Acute DNase1 treatment improves left ventricular remodeling after myocardial infarction by disruption of free chromatin

Basic Research in Cardiology

Volumn 110, Issue 2, 2015, Pages

  Vogel, Benjamin ^a   Shinagawa, Hisahito ^a,b   Hofmann, Ulrich ^a,c   Ertl, Georg ^a   Frantz, Stefan ^a,c  

^a UNIVERSITY HOSPITAL WÜRZBURG   (Germany)

^b KITASATO UNIVERSITY   (Japan)

^c MARTIN LUTHER UNIVERSITÄT HALLE WITTENBERG   (Germany)

Author keywords

Dornase alfa; Histone toxicity; Myocardial necrosis; Neutrophil extracellular trap; Pulmozyme

Indexed keywords

DEOXYRIBONUCLEASE I; DNA; DOUBLE STRANDED DNA; HISTONE; CHROMATIN;

ANIMAL EXPERIMENT; ARTICLE; CELL DEATH; CELL SURVIVAL; CHROMATIN; CONTROLLED STUDY; CORONARY ARTERY LIGATION; CYTOTOXICITY; ECHOCARDIOGRAPHY; GENE DISRUPTION; HEART INFARCTION; HEART INFARCTION SIZE; HEART LEFT VENTRICLE FAILURE; HEART MUSCLE CELL; HEART VENTRICLE REMODELING; IN VITRO STUDY; IN VIVO STUDY; MORTALITY; MOUSE; MUSCLE CELL; NONHUMAN; NUCLEOSOME; RAT; ANIMAL; C57BL MOUSE; DISEASE MODEL; DRUG EFFECTS; FLUORESCENT ANTIBODY TECHNIQUE; PATHOLOGY; PHYSIOLOGY; REAL TIME POLYMERASE CHAIN REACTION; TUNEL ASSAY; WESTERN BLOTTING; WISTAR RAT;

ANIMALS; BLOTTING, WESTERN; CHROMATIN; DEOXYRIBONUCLEASE I; DISEASE MODELS, ANIMAL; FLUORESCENT ANTIBODY TECHNIQUE; IN SITU NICK-END LABELING; MICE; MICE, INBRED C57BL; MYOCARDIAL INFARCTION; RATS; RATS, WISTAR; REAL-TIME POLYMERASE CHAIN REACTION; VENTRICULAR REMODELING;

EID: 84936804715     PISSN: 03008428     EISSN: 14351803     Source Type: Journal    
DOI: 10.1007/s00395-015-0472-y     Document Type: Article

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