Age-related differences in signaling efficiency of human lens cells underpin differential wound healing response rates following cataract surgery

Investigative Ophthalmology and Visual Science

Volumn 54, Issue 1, 2013, Pages 333-342

  Dawes, Lucy Jean ^a,b   Duncan, George ^a   Wormstone, Ian Michael ^a  

^a UNIVERSITY OF EAST ANGLIA   (United Kingdom)

^b UNIVERSITY OF SYDNEY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; FIBROBLAST GROWTH FACTOR; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 13; INTERLEUKIN 1BETA; INTERLEUKIN 6; SCATTER FACTOR; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; VASCULOTROPIN; INTERLEUKIN DERIVATIVE;

ADULT; AGED; AGING; ARTICLE; CAPSULORHEXIS; CATARACT; CATARACT EXTRACTION; CELL DIFFERENTIATION; CELL GROWTH; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITHELIUM CELL; ETHICS; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; WOUND HEALING; CELL CULTURE; CELL PROLIFERATION; COMPARATIVE STUDY; DISEASE COURSE; LENS; METABOLISM; MIDDLE AGED; PATHOLOGY; SIGNAL TRANSDUCTION;

ADULT; AGING; CATARACT; CATARACT EXTRACTION; CELL PROLIFERATION; CELLS, CULTURED; DISEASE PROGRESSION; ENZYME-LINKED IMMUNOSORBENT ASSAY; FIBROBLAST GROWTH FACTORS; HEPATOCYTE GROWTH FACTOR; HUMANS; INTERLEUKINS; LENS, CRYSTALLINE; MIDDLE AGED; SIGNAL TRANSDUCTION; WOUND HEALING;

MLCS; MLOWN;

EID: 84874516162     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.12-10425     Document Type: Article

References (42)

