메뉴 건너뛰기




Volumn 50, Issue 2, 2015, Pages 146-151

The role of lipin-1 in the pathogenesis of alcoholic fatty liver

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; LIPIN 1; PHOSPHATIDATE PHOSPHATASE; PROTEIN; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; UNCLASSIFIED DRUG; VERY LOW DENSITY LIPOPROTEIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; LOW DENSITY LIPOPROTEIN; LPIN1 PROTEIN, MOUSE; NUCLEAR PROTEIN; RNA BINDING PROTEIN; SIRTUIN 1; TRA2B PROTEIN, MOUSE; TRIACYLGLYCEROL;

EID: 84936154051     PISSN: 07350414     EISSN: 14643502     Source Type: Journal    
DOI: 10.1093/alcalc/agu102     Document Type: Article
Times cited : (35)

References (40)
  • 1
    • 60649101944 scopus 로고    scopus 로고
    • The level and compartmentalization of phosphatidate phosphatase-1 (lipin-1) control the assembly and secretion of hepatic VLDL
    • Bou Khalil M, Sundaram M, Zhang HY et al. (2009) The level and compartmentalization of phosphatidate phosphatase-1 (lipin-1) control the assembly and secretion of hepatic VLDL. J Lipid Res 50:47-58.
    • (2009) J Lipid Res , vol.50 , pp. 47-58
    • Bou Khalil, M.1    Sundaram, M.2    Zhang, H.Y.3
  • 2
    • 77957967787 scopus 로고    scopus 로고
    • Lipin-the bridge between hepatic glycerolipid biosynthesis and lipoprotein metabolism
    • Bou Khalil M, Blais A, Figeys D et al. (2010) Lipin-the bridge between hepatic glycerolipid biosynthesis and lipoprotein metabolism. Biochim Biophys Acta 1801:1249-59.
    • (2010) Biochim Biophys Acta , vol.1801 , pp. 1249-1259
    • Bou Khalil, M.1    Blais, A.2    Figeys, D.3
  • 3
    • 53449092350 scopus 로고    scopus 로고
    • Alterations in hepatic metabolism in fld mice reveal a role for lipin 1 in regulating VLDL-triacylglyceride secretion
    • Chen Z, Gropler MC, Norris J et al. (2008) Alterations in hepatic metabolism in fld mice reveal a role for lipin 1 in regulating VLDL-triacylglyceride secretion. Arterioscler Thromb Vasc Biol 28:1738-44.
    • (2008) Arterioscler Thromb Vasc Biol , vol.28 , pp. 1738-1744
    • Chen, Z.1    Gropler, M.C.2    Norris, J.3
  • 4
    • 77955642188 scopus 로고    scopus 로고
    • Lipins: multifunctional lipid metabolism proteins
    • Csaki LS, Reue K. (2010) Lipins: multifunctional lipid metabolism proteins. Annu Rev Nutr 30:257-72.
    • (2010) Annu Rev Nutr , vol.30 , pp. 257-272
    • Csaki, L.S.1    Reue, K.2
  • 5
    • 84877615840 scopus 로고    scopus 로고
    • Lipins, lipinopathies, and the modulation of cellular lipid storage and signaling
    • Csaki LS, Dwyer JR, Fong LG et al. (2013) Lipins, lipinopathies, and the modulation of cellular lipid storage and signaling. Prog Lipid Res 52:305-16.
    • (2013) Prog Lipid Res , vol.52 , pp. 305-316
    • Csaki, L.S.1    Dwyer, J.R.2    Fong, L.G.3
  • 6
    • 33947542353 scopus 로고    scopus 로고
    • Three mammalian lipins act as phosphatidate phosphatases with distinct tissue expression patterns
    • Donkor J, Sariahmetoglu M, Dewald J et al. (2007) Three mammalian lipins act as phosphatidate phosphatases with distinct tissue expression patterns. J Biol Chem 282:3450-7.
