Performance enhancement: What are the physiological limits?

Physiology

Volumn 30, Issue 4, 2015, Pages 282-292

  Lundby, C ^a,b   Robach, P ^c  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b UNIVERSITY OF GOTHENBURG   (Sweden)

^c Ecole Nationale des Sports de Montagne   (France)

Author keywords

[No Author keywords available]

Indexed keywords

LACTIC ACID;

ACCLIMATIZATION; ADAPTATION; ALTITUDE; ANAEROBIC THRESHOLD; ANOXIA; ENDURANCE; EXERCISE; HUMAN; METABOLISM; MUSCLE CONTRACTION; MUSCLE FATIGUE; MUSCLE STRENGTH; OXYGEN CONSUMPTION; PATHOPHYSIOLOGY; PHYSIOLOGY; PROCEDURES; SKELETAL MUSCLE;

ACCLIMATIZATION; ADAPTATION, PHYSIOLOGICAL; ALTITUDE; ANAEROBIC THRESHOLD; ANOXIA; EXERCISE; HUMANS; LACTIC ACID; MUSCLE CONTRACTION; MUSCLE FATIGUE; MUSCLE STRENGTH; MUSCLE, SKELETAL; OXYGEN CONSUMPTION; PHYSICAL CONDITIONING, HUMAN; PHYSICAL ENDURANCE;

EID: 84936162108     PISSN: 15489213     EISSN: 15489221     Source Type: Journal    
DOI: 10.1152/physiol.00052.2014     Document Type: Article

References (109)

