Age-dependent control of lens growth by hypoxia

Investigative Ophthalmology and Visual Science

Volumn 49, Issue 3, 2008, Pages 1023-1029

  Shui, Ying Bo ^a   Beebe, David C ^a  

^a WASHINGTON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

OXYGEN; BROXURIDINE;

AGE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CATARACT; CELL PROLIFERATION; CONTROLLED STUDY; GROWTH; HYPOXIA; LENS; LENS EPITHELIUM; NONHUMAN; PRIORITY JOURNAL; RAT; AGING; ANIMAL; ANOXIA; CELL COUNT; CYTOLOGY; EPITHELIUM CELL; GROWTH, DEVELOPMENT AND AGING; HYPEROXIA; METABOLISM; NEWBORN; NICK END LABELING; ORGAN SIZE; PHYSIOLOGY;

AGING; ANIMALS; ANIMALS, NEWBORN; ANOXIA; BROMODEOXYURIDINE; CELL COUNT; CELL PROLIFERATION; EPITHELIAL CELLS; HYPEROXIA; IN SITU NICK-END LABELING; LENS, CRYSTALLINE; ORGAN SIZE; OXYGEN; RATS;

EID: 41949131757     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.07-1164     Document Type: Article

References (70)

1. McCarty CA, Nanjan MB, Taylor HR. Attributable risk estimates for cataract to prioritize medical and public health action. Invest Ophthalmol Vis Sci. 2000;41:3720-3725.
2. Hammond CJ, Duncan DD, Snieder H, et al. The heritability of age-related cortical cataract: the Twin Eye Study. Invest Ophthalmol Vis Sci. 2001;42:601-605.
3. Hammond CJ, Snieder H, Spector TD, Gilbert CE. Genetic and environmental factors in age-related nuclear cataracts in monozygotic and dizygotic twins. N Engl J Med. 2000;342:1786-1790.
4. Heiba IM, Elston RC, Klein BE, Klein R. Genetic etiology of nuclear cataract: evidence for a major gene. Am J Med Genet. 1993;47:1208-1214.
5. Heiba IM, Elston RC, Klein BE, Klein R. Evidence for a major gene for cortical cataract. Invest Ophthalmol Vis Sci. 1995;36:227-235.
6. Iyengar SK, Klein BEK, Klein R, et al. Identification of a major locus for age-related cortical cataract on chromosome 6p12-q12 in the Beaver Dam Eye Study. Proc Natl Acad Sci USA. 2004;101:14485-14490.
7. Bassnett S. Lens organelle degradation. Exp Eye Res. 2002;74:1-6.
8. Beebe D. Lens. In: Kaufman PL, Aim A, eds. Adler's Physiology of the Eye. St. Louis, MO: Mosby; 2003:117-158.
9. Augusteyn RC. Growth of the human eye lens. Moll Vis. 2007;13:252-257.
10. Scammon RE, Hesdorfer MB. Growth in mass and volume of the human lens in postnatal life. Arch Ophthalmol. 1937;17:104-112.
11. Bours J, Fodisch H. Human fetal lens: wet and dry weight with increasing gestational age. Ophthalmic Res. 1986;18:363-368.
12. Brewitt B, Clark J. Growth and transparency in the lens, an epithelial tissue, stimulated by pulses of PDGF. Science. 1988;242:777-779.
13. Chen K, Zhou Y, Xing K, Krysan K, Lou MF. Platelet-derived growth factor (PDGF)-induced reactive oxygen species in the lens epithelial cells: the redox signaling. Exp Eye Res. 2004;78:1057-1067.
14. Reneker LW, Overbeek PA. Lens-specific expression of PDGF-A alters lens growth and development. Dev Biol. 1996;180:554-565.
15. Ray S, Gao C, Wyatt K, et al. Platelet-derived growth factor D, tissue-specific expression in the eye, and a key role in control of lens epithelial cell proliferation. J. Biol Chem. 2005;280:8494-8502.
16. Schulz MW, Chamberlain CG, de Iongh RU, McAvoy JW. Acidic and basic FGF in ocular media and lens: implications for lens polarity and growth patterns. Development. 1993;118:117-126.
17. Liu J, Chamberlain CG, McAvoy JW. IGF enhancement of FGFinduced fibre differentiation and DNA synthesis in lens expiants. Exp Eye Res. 1996;63:621-629.
18. Blanquet P, Patte C, Fayein N, Courtois Y. Identification and isolation from bovine epithelial lens cells of two basic fibroblast growth factor receptors that possess bFGF-enhanced phosphorylation activities. Biochem Biophys Res Commun. 1989;160:1124-1131.
19. Wormstone IM, Del Rio-Tsonis K, McMahon G, et al. FGF: an autocrine regulator of human lens cell growth independent of added stimuli. Invest Ophthalmol Vis Sci. 2001;42:1305-1311.
20. Le AC, Musil LS. FGF signaling in chick lens development. Dev Biol. 2001;233:394-411.