    • (2007) J Biol Chem , vol.282 , pp. 3450-3457
    • Donkor, J.1    Sariahmetoglu, M.2    Dewald, J.3
  • 7
    • 77950622833 scopus 로고    scopus 로고
    • Epigenetic regulation of hepatic endoplasmic reticulum stress pathways in the ethanolfed cystathionine beta synthase-deficient mouse
    • Esfandiari F, Medici V, Wong DH et al. (2010) Epigenetic regulation of hepatic endoplasmic reticulum stress pathways in the ethanolfed cystathionine beta synthase-deficient mouse. Hepatology 51:932-41.
    • (2010) Hepatology , vol.51 , pp. 932-941
    • Esfandiari, F.1    Medici, V.2    Wong, D.H.3
  • 8
    • 84863967084 scopus 로고    scopus 로고
    • EASL clinical practical guidelines: management of alcoholic liver disease
    • European Association for the Study of the Liver (2012) EASL clinical practical guidelines: management of alcoholic liver disease. J Hepatol 57:399-420.
    • (2012) J Hepatol , vol.57 , pp. 399-420
  • 9
    • 84882577354 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress leads to lipid accumulation through upregulation of SREBP-1c in normal hepatic and hepatoma cells
    • Fang DL, Wan Y, Shen W et al. (2013) Endoplasmic reticulum stress leads to lipid accumulation through upregulation of SREBP-1c in normal hepatic and hepatoma cells. Mol Cell Biochem 381:127-37.
    • (2013) Mol Cell Biochem , vol.381 , pp. 127-137
    • Fang, D.L.1    Wan, Y.2    Shen, W.3
  • 10
    • 33747853190 scopus 로고    scopus 로고
    • Lipin 1 is an inducible amplifier of the hepatic PGC-1a/PPARa regulatory pathway
    • Finck BN, Gropler MC, Chen Z et al. (2006) Lipin 1 is an inducible amplifier of the hepatic PGC-1a/PPARa regulatory pathway. Cell Metab 4:199-210.
    • (2006) Cell Metab , vol.4 , pp. 199-210
    • Finck, B.N.1    Gropler, M.C.2    Chen, Z.3
  • 11
    • 57649213401 scopus 로고    scopus 로고
    • Temporal and spatial regulation of the phosphatidate phosphatases lipin 1 and 2
    • Grimsey N, Han GS, O'Hara L et al. (2008) Temporal and spatial regulation of the phosphatidate phosphatases lipin 1 and 2. J Biol Chem 283:29166-74.
    • (2008) J Biol Chem , vol.283 , pp. 29166-29174
    • Grimsey, N.1    Han, G.S.2    O'Hara, L.3
  • 12
    • 77951979740 scopus 로고    scopus 로고
    • Characterization of the human LPIN1-encoded phosphatidate phosphatase isoforms
    • Han GS, Carman GM. (2010) Characterization of the human LPIN1-encoded phosphatidate phosphatase isoforms. J Biol Chem 285:14628-38.
    • (2010) J Biol Chem , vol.285 , pp. 14628-14638
    • Han, G.S.1    Carman, G.M.2
  • 13
    • 33646920976 scopus 로고    scopus 로고
    • The Saccharomyces cerevisiae Lipin homolog is a Mg2+-dependent phosphatidate phosphatase enzyme
    • Han GS, Wu WI, Carman GM. (2006) The Saccharomyces cerevisiae Lipin homolog is a Mg2+-dependent phosphatidate phosphatase enzyme. J Biol Chem 281:9210-8.
    • (2006) J Biol Chem , vol.281 , pp. 9210-9218
    • Han, G.S.1    Wu, W.I.2    Carman, G.M.3
  • 14
    • 84896858573 scopus 로고    scopus 로고
    • AMPK in the small intestine in normal and pathophysiological conditions
    • Harmel E, Grenier E, Bendjoudi Ouadda A et al. (2014) AMPK in the small intestine in normal and pathophysiological conditions. Endocrinology 155:873-88.
    • (2014) Endocrinology , vol.155 , pp. 873-888
    • Harmel, E.1    Grenier, E.2    Bendjoudi Ouadda, A.3
  • 15
    • 0036251153 scopus 로고    scopus 로고
    • SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
    • Horton JD, Goldstein JL, Brown MS. (2002) SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J Clin Invest 109:1125-31.
