-
2
-
-
84863694517
-
Mechanisms of inflammatory responses in obese adipose tissue
-
Sun S, Ji Y, Kersten S, Qi L. Mechanisms of inflammatory responses in obese adipose tissue. Annu Rev Nutr. 2012;32:261–286.
-
(2012)
Annu Rev Nutr
, vol.32
, pp. 261-286
-
-
Sun, S.1
Ji, Y.2
Kersten, S.3
Qi, L.4
-
3
-
-
84915803968
-
Interplay between the immune system and adipose tissue in obesity
-
Exley MA, Hand L, O’Shea D, Lynch L. Interplay between the immune system and adipose tissue in obesity. J Endocrinol. 2014; 223:R41–R48.
-
(2014)
J Endocrinol
, vol.223
, pp. 41-48
-
-
Exley, M.A.1
Hand, L.2
O’Shea, D.3
Lynch, L.4
-
4
-
-
84904392112
-
Macrophages, immunity, and metabolic disease
-
McNelis JC, Olefsky JM. Macrophages, immunity, and metabolic disease. Immunity. 2014;41:36–48.
-
(2014)
Immunity
, vol.41
, pp. 36-48
-
-
McNelis, J.C.1
Olefsky, J.M.2
-
5
-
-
33846302361
-
Attenuation of obesity-induced adipose tissue inflammation in C3H/HeJ mice carrying a Toll-like receptor 4 mutation
-
Suganami T, Mieda T, Itoh M, Shimoda Y, Kamei Y, Ogawa Y. Attenuation of obesity-induced adipose tissue inflammation in C3H/HeJ mice carrying a Toll-like receptor 4 mutation. Biochem Biophys Res Commun. 2007;354:45–49.
-
(2007)
Biochem Biophys Res Commun
, vol.354
, pp. 45-49
-
-
Suganami, T.1
Mieda, T.2
Itoh, M.3
Shimoda, Y.4
Kamei, Y.5
Ogawa, Y.6
-
6
-
-
26244448904
-
A paracrine loop between adipocytes and macrophages aggravates inflammatory changes: Role of free fatty acids and tumor necrosis factor _
-
Suganami T, Nishida J, Ogawa Y. A paracrine loop between adipocytes and macrophages aggravates inflammatory changes: role of free fatty acids and tumor necrosis factor _. Arterioscler Thromb Vasc Biol. 2005;25:2062–2068.
-
(2005)
Arterioscler Thromb Vasc Biol
, vol.25
, pp. 2062-2068
-
-
Suganami, T.1
Nishida, J.2
Ogawa, Y.3
-
7
-
-
34347399563
-
Metabolic endotoxemia initiates obesity and insulin resistance
-
Cani PD, Amar J, Iglesias MA, et al. Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes. 2007;56:1761–1772.
-
(2007)
Diabetes
, vol.56
, pp. 1761-1772
-
-
Cani, P.D.1
Amar, J.2
Iglesias, M.A.3
-
8
-
-
84861978076
-
Host-gut microbiota metabolic interactions
-
Nicholson JK, Holmes E, Kinross J, et al. Host-gut microbiota metabolic interactions. Science. 2012;336:1262–1267.
-
(2012)
Science
, vol.336
, pp. 1262-1267
-
-
Nicholson, J.K.1
Holmes, E.2
Kinross, J.3
-
10
-
-
77951630780
-
Martínez-Clemente M, et al. 5-lipoxygenase activating protein signals adipose tissue inflammation and lipid dysfunction in experimental obesity
-
Horrillo R, González-Périz A, Martínez-Clemente M, et al. 5-lipoxygenase activating protein signals adipose tissue inflammation and lipid dysfunction in experimental obesity. J Immunol. 2010; 184:3978–3987.
-
(2010)
J Immunol
, vol.184
, pp. 3978-3987
-
-
Horrillo, R.1
González-Périz, A.2
-
11
-
-
84865497318
-
Adipocytes secrete leukotrienes: Contribution to obesity-associated inflammation and insulin resistance in mice
-
Mothe-Satney I, Filloux C, Amghar H, et al. Adipocytes secrete leukotrienes: contribution to obesity-associated inflammation and insulin resistance in mice. Diabetes. 2012;61:2311–2319.