21. Reddan JR, Wilson-Dziedzic D. Insulin growth factor and epidermal growth factor trigger mitosis in lenses cultured in a serum-free medium. Invest Ophthalmol Vis Sci. 1983;24:409-416.
22. Reid T, Reid W. The labile nature of the insulin signal(s) for the stimulation of DNA synthesis in mouse lens epithelial and 3T3 cells. J Biol Chem. 1987;262:229-233.
23. Wickstrom K, Madsen K. The effect of transforming growth factoralpha (TGF alpha) on rabbit and primate lens epithelial cells in vitro. Curr Eye Res. 1993;12:1123-1129.
24. Ibaraki N, Lin LR, Reddy VN. Effects of growth factors on proliferation and differentiation in human lens epithelial cells in early subculture. Invest Ophthalmol Vis Sci. 1995;36:2304-2312.
25. Majima K. Human lens epithelial cens proliferate in response to exogenous EGF and have EGF and EGF receptor. Ophthalmic Res. 1995;27:356-365.
26. Ibaraki N, Lin LR, Reddy VN. A study of growth factor receptors in human lens epithelial cells and their relationship to fiber differentiation. Exp Eye Res. 1996;63:683-692.
27. Ireland ME, Mrock LK. Expression and activation of the epidermal growth factor receptor in differentiating cells of the developing and post-hatching chicken lens. Exp Eye Res. 2004;79:305-312.
28. Ireland ME. Activated epidermal growth factor receptors in the adult human lens. Exp Eye Res. 2005;80:443-445.
29. Fleming TP, Song Z, Andley UP. Expression of growth control and differentiation genes in human lens epithelial cells with extended life span. Invest Ophthalmol Vis Sci. 1998;39:1387-1398.
30. Weng J, Liang Q, Mohan RR, Li Q, Wilson SE. Hepatocyte growth factor, keratinocyte growth factor, and other growth factor-receptor systems in the lens. Invest Ophthalmol Vis Sci. 1997;38:1543-1554.
31. Fitch CL, Swedberg SH, Livesey JC. Measurement and manipulation of the partial pressure of oxygen in the rat anterior chamber. Curr Eye Res. 2000;20:121-126.
32. Barbazetto IA, Liang J, Chang S, Zheng L, Spector A, Dillon JP. Oxygen tension in the rabbit lens and vitreous before and after vitrectomy. Exp Eye Res. 2004;78:917-924.
33. Holekamp NM, Shui YB, Beebe DC. Vitrectomy surgery increases oxygen exposure to the lens: a possible mechanism for nuclear cataract formation. Am J Ophthalmol. 2005;139:302-310.
34. Shui Y-B, Fu J-J, Garcia C, et al. Oxygen distribution in the rabbit eye and oxygen consumption by the lens. Invest Ophthalmol Vis Sci. 2006;47:1571-1580.
35. Helbig H, Hinz JP, Kellner U, Foerster MH. Oxygen in the anterior chamber of the human eye. Ger J Ophthalmol. 1993;2:161-164.
36. Palmquist BM, Philipson B, Barr PO. Nuclear cataract and myopia during hyperbaric oxygen therapy. Br J Ophthalmol. 1984;68:113-117.
37. Giblin FJ, Padgaonkar VA, Leverenz VR, et al. Nuclear light scattering, disulfide formation and membrane damage in lenses of older guinea pigs treated with hyperbaric oxygen. Exp Eye Res. 1995;60:219-235.
38. Harocopos GJ, Shui Y-B, McKinnon M, Holekamp NM, Gordon MO, Beebe DC. Importance of vitreous liquefaction in age-related cataract. Invest Ophthalmol Vis Sci. 2004;45:77-85.
39. Klein B, Klein R, Moss S. Correlates of lens thickness: the Beaver Dam Eye Study. Invest Ophthalmol Vis Sci. 1998;39:1507-1510.
40. Klein BE, Klein R, Moss SE. Lens thickness and five-year cumulative incidence of cataracts: the Beaver Dam Eye Study. Ophthalmic Epidemiol. 2000;7:243-248.
41. Bassnett S, McNulty R. The effect of elevated intraocular oxygen on organelle degradation in the embryonic chicken lens. J. Exp Biol. 2003;206:4353-4361.
42. McLaren JW, Dinslage S, Dillon JP, Roberts JE, Brubaker RF. Measuring oxygen tension in the anterior chamber of rabbits. Invest Ophthalmol Vis Sci. 1998;39:1899-1909.
43. Kwan M, Niinikoski J, Hunt TK. In vivo measurements of oxygen tension in the cornea, aqueous humor, and anterior lens of the open eye. Invest Ophthalmol. 1972;11:108-114.
44. McNulty R, Wang H, Mathias RT, Ortwerth BJ, Truscott RJ, Bassnett S. Regulation of tissue oxygen levels in the mammalian lens. J Physiol. 2004;559:883-898.
