Controlled Dissolution of Griseofulvin Solid Dispersions from Electrosprayed Enteric Polymer Micromatrix Particles: Physicochemical Characterization and in Vitro Evaluation

Molecular Pharmaceutics

Volumn 12, Issue 7, 2015, Pages 2254-2264

  Roine, Jorma ^a   Kaasalainen, Martti ^a   Peurla, Markus ^a   Correia, Alexandra ^b   Araújo, Francisca ^b,c,d   Santos, Hélder A ^b   Murtomaa, Matti ^a   Salonen, Jarno ^a  

^a UNIVERSITY OF TURKU   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

^c INEB INSTITUTO DE ENGENHARIA BIOMÉDICA   (Portugal)

^d UNIVERSITY OF PORTO   (Portugal)

Author keywords

drug dissolution; drug permeability; electrospraying; enteric release; improved bioavailability; porous silicon; solid dispersion

Indexed keywords

EUDRAGIT; GRISEOFULVIN; SILICON; ACRYLIC ACID RESIN; DRUG CARRIER; EUDRAGIT L100-55; NANOPARTICLE; POLYMER; WATER;

ARTICLE; CACO 2 CELL LINE; DISPERSION; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG PENETRATION; DRUG RELEASE; DRUG SCREENING; DRUG SOLUBILITY; DRUG SOLUTION; ELECTROSPRAY; HT 29 CELL LINE; IN VITRO STUDY; INTESTINE CELL; PH; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; TRANSMISSION ELECTRON MICROSCOPY; X RAY DIFFRACTION; BIOAVAILABILITY; CHEMISTRY; DRUG EFFECTS; HUMAN; INTESTINE ABSORPTION; PERMEABILITY; PHARMACEUTICS; PROCEDURES; SOLUBILITY; TUMOR CELL LINE;

ACRYLIC RESINS; BIOLOGICAL AVAILABILITY; CACO-2 CELLS; CELL LINE, TUMOR; DRUG CARRIERS; GRISEOFULVIN; HT29 CELLS; HUMANS; INTESTINAL ABSORPTION; NANOPARTICLES; PERMEABILITY; POLYMERS; SILICON; SOLUBILITY; TECHNOLOGY, PHARMACEUTICAL; WATER;

EID: 84936792232     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp500787b     Document Type: Article

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