A novel human R25C-phospholamban mutation is associated with super-inhibition of calcium cycling and ventricular arrhythmia

Cardiovascular Research

Volumn 107, Issue 1, 2015, Pages 164-174

  Liu, Guan Sheng ^a   Morales, Ana ^b,c   Vafiadaki, Elizabeth ^d   Lam, Chi Keung ^a   Cai, Wen Feng ^a   Haghighi, Kobra ^a   Adly, George ^a   Hershberger, Ray E ^b,c   Kranias, Evangelia G ^a,d  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b THE OHIO STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

^c OHIO STATE UNIVERSITY   (United States)

^d BIOMEDICAL RESEARCH FOUNDATION   (Greece)

Author keywords

Calcium cycling; Dilated cardiomyopathy; Mutation

Indexed keywords

ANGIOTENSIN RECEPTOR ANTAGONIST; ARGININE; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CALCIUM ION; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYSTEINE; ISOPRENALINE; PHOSPHOLAMBAN; RYANODINE RECEPTOR 2; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; SERINE; THREONINE; CALCIUM; CALCIUM BINDING PROTEIN; RYANODINE RECEPTOR;

ADULT; AGED; AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARRHYTHMOGENESIS; ARTICLE; BINDING AFFINITY; CARDIOVERSION; CASE REPORT; CHRONIC ATRIAL FIBRILLATION; CONGESTIVE CARDIOMYOPATHY; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; EXOME; EXOME SEQUENCING; FEMALE; GENE OVEREXPRESSION; HEART FAILURE; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILITY; HEART TRANSPLANTATION; HEART VENTRICLE ARRHYTHMIA; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MIDDLE AGED; MISSENSE MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; RAT; SARCOPLASMIC RETICULUM; SEQUENCE ANALYSIS; STRESS; SUDDEN CARDIAC DEATH; VERY ELDERLY; ANIMAL; ARRHYTHMIAS, CARDIAC; CARDIAC MUSCLE CELL; CELL CULTURE; GENETICS; HEK293 CELL LINE; METABOLISM; MUTATION;

AGED; ANIMALS; ARRHYTHMIAS, CARDIAC; CALCIUM; CALCIUM-BINDING PROTEINS; CARDIOMYOPATHY, DILATED; CELLS, CULTURED; CYCLIC AMP-DEPENDENT PROTEIN KINASES; HEK293 CELLS; HUMANS; ISOPROTERENOL; MALE; MIDDLE AGED; MUTATION; MYOCYTES, CARDIAC; RATS; RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL; SARCOPLASMIC RETICULUM; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES;

EID: 84936753980     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvv127     Document Type: Article

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