    • (2002) J Clin Invest , vol.109 , pp. 1125-1131
    • Horton, J.D.1    Goldstein, J.L.2    Brown, M.S.3
  • 16
    • 84856379516 scopus 로고    scopus 로고
    • Regulation of hepatic lipin-1 by ethanol: role of AMP-activated protein kinase/sterol regulatory element-binding protein 1 signaling in mice
    • Hu M, Wang F, Li X et al. (2012) Regulation of hepatic lipin-1 by ethanol: role of AMP-activated protein kinase/sterol regulatory element-binding protein 1 signaling in mice. Hepatology (Baltimore, Md) 55:437-46.
    • (2012) Hepatology (Baltimore, Md) , vol.55 , pp. 437-446
    • Hu, M.1    Wang, F.2    Li, X.3
  • 17
    • 84888306160 scopus 로고    scopus 로고
    • Hepatic-specific lipin-1 deficiency exacerbates experimental alcohol-induced steatohepatitis in mice
    • Hu M, Yin H, Mitra MS et al. (2013) Hepatic-specific lipin-1 deficiency exacerbates experimental alcohol-induced steatohepatitis in mice. Hepatology 58:1953-63.
    • (2013) Hepatology , vol.58 , pp. 1953-1963
    • Hu, M.1    Yin, H.2    Mitra, M.S.3
  • 19
    • 84856471735 scopus 로고    scopus 로고
    • SREBPs: metabolic integrators in physiology and metabolism
    • Jeon TI, Osborne TF. (2012) SREBPs: metabolic integrators in physiology and metabolism. Trends Endocrinol Metab 23:65-72.
    • (2012) Trends Endocrinol Metab , vol.23 , pp. 65-72
    • Jeon, T.I.1    Osborne, T.F.2
  • 20
    • 84906683747 scopus 로고    scopus 로고
    • AMP-activated protein kinase: an emerging target for ginseng
    • Jeong KJ, Kim GW, Chung SH. (2014) AMP-activated protein kinase: an emerging target for ginseng. J Ginseng Res 38:83-8.
    • (2014) J Ginseng Res , vol.38 , pp. 83-88
    • Jeong, K.J.1    Kim, G.W.2    Chung, S.H.3
  • 21
    • 77953400436 scopus 로고    scopus 로고
    • Lipin 1 represses NFATc4 transcriptional activity in adipocytes to inhibit secretion of inflammatory factors
    • Kim HB, Kumar A, Wang L et al. (2010) Lipin 1 represses NFATc4 transcriptional activity in adipocytes to inhibit secretion of inflammatory factors. Mol Cell Biol 30:3126-39.
    • (2010) Mol Cell Biol , vol.30 , pp. 3126-3139
    • Kim, H.B.1    Kumar, A.2    Wang, L.3
  • 22
    • 79953755370 scopus 로고    scopus 로고
    • AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice
    • Li Y, Xu S, Mihaylova MM et al. (2011) AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice. Cell Metab 13:376-88.
    • (2011) Cell Metab , vol.13 , pp. 376-388
    • Li, Y.1    Xu, S.2    Mihaylova, M.M.3
  • 23
    • 57349175059 scopus 로고    scopus 로고
    • LPS and proinflammatory cytokines decrease lipin-1 in mouse adipose tissue and 3T3-L1 adipocytes
    • Lu B, Lu Y, Moser AH et al. (2008) LPS and proinflammatory cytokines decrease lipin-1 in mouse adipose tissue and 3T3-L1 adipocytes. Am J Physiol Endocrinol Metab 295:E1502-9.
    • (2008) Am J Physiol Endocrinol Metab , vol.295 , pp. E1502-E1509
    • Lu, B.1    Lu, Y.2    Moser, A.H.3
  • 24
    • 0023025701 scopus 로고
    • Histologic spectrum of alcoholic liver disease
    • MacSween RN, Burt AD. (1986) Histologic spectrum of alcoholic liver disease. Semin Liver Dis 6:221-32.
