Defect of mitotic vimentin phosphorylation causes microophthalmia and cataract via aneuploidy and senescence in lens epithelial cells

Journal of Biological Chemistry

Volumn 288, Issue 50, 2013, Pages 35626-35635

  Matsuyama, Makoto ^a   Tanaka, Hiroki ^a   Inoko, Akihito ^a   Goto, Hidemasa ^a,b   Yonemura, Shigenobu ^c   Kobori, Kyoko ^a   Hayashi, Yuko ^a   Kondo, Eisaku ^a,b   Itohara, Shigeyoshi ^d   Izawa, Ichiro ^a   Inagaki, Masaki ^a,b  

^a AICHI CANCER CENTER HOSPITAL   (Japan)

^b NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c RIKEN Center for Biosystems Dynamics Research   (Japan)

^d RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE RESIDUES; CAUSAL RELATIONSHIPS; CHROMOSOMAL INSTABILITY; FIBER MEMBRANES; INTERMEDIATE FILAMENTS; LENS EPITHELIAL CELLS; MULTINUCLEATION; PREMATURE AGING;

AMINO ACIDS; CHROMOSOMES; CONTACT LENSES; MAMMALS;

PHOSPHORYLATION;

CYCLIN DEPENDENT KINASE INHIBITOR 2A; MESSENGER RNA; PROTEIN P21; VIMENTIN;

AMINO ACID SUBSTITUTION; ANEUPLOIDY; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CATARACT; CHROMOSOMAL INSTABILITY; CONTROLLED STUDY; EMBRYO; EYE MALFORMATION; GENE; HETEROZYGOTE; HOMOZYGOTE; LENS EPITHELIUM; MICROOPHTHALMIA; MITOSIS; MOUSE; N MYC DOWNSTREAM REGULATED GENE 2; NONHUMAN; P16INK4A GENE; P19ARF GENE; P21 GENE; PREMATURE AGING; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

ANEUPLOIDY; CATARACT; CELL DIVISION; CHROMOSOMAL INSTABILITY; CYTOKINESIS; MITOSIS; PHOSPHORYLATION; SENESCENCE; VIMENTIN;

ALLELES; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANEUPLOIDY; ANIMALS; CATARACT; CELL AGING; CELL NUCLEUS; ENDOPHTHALMITIS; EPITHELIAL CELLS; GENE KNOCK-IN TECHNIQUES; LENS, CRYSTALLINE; MICE; MITOSIS; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; VIMENTIN;

EID: 84890364310     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.514737     Document Type: Article

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