Free fatty acid determination in plasma by GC-MS after conversion to Weinreb amides

Analytical and Bioanalytical Chemistry

Volumn 405, Issue 6, 2013, Pages 1929-1935

  Ubhayasekera, Sarojini J K A ^a   Staaf, Johan ^a   Forslund, Anders ^a   Bergsten, Peter ^a   Bergquist, Jonas ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

Free fatty acids; Obesity; Weinreb amides

Indexed keywords

AMIDES; ENERGY UTILIZATION; FLUORINE COMPOUNDS; MASS SPECTROMETRY; PALMITIC ACID;

CAPILLARY GAS CHROMATOGRAPHY; COEFFICIENT OF VARIATION; CORRELATION COEFFICIENT; FREE FATTY ACID; GAS CHROMATOGRAPHY-MASS SPECTROMETRIES (GC-MS); OBESITY; TYPE 2 DIABETES MELLITUS; WEINREB AMIDES;

GAS CHROMATOGRAPHY;

EID: 84873725474     PISSN: 16182642     EISSN: 16182650     Source Type: Journal    
DOI: 10.1007/s00216-012-6658-3     Document Type: Article

References (29)

1. Boden G (2011) Obesity, insulin resistance and free fatty acids. Curr Opin Endocrinol Diabetes Obes 18(2):139-143
2. Sargsyan E, Ortsater H, Thorn K, Bergsten P (2008) Diazoxide-induced beta-cell rest reduces endoplasmic reticulum stress in lipotoxic beta-cells. J Endocrinol 199(1):41-50
3. Hovsepyan M, Sargsyan E, Bergsten P (2010) Palmitate-induced changes in protein expression of insulin secreting INS-1E cells. J Proteomics 73(6):1148-1155
4. Capurso C, Capurso A (2012) From excess adiposity to insulin resistance: the role of free fatty acids. Vascul Pharmacol 57(2-4):91-97
5. Rider OJ, Holloway CJ, Emmanuel Y, Bloch E, Clarke K, Neubauer S (2012) Increasing plasma free fatty acids in healthy subjects induces aortic distensibility changes seen in obesity. Circ Cardiovasc Imaging 5(3):367-375
6. Folch J, Lees M, Sloane Stanley GHA (1957) Simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem 226(1):497-509
7. Bligh EG, Dyer WJA (1959) Rapid method of total lipid extraction and purification. Can J Biochem Physiol 37(8):911-917
8. Hara A, Radin NS (1978) Lipid extraction of tissues with a low-toxicity solvent. Anal Biochem 90(1):420-426
9. Christie WW (1985) Rapid separation and quantification of lipid classes by high performance liquid chromatography and mass (light-scattering) detection. J Lipid Res 26(4):507-512
10. Notter SJ, Stuart BH, Dent BB, Keegan J (2008) Solid-phase extraction in combination with GC-MS for the quantification of free fatty acids in adipocere. Euro J Lipid Sci Tech 110(1):73-80
11. Pilitsis JG, Diaz FG, Wellwood JM, Oregan MH, Fairfax MR, Phillis JW, Coplin WM (2001) Quantification of free fatty acids in human cerebrospinal fluid. Neurochem Res 26(12):1265-1270
12. Gerasimenko EO, Tur'yan YI (2012) Automated flow pH-method for the determination of total free fatty acids content in edible oils. Food Che 132(3):1562-1565
13. Kwon D, Rhee J (1986) A simple and rapid colorimetric method for determination of free fatty acids for lipase assay. J Ame Oil Che Soc 63(1):89-92
14. Mizuno K, Toyosato M, Yabumoto S, Tanimizu I, Hirakawa H (1980) A new enzymatic method for colorimetric determination of free fatty acids. Anal Biochem 108(1):6-10
15. Christie WW (1998) Gas chromatography-mass spectrometry methods for structural analysis of fatty acids. Lipids 33(4):343-353
16. Tan B, Liang Y, Yi L, Li H, Zhou Z, Ji X, Deng J (2010) Identification of free fatty acids profiling of type 2 diabetes mellitus and exploring possible biomarkers by GC-MS coupled with chemometrics. Metabolomics 6(2):219-228
17. Brondz I (2002) Development of fatty acid analysis by high-performance liquid chromatography, gas chromatography, and related techniques. Anal Chim Acta 465(1-2):1-37
18. Tunoori AR, White JM, Georg GI (2000) A one-flask synthesis of Weinreb amides from chiral and achiral carboxylic acids using the Deoxo-Fluor fluorinating reagent. Org Lett 2(25):4091-4093
19. Kangani CO, Kelley DE, Delany JP (2008) New method for GC-FID and GC-C-IRMS analysis of plasma free fatty acid concentration and isotopic enrichment. J Chromatogr B Analyt Technol Biomed Life Sci 873(1):95-101
20. Dole VP, Meinertz H (1960) Microdetermination of long-chain fatty acids in plasma and tissues. The J biol che 235:2595-2599
21. Wilding JP (2007) The importance of free fatty acids in the development of type 2 diabetes. Diabet Med 24(9):934-945
22. Burns SF, Tfayli H, Gungor N, Arslanian SA (2011) Declining beta-cell function relative to insulin sensitivity with escalating OGTT 2-h glucose concentrations in the nondiabetic through the diabetic range in overweight youth. Diabetes Care 34(9):2033-2040
23. Kangani CO, Kelley DE (2005) One pot direct synthesis of amides or oxazolines from carboxylic acids using Deoxo-Fluor reagent. Tetrahedron Lett 46(51):8917-8920
24. Kangani CO, Kelley DE, Day BW (2006) One pot direct synthesis of oxazolines, benzoxazoles, and oxadiazoles from carboxylic acids using the Deoxo-Fluor reagent. Tetrahedron Lett 47(37):6497-6499
25. Malecka-Tendera E, Mazur A (2006) Childhood obesity: a pandemic of the twenty-first century. Int J Obes (Lond) 30(Suppl 2):S1-S3
26. Yi L, He J, Liang Y, Yuan D, Gao H, Zhou H (2007) Simultaneously quantitative measurement of comprehensive profiles of esterified and non-esterified fatty acid in plasma of type 2 diabetic patients. Chem Phys Lipids 150(2):204-216
27. Thorn K, Bergsten P (2010) Fatty acid-induced oxidation and triglyceride formation is higher in insulin-producing MIN6 cells exposed to oleate to palmitate. J Cell Biochem 111(2):497-507
28. Morgan NG, Dhayal S, Diakogiannaki E, Welters HJ (2008) The cytoprotective actions of long-chain mono-unsaturated fatty acids in pancreatic beta-cells. Biochem Soc Trans 36(Pt 5):905-908
29. Stefan N, Kantartzis K, Celebi N, Staiger H, Machann J, Schick F, Cegan A, Elcnerova M, Schleicher E, Fritsche A, Haring HU (2010) Circulating palmitoleate strongly and independently predicts insulin sensitivity in humans. Diabetes Care 33(2):405-407