메뉴 건너뛰기




Volumn 12, Issue 3, 2015, Pages 3615-3620

Adrenomedullin improves intestinal epithelial barrier function by downregulating Myosin light chain phosphorylation in ulcerative colitis rats

Author keywords

Adrenomedullin; Cytokine; Myosin light chain; Myosin light chain kinase; Ulcerative colitis

Indexed keywords

ADRENOMEDULLIN; INTERLEUKIN 6; MYOSIN LIGHT CHAIN; MYOSIN LIGHT CHAIN KINASE; PROTEIN ZO1; TRINITROBENZENESULFONIC ACID; TUMOR NECROSIS FACTOR ALPHA; ANTIHYPERTENSIVE AGENT;

EID: 84935512394     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2015.3887     Document Type: Article
Times cited : (19)

References (35)
  • 1
    • 70350509805 scopus 로고    scopus 로고
    • Intestinal mucosal barrier function in health and disease
    • Turner JR: Intestinal mucosal barrier function in health and disease. Nat Rev Immunol 9:799-809, 2009.
    • (2009) Nat Rev Immunol , vol.9 , pp. 799-809
    • Turner, J.R.1
  • 3
    • 0028103683 scopus 로고
    • Intestinal permeability in patients with Crohn's disease and ulcerative colitis and their first degree relatives
    • Munkholm P, Langholz E, Hollander D, Thornberg K, Orholm M, Katz KD and Binder V: Intestinal permeability in patients with Crohn's disease and ulcerative colitis and their first degree relatives. Gut 35:68-72, 1994.
    • (1994) Gut , vol.35 , pp. 68-72
    • Munkholm, P.1    Langholz, E.2    Hollander, D.3    Thornberg, K.4    Orholm, M.5    Katz, K.D.6    Binder, V.7
  • 4
    • 73349093417 scopus 로고    scopus 로고
    • Adrenomedullin treatment reduces intestinal inflammation and maintains epithelial barrier function in mice administered dextran sulphate sodium
    • Ashizuka S, Inagaki-Ohara K, Kuwasako K, Kato J, Inatsu H and Kitamura K: Adrenomedullin treatment reduces intestinal inflammation and maintains epithelial barrier function in mice administered dextran sulphate sodium. Microbiol Immunol 53:573-581, 2009.
    • (2009) Microbiol Immunol , vol.53 , pp. 573-581
    • Ashizuka, S.1    Inagaki-Ohara, K.2    Kuwasako, K.3    Kato, J.4    Inatsu, H.5    Kitamura, K.6
  • 6
    • 2142813761 scopus 로고    scopus 로고
    • A porous defense: The leaky epithelial barrier in intestinal disease
    • Clayburgh DR, Shen L and Turner JR: A porous defense: The leaky epithelial barrier in intestinal disease. Lab Invest 84:282-291, 2004.
    • (2004) Lab Invest , vol.84 , pp. 282-291
    • Clayburgh, D.R.1    Shen, L.2    Turner, J.R.3
  • 7
    • 9344257937 scopus 로고    scopus 로고
    • Increased gut permeability in Crohn's disease: Is TNF the link?
    • Gibson PR: Increased gut permeability in Crohn's disease: Is TNF the link? Gut 53:1724-1725, 2004.
    • (2004) Gut , vol.53 , pp. 1724-1725
    • Gibson, P.R.1
  • 8
    • 0033672942 scopus 로고    scopus 로고
    • Molecular physiology and pathophysiology of tight junctions. IV. Regulation of tight junctions by extracellular stimuli: Nutrients, cytokines, and immune cells
    • Nusrat A, Turner JR and Madara JL: Molecular physiology and pathophysiology of tight junctions. IV. Regulation of tight junctions by extracellular stimuli: Nutrients, cytokines, and immune cells. Am J Physiol Gastrointest Liver Physiol 279:G851-G857, 2000.
    • (2000) Am J Physiol Gastrointest Liver Physiol , vol.279 , pp. G851-G857
    • Nusrat, A.1    Turner, J.R.2    Madara, J.L.3
  • 9