-
(2012)
Diabetes
, vol.61
, pp. 2311-2319
-
-
Mothe-Satney, I.1
Filloux, C.2
Amghar, H.3
-
13
-
-
0036892335
-
Comparison of PGE2, prostacyclin and leptin release by human adipocytes versus explants of adipose tissue in primary culture
-
Fain JN, Kanu A, Bahouth SW, Cowan GS Jr, Hiler ML, Leffler CW. Comparison of PGE2, prostacyclin and leptin release by human adipocytes versus explants of adipose tissue in primary culture. Prostaglandins Leukot Essent Fatty Acids. 2002;67:467–473.
-
(2002)
Prostaglandins Leukot Essent Fatty Acids
, vol.67
, pp. 467-473
-
-
Fain, J.N.1
Kanu, A.2
Bahouth, S.W.3
Cowan, G.S.4
Hiler, M.L.5
Leffler, C.W.6
-
14
-
-
84922485401
-
Prostaglandin E2-induced inflammation: Relevance of prostaglandin
-
Kawahara K, Hohjoh H, Inazumi T, Tsuchiya S, Sugimoto Y. Prostaglandin E2-induced inflammation: relevance of prostaglandin E receptors. Biochim Biophys Acta. 2015;1851:414–421.
-
(1851)
E Receptors. Biochim Biophys Acta
, vol.2015
, pp. 414-421
-
-
Kawahara, K.1
Hohjoh, H.2
Inazumi, T.3
Tsuchiya, S.4
Sugimoto, Y.5
-
15
-
-
78650953860
-
Cyclooxygenase-2 deficiency attenuates adipose tissue differentiation and inflammation in mice
-
Ghoshal S, Trivedi DB, Graf GA, Loftin CD. Cyclooxygenase-2 deficiency attenuates adipose tissue differentiation and inflammation in mice. J Biol Chem. 2011;286:889–898.
-
(2011)
J Biol Chem
, vol.286
, pp. 889-898
-
-
Ghoshal, S.1
Trivedi, D.B.2
Graf, G.A.3
Loftin, C.D.4
-
16
-
-
75149164466
-
Suppressive effect of COX2 inhibitor on the progression of adipose inflammation in high-fat-induced obese rats
-
Hsieh PS, Lu KC, Chiang CF, Chen CH. Suppressive effect of COX2 inhibitor on the progression of adipose inflammation in high-fat-induced obese rats. Eur J Clin Invest. 2010;40:164–171.
-
(2010)
Eur J Clin Invest
, vol.40
, pp. 164-171
-
-
Hsieh, P.S.1
Lu, K.C.2
Chiang, C.F.3
Chen, C.H.4
-
17
-
-
67650484314
-
COX- 2-mediated inflammation in fat is crucial for obesity-linked insulin resistance and fatty liver
-
Hsieh PS, Jin JS, Chiang CF, Chan PC, Chen CH, Shih KC. COX- 2-mediated inflammation in fat is crucial for obesity-linked insulin resistance and fatty liver. Obesity (Silver Spring). 2009;17:1150–1157.
-
(2009)
Obesity (Silver Spring)
, vol.17
, pp. 1150-1157
-
-
Hsieh, P.S.1
Jin, J.S.2
Chiang, C.F.3
Chan, P.C.4
Chen, C.H.5
Shih, K.C.6
-
18
-
-
84880651211
-
Increased saturated fatty acids in obesity alter resolution of inflammation in part by stimulating prostaglandin production
-
Hellmann J, Zhang MJ, Tang Y, Rane M, Bhatnagar A, Spite M. Increased saturated fatty acids in obesity alter resolution of inflammation in part by stimulating prostaglandin production. J Immunol. 2013;191:1383–1392.