1. Aagaard P, Andersen JL. Effects of strength training on endurance capacity in top-level endurance athletes. Scand J Med Sci Sports20: 39–47, 2010
2. Abergel E, Chatellier G, Hagege AA, Oblak A, Linhart A, Ducardonnet A, Menard J. Serial left ventricular adaptations in world-class professional cyclists: implications for disease screening and follow-up. J Am Coll Cardiol44: 144–149, 2004
3. Arbab-Zadeh A, Perhonen M, Howden E, Peshock RM, Zhang R, Adams-Huet B, Haykowsky MJ, Levine BD. Cardiac remodeling in response to 1 year of intensive endurance training. Circulation130: 2152–2161, 2014
4. Bacon AP, Carter RE, Ogle EA, Joyner MJ.V˙ O2max trainability and high intensity interval training in humans: a meta-analysis. PLos One8: e73182, 2013
5. Bailey SJ, Romer LM, Kelly J, Wilkerson DP, DiMenna FJ, Jones AM. Inspiratory muscle training enhances pulmonary O2 uptake kinetics and high-intensity exercise tolerance in humans. J Appl Physiol109: 457–468, 2010
6. Bailey SJ, Wilkerson DP, Dimenna FJ, Jones AM. Influence of repeated sprint training on pulmonary O2 uptake and muscle deoxygenation kinetics in humans. J Appl Physiol106: 1875–1887, 2009
7. Bailey SJ, Winyard P, Vanhatalo A, Blackwell JR, DiMenna FJ, Wilkerson DP, Tarr J, Benjamin N, Jones AM. Dietary nitrate supplementation reduces the O2 cost of low-intensity exercise and enhances tolerance to high-intensity exercise in humans. J Appl Physiol107: 1144–1155, 2009
8. Bastiaans JJ, van Diemen AB, Veneberg T, Jeukendrup AE. The effects of replacing a portion of endurance training by explosive strength training on performance in trained cyclists. Eur J Appl Physiol86: 79–84, 2001
9. Bonne TC, Doucende G, Flück D, Jacobs RA, Nordsborg NB, Robach P, Walther G, Lundby C. Phlebotomy eliminates the maximal cardiac output response to six weeks of exercise training. Am J Physiol Regul Integr Comp Physiol306: R752–R760, 2014
10. Bonne TC, Lundby C, Jorgensen S, Johansen L, Mrgan M, Bech SR, Sander M, Papoti M, Nordsborg NB. “Live hightrain high” increases hemoglobin mass in Olympic swimmers. Eur J Appl Physiol114: 1439–1449, 2014
11. Boorsma RK, Whitfield J, Spriet LL. Beetroot juice supplementation does not improve performance in elite 1500-m runners. Med Sci Sports Exerc46: 2326, 2014
12. Bouchard C, Blair SN, Church TS, Earnest CP, Hagberg JM, Hakkinen K, Jenkins NT, Karavirta L, Kraus WE, Leon AS, Rao DC, Sarzynski MA, Skinner JS, Slentz CA, Rankinen T. Adverse metabolic response to regular exercise: is it a rare or common occurrence? PLos One7: e37887, 2012
13. Buick FJ, Gledhill N, Froese AB, Spriet L, Meyers EC. Effect of induced erythrocythemia on aerobic work capacity. J Appl Physiol48: 636–642, 1980
14. Burtscher M, Nachbauer W, Wilber RL. The upper limit of aerobic power in humans. Eur J Appl Physiol10: 2625–2628, 2011
15. Calbet JAL, Holmberg HC, Rosdahl H, van Hall G, Jensen- Urstad M, Saltin B. Why do arms extract less oxygen than legs during exercise? Am J Physiol Regul Integr Comp Physiol289: R1448–R1458, 2005
16. Cermak NM, Gibala MJ, van Loon LJ. Nitrate supplementation’s improvement of 10-km time-trial performance in trained cyclists. Int J Sport Nutr Exerc Metab22: 64–71, 2012
17. Chapman RF, Stray-Gundersen J, Levine BD. Individual variation in response to altitude training. J Appl Physiol85: 1448–1456, 1998
18. Christensen PM, Nyberg M, Bangsbo J. Influence of nitrate supplementation on V˙ O2 kinetics and endurance of elite cyclists. Scand J Med Sci Sports23: e21–e31, 2013
19. Coyle EF. Improved muscular efficiency displayed as Tour de France champion matures. J Appl Physiol98: 2191–2196, 2005
20. Coyle EF. Reconsideration of a Tour de France cyclist. J Appl Physiol114: 1361, 2013
21. Coyle EF, Martin WH, Sinacore DR, Joyner MJ, Hagberg JM, Holloszy JO. Time course of loss of adaptations after stopping prolonged intense endurance training. J Appl Physiol57: 1857–1864, 1984
22. Coyle EF, Sidossis LS, Horowitz JF, Beltz JD. Cycling efficiency is related to the percentage of type I muscle fibers. Med Sci Sports Exerc24: 782–788, 1992