    • 33644981348 scopus 로고    scopus 로고
    • Molecular mechanism of tumor necrosis factor-alpha modulation of intestinal epithelial tight junction barrier
    • Ye D, Ma I and Ma TY: Molecular mechanism of tumor necrosis factor-alpha modulation of intestinal epithelial tight junction barrier. Am J Physiol Gastrointest Liver Physiol 290:G496-G504, 2006.
    • (2006) Am J Physiol Gastrointest Liver Physiol , vol.290 , pp. G496-G504
    • Ye, D.1    Ma, I.2    Ma, T.Y.3
  • 10
    • 79956223990 scopus 로고    scopus 로고
    • Berberine ameliorates intestinal epithelial tight-junction damage and down-regulates myosin light chain kinase pathways in a mouse model of endotoxinemia
    • Gu L, Li N, Gong J, Li Q, Zhu W and Li J: Berberine ameliorates intestinal epithelial tight-junction damage and down-regulates myosin light chain kinase pathways in a mouse model of endotoxinemia. J Infect Dis 203:1602-1612, 2011.
    • (2011) J Infect Dis , vol.203 , pp. 1602-1612
    • Gu, L.1    Li, N.2    Gong, J.3    Li, Q.4    Zhu, W.5    Li, J.6
  • 11
    • 67649195008 scopus 로고    scopus 로고
    • Pentoxifylline modulates intestinal tight junction signaling after burn injury: Effects on myosin light chain kinase
    • discussion 24-25
    • Costantini T W, Loomis WH, Putnam JG, et al: Pentoxifylline modulates intestinal tight junction signaling after burn injury: Effects on myosin light chain kinase. J Trauma 66:17-24; discussion 24-25, 2009.
    • (2009) J Trauma , vol.66 , pp. 17-24
    • Costantini, T.W.1    Loomis, W.H.2    Putnam, J.G.3
  • 12
    • 84862834603 scopus 로고    scopus 로고
    • Tight junctions on the move: Molecular mechanisms for epithelial barrier regulation
    • Shen L: Tight junctions on the move: Molecular mechanisms for epithelial barrier regulation. Ann NY Acad Sci 1258:9-18, 2012.
    • (2012) Ann NY Acad Sci , vol.1258 , pp. 9-18
    • Shen, L.1
  • 13
    • 84873157865 scopus 로고    scopus 로고
    • Myosin light chain kinase inhibitor inhibits dextran sulfate sodium-induced colitis in mice
    • Liu X, Xu J, Mei Q, Han L and Huang J: Myosin light chain kinase inhibitor inhibits dextran sulfate sodium-induced colitis in mice. Dig Dis Sci 58:107-114, 2013.
    • (2013) Dig Dis Sci , vol.58 , pp. 107-114
    • Liu, X.1    Xu, J.2    Mei, Q.3    Han, L.4    Huang, J.5
  • 14
    • 0037090768 scopus 로고    scopus 로고
    • Adrenomedullin has multiple roles in disease stress: Development and remission of the inflammatory response
    • Elsasser TH and Kahl S: Adrenomedullin has multiple roles in disease stress: Development and remission of the inflammatory response. Microsc Res Tech 57:120-129, 2002.
    • (2002) Microsc Res Tech , vol.57 , pp. 120-129
    • Elsasser, T.H.1    Kahl, S.2
  • 16
  • 18
    • 33646779859 scopus 로고    scopus 로고
    • Therapeutic effect of urocortin and adrenomedullin in a murine model of Crohn's disease
    • Gonzalez-Rey E, Fernandez-Martin A, Chorny A and Delgado M: Therapeutic effect of urocortin and adrenomedullin in a murine model of Crohn's disease. Gut 55:824-832, 2006.
    • (2006) Gut , vol.55 , pp. 824-832
    • Gonzalez-Rey, E.1    Fernandez-Martin, A.2    Chorny, A.3    Delgado, M.4
  • 19
    • 80755186517 scopus 로고    scopus 로고
    • Vascular contribution of adrenomedullin to microcirculatory improvement in experimental colitis