-
(2013)
J Immunol
, vol.191
, pp. 1383-1392
-
-
Hellmann, J.1
Zhang, M.J.2
Tang, Y.3
Rane, M.4
Bhatnagar, A.5
Spite, M.6
-
19
-
-
84892841890
-
Termination mechanism of CREB-dependent activation of COX-2 expression in early phase of adipogenesis
-
Fujimori K, Yano M, Miyake H, Kimura H. Termination mechanism of CREB-dependent activation of COX-2 expression in early phase of adipogenesis. Mol Cell Endocrinol. 2014;384:12–22.
-
(2014)
Mol Cell Endocrinol
, vol.384
, pp. 12-22
-
-
Fujimori, K.1
Yano, M.2
Miyake, H.3
Kimura, H.4
-
20
-
-
74849132740
-
Up-regulation of adipogenesis in adipocytes expressing stably cyclooxygenase- 2 in the antisense direction
-
Chu X, Nishimura K, Jisaka M, Nagaya T, Shono F, Yokota K. Up-regulation of adipogenesis in adipocytes expressing stably cyclooxygenase- 2 in the antisense direction. Prostaglandins Other Lipid Mediat. 2010;91:1–9.
-
(2010)
Prostaglandins Other Lipid Mediat
, vol.91
, pp. 1-9
-
-
Chu, X.1
Nishimura, K.2
Jisaka, M.3
Nagaya, T.4
Shono, F.5
Yokota, K.6
-
21
-
-
84866142076
-
Synergistic suppression of early phase of adipogenesis by microsomal PGE synthase-1 (PTGES1)- produced PGE2 and aldo-keto reductase 1B3-produced PGF2α
-
Fujimori K, Yano M, Ueno T. Synergistic suppression of early phase of adipogenesis by microsomal PGE synthase-1 (PTGES1)- produced PGE2 and aldo-keto reductase 1B3-produced PGF2α. PLoS One. 2012;7:e44698.
-
(2012)
Plos One
, vol.7
-
-
Fujimori, K.1
Yano, M.2
Ueno, T.3
-
22
-
-
84874247282
-
Implication of inflammatory signaling pathways in obesity-induced insulin resistance
-
Tanti JF, Ceppo F, Jager J, Berthou F. Implication of inflammatory signaling pathways in obesity-induced insulin resistance. Front Endocrinol (Lausanne). 2013;3:181.
-
(2013)
Front Endocrinol (Lausanne)
, vol.3
, pp. 181
-
-
Tanti, J.F.1
Ceppo, F.2
Jager, J.3
Berthou, F.4
-
24
-
-
17744371331
-
TNF- α induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway
-
Dumitru CD, Ceci JD, Tsatsanis C, et al. TNF- α induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway. Cell. 2000;103:1071–1083.
-
(2000)
Cell
, vol.103
, pp. 1071-1083
-
-
Dumitru, C.D.1
Ceci, J.D.2
Tsatsanis, C.3
-
25
-
-
38949132532
-
TPL2-mediated activation of ERK1 and ERK2 regulates the processing of pre-TNF α in LPS-stimulated macrophages
-
Rousseau S, Papoutsopoulou M, Symons A, et al. TPL2-mediated activation of ERK1 and ERK2 regulates the processing of pre-TNF α in LPS-stimulated macrophages. J Cell Sci. 2008;121:149–154.
-
(2008)
J Cell Sci
, vol.121
, pp. 149-154
-
-
Rousseau, S.1
Papoutsopoulou, M.2
Symons, A.3
-
26
-
-
76249111625
-
Tumor progression locus 2 (Map3k8) is critical for host defense against listeria monocytogenes and IL-1β production
-
Mielke LA, Elkins KL, Wei L, et al. Tumor progression locus 2 (Map3k8) is critical for host defense against listeria monocytogenes and IL-1β production. J Immunol. 2009;183:7984–7993.
-
(2009)
J Immunol
, vol.183
, pp. 7984-7993
-
-
Mielke, L.A.1
Elkins, K.L.2
Wei, L.3
-
28
-
-
78650887845
-
Regulation and function of TPL-2, an IκB kinase-regulatedMAPkinase kinase kinase
-
Gantke T, Sriskantharajah S, Ley SC. Regulation and function of TPL-2, an IκB kinase-regulatedMAPkinase kinase kinase. Cell Res. 2011;21:131–145.