45. Yu DY, Cringle SJ, Alder VA. The response of rat vitreal oxygen tension to stepwise increases in inspired percentage oxygen. Invest Ophthalmol Vis Sci. 1990;31:2493-2499.
46. Carmeliet P, Dor Y, Herbert JM, et al. Role of HIF-1α in hypoxiamediated apoptosis, cell proliferation and tumour angiogenesis. Nature. 1998;394:485-490.
47. Goda N, Dozier SJ, Johnson RS. HIF-1 in cell cycle regulation, apoptosis, and tumor progression. Antioxid Redox Signal. 2003;5:467-473.
48. Galvin DJ, Watson RW, O'Neill A, et al. Hypoxia inhibits human bladder smooth muscle cell proliferation: a potential mechanism of bladder dysfunction. Neurourol Urodyn. 2004;23:342-348.
49. Lee JW, Bae SH, Jeong JW, Kim SH, Kim KW. Hypoxia-inducible factor (HIF-l)alpha: its protein stability and biological functions. Exp Mol Med. 2004;36:1-12.
50. de Iongh RU, Lovicu FJ, Hanneken A, Baird A, McAvoy JW. FGF receptor-1 (fig) expression is correlated with fibre differentiation during rat lens morphogenesis and growth. Dev Dyn. 1996;206:412-426.
51. Kurosaka D, Nagamoto T. Inhibitory effect of TGF-β2 in human aqueous humor on bovine lens epithelial cell proliferation. Invest Ophthalmol Vis Sci. 1994;35:3408-3412.
52. Iyengar L, Patkunanathan B, Lynch OT, McAvoy JW, Rasko JEJ, Lovicu FJ. Aqueous humour and growth factor-induced lens cell proliferation is dependent on MAPK/ERK1/2 and Akt/PI3-K signalling. Exp Eye Res. 2006;83:667-678.
53. Truscott RJW. Age-related nuclear cataract-oxidation is the key. Exp Eye Res. 2004;80:709-725.
54. Holekamp NM, Shui Y-B, Beebe D. Lower intraocular oxygen tension in diabetic patients: possible contribution to decreased incidence of nuclear sclerotic cataract. Am J Ophthalmol. 2006;141:1027-1032.
55. Schaal S, Beiran I, Rubinstein I, Miller B, Dovrat A. Lenticular oxygen toxicity. Invest Ophthalmol Vis Sci. 2003;44:3476-3484.
56. Dische Z, Zil HA. Studies on the oxidation of cysteine to cystine in lens proteins during cataract formation. Am J Ophthalmol. 1951;34:104-113.
57. Truscott RJ, Augusteyn RC. Oxidative changes in human lens proteins during senile nuclear cataract formation. Biochim Biophys Acta. 1977;492:43-52.
58. Spector A. The search for a solution to senile cataracts: Proctor lecture. Invest Ophthalmol Vis Sci. 1984;25:130-146.
59. Lohmann W, Schmehl W, Strobel J. Nuclear cataract: oxidative damage to the lens. Exp Eye Res. 1986;43:859-862.
60. Giblin FJ, Schrimscher L, Chakrapani B, Reddy VN. Exposure of rabbit lens to hyperbaric oxygen in vitro: regional effects on GSH level. Invest Ophthalmol Vis Sci. 1988;29:1312-1319.
61. Giblin FJ. Glutathione: a vital lens antioxidant. J. Ocul Pharmacol Ther. 2000;16:121-135.
62. Calvin H, Medvedovsky C, David J, et al. Rapid deterioration of lens fibers in GSH-depleted mouse pups. Invest Ophthalmol Vis Sci. 1991;32:1916-1924.
63. Shestopalov VI, Bassnett S. Expression of autofluorescent proteins reveals a novel protein permeable pathway between cells in the lens core. J Cell Sci. 2000;113:1913-1921.
64. Shestopalov VI, Bassnett S. Development of a macromolecular diffusion pathway in the lens. J Cell Sci. 2003;116:4191-4199.
65. Sweeney MH, Truscott RJ. An impediment to glutathione diffusion in older normal human lenses: a possible precondition for nuclear cataract. Exp Eye Res. 1998;67:587-595.
66. Lou MF. Thiol regulation in the lens. J. Ocul Pharmacol Ther. 2000;16:137-148.
67. Reddy V. Glutathione and its function in the lens-an overview. Exp Eye Res. 1990;50:771-778.
68. Moffat BA, Pope JM. Anisotropic water transport in the human eye lens studied by diffusion tensor NMR micro-imaging. Exp Eye Res. 2002;74:677-687.
69. Moffat BA, Landman KA, Truscott RJ, Sweeney MH, Pope JM. Age-related changes in the kinetics of water transport in normal human lenses. Exp Eye Res. 1999;69:660-669.
70. Truscott RJ. Age-related nuclear cataract: a lens transport problem. Ophthalmic Res. 2000;32:185-194.