Monozygotic twins discordant for common variable immunodeficiency reveal impaired DNA demethylation during naïve-to-memory B-cell transition

Nature Communications

Volumn 6, Issue , 2015, Pages

  Rodríguez Cortez, Virginia C ^a   Del Pino Molina, Lucia ^b,c   Rodríguez Ubreva, Javier ^a   Ciudad, Laura ^a   Gómez Cabrero, David ^d   Company, Carlos ^a   Urquiza, José M ^a   Tegnér, Jesper ^d   Rodríguez Gallego, Carlos ^e   López Granados, Eduardo ^b,c   Ballestar, Esteban ^a  

^a BELLVITGE BIOMEDICAL RESEARCH INSTITUTE IDIBELL   (Spain)

^b HOSPITAL UNIVERSITARIO LA PAZ   (Spain)

^c HOSPITAL UNIVERSITARIO LA PAZ IDIPAZ   (Spain)

^d KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^e HOSPITAL UNIVERSITARIO SON ESPASES   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

DUAL SPECIFICITY PHOSPHATASE 2; HISTONE DEACETYLASE 4; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE 3 KINASE; RANTES; TRANSCRIPTION FACTOR 7 LIKE 1; WNT5A PROTEIN;

DNA; GENE EXPRESSION; GERM CELL; MEMORY; METHYLATION;

3' UNTRANSLATED REGION; ARTICLE; B LYMPHOCYTE; CELL ADHESION; CELL DEATH; CELL DIFFERENTIATION; CELL FATE; CELL GROWTH; CELL PROLIFERATION; CELL SURVIVAL; COHORT ANALYSIS; COMMON VARIABLE IMMUNODEFICIENCY; CONTROLLED STUDY; CPG ISLAND; DEMETHYLATION; DNA DAMAGE; DNA METHYLATION; EPIGENETICS; HIGH THROUGHPUT SEQUENCING; HUMAN; HUMAN CELL; MEMORY CELL; MONOZYGOTIC TWINS; TWIN DISCORDANCE; UPREGULATION; CASE CONTROL STUDY; GENE EXPRESSION REGULATION; IMMUNOLOGICAL MEMORY; METABOLISM; TWINS;

B-LYMPHOCYTES; CASE-CONTROL STUDIES; COMMON VARIABLE IMMUNODEFICIENCY; DNA METHYLATION; GENE EXPRESSION REGULATION; HUMANS; IMMUNOLOGIC MEMORY; TWINS, MONOZYGOTIC;

EID: 84935897991     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms8335     Document Type: Article

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