A dimensionless ordered pull-through model of the mammalian lens epithelium evidences scaling across species and explains the age-dependent changes in cell density in the human lens

Journal of the Royal Society Interface

Volumn 12, Issue 108, 2015, Pages

  Wu, Jun Jie ^a   Wu, Weiju ^a,b   Tholozan, Frederique M ^a,c   Saunter, Christopher D ^a   Girkin, John M ^a   Quinlan, Roy A ^a  

^a DURHAM UNIVERSITY   (United Kingdom)

^b GUY S HOSPITAL   (United Kingdom)

^c NETPark Incubator Thomas Wright Way   (United Kingdom)

Author keywords

Ageing; Cataract; Cell proliferation; Eye lens; Mathematical model; Scaling

Indexed keywords

CELL PROLIFERATION; CELLS; CYTOLOGY; MATHEMATICAL MODELS;

AGEING; BETA-ALPHA RATIO; CATARACT; DIMENSIONLESS PARAMETERS; EYE LENS; PROLIFERATION RATE; SCALING; SPECIES COMPARISONS;

MAMMALS;

FIBROBLAST GROWTH FACTOR 2; MORPHOGEN;

ADULT; AGE; AGED; ANIMAL CELL; APOPTOSIS; ARTICLE; BOVINE MODEL; CELL DENSITY; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SURVIVAL; CELLULAR DISTRIBUTION; CONTROLLED STUDY; HUMAN; HUMAN CELL; JUVENILE ANIMAL; LENS EPITHELIUM CELL; MATHEMATICAL MODEL; MIDDLE AGED; MOUSE; NONHUMAN; RABBIT MODEL; SPECIES COMPARISON; VERY ELDERLY; YOUNG ADULT; AGING; ANIMAL; BIOLOGICAL MODEL; BOVINE; EPITHELIUM; FEMALE; LENS; MALE; METABOLISM; PATHOLOGY; RABBIT; RAT; SPECIES DIFFERENCE;

BOVINAE; MAMMALIA; ORYCTOLAGUS CUNICULUS; RATTUS;

ADULT; AGED; AGED, 80 AND OVER; AGING; ANIMALS; CATTLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SURVIVAL; EPITHELIUM; FEMALE; HUMANS; LENS, CRYSTALLINE; MALE; MICE; MIDDLE AGED; MODELS, BIOLOGICAL; RABBITS; RATS; SPECIES SPECIFICITY;

EID: 84936752673     PISSN: 17425689     EISSN: 17425662     Source Type: Journal    
DOI: 10.1098/rsif.2015.0391     Document Type: Article

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