Inspiratory muscle training enhances pulmonary O2 uptake kinetics and high-intensity exercise tolerance in humans

Journal of Applied Physiology

Volumn 109, Issue 2, 2010, Pages 457-468

  Bailey, Stephen J ^a   Romer, Lee M ^b   Kelly, James ^a   Wilkerson, Daryl P ^a   DiMenna, Fred J ^a   Jones, Andrew M ^a  

^a UNIVERSITY OF EXETER   (United Kingdom)

^b BRUNEL UNIVERSITY   (United Kingdom)

Author keywords

Dyspnea; Exercise performance; Inspiratory muscle fatigue; Pulmonary ventilation; V o2 slow component

Indexed keywords

BIOLOGICAL MARKER; LACTIC ACID; OXYGEN;

ADAPTATION; ADULT; BLOOD; BLOOD FLOW; BREATHING EXERCISE; BREATHING MUSCLE; CONTROLLED STUDY; DYSPNEA; EXERCISE TEST; EXERCISE TOLERANCE; FEMALE; HEART RATE; HUMAN; INHALATION; KINETICS; LUNG GAS EXCHANGE; MALE; METABOLISM; MUSCLE CONTRACTION; MUSCLE FATIGUE; OXYGEN CONSUMPTION; PATHOPHYSIOLOGY; PHYSIOLOGY; RANDOMIZED CONTROLLED TRIAL; SKELETAL MUSCLE; VASCULARIZATION; YOUNG ADULT;

ADAPTATION, PHYSIOLOGICAL; ADULT; BIOLOGICAL MARKERS; BREATHING EXERCISES; DYSPNEA; EXERCISE TEST; EXERCISE TOLERANCE; FEMALE; HEART RATE; HUMANS; INHALATION; KINETICS; LACTIC ACID; MALE; MUSCLE CONTRACTION; MUSCLE FATIGUE; MUSCLE, SKELETAL; OXYGEN; OXYGEN CONSUMPTION; PULMONARY GAS EXCHANGE; REGIONAL BLOOD FLOW; RESPIRATORY MUSCLES; YOUNG ADULT;

EID: 77955616252     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.00077.2010     Document Type: Article

References (74)