23. Craib MW, Mitchell VA, BFK, Cooper TR, Hopewell R, WMD. The association between flexibility and running economy in sub-elite male distance runner. Med Sci Sports Exerc28: 737–743, 1996
24. Dempsey JA, Reddan WG, Birnbaum ML, Forster HV, Thoden JS, Grover RF, Rankin J. Effects of acute through life-long hypoxic exposure on exercise pulmonary gas exchange. Respir Physiol13: 62–89, 1971
25. Ekblom B, Astrand PO, Saltin B, Stenberg J, Wallström B. Effect of training on circulatory response to exercise. J Appl Physiol24: 518–528, 1968
26. Ekblom B, Hermansen L. Cardiac output in athletes. J Appl Physiol25: 619–625, 1968
27. Engfred K, Kjaer M, Secher NH, Friedman DB, Hanel B, Nielsen OJ, Bach FW, Galbo H, Levine BD. Hypoxia and training-induced adaptation of hormonal responses to exercise in humans. Eur J Appl Physiol68: 303–309, 1994
28. Fagard R. Athlete’s heart. Heart 89: 1455–1461, 2003
29. Fan W, Atkins AR, Yu RT, Downes M, Evans RM. Road to exercise mimetics: targeting nuclear receptors in skeletal muscle. J Mol Endocrinol51: T87–T100, 2013
30. Florence S, Weir JP. Relationship of critical velocity to marathon running performance. Eur J Appl Physiol75: 274–278, 1997
31. Franch J, Madsen K, Djurhuus MS, Pedersen PK. Improved running economy following intensified training correlates with reduced ventilatory demands. Med Sci Sports Exerc30: 1250–1256, 1998
32. Friedmann-Bette B. Classical altitude training. Scand J Med Sci Sports18: 11–20, 2008
33. Gaesser GA, Poole DC. The slow component of oxygen uptake kinetics in humans. Exerc Sport Sci Rev24: 35–71, 1996
34. Garcia-Pallares J, Garcia-Fernandez M, Sanchez-Medina L, Izquierdo M. Performance changes in world-class kayakers following two different training periodization models. Eur J Appl Physiol110: 99–107, 2010
35. Gilbert CA, Nutter DO, Felner JM, Perkins JV, Heymsfield SB, Schlant RC. Echocardiographic study of cardiac dimensions and function in the endurance-trained athlete. Am J Cardiol40: 528–533, 1977
36. Gore CJ, Hahn AG, Aughey RJ, Martin DT, Ashenden MJ, Clark SA, Garnham AP, Roberts AD, Slater GJ, McKenna MJ. Live high:train low increases muscle buffer capacity and submaximal cycling efficiency. Acta Physiol Scand173: 275–286, 2001
37. Gore CJ, Hahn AG, Scroop GC, Watson DB, Norton KI, Wood RJ, Campbell DP, Emonson DL. Increased arterial desaturation in trained cyclists during maximal exercise at 580 m altitude. J Appl Physiol80: 2204–2210, 1996
38. Hagberg JM, Coyle EF. Physiological determinants of endurance performance as studied in competitive racewalkers. Med Sci Sports Exerc15: 287–289, 1983
39. Hickson RC, Bomze HA, Holloszy JO. Linear increase in aerobic power induced by a strenuous program of endurance exercise. J Appl Physiol Respir Environ Exercise Physiol42: 372–376, 1977
40. Holliss BA, Fulford J, Vanhatalo A, Pedlar CR, Jones AM. Influence of intermittent hypoxic training on muscle energetics and exercise tolerance. J Appl Physiol114: 611–619, 2013
41. Hoppeler H, Klossner S, Vogt M. Training in hypoxia and its effects on skeletal muscle tissue. Scand J Med Sci Sports18: 38–49, 2008
42. Jacobs RA, Rasmussen P, Siebenmann C, Díaz V, Gassmann M, Pesta D, Gnaiger E, Nordsborg NB, Robach P, Lundby C. Determinants of time trial performance and maximal incremental exercise in highly trained endurance athletes. J Appl Physiol111: 1422–1430, 2011
43. Jelkmann W, Lundby C. Blood doping and its detection. Blood118: 2395–2404, 2011
44. Jeukendrup AE, Craig NP, Hawley JA. The bioenergetics of World Class Cycling. J Sci Med Sport3: 414–433, 2000
45. Jones AM. The physiology of the world recod holder for the Women’s Marathon. Int J Sport Sci Coaching1: 101–106, 2006
46. Jones AM. Running economy is negatively related to sit-and-reach test performance in international- standard distance runners. Int J Sports Medicine23: 40–43, 2002