    • Talero E, Alvarez de Sotomayor M, Sánchez-Fidalgo S and Motilva V: Vascular contribution of adrenomedullin to microcirculatory improvement in experimental colitis. Eur J Pharmacol 670:601-607, 2 011.
    • (2011) Eur J Pharmacol , vol.670 , pp. 601-607
    • Talero, E.1    Alvarez De Sotomayor, M.2    Sánchez-Fidalgo, S.3    Motilva, V.4
  • 21
    • 33846424259 scopus 로고    scopus 로고
    • Adrenomedullin and adrenomedullin-binding protein-1 downregulate inflammatory cytokines and attenuate tissue injury after gut ischemia-reperfusion
    • Carrizo GJ, Wu R, Cui X, Dwivedi AJ, Simms HH and Wang P: Adrenomedullin and adrenomedullin-binding protein-1 downregulate inflammatory cytokines and attenuate tissue injury after gut ischemia-reperfusion. Surgery 141:245-253, 2007.
    • (2007) Surgery , vol.141 , pp. 245-253
    • Carrizo, G.J.1    Wu, R.2    Cui, X.3    Dwivedi, A.J.4    Simms, H.H.5    Wang, P.6
  • 22
    • 84892183497 scopus 로고    scopus 로고
    • Study on the interactions between transplanted bone marrow-derived mesenchymal stem cells and regulatory T cells for the treatment of experimental colitis
    • Zuo D, Liu X, Shou Z, Fan H, Tang Q, Duan X, Cao D, Zou Z and Zhang L: Study on the interactions between transplanted bone marrow-derived mesenchymal stem cells and regulatory T cells for the treatment of experimental colitis. Int J Mol Med 32:1337-1344, 2013.
    • (2013) Int J Mol Med , vol.32 , pp. 1337-1344
    • Zuo, D.1    Liu, X.2    Shou, Z.3    Fan, H.4    Tang, Q.5    Duan, X.6    Cao, D.7    Zou, Z.8    Zhang, L.9
  • 23
    • 84902497836 scopus 로고    scopus 로고
    • Somatostatin regulates tight junction proteins expression in colitis mice
    • Li X, Wang Q, Xu H, Tao L, Lu J, Cai L and Wang C: Somatostatin regulates tight junction proteins expression in colitis mice. Int J Clin Exp Pathol 7:2153-2162, 2014.
    • (2014) Int J Clin Exp Pathol , vol.7 , pp. 2153-2162
    • Li, X.1    Wang, Q.2    Xu, H.3    Tao, L.4    Lu, J.5    Cai, L.6    Wang, C.7
  • 24
    • 0034522401 scopus 로고    scopus 로고
    • Diarrhea in ulcerative colitis. The role of altered colonic sodium transport
    • Greig E and Sandle GI: Diarrhea in ulcerative colitis. The role of altered colonic sodium transport. Ann NY Acad Sci 915:327-332, 2000.
    • (2000) Ann NY Acad Sci , vol.915 , pp. 327-332
    • Greig, E.1    Sandle, G.I.2
  • 26
    • 84878667737 scopus 로고    scopus 로고
    • Adalimumab prevents barrier dysfunction and antagonizes distinct effects of TNF-α on tight junction proteins and signaling pathways in intestinal epithelial cells
    • Fischer A, Gluth M, Pape UF, Wiedenmann B, Theuring F and Baumgart DC: Adalimumab prevents barrier dysfunction and antagonizes distinct effects of TNF-α on tight junction proteins and signaling pathways in intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol 304:G970-G979, 2013.
    • (2013) Am J Physiol Gastrointest Liver Physiol , vol.304 , pp. G970-G979
    • Fischer, A.1    Gluth, M.2    Pape, U.F.3    Wiedenmann, B.4    Theuring, F.5    Baumgart, D.C.6
  • 27
    • 13844308129 scopus 로고    scopus 로고
    • Mechanism of TNF-{alpha} modulation of Caco-2 intestinal epithelial tight junction barrier: Role of myosin light-chain kinase protein expression
    • Ma TY, Boivin MA, Ye D, Pedram A and Said HM: Mechanism of TNF-{alpha} modulation of Caco-2 intestinal epithelial tight junction barrier: Role of myosin light-chain kinase protein expression. Am J Physiol Gastrointest Liver Physiol 288:G422-G430, 2005.