1. Aaron EA, Seow KC, Johnson BD, Dempsey JA. Oxygen cost of exercise hyperpnea: implications for performance. J Appl Physiol 72: 1818-1825, 1992.
2. Babcock MA, Pegelow DF, Harms CA, Dempsey JA. Effects of respiratory muscle unloading on exercise-induced diaphragm fatigue. J Appl Physiol 93: 201-206, 2002.
3. Babcock MA, Pegelow DF, Taha BH, Dempsey JA. High frequency diaphragmatic fatigue detected with paired stimuli in humans. Med Sci Sports Exerc 30: 506-511, 1998.
4. 2 uptake kinetics and severe-intensity exercise tolerance. J Appl Physiol 107: 1743-1756, 2009.
5. 2 uptake and muscle deoxygenation kinetics in humans. J Appl Physiol 106: 1875-1887, 2009.
6. 2 cost of low-intensity exercise and enhances tolerance to high-intensity exercise in humans. J Appl Physiol 107: 1144-1155, 2009.
7. Balzamo E, Lagier-Tessonnier F, Jammes Y. Fatigue-induced changes in diaphragmatic afferent and cortical activity in the cat. Respir Physiol 90: 213-226, 1992.
8. Bangsbo J, Krustrup P, González-Alonso J, Saltin B. ATP production and efficiency of human skeletal muscle during intense exercise: effect of previous exercise. Am J Physiol Endocrinol Metab 280: E956-E964, 2001.
9. Barstow TJ, Jones AM, Nguyen PH, Casaburi R. Influence of muscle fiber type and pedal frequency on oxygen uptake kinetics of heavy exercise. J Appl Physiol 81: 1642-1650, 1996.
10. Boutellier U, Buchel R, Kundert A, Spengler C. The respiratory system as an exercise limiting factor in normal trained subjects. Eur J Appl Physiol 65: 347-353, 1992.
11. Boutellier U, Piwko P. The respiratory system as an exercise limiting factor in normal sedentary subjects. Eur J Appl Physiol 64: 145-152, 1992.
12. Brown PI, Sharpe GR, Johnson MA. Inspiratory muscle training reduces blood lactate concentration during volitional hyperpnoea. Eur J Appl Physiol 104: 111-1117, 2008.
13. Burnley M, Doust JH, Carter H, Jones AM. Effects of prior exercise and recovery duration on oxygen uptake kinetics during heavy exercise in humans. Exp Physiol 86: 417-425, 2001.
14. Burnley M, Jones AM. Oxygen uptake kinetics as a determinant of sports performance. Eur J Sports Sci 7: 63-79, 2007.
15. Candau R, Belli A, Millet GY, Georges D, Barbier B, Rouillon JD. Energy cost and running mechanics during a treadmill run to voluntary exhaustion in humans. Eur J Appl Physiol Occup Physiol 77: 479-485, 1998.
16. 2 uptake kinetics. J Appl Physiol 94: 2448-2455, 2003.
17. 2 uptake kinetics during exercise performed above the respiratory compensation threshold. Exp Physiol 95: 172-183, 2010.
18. Dempsey JA. JB Wolffe Memorial Lecture. Is the lung built for exercise? Med Sci Sports Exerc 18: 143-155, 1986.
19. Derchak PA, Sheel AW, Morgan BJ, Dempsey JA. Effects of expiratory muscle work on muscle sympathetic nerve activity. J Appl Physiol 92: 1539-1552, 2002.
20. Edwards AM, Cooke CB. Oxygen uptake kinetics and maximal aerobic power are unaffected by inspiratory muscle training in healthy subjects where time to exhaustion is extended. Eur J Appl Physiol 93: 139-144, 2004.
21. 2uptake kinetics in humans: implications for metabolic control. J Appl Physiol 80: 988-998, 1996.
22. Green M, Road J, Sieck GC, Similowski T. ATS/ERS Statement on Respiratory Muscle Testing Tests of Respiratory Muscle Strength. Am J Respir Crit Care Med 166: 528-542, 2002.
23. Griffiths LA, McConnell AK. The influence of inspiratory and expiratory muscle training upon rowing performance. Eur J Appl Physiol 99: 457- 466, 2007.
24. Harms CA, Babcock MA, McClaran SR, Pegelow DF, Nickele GA, Nelson WB, Dempsey JA. Respiratory muscle work compromises leg blood flow during maximal exercise. J Appl Physiol 82: 1573-1583, 1997.
25. Harms CA, Wetter TJ, McClaran SR, Pegelow DF, Nickele GA, Nelson WB, Hanson P, Dempsey JA. Effects of respiratory muscle work on cardiac output and its distribution during maximal exercise. J Appl Physiol 85: 609-618, 1998.
