Brain and skin do not contribute to the systemic rise in erythropoietin during acute hypoxia in humans

FASEB Journal

Volumn 26, Issue 5, 2012, Pages 1831-1834

  Rasmussen, Peter ^a,b,d   Nordsborg, Nikolai ^d   Taudorf, Sarah ^b   Sørensen, Henrik ^b   Berg, Ronan M G ^b   Jacobs, Robert A ^a   Bailey, Damian M ^e   Olsen, Niels V ^b,d   Secher, Niels H ^b   Møller, Kirsten ^b,c,d   Lundby, Carsten ^a,b  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b Rigshospitalet   (Denmark)

^c BISPEBJERG HOSPITAL   (Denmark)

^d UNIVERSITY OF COPENHAGEN   (Denmark)

^e UNIVERSITY OF GLAMORGAN   (United Kingdom)

Author keywords

Cerebrospinal fluid; Epidermal; O2 sensing; Synthesis

Indexed keywords

ERYTHROPOIETIN;

ADULT; ARTICLE; BLOOD LEVEL; BRAIN; CEREBROSPINAL FLUID LEVEL; CONTROLLED STUDY; DERMIS; ENZYME LINKED IMMUNOSORBENT ASSAY; EPIDERMIS; ERYTHROCYTE; HUMAN; HUMAN EXPERIMENT; HYPOXIA; MALE; NORMAL HUMAN; OXYGEN SENSING; OXYGENATION; PLASMA; PRIORITY JOURNAL; SKIN;

ACUTE DISEASE; ADULT; ANOXIA; BRAIN; ERYTHROPOIETIN; FEMALE; HUMANS; MALE; SKIN;

MUS;

EID: 84860895927     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.11-191692     Document Type: Article

References (14)

1. Lundby, C., Thomsen, J. J., Boushel, R., Koskolou, M., Warberg, J., Calbet, J. A., and Robach, P. (2007) Erythropoietin treatment elevates haemoglobin concentration by increasing red cell volume and depressing plasma volume. J. Physiol. 578, 309-314 (Pubitemid 44971127)
2. Olsen, N. V., Aachmann-Andersen, N. J., Oturai, P., Munch-Andersen, T., Borno, A., Hulston, C., Holstein-Rathlou, N. H., Robach, P., and Lundby, C. (2011) Erythropoietin down-regulates proximal renal tubular reabsorption and causes a fall in glomerular filtration rate in humans. J. Physiol. 589, 1273-1281
3. Boutin, A. T., Weidemann, A., Fu, Z., Mesropian, L., Gradin, K., Jamora, C., Wiesener, M., Eckardt, K. U., Koch, C. J., Ellies, L. G., Haddad, G., Haase, V. H., Simon, M. C., Poellinger, L., Powell, F. L., and Johnson, R. S. (2008) Epidermal sensing of oxygen is essential for systemic hypoxic response. Cell 133, 223-234 (Pubitemid 351508305)
4. Bernaudin, M., Bellail, A., Marti, H. H., Yvon, A., Vivien, D., Duchatelle, I., Mackenzie, E. T., and Petit, E. (2000) Neurons and astrocytes express EPO mRNA: oxygen-sensing mechanisms that involve the redox-state of the brain. Glia 30, 271-278 (Pubitemid 30259666)
5. Weidemann, A., Kerdiles, Y. M., Knaup, K. X., Rafie, C. A., Boutin, A. T., Stockmann, C., Takeda, N., Scadeng, M., Shih, A. Y., Haase, V. H., Simon, M. C., Kleinfeld, D., and Johnson, R. S. (2009) The glial cell response is an essential component of hypoxia-induced erythropoiesis in mice. J. Clin. Invest. 119, 3373-3383
6. Bodo, E., Kromminga, A., Funk, W., Laugsch, M., Duske, U., Jelkmann, W., and Paus, R. (2007) Human hair follicles are an extrarenal source and a nonhematopoietic target of erythropoietin. FASEB J. 21, 3346-3354 (Pubitemid 47565553)
7. Rasmussen, P., Dawson, E. A., Nybo, L., van Lieshout, J. J., Secher, N. H., and Gjedde, A. (2007) Capillary-oxygenation-level-dependent near-infrared spectrometry in frontal lobe of humans. J. Cereb. Blood Flow Metab. 27, 1082-1093 (Pubitemid 46659036)
8. Gonzalez, N. C., Sokari, A., and Clancy, R. L. (1991) Maximum oxygen uptake and arterial blood oxygenation during hypoxic exercise in rats. J. Appl. Physiol. 71, 1041-1049
9. Knaupp, W., Khilnani, S., Sherwood, J., Scharf, S., and Steinberg, H. (1992) Erythropoietin response to acute normobaric hypoxia in humans. J. Appl. Physiol. 73, 837-840
10. Robach, P., Cairo, G., Gelfi, C., Bernuzzi, F., Pilegaard, H., Vigano, A., Santambrogio, P., Cerretelli, P., Calbet, J. A., Moutereau, S., and Lundby, C. (2007) Strong iron demand during hypoxia-induced erythropoiesis is associated with down-regulation of iron-related proteins and myoglobin in human skeletal muscle. Blood 109, 4724-4731 (Pubitemid 46827764)
11. Abbrecht, P. H., and Malvin, R. L. (1966) Renal production of erythropoietin in the dog. Am. J. Physiol. 210, 237-242
12. Pellegri, G., Rossier, C., Magistretti, P., and Martin, J. (1996) Cloning, localization and induction of mouse brain glycogen synthase. Brain Res. Mol. Brain Res. 38, 191-199 (Pubitemid 26168278)
13. Rasmussen, P., Foged, E. M., Krogh-Madsen, R., Nielsen, J., Nielsen, T. R., Olsen, N. V., Petersen, N. C., Sorensen, T. A., Secher, N. H., and Lundby, C. (2010) Effects of erythropoietin administration on cerebral metabolism and exercise capacity in men. J. Appl. Physiol. 109, 476-483
14. Simmons, G. H., Minson, C. T., Cracowski, J. L., and Halliwill, J. R. (2007) Systemic hypoxia causes cutaneous vasodilation in healthy humans. J. Appl. Physiol. 103, 608-615 (Pubitemid 47204980)