The active Hsc70/tau complex can be exploited to enhance tau turnover without damaging microtubule dynamics

Human Molecular Genetics

Volumn 24, Issue 14, 2015, Pages 3971-3981

  Fontaine, Sarah N ^a,b   Martin, Mackenzie D ^a   Akoury, Elias ^c,d,e   Assimon, Victoria A ^f   Borysov, Sergiy ^a   Nordhues, Bryce A ^a,b   Sabbagh, Jonathan J ^a,b   Cockman, Matt ^a   Gestwicki, Jason E ^f   Zweckstetter, Markus ^c,d,e   Dickey, Chad A ^a,b  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

^d GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

^e UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

^f UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHAPERONE; HEAT SHOCK COGNATE PROTEIN 70; TAU PROTEIN; ISOPROTEIN; MAPT PROTEIN, HUMAN;

ARTICLE; BRAIN CELL; BRAIN TISSUE; CELL DISRUPTION; CONTROLLED STUDY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IN VIVO STUDY; MICROTUBULE; MICROTUBULE ASSEMBLY; PRIORITY JOURNAL; PROTEIN METABOLISM; TAUOPATHY; ANIMAL; BRAIN; GENE EXPRESSION REGULATION; GENETICS; HEK293 CELL LINE; KNOCKOUT MOUSE; METABOLISM; NERVE CELL; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OOCYTE; PHOSPHORYLATION; TAUOPATHIES; XENOPUS;

ANIMALS; BRAIN; GENE EXPRESSION REGULATION; HEK293 CELLS; HSC70 HEAT-SHOCK PROTEINS; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MICE, KNOCKOUT; MICROTUBULES; NEURONS; OOCYTES; PHOSPHORYLATION; PROTEIN ISOFORMS; TAU PROTEINS; TAUOPATHIES; XENOPUS;

EID: 84936747794     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddv135     Document Type: Article

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