26. Harms CA, Wetter TJ, St. Croix CM, Pegelow DF, Dempsey JA. Effects of respiratory muscle work on exercise performance. J Appl Physiol 89: 131-138, 2000.
27. Johnson BD, Aaron EA, Babcock MA, Dempsey JA. Respiratory muscle fatigue during exercise: implications for performance. Med Sci Sports Exerc 28: 1129-1137, 1996.
28. Johnson BD, Babcock MA, Suman OE, Dempsey JA. Exercise-induced diaphragmatic fatigue in healthy humans. J Physiol 460: 385-405, 1993.
29. Johnson MA, Sharpe GR, Brown PI. Inspiratory muscle training improves cycling time-trial performance and anaerobic work capacity but not critical power. Eur J Appl Physiol 101: 761-770, 2007.
30. Jones AM, Burnley M. Oxygen uptake kinetics: an under-appreciated determinant of exercise performance. Int J Sports Physiol Perform 4: 524-532, 2009.
31. Jones AM, Carter H. The effect of endurance training on parameters of aerobic fitness. Sports Med 29: 373-386, 2000.
32. Jones AM, Koppo K, Burnley M. Effects of prior exercise on metabolic and gas exchange responses to exercise. Sports Med 33: 949-971, 2003.
33. Jones AM, Wilkerson DP, DiMenna F, Fulford J, Poole DC. Muscle metabolic responses to exercise above and below the "critical power" assessed using 31P-MRS. Am J Physiol Regul Integr Comp Physiol 294: R585-R593, 2008.
34. 2 uptake kinetics during heavy-intensity cycle exercise. J Appl Physiol 96: 1033-1038, 2004.
35. Koga S, Shiojiri T, Shibasaki M, Kondo N, Fukuba Y, Barstow TJ. Kinetics of oxygen uptake during supine and upright heavy exercise. J Appl Physiol 87: 253-260, 1999.
36. Krogh A, Lindhard J. The changes in respiration at the transition from work to rest. J Physiol 53: 431-439, 1920.
37. 2 uptake kinetics during moderate- and highintensity sub-maximal knee-extensor exercise in humans. J Physiol 587: 1843-1856, 2009.
38. Krustrup P, Soderlund K, Mohr M, Bangsbo J. The slow component of oxygen uptake during intense, sub-maximal exercise in man is associated with additional fibre recruitment. Pflügers Arch 447: 855-866, 2004.
39. Lamarra N, Whipp BJ, Ward SA, Wasserman K. Effect of interbreath fluctuations on characterising exercise gas exchange kinetics. J Appl Physiol 62: 2003-2012, 1987.
40. Leddy JJ, Limprasertkul A, Patel S, Modlich F, Buyea C, Pendergast DR, Lundgren CEG. Isocapnic hyperpnea training improves performance in competitive male runners. Eur J Appl Physiol 99: 665-676, 2007.
41. 2 kinetics in heavy submaximal exercise by hyperoxia and prior high-intensity exercise. J Appl Physiol 83: 1318-1325, 1997.
42. Markov G, Spengler CM, Knöpfli-Lenzin C, Stuessi C, Boutellier U. Respiratory muscle training increases cycling endurance without affecting cardiovascular responses to exercise. Eur J Appl Physiol 85: 233-239, 2001.
43. McConnell AK, Lomax M. The influence of inspiratory muscle work history and specific inspiratory muscle training upon human limb muscle fatigue. J Physiol 577: 445-457, 2006.
44. McConnell AK, Romer LM. Respiratory muscle training in healthy humans: resolving the controversy. Int J Sports Med 25: 284-293, 2004.
45. Poole DC, Barstow TJ, McDonough P, Jones AM. Control of oxygen uptake during exercise. Med Sci Sports Exerc 40: 462-474, 2008.
46. Poole DC, Schaffartzik W, Knight DR, Derion T, Kennedy B, Guy HJ, Prediletto R, Wagner PD. Contribution of exercising legs to the slow component of oxygen uptake kinetics in humans. J Appl Physiol 71: 1245-1260, 1991.
47. Poole DC, Ward SA, Gardner GW, Whipp BJ. Metabolic and respiratory profile of the upper limit for prolonged exercise in man. Ergonomics 31: 1265-1279, 1988.
48. 2max. Int J Sports Med 7: 217-221, 1986.
49. 2max. J Appl Physiol 66: 2491-2495, 1989.