-
(2011)
Cell Res
, vol.21
, pp. 131-145
-
-
Gantke, T.1
Sriskantharajah, S.2
Ley, S.C.3
-
29
-
-
77449103988
-
The Tpl2 kinase is upregulated in adipose tissue in obesity and may mediate IL-1β and TNF-α effects on ERK activation and lipolysis
-
Jager J, Grémeaux T, Gonzalez T, et al. The Tpl2 kinase is upregulated in adipose tissue in obesity and may mediate IL-1β and TNF-α effects on ERK activation and lipolysis. Diabetes. 2010;59: 61–70.
-
(2010)
Diabetes
, vol.59
, pp. 61-70
-
-
Jager, J.1
Grémeaux, T.2
Gonzalez, T.3
-
30
-
-
84896864312
-
Implication of the Tpl2 kinase in inflammatory changes and insulin resistance induced by the interaction between adipocytes and macrophages
-
Ceppo F, Berthou F, Jager J, Dumas K, Cormont M, Tanti JF. Implication of the Tpl2 kinase in inflammatory changes and insulin resistance induced by the interaction between adipocytes and macrophages. Endocrinology. 2014;155:951–964.
-
(2014)
Endocrinology
, vol.155
, pp. 951-964
-
-
Ceppo, F.1
Berthou, F.2
Jager, J.3
Dumas, K.4
Cormont, M.5
Tanti, J.F.6
-
31
-
-
79953227706
-
Tumor progression locus 2 (TPL2) regulates obesity-associated inflammation and insulin resistance
-
Perfield JW 2nd, Lee Y, Shulman GI, et al. Tumor progression locus 2 (TPL2) regulates obesity-associated inflammation and insulin resistance. Diabetes. 2011;60:1168–1176.
-
(2011)
Diabetes
, vol.60
, pp. 1168-1176
-
-
Perfield, J.W.1
Lee, Y.2
Shulman, G.I.3
-
32
-
-
84896093461
-
MAP3K8 (TPL2/ COT) affects obesity-induced adipose tissue inflammation without systemic effects in humans and in mice
-
Ballak DB, van Essen P, van Diepen JA, et al. MAP3K8 (TPL2/ COT) affects obesity-induced adipose tissue inflammation without systemic effects in humans and in mice. PLoS One. 2014;9:e89615.
-
(2014)
Plos One
, vol.9
-
-
Ballak, D.B.1
Van Essen, P.2
Van Diepen, J.A.3
-
33
-
-
84862189240
-
Tumor progression locus 2 (Tpl2) deficiency does not protect against obesity-induced metabolic disease
-
Lancaster GI, Kowalski GM, Estevez E, et al. Tumor progression locus 2 (Tpl2) deficiency does not protect against obesity-induced metabolic disease. PLoS One. 2012;7:e39100.
-
(2012)
Plos One
, vol.7
-
-
Lancaster, G.I.1
Kowalski, G.M.2
Estevez, E.3
-
34
-
-
34250620918
-
Cot/Tpl2 and PKCζ cooperate in the regulation of the transcriptional activity of NFATc2 through the phosphorylation of its amino-terminal domain
-
Gómez-Casero E, San-Antonio B, Iñiguez MA, Fresno M. Cot/Tpl2 and PKCζ cooperate in the regulation of the transcriptional activity of NFATc2 through the phosphorylation of its amino-terminal domain. Cell Signal. 2007;19:1652–1661.
-
(2007)
Cell Signal
, vol.19
, pp. 1652-1661
-
-
Gómez-Casero, E.1
San-Antonio, B.2
Iñiguez, M.A.3
Fresno, M.4
-
35
-
-
0035920233
-
Cot kinase induces cyclooxygenase-2 expression in T cells through activation of the nuclear factor of activated T cells
-
de Gregorio R, Iñiguez MA, Fresno M, Alemany S. Cot kinase induces cyclooxygenase-2 expression in T cells through activation of the nuclear factor of activated T cells. J Biol Chem. 2001;276: 27003–27009.