47. Jones AM, Carter H. The effect of endurance training on parameters of aerobic fitness. Sports Med29: 373–386, 2000
48. Jones AM, Vanhatalo A, Burnley M, Morton RH, Poole DC. Critical power: implications for determination of V˙ O2max and exercise tolerance. Med Sci Sports Exerc42: 1876–1890, 2010
49. Jones AM, Wilkerson DP, Berger NJ, Fulford J. Influence of endurance training on muscle [PCr] kinetics during high-intensity exercise. Am J Physiol Regul Integr Comp Physiol293: R392–R401, 2007
50. Jones AM, Wilkerson DP, DiMenna F, Fulford J, Poole DC. Muscle metabolic responses to exercise above and below the “critical power” assessed using 31P-MRS. Am J Physiol Regul Integr Comp Physiol294: R585–R593, 2008
51. Joyner MJ, Coyle EF. Endurance exercise performance: the physiology of champions. J Physiol586: 35–44, 2008
52. Joyner MJ, Ruiz JR, Lucia A. The two-hour marathon: who and when? J Appl Physiol110: 275–277, 2011
53. Kalliokoski KK, Oikonen V, Takala TO, Sipilä H, Knuuti J, Nuutila P. Enhanced oxygen extraction and reduced flow heterogeneity in exercising muscle in endurance-trained men. Am J Physiol Endocrinol Metab280: E1015–E1021, 2001
54. Klausen K, Secher NH, Clausen JP, Hartling O, Trap-Jensen J. Central and regional circulatory adaptations to one-leg training. J Appl Physiol Respir Environ Exercise Physiol52: 976–983, 1982
55. Kruse TN, Carter RE, Rosedahl JK, Joyner MJ. Speed trends in male distance running. PLos One9: e112978, 2014
56. Krustrup P, Söderlund K, Mohr M, Bangsbo J. The slow component of oxygen uptake during intense, sub-maximal exercise in man is associated with additional fibre recruitment. Pflügers Arch447: 855–866, 2004
57. Lansley KE, Winyard PG, Bailey SJ, vanhatalo A, Wilkerson DP, Blackwell JR, Gilchrist M, Benjamin N, Jones AM. Acute dietary nitrate supplementation improves cycling time trial performance. Med Sci Sports Exerc43: 1125–1131, 2011
58. Lansley KE, Winyard PG, Fulford J, Vanhatalo A, Bailey SJ, Blackwell JR, DiMenna FJ, Gilchrist M, Benjamin N, Jones AM. Dietary nitrate supplementation reduces the O2 cost of walking and running: a placebo-controlled study. J Appl Physiol110: 591–600, 2011
59. Larsen FJ, Schiffer TA, Borniquel S, Sahlin K, Ekblom B, Lundberg JO, Weitzberg E. Dietary inorganic nitrate improves mitochondrial efficiency in humans. Cell Metab13: 149–159, 2011
60. Larsen FJ, Weitzberg E, Lundberg JO, Ekblom B. Effects of dietary nitrate on oxygen cost during exercise. Acta Physiol (Oxf)191: 59–66, 2007
61. Lecoultre V, Boss A, Tappy L, Borrani F, Tran C, Schneiter P, Schutz Y. Training in hypoxia fails to further enhance endurance performance and lactate clearance in well-trained men and impairs glucose metabolism during prolonged exercise. Exp Physiol95: 315–330, 2010
62. Levine BD. V˙O2max: what do we know, and what do we still need to know? J Physiol586: 25–34, 2008
63. Levine BD, Lane LD, Buckey JC, Friedman DB, Blomqvist CG. Left ventricular pressure-volume and Frank-Starling relations in endurance athletes. Implications for orthostatic tolerance and exercise performance. Circulation 84: 1016–1023, 1991
64. Levine BD, Stray-Gundersen J. “Living high-training low”: effect of moderate-altitude acclimatization with low-altitude training on performance. J Appl Physiol83: 102–112, 1997
65. Lucia A, Esteve-Lanao J, Oliván J, Gómez-Gallego F, San Juan AF, Santiago C, Pérez M, Chamorro-Viña C, Foster C. Physiological characteristics of the best Eritrean runners exceptional running economy. Appl Physiol Nutr Metab31: 530–540, 2006
66. Lucia A, Hoyos J, Perez M, Santalla A, Chicharro JL. Inverse relationship between V˙ O2max and economy/efficiency in world-class cyclists. Med Sci Sports Exerc34: 2079–2084, 2002
67. Lucia A, Oliván J, Bravo J, Gonzalez-Freire M, Foster C. The key to top-level endurance running performance: a unique example. Br J Sports Med42: 172–174, 2008
68. Lundby C, Calbet JAL, van Hall G, Saltin B, Sander M. Pulmonary gas exchange at maximal exercise in Danish lowlanders during 8 wk of acclimatization to 4,100 m and in high-altitude Aymara natives. Am J Physiol Regul Integr Comp Physiol287: R1202–R1208, 2004