    • (1986) Semin Liver Dis , vol.6 , pp. 221-232
    • MacSween, R.N.1    Burt, A.D.2
  • 25
    • 84880414748 scopus 로고    scopus 로고
    • Alcoholic liver disease: pathogenesis, management, and novel targets for therapy
    • Orman ES, Odena G, Bataller R. (2013) Alcoholic liver disease: pathogenesis, management, and novel targets for therapy. J Gastroenterol Hepatol 28 Suppl 1:77-84.
    • (2013) J Gastroenterol Hepatol 28 Suppl , vol.1 , pp. 77-84
    • Orman, E.S.1    Odena, G.2    Bataller, R.3
  • 26
    • 0035163850 scopus 로고    scopus 로고
    • Lipodystrophy in the fld mouse results from mutation of a new gene encoding a nuclear protein, lipin
    • Peterfy M, Phan J, Xu P et al. (2001) Lipodystrophy in the fld mouse results from mutation of a new gene encoding a nuclear protein, lipin. Nat Genet 27:121-4.
    • (2001) Nat Genet , vol.27 , pp. 121-124
    • Peterfy, M.1    Phan, J.2    Xu, P.3
  • 27
    • 25444465996 scopus 로고    scopus 로고
    • Alternatively spliced lipin isoforms exhibit distinct expression pattern, subcellular localization, and role in adipogenesis
    • Peterfy M, Phan J, Reue K. (2005) Alternatively spliced lipin isoforms exhibit distinct expression pattern, subcellular localization, and role in adipogenesis. J Biol Chem 280:32883-9.
    • (2005) J Biol Chem , vol.280 , pp. 32883-32889
    • Peterfy, M.1    Phan, J.2    Reue, K.3
  • 28
    • 77950467109 scopus 로고    scopus 로고
    • Insulin-stimulated interaction with 14-3-3 promotes cytoplasmic localization of lipin-1 in adipocytes
    • Peterfy M, Harris TE, Fujita N et al. (2010) Insulin-stimulated interaction with 14-3-3 promotes cytoplasmic localization of lipin-1 in adipocytes. J Biol Chem 285:3857-64.
    • (2010) J Biol Chem , vol.285 , pp. 3857-3864
    • Peterfy, M.1    Harris, T.E.2    Fujita, N.3
  • 29
    • 79961165137 scopus 로고    scopus 로고
    • mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway
    • Peterson TR, Sengupta SS, Harris TE et al. (2011) mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway. Cell 146:408-20.
    • (2011) Cell , vol.146 , pp. 408-420
    • Peterson, T.R.1    Sengupta, S.S.2    Harris, T.E.3
  • 30
    • 79960961204 scopus 로고    scopus 로고
    • Expression of the splicing factor gene SFRS10 is reduced in human obesity and contributes to enhanced lipogenesis
    • Pihlajamaki J, Lerin C, Itkonen P et al. (2011) Expression of the splicing factor gene SFRS10 is reduced in human obesity and contributes to enhanced lipogenesis. Cell Metab 14:208-18.
    • (2011) Cell Metab , vol.14 , pp. 208-218
    • Pihlajamaki, J.1    Lerin, C.2    Itkonen, P.3
  • 31
    • 0022220132 scopus 로고
    • Interactions of insulin, glucagon and dexamethasone in controlling the activity of glycerol phosphate acyltransferase and the activity and subcellular distribution of phosphatidate phosphohydrolase in cultured rat hepatocytes
    • Pittner RA, Fears R, Brindley DN. (1985) Interactions of insulin, glucagon and dexamethasone in controlling the activity of glycerol phosphate acyltransferase and the activity and subcellular distribution of phosphatidate phosphohydrolase in cultured rat hepatocytes. Biochem J 230:525-34.
    • (1985) Biochem J , vol.230 , pp. 525-534
    • Pittner, R.A.1    Fears, R.2    Brindley, D.N.3
  • 32
    • 77956703908 scopus 로고    scopus 로고
    • A phosphatidic acid binding/nuclear localization motif determines lipin1 function in lipid metabolism and adipogenesis
    • Ren H, Federico L, Huang H et al. (2010) A phosphatidic acid binding/nuclear localization motif determines lipin1 function in lipid metabolism and adipogenesis. Mol Biol Cell 21:3171-81.