-
(2001)
J Biol Chem
, vol.276
, pp. 27003-27009
-
-
De Gregorio, R.1
Iñiguez, M.A.2
Fresno, M.3
Alemany, S.4
-
36
-
-
21244463215
-
Tpl2/cot signals activate ERK, JNK, and NF-κB in a cell-type and stimulus-specific manner
-
Das S, Cho J, Lambertz I, et al. Tpl2/cot signals activate ERK, JNK, and NF-κB in a cell-type and stimulus-specific manner. J Biol Chem. 2005;280:23748–23757.
-
(2005)
J Biol Chem
, vol.280
, pp. 23748-23757
-
-
Das, S.1
Cho, J.2
Lambertz, I.3
-
37
-
-
84874094810
-
Altered prostanoid signaling contributes to increased skin tumorigenesis in Tpl2 knockout mice
-
DeCicco-Skinner KL, Nolan SJ, et al. Altered prostanoid signaling contributes to increased skin tumorigenesis in Tpl2 knockout mice. PLoS One. 2013;8:e56212.
-
(2013)
Plos One
, vol.8
-
-
Decicco-Skinner, K.L.1
Nolan, S.J.2
-
38
-
-
77958573595
-
Cot/tpl2 (MAP3K8) mediates myeloperoxidase activity and hypernociception following peripheral inflammation
-
Soria-Castro I, Krzyzanowska A, Pelaéz ML, et al. Cot/tpl2 (MAP3K8) mediates myeloperoxidase activity and hypernociception following peripheral inflammation. J Biol Chem. 2010;285: 33805–33815.
-
(2010)
J Biol Chem
, vol.285
, pp. 33805-33815
-
-
Soria-Castro, I.1
Krzyzanowska, A.2
Pelaéz, M.L.3
-
39
-
-
0037119996
-
Induction of COX-2 by LPS in macrophages is regulated by Tpl2-dependent CREB activation signals
-
Eliopoulos AG, Dumitru CD, Wang CC, Cho J, Tsichlis PN. Induction of COX-2 by LPS in macrophages is regulated by Tpl2-dependent CREB activation signals. EMBO J. 2002;21:4831–4840.
-
(2002)
EMBO J
, vol.21
, pp. 4831-4840
-
-
Eliopoulos, A.G.1
Dumitru, C.D.2
Wang, C.C.3
Cho, J.4
Tsichlis, P.N.5
-
40
-
-
40949109810
-
Proteinase-activated receptor-1-triggered activation of tumor progression locus-2 promotes actin cytoskeleton reorganization and cell migration
-
Hatziapostolou M, Polytarchou C, Panutsopulos D, Covic L, Tsichlis PN. Proteinase-activated receptor-1-triggered activation of tumor progression locus-2 promotes actin cytoskeleton reorganization and cell migration. Cancer Res. 2008;68:1851–1861.
-
(2008)
Cancer Res
, vol.68
, pp. 1851-1861
-
-
Hatziapostolou, M.1
Polytarchou, C.2
Panutsopulos, D.3
Covic, L.4
Tsichlis, P.N.5
-
41
-
-
26844453571
-
Inhibition of Tpl2 kinase and TNF- α production with 1,7-naphthyridine-3-carbonitriles: Synthesis and structure-activity relationships
-
Gavrin LK, Green N, Hu Y, et al. Inhibition of Tpl2 kinase and TNF- α production with 1,7-naphthyridine-3-carbonitriles: synthesis and structure-activity relationships. Bioorg Med Chem Lett. 2005;15:5288–5292.
-
(2005)
Bioorg Med Chem Lett
, vol.15
, pp. 5288-5292
-
-
Gavrin, L.K.1
Green, N.2
Hu, Y.3
-
42
-
-
33845873659
-
Interleukin-1 β induced insulin resistance in adipocytes through down-regulation of insulin receptor substrate-1 expression
-
Jager J, Grémeaux T, Cormont M, Le Marchand-Brustel Y, Tanti JF. Interleukin-1 β induced insulin resistance in adipocytes through down-regulation of insulin receptor substrate-1 expression. Endocrinology. 2007;148:241–251.