69. Lundby C, Millet GP, Calbet JA, Bartsch P, Subudhi AW. Does ‘altitude training’ increase exercise performance in elite athletes? Br J Sports Med46: 792–795, 2012
70. Lundby C, Robach P, Boushel R, Thomsen JJ, Rasmussen P, Koskolou M, Calbet JAL. Does recombinant human Epo increase exercise capacity by means other than augmenting oxygen transport? J Appl Physiol105: 581–587, 2008
71. Madsen K, Pedersen PK, Djurhuus MS, Klitgaard NA. Effects of detraining on endurance capacity and metabolic changes during prolonged exhaustive exercise. J Appl Physiol75: 1444–1451, 1993
72. Malczewska-Lenczowska J, Orysiak J, Majorczyk E, Pokrywka A, Kaczmarski J, Szygula Z, Sitkowski D. No association between tHbmass and polymorphisms in the HBB gene in endurance athletes. Biol Sport31: 115–119, 2014
73. McLean BD, Gore CJ, Kemp J. Application of ‘live low-train high’ for enhancing normoxic exercise performance in team sport athletes. Sports Med44: 1275–1287, 2014
74. Mogensen M, Bagger M, Pedersen PK, Fernström M, Sahlin K. Cycling efficiency in humans is related to low UCP3 content and to type I fibres but not to mitochondrial efficiency. J Physiol571: 669–681, 2006
75. Nonaka H, Mita K, Watakabe M, Akataki K, Suzuki N, Okuwa T, Yabe K. Age-related changes in the interactive mobility of the hip and knee joints: a geometrical analysis. Gait Posture15: 236–243, 2002
76. Olds T, Norton K, Craig N, Olive S, Lowe E. The limits of the possible: models of power supply and demand in cycling. Aust J Sci Med Sport27: 29–33, 1995
77. Olson TP, Taylor BJ, Johnson RD. The two-hour marathon: the importance of breathing economy. J Appl Physiol110: 291, 2011
78. Peeling P, Cox GR, Bullock N, Burke LM. Beetroot juice improves on-water 500 m time-trial performance, and laboratory-based paddling economy in national and international-level kayak athletes. Int J Sport Nutr Exerc Metab. In press
79. Pelliccia A, Maron BJ, Spataro A, Proschan MA, Spirito P. The upper limit of physiologic cardiac hypertrophy in highly trained elite athletes. N Engl J Med324: 295–301, 1991
80. Pilegaard H, Bangsbo J, Richter EA, Juel C. Lactate transport studied in sarcolemmal giant vesicles from human muscle biopsies: relation to training status. J Appl Physiol77: 1858–1862, 1994
81. Poole DC, Ward SA, Gardner GW, Whipp BJ. Metabolic and respiratory profile of the upper limit for prolonged exercise in man. Ergonomics31: 1265–1279, 1988
82. Porcelli S, Ramaglia M, Bellistri G, Pavei G, Pugliese L, Montorsi M, Rasica L, Marzorati M. Aerobic fitness affects the exercise performance responses to nitrate supplementation. Med Sci Sports Exerc. In press
83. Rasmussen P, Nordsborg N, Taudorf S, Sørensen H, Berg RMG, Jacobs RA, Bailey DM, Olsen NV, Secher NH, Møller K, Lundby C. Brain and skin do not contribute to the systemic rise in erythropoietin during acute hypoxia in humans. FASEB J26: 1831–1834, 2012
84. Rasmussen P, Siebenmann C, Diaz V, Lundby C. Red cell volume expansion at altitude: a metaanalysis and Monte Carlo simulation. Med Sci Sports Exerc45: 1767–1772, 2013
85. Robach P, Bonne T, Fluck D, Burgi S, Toigo M, Jacobs RA, Lundby C. Hypoxic training: effect on mitochondrial function and aerobic performance in hypoxia. Med Sci Sports Exerc46: 1936–1945, 2014
86. Robach P, Lundby C. Is live high-train low altitude training relevant for elite athletes with already high total hemoglobin mass? Scand J Med Sci Sports22: 303–305, 2012
87. Robertson EY, Saunders PU, Pyne DB, Aughey RJ, Anson JM, Gore CJ. Reproducibility of performance changes to simulated live high/train low altitude. Med Sci Sports Excerc42: 394–401, 2010
88. Roca J, Agusti AG, Alonso A, Poole DC, Viegas C, Barbera JA, Rodriguez-Roisin R, Ferrer A, Wagner PD. Effects of training on muscle O2 transport at V˙O2max. J Appl Physiol73: 1067–1076, 1992
