y., Orkin, S. H. and Zuniga-Pflucker, J. C. 2006. Notch signaling requires GATA-2 to inhibit myelopoiesis from embryonic stem cells and primary hemopoietic progenitors. J. Immunol. 176:5267.
42. Mossadegh-Keller, N., Sarrazin, S., Kandalla, P. K. et al. 2013. MCSF instructs myeloid lineage fate in single haematopoietic stem cells. Nature 497:239.
43. Awong, G., La Motte-Mohs, R. N. and Zuniga-Pflucker, J. C. 2007. Generation of pro-T cells in vitro: potential for immune reconstitution. Semin. Immunol. 19:341.