-
(2007)
Endocrinology
, vol.148
, pp. 241-251
-
-
Jager, J.1
Grémeaux, T.2
Cormont, M.3
Le Marchand-Brustel, Y.4
Tanti, J.F.5
-
43
-
-
70349188457
-
High efficiency lipid-based siRNA transfection of adipocytes in suspension
-
Kilroy G, Burk DH, Floyd ZE. High efficiency lipid-based siRNA transfection of adipocytes in suspension. PLoS One. 2009;4:e6940.
-
(2009)
Plos One
, vol.4
-
-
Kilroy, G.1
Burk, D.H.2
Floyd, Z.E.3
-
44
-
-
33847638036
-
New approaches to the modulation of the cyclooxygenase-2 and 5-lipoxygenase pathways
-
González-Périz A, Clària J. New approaches to the modulation of the cyclooxygenase-2 and 5-lipoxygenase pathways. Curr Top Med Chem. 2007;7:297–309.
-
(2007)
Curr Top Med Chem
, vol.7
, pp. 297-309
-
-
González-Périz, A.1
Clària, J.2
-
45
-
-
79551597189
-
Deficiency in the extracellular signal-regulated kinase 1 (ERK1) protects leptin-deficient mice from insulin resistance without affecting obesity
-
Jager J, Corcelle V, Grémeaux T, et al. Deficiency in the extracellular signal-regulated kinase 1 (ERK1) protects leptin-deficient mice from insulin resistance without affecting obesity. Diabetologia. 2011;54:180–189.
-
(2011)
Diabetologia
, vol.54
, pp. 180-189
-
-
Jager, J.1
Corcelle, V.2
Grémeaux, T.3
-
46
-
-
84908519207
-
Intestinal myofibroblast-specific Tpl2-Cox-2-PGE2 pathway links innate sensing to epithelial homeostasis
-
Roulis M, Nikolaou C, Kotsaki E, et al. Intestinal myofibroblast-specific Tpl2-Cox-2-PGE2 pathway links innate sensing to epithelial homeostasis. Proc Natl Acad Sci USA. 2014;111:E4658–E4667.
-
(2014)
Proc Natl Acad Sci USA
, vol.111
, pp. 4658-4667
-
-
Roulis, M.1
Nikolaou, C.2
Kotsaki, E.3
-
47
-
-
77954949360
-
Leukotriene B(4) BLT receptor signaling regulates the level and stability of cyclooxygenase-2 (COX-2) mRNA through restricted activation of Ras/Raf/ERK/p42 AUF1 pathway
-
Zhai B, Yang H, Mancini A, He Q, Antoniou J, Di Battista JA. Leukotriene B(4) BLT receptor signaling regulates the level and stability of cyclooxygenase-2 (COX-2) mRNA through restricted activation of Ras/Raf/ERK/p42 AUF1 pathway. J Biol Chem. 2010; 285:23568–23580.
-
(2010)
J Biol Chem
, vol.285
, pp. 23568-23580
-
-
Zhai, B.1
Yang, H.2
Mancini, A.3
He, Q.4
Antoniou, J.5
Di Battista, J.A.6
-
48
-
-
33846323706
-
Role of the Toll-like receptor 4/NF- κ B pathway in saturated fatty acid-induced inflammatory changes in the interaction between adipocytes and macrophages
-
Suganami T, Tanimoto-Koyama K, Nishida J, et al. Role of the Toll-like receptor 4/NF- κ B pathway in saturated fatty acid-induced inflammatory changes in the interaction between adipocytes and macrophages. Arterioscler Thromb Vasc Biol. 2007; 27:84–91.
-
(2007)
Arterioscler Thromb Vasc Biol
, vol.27
, pp. 84-91
-
-
Suganami, T.1
Tanimoto-Koyama, K.2
Nishida, J.3
|