Study on the interactions between transplanted bone marrow-derived mesenchymal stem cells and regulatory T cells for the treatment of experimental colitis

International Journal of Molecular Medicine

Volumn 32, Issue 6, 2013, Pages 1337-1344

  Zuo, Dongmei ^a   Liu, Xingxing ^a   Shou, Zhexing ^a   Fan, Heng ^a   Tang, Qing ^a   Duan, