MAP3K8 (TPL2/COT) affects obesity-induced adipose tissue inflammation without systemic effects in humans and in mice

PLoS ONE

Volumn 9, Issue 2, 2014, Pages

  Ballak, Dov B ^a   Van Essen, Peter ^a   Van Diepen, Janna A ^a   Jansen, Henry ^a   Hijmans, Anneke ^a   Matsuguchi, Tetsuya ^b   Sparrer, Helmut ^c   Tack, Cees J ^a   Netea, Mihai G ^a   Joosten, Leo A B ^a   Stienstra, Rinke ^a,d  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b KAGOSHIMA UNIVERSITY   (Japan)

^c NOVARTIS PHARMA AG   (Switzerland)

^d WAGENINGEN UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; CXCL1 CHEMOKINE; GLUCOSE; INSULIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; MAP3K8 PROTEIN; MESSENGER RNA; PROTEIN SERINE THREONINE KINASE; SERUM AMYLOID A; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; MAP3K8 PROTEIN, HUMAN; MAP3K8 PROTEIN, MOUSE; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE; ONCOPROTEIN; PLASMA PROTEIN;

ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; BODY MASS; BODY WEIGHT; CELL INFILTRATION; CELL SIZE; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE MARKER; GENE EXPRESSION; GLUCOSE BLOOD LEVEL; HISTOCHEMISTRY; HUMAN; HUMAN TISSUE; INFLAMMATION; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; MACROPHAGE; MOUSE; NONHUMAN; OBESITY; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; ANIMAL; C57BL MOUSE; CELL CULTURE; COMPARATIVE STUDY; COMPLICATION; ENZYME IMMUNOASSAY; GENETICS; GLUCOSE TOLERANCE TEST; IMMUNOLOGY; KNOCKOUT MOUSE; LIPID DIET; METABOLISM; PATHOLOGY; PHYSIOLOGY; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ADIPOSE TISSUE; ANIMALS; BLOOD PROTEINS; BLOTTING, WESTERN; BODY MASS INDEX; CELLS, CULTURED; DIET, HIGH-FAT; GLUCOSE TOLERANCE TEST; HUMANS; IMMUNOENZYME TECHNIQUES; INFLAMMATION; INSULIN; INSULIN RESISTANCE; INTERLEUKIN-1BETA; INTERLEUKIN-6; INTERLEUKIN-8; MAP KINASE KINASE KINASES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; OBESITY; PROTO-ONCOGENE PROTEINS; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84896093461     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0089615     Document Type: Article

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