    • (2005) Am J Physiol Gastrointest Liver Physiol , vol.288 , pp. G422-G430
    • Ma, T.Y.1    Boivin, M.A.2    Ye, D.3    Pedram, A.4    Said, H.M.5
  • 29
    • 84905048976 scopus 로고    scopus 로고
    • Interleukin-6, but not the interleukin-6 receptor plays a role in recovery from dextran sodium sulfate-induced colitis
    • Sommer J, Engelowski E, Baran P, Garbers C, Floss DM and Scheller J: Interleukin-6, but not the interleukin-6 receptor plays a role in recovery from dextran sodium sulfate-induced colitis. Int J Mol Med 34:651-660, 2014.
    • (2014) Int J Mol Med , vol.34 , pp. 651-660
    • Sommer, J.1    Engelowski, E.2    Baran, P.3    Garbers, C.4    Floss, D.M.5    Scheller, J.6
  • 30
    • 0034465898 scopus 로고    scopus 로고
    • Increased intestinal permeability precedes the onset of Crohn's disease in a subject with familial risk
    • Irvine EJ and Marshall JK: Increased intestinal permeability precedes the onset of Crohn's disease in a subject with familial risk. Gastroenterology 119:1740-1744, 2000.
    • (2000) Gastroenterology , vol.119 , pp. 1740-1744
    • Irvine, E.J.1    Marshall, J.K.2
  • 31
    • 0027217379 scopus 로고
    • Intestinal permeability and the prediction of relapse in Crohn's disease
    • Wyatt J, Vogelsang H, Hübl W, Waldhöer T and Lochs H: Intestinal permeability and the prediction of relapse in Crohn's disease. Lancet 341:1437-1439, 1993.
    • (1993) Lancet , vol.341 , pp. 1437-1439
    • Wyatt, J.1    Vogelsang, H.2    Hübl, W.3    Waldhöer, T.4    Lochs, H.5
  • 32
    • 13244298599 scopus 로고    scopus 로고
    • Interferon-gamma and tumor necrosis factor-alpha synergize to induce intestinal epithelial barrier dysfunction by up-regulating myosin light chain kinase expression
    • Wang F, Graham W V, Wang Y, Witkowski ED, Schwarz BT and Turner JR: Interferon-gamma and tumor necrosis factor-alpha synergize to induce intestinal epithelial barrier dysfunction by up-regulating myosin light chain kinase expression. Am J Pathol 166:409-419, 2005.
    • (2005) Am J Pathol , vol.166 , pp. 409-419
    • Wang, F.1    Graham, W.V.2    Wang, Y.3    Witkowski, E.D.4    Schwarz, B.T.5    Turner, J.R.6
  • 33
    • 0031898947 scopus 로고    scopus 로고
    • Autocrine regulation of epithelial permeability by hypoxia: Role for polarized release of tumor necrosis factor alpha
    • Taylor CT, Dzus AL and Colgan SP: Autocrine regulation of epithelial permeability by hypoxia: Role for polarized release of tumor necrosis factor alpha. Gastroenterology 114:657-668, 1998.
    • (1998) Gastroenterology , vol.114 , pp. 657-668
    • Taylor, C.T.1    Dzus, A.L.2    Colgan, S.P.3
  • 35
    • 57349177746 scopus 로고    scopus 로고
    • Gut hyperpermeability after ischemia and reperfusion: Attenuation with adrenomedullin and its binding protein treatment
    • Higuchi S, Wu R, Zhou M, Marini C P, Ravikumar TS and Wang P: Gut hyperpermeability after ischemia and reperfusion: Attenuation with adrenomedullin and its binding protein treatment. Int J Clin Exp Pathol 1:409-418, 2008.
    • (2008) Int J Clin Exp Pathol , vol.1 , pp. 409-418
    • Higuchi, S.1    Wu, R.2    Zhou, M.3    Marini, C.P.4    Ravikumar, T.S.5    Wang, P.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.