89. Romer LM, McConnell AK, Jones DA. Inspiratory muscle fatigue in trained cyclists: effects of inspiratory muscle training. Med Sci Sports Exerc34: 785–792, 2002
90. Rusko HK. Development of aerobic power in relation to age and training in cross-country skiers. Med Sci Sports Exerc24: 1040–1047, 1992
91. Saltin B, Blomquist G, Mitchell JH, Johnson RL, Wildenthal K, Chapman CB. Response to exercise after bed rest and after training. Circulation38: 1–78, 1968
92. Saltin B, Larsen H, Terrados N, Bangsbo J, Bak T, Kim CK, Svendenhag J, Rolf CJ. Aerobic exercise capacity at sea level and at altitude in Kenyan boys, junior and senior runners compared with Scandinavian runners. Scand J Med Sci Sports5: 209–221, 1995
93. Saunders PU, Pyne DB, Telford RD, Hawley JA. Factors affecting running economy in trained distance runners. Sports Med34: 465–485, 2004
94. Sawka MN, Convertino VA, Eichner EA, Schneider SM, Young AJ. Blood volume: importance and adaptations to exercise training, environmental stresses, and trauma/sickness. Med Sci Sports Exerc32: 332–348, 2000
95. Scharhag J, Schneider G, Urhausen A, Rochette V, Kramann B, Kindermann W. Athlete’s heart: Right and left ventricular mass and function in male endurance athletes and untrained individuals determined by magnetic resonance imaging. J Am Coll Cardiol40: 1856–1863, 2002
96. Siebenmann C, Rasmussen P, Sorensen H, Zaar M, Hvidfeldt M, Pichon A, Secher NH, Lundby C. Cardiac output during exercise: a comparison of four methods. Scand J Med Sci Sports March20: 2014
97. Siebenmann C, Robach P, Jacobs RA, Rasmussen P, Nordsborg NB, Diaz V, Christ A, Olsen NV, Maggiorini M, Lundby C. “Live high-train low” using normobaric hypoxia: a double-blinded, placebo- controlled study. J Appl Physiol112: 106–117, 2012
98. Sjodin B, Jacobs I. Onset of blood lactate accumulation and marathon running performance. Int J Sports Med2: 23–26, 1981
99. Sonetti DA, Wetter TJ, Pegelow DF, Dempsey JA. Effects of respiratory muscle training versus placebo on endurance exercise performance. Respir Physiol127: 185–199, 2001
100. Thomsen J, Rentsch R, Robach P, Calbet J, Boushel R, Rasmussen P, Juel C, Lundby C. Prolonged administration of recombinant human erythropoietin increases submaximal performance more than maximal aerobic capacity. Eur J Appl Physiol101: 481–486, 2007
101. Tong TK, McConnell AK, Lin H, Nie J, Zhang H, Wang J. ‘Functional’ inspiratory and core muscle training enhances running performance and economy. J Strength Cond Res. In press
102. Trehearn TL, Buresch RJ. Sit-and-reach flexibility and running economy of men and women collegiate distance runners. J Strength Cond Res23: 158–162, 2009
103. Vanhatalo A, Bailey SJ, Blackwell JR, DiMenna FJ, Pavey TG, Wilkerson DP, Benjamin N, Winyard PG, Jones AM. Acute and chronic effects of dietary nitrate supplementation on blood pressure and the physiological responses to moderateintensity and incremental exercise. Am J Physiol Regul Integr Comp Physiol299: R1121–R1131, 2010
104. Vanhatalo A, Doust JH, Burnley M. A 3-min allout cycling test is sensitive to a change in critical power. Med Sci Sports Exerc40: 1693–1699, 2008
105. Westgarth-Taylor C, Hawley JA, Rickards S, Myburgh KH, Noakes TD, Dennis SC. Metabolic and performance adaptations to interval training in endurance-trained cyclists. Eur J Appl Physiol75: 298–304, 1997
106. Whipp BJ. The slow component of O2 uptake kinetics during heavy exercise. Med Sci Sports Exerc26: 1319–1326, 1994
107. Wilson TM, Tanaka H. Meta-analysis of the ageassociated decline in maximal aerobic capacity in men: relation to training status. Am J Physiol Heart Circ Physiol278: H829–H834, 2000
108. Yoshida T, Chida M, Ichioka M, Suda Y. Blood lactate parameters related to aerobic capacity and endurance performance. Eur J Appl Physiol Occup Physiol56: 7–11, 1987
109. Zoladz JA, Gladden LB, Hogan MC, Nieckarz Z, Grassi B. Progressive recruitment of muscle fibers is not necessary for the slow component of V˙O2 kinetics. J Appl Physiol105: 575–580, 2008.