Effects of copper overload in P19 neurons: Impairment of glutathione redox homeostasis and crosstalk between caspase and calpain protease systems in ROS-induced apoptosis

BioMetals

Volumn 27, Issue 6, 2014, Pages 1303-1322

  Jazvinšćak Jembrek, Maja ^a,b   Vlainić, Josipa ^a   Radovanović, Vedrana ^a   Erhardt, Julija ^c   Oršolić, Nada ^c  

^a RUDER BO KOVI INSTITUTE   (Croatia)

^b Croatian Academy of Medical Sciences Zagreb   (Croatia)

^c UNIVERSITY OF ZAGREB   (Croatia)

Author keywords

Apoptosis; Calpain; Copper toxicity; ERK pathway; Glutathione; Lactate dehydrogenase; P19 neurons

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; ADENOSINE TRIPHOSPHATE; BETA ACTIN; CALCIUM; CALCIUM CHANNEL L TYPE; CALPAIN; CASPASE 3; CASPASE 7; COPPER SULFATE; CYCLIC AMP DEPENDENT PROTEIN KINASE; DIZOCILPINE; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; GLUTATHIONE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; LACTATE DEHYDROGENASE; LEUPEPTIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; NIFEDIPINE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN C FOS; PROTEIN KINASE C; PROTEIN P53; QUERCETIN; REACTIVE OXYGEN METABOLITE; APOPTOSIS REGULATORY PROTEIN; CASPASE; CHELATING AGENT; CHROMATIN; DIZOCILPINE MALEATE; PROTEIN KINASE INHIBITOR; PROTEINASE INHIBITOR; TUMOR PROTEIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CELL FUNCTION; CELL SURVIVAL; CELL VIABILITY; CHROMATIN CONDENSATION; CONTROLLED STUDY; CYTOSOL; DOSE RESPONSE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INACTIVATION; GENE OVEREXPRESSION; IN VITRO STUDY; INTRACELLULAR SIGNALING; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; MOUSE; NERVE CELL DIFFERENTIATION; NEUROTOXICITY; NONHUMAN; OXIDATION REDUCTION STATE; OXIDATIVE PHOSPHORYLATION; OXIDATIVE STRESS; PROTEIN EXPRESSION; TERATOCARCINOMA CELL LINE; ANIMAL; BIOSYNTHESIS; CHROMATIN; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; NERVE CELL; OXIDATION REDUCTION REACTION; PATHOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION; TERATOCARCINOMA; TUMOR CELL LINE; ULTRASTRUCTURE;

ADENOSINE TRIPHOSPHATE; ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CALPAIN; CASPASES; CELL LINE, TUMOR; CHELATING AGENTS; CHROMATIN; COPPER SULFATE; DIZOCILPINE MALEATE; GENE EXPRESSION REGULATION; GLUTATHIONE; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE (PHOSPHORYLATING); LEUPEPTINS; MICE; NEOPLASM PROTEINS; NEURONS; NIFEDIPINE; OXIDATION-REDUCTION; OXIDATIVE STRESS; PROTEASE INHIBITORS; PROTEIN KINASE INHIBITORS; REACTIVE OXYGEN SPECIES; RNA, MESSENGER; SIGNAL TRANSDUCTION; TERATOCARCINOMA;

EID: 84935890159     PISSN: 09660844     EISSN: 15728773     Source Type: Journal    
DOI: 10.1007/s10534-014-9792-x     Document Type: Article

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