    • (2010) Mol Biol Cell , vol.21 , pp. 3171-3181
    • Ren, H.1    Federico, L.2    Huang, H.3
  • 33
    • 67049135868 scopus 로고    scopus 로고
    • The lipin family: mutations and metabolism
    • Reue K. (2009) The lipin family: mutations and metabolism. Curr Opin Lipidol 20:165-70.
    • (2009) Curr Opin Lipidol , vol.20 , pp. 165-170
    • Reue, K.1
  • 34
    • 84901724383 scopus 로고    scopus 로고
    • Identification of 50 AMP activated kinase as a target of reactive aldehydes during chronic ingestion of high concentrations of ethanol
    • Shearn CT, Backos DS, Orlicky DJ et al. (2014) Identification of 50 AMP activated kinase as a target of reactive aldehydes during chronic ingestion of high concentrations of ethanol. J Biol Chem 289:5449-62.
    • (2014) J Biol Chem , vol.289 , pp. 5449-5462
    • Shearn, C.T.1    Backos, D.S.2    Orlicky, D.J.3
  • 35
    • 84887568463 scopus 로고    scopus 로고
    • Transcriptional control of hepatic lipid metabolism by SREBP and ChREBP
    • Xu X, So JS, Park JG et al. (2013) Transcriptional control of hepatic lipid metabolism by SREBP and ChREBP. Semin Liver Dis 33:301-11.
    • (2013) Semin Liver Dis , vol.33 , pp. 301-311
    • Xu, X.1    So, J.S.2    Park, J.G.3
  • 36
    • 84858968923 scopus 로고    scopus 로고
    • MicroRNA-217 promotes ethanol-induced fat accumulation in hepatocytes by downregulating SIRT1
    • Yin H, Hu M, Zhang R et al. (2012) MicroRNA-217 promotes ethanol-induced fat accumulation in hepatocytes by downregulating SIRT1. J Biol Chem 287:9817-26.
    • (2012) J Biol Chem , vol.287 , pp. 9817-9826
    • Yin, H.1    Hu, M.2    Zhang, R.3
  • 37
    • 84894348922 scopus 로고    scopus 로고
    • Deletion of SIRT1 from hepatocytes in mice disrupts lipin-1 signaling and aggravates alcoholic fatty liver
    • Yin H, Hu M, Liang X et al. (2014) Deletion of SIRT1 from hepatocytes in mice disrupts lipin-1 signaling and aggravates alcoholic fatty liver. Gastroenterology 146:801-11.
    • (2014) Gastroenterology , vol.146 , pp. 801-811
    • Yin, H.1    Hu, M.2    Liang, X.3
  • 38
    • 9644290860 scopus 로고    scopus 로고
    • The role of AMP-activated protein kinase in the action of ethanol in the liver
    • You M, Matsumoto M, Pacold CM et al. (2004) The role of AMP-activated protein kinase in the action of ethanol in the liver. Gastroenterology 127:1798-808.
    • (2004) Gastroenterology , vol.127 , pp. 1798-1808
    • You, M.1    Matsumoto, M.2    Pacold, C.M.3
  • 39
    • 24144496133 scopus 로고    scopus 로고
    • Role of adiponectin in the protective action of dietary saturated fat against alcoholic fatty liver in mice
    • You M, Considine RV, Leone TC et al. (2005) Role of adiponectin in the protective action of dietary saturated fat against alcoholic fatty liver in mice. Hepatology 42:568-77.
    • (2005) Hepatology , vol.42 , pp. 568-577
    • You, M.1    Considine, R.V.2    Leone, T.C.3
  • 40
    • 84901923852 scopus 로고    scopus 로고
    • Involvement of insulin resistance in the protective effect of metformin against alcoholic liver injury
    • Zhu Z, Jiang Z, Zhou J et al. (2014) Involvement of insulin resistance in the protective effect of metformin against alcoholic liver injury. Alcohol Clin Exp Res 38:1510-8.
    • (2014) Alcohol Clin Exp Res , vol.38 , pp. 1510-1518
    • Zhu, Z.1    Jiang, Z.2    Zhou, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.