50. Ramirez-Sarmiento A, Orozco-Levi M, Guell R, Barreiro E, Hernandez N, Mota S, Sangenis M, Broquetas JM, Casan P, Gea J. Inspiratory muscle training in patients with chronic obstructive pulmonary disease: structural adaptation and physiologic outcomes. Am J Respir Crit Care Med 166: 1491-1497, 2002.
51. Rodman JR, Henderson KS, Smith CA, Dempsey JA. Cardiovascular effects of the respiratory muscle metaboreflexes in dogs: rest and exercise. J Appl Physiol 95: 1159-1169, 2003.
52. Romer LM, Haverkamp HC, Lovering AT, Pegelow DF, Dempsey JA. Effect of exercise-induced arterial hypoxemia on quadriceps muscle fatigue in healthy humans. Am J Physiol Regul Integr Comp Physiol 290: R365-R375, 2006.
53. Romer LM, Lovering AT, Haverkamp HC, Pegelow DF, Dempsey JA. Effect of inspiratory muscle work on peripheral fatigue of locomotor muscles in healthy humans. J Physiol 571: 425-439, 2006.
54. Romer LM, McConnell AK, Jones DA. Inspiratory muscle fatigue in trained cyclists: effects of inspiratory muscle training. Med Sci Sports Exerc 34: 785-792, 2002.
55. Romer LM, Miller JD, Haverkamp HC, Pegelow DF, Dempsey JA. Inspiratory muscles do not limit maximal incremental exercise performance in healthy subjects. Respir Physiol Neurobiol 156: 353-361, 2007.
56. Romer LM, Polkey MI. Exercise-induced respiratory muscle fatigue: implications for performance. J Appl Physiol 104: 879-888, 2008.
57. 2 uptake during exercise. J Appl Physiol 93: 2059-2069, 2002.
58. Saltin B, Strange S. Maximal oxygen uptake: "old" and "new" arguments for a cardiovascular limitation. Med Sci Sports Exerc 24: 30-37, 1992.
59. Sheel AW. Respiratory muscle training in healthy individuals: physiological rationale and implications for exercise performance. Sports Med 32: 567-581, 2002.
60. Sheel AW, Derchak PA, Morgan BJ, Pegelow DF, Jacques AJ, Dempsey JA. Fatiguing inspiratory muscle work causes reflex reduction in resting leg blood flow in humans. J Physiol 537: 277-289, 2001.
61. Sheel AW, Derchak PA, Pegelow DF, Dempsey JA. Threshold effects of respiratory muscle work on limb vascular resistance. Am J Physiol Heart Circ Physiol 282: H1732-H1738, 2002.
62. Spengler CM, Roos M, Laube SM, Boutellier U. Decreased exercise blood lactate concentrations after respiratory endurance training in humans. Eur J Appl Physiol 79: 299-305, 1999.
63. St Croix CM, Morgan BJ, Wetter TJ, Dempsey JA. Fatiguing inspiratory muscle work causes reflex sympathetic activation in humans. J Physiol 529: 493-504, 2000.
64. Stuessi C, Spengler CM, Knopfli-Lenzin C, Markov G, Boutellier U. Respiratory muscle endurance training in humans increases cycling endurance without affecting blood gas concentrations. Eur J Appl Physiol 84: 582-586, 2001.
65. Volianitis S, McConnell AK, Koutedakis Y, McNaughton L, Backx K, Jones DA. Inspiratory muscle training improves rowing performance. Med Sci Sports Exerc 33: 803-809, 2001.
66. 2max. Exerc Sport Sci Rev 28: 10-14, 2000.
67. Whipp BJ, Davis JA, Torres F, Wasserman K. A test to determine parameters of aerobic function during exercise. J Appl Physiol 50: 217- 221, 1981.
68. Whipp BJ, Ward SA, Lamarra N, Davis JA, Wasserman K. Parameters of ventilatory and gas exchange dynamics during exercise. J Appl Physiol 52: 1506-1513, 1982.
69. Whipp BJ, Wasserman K. Oxygen uptake kinetics for various intensities of constant-load work. J Appl Physiol 33: 351-356, 1972.
70. 2 uptake kinetics following the onset of exercise in humans. Respir Physiol Neurobiol 153: 92-106, 2006.
71. 2 uptake response to exercise. Respir Physiol Neurobiol 142: 211-23, 2004.
72. 2 uptake kinetics during exercise in humans. J Physiol 568: 639-652, 2005.
73. Williams JS, Wongsathikun J, Boon SM, Acevedo EO. Inspiratory muscle training fails to improve endurance capacity in athletes. Med Sci Sports Exerc 34: 1194-1198, 2002.
74. Witt JD, Guenette JA, Rupert JL, McKenzie DC, Sheel AW. Inspiratory muscle training attenuates the human respiratory muscle metaboreflex. J Physiol 584: 1019-1028, 2007.