1. Duncan G, Wormstone IM, Davies PD. The aging human lens: structure, growth, and physiological behaviour. Br J Ophthalmol. 1997;81:818-823.
2. Wormstone IM, Wang L, Liu CS. Posterior capsule opacification. Exp Eye Res. 2009;88:257-269.
3. Moisseiev J, Bartov E, Schochat A, Blumenthal M. Long-term study of the prevalence of capsular opacification following extracapsular cataract extraction. J Cataract Refract Surg. 1989;15:531-533.
4. Wormstone IM. Posterior capsule opacification: a cell biological perspective. Exp Eye Res. 2002;74:337-347.
5. Liu CS, Wormstone IM, Duncan G, Marcantonio JM, Webb SF, Davies PD. A study of human lens cell growth in vitro. A model for posterior capsule opacification. Invest Ophthalmol Vis Sci. 1996;37:906-914.
6. Wormstone IM, Liu CS, Rakic JM, Marcantonio JM, Vrensen GF, Duncan G. Human lens epithelial cell proliferation in a protein-free medium. Invest Ophthalmol Vis Sci. 1997;38: 396-404.
7. Li Y, Yan Q, Wolf NS. Long-term caloric restriction delays agerelated decline in proliferation capacity of murine lens epithelial cells in vitro and in vivo. Invest Ophthalmol Vis Sci. 1997;38:100-107.
8. Aubert G, Lansdorp PM. Telomeres and aging. Physiol Rev. 2008;88:557-579.
9. Aviv A, Valdes AM, Spector TD. Human telomere biology: pitfalls of moving from the laboratory to epidemiology. Int J Epidemiol. 2006;35:1424-1429.
10. Shay JW, Wright WE. Senescence and immortalization: role of telomeres and telomerase. Carcinogenesis. 2005;26:867-874.
11. Wyllie FS, Jones CJ, Skinner JW, et al. Telomerase prevents the accelerated cell ageing of Werner syndrome fibroblasts. Nat Genet. 2000;24:16-17.
12. Colitz CM, Davidson MG, McGahan MC. Telomerase activity in lens epithelial cells of normal and cataractous lenses. Exp Eye Res. 1999;69:641-649.
13. Ball AJ, Levine F. Telomere-independent cellular senescence in human fetal cardiomyocytes. Aging Cell. 2005;4:21-30.
14. Guney I, Sedivy JM. Cellular senescence, epigenetic switches and c-Myc. Cell Cycle. 2006;5:2319-2323.
15. Passos JF, Von Zglinicki T. Oxygen free radicals in cell senescence: are they signal transducers? Free Radic Res. 2006;40:1277-1283.
16. Crosby LM, Waters CM. Epithelial repair mechanisms in the lung. Am J Physiol Lung Cell Mol Physiol. 2010;298:L715-L731.
17. Geiser T, Jarreau PH, Atabai K, Matthay MA. Interleukin-1beta augments in vitro alveolar epithelial repair. Am J Physiol Lung Cell Mol Physiol. 2000;279:L1184-L1190.
18. Lee HS, Myers A, Kim J. Vascular endothelial growth factor drives autocrine epithelial cell proliferation and survival in chronic rhinosinusitis with nasal polyposis. Am J Respir Crit Care Med. 2009;180:1056-1067.
19. Li Y, de Haar C, Chen M, et al. Disease-related expression of the IL6/STAT3/SOCS3 signalling pathway in ulcerative colitis and ulcerative colitis-related carcinogenesis. Gut. 2009;59: 227-235.
20. Scholzen T, Hartmeyer M, Fastrich M, et al. Ultraviolet light and interleukin-10 modulate expression of cytokines by transformed human dermal microvascular endothelial cells (HMEC-1). J Invest Dermatol. 1998;111:50-56.
21. Nagata J, Kijima H, Hatanaka H, et al. Correlation between interleukin 10 and vascular endothelial growth factor expression in human esophageal cancer. Int J Mol Med. 2002;10:169-172.
22. Saint-Geniez M, Kurihara T, D'Amore PA. Role of cell and matrix-bound VEGF isoforms in lens development. Invest Ophthalmol Vis Sci. 2009;50:311-321.
23. Wormstone IM, Tamiya S, Eldred JA, et al. Characterisation of TGF-beta2 signalling and function in a human lens cell line. Exp Eye Res. 2004;78:705-714.
24. Wormstone IM, Tamiya S, Marcantonio JM, Reddan JR. Hepatocyte growth factor function and c-Met expression in human lens epithelial cells. Invest Ophthalmol Vis Sci. 2000; 41:4216-4222.
25. Choi J, Park SY, Joo CK. Hepatocyte growth factor induces proliferation of lens epithelial cells through activation of ERK1/2 and JNK/SAPK. Invest Ophthalmol Vis Sci. 2004;45: 2696-2704.
26. McAvoy JW, Chamberlain CG. Fibroblast growth factor (FGF) induces different responses in lens epithelial cells depending on its concentration. Development. 1989;107:221-228.
27. Wormstone IM, Del Rio-Tsonis K, McMahon G, et al. FGF: an autocrine regulator of human lens cell growth independent of added stimuli. Invest Ophthalmol Vis Sci. 2001;42:1305-1311.
28. Boswell BA, VanSlyke JK, Musil LS. Regulation of lens gap junctions by transforming growth factor beta. Mol Biol Cell. 2010;21:1686-1697.
29. Iyengar L, Patkunanathan B, Lynch OT, McAvoy JW, Rasko JE, Lovicu FJ. Aqueous humour-and growth factor-induced lens cell proliferation is dependent on MAPK/ERK1/2 and Akt/PI3-K signalling. Exp Eye Res. 2006;83:667-678.
30. Asada M, Shinomiya M, Suzuki M, et al. Glycosaminoglycan affinity of the complete fibroblast growth factor family. Biochim Biophys Acta. 2009;1790:40-48.
31. Catlow K, Deakin JA, Delehedde M, et al. Hepatocyte growth factor/scatter factor and its interaction with heparan sulphate and dermatan sulphate. Biochem Soc Trans. 2003;31:352-353.
32. Harmer NJ, Chirgadze D, Hyun Kim K, Pellegrini L, Blundell TL. The structural biology of growth factor receptor activation. Biophys Chem. 2003;100:545-553.
33. Kemp LE, Mulloy B, Gherardi E. Signalling by HGF/SF and Met: the role of heparan sulphate co-receptors. Biochem Soc Trans. 2006;34:414-417.
34. Selleck SB. Shedding light on the distinct functions of proteoglycans. Sci STKE. 2006;2006:pe17.
35. Lovicu FJ, McAvoy JW. Localization of acidic fibroblast growth factor, basic fibroblast growth factor, and heparan sulphate proteoglycan in rat lens: implications for lens polarity and growth patterns. Invest Ophthalmol Vis Sci. 1993;34:3355-3365.
36. Huang C, Jacobson K, Schaller MD. MAP kinases and cell migration. J Cell Sci. 2004;117:4619-4628.
37. Weston CR, Lambright DG, Davis RJ. Signal transduction. MAP kinase signaling specificity. Science. 2002;296:2345-2347.
38. Chamberlain CG, McAvoy JW. Induction of lens fibre differentiation by acidic and basic fibroblast growth factor (FGF). Growth Factors. 1989;1:125-134.
39. Wormstone IM, Tamiya S, Anderson I, Duncan G. TGF-beta2-induced matrix modification and cell transdifferentiation in the human lens capsular bag. Invest Ophthalmol Vis Sci. 2002; 43:2301-2308.
40. Dawes LJ, Eldred JA, Anderson IK, et al. TGF beta-induced contraction is not promoted by fibronectin-fibronectin receptor interaction, or alpha SMA expression. Invest Ophthalmol Vis Sci. 2008;49:650-661.
41. Dawes LJ, Elliott RM, Reddan JR, Wormstone YM, Wormstone IM. Oligonucleotide microarray analysis of human lens epithelial cells: TGFbeta regulated gene expression. Mol Vis. 2007;13:1181-1197.
42. Wormstone IM, Anderson IK, Eldred JA, Dawes LJ, Duncan G. Short-term exposure to transforming growth factor beta induces long-term fibrotic responses. Exp Eye Res. 2006;83: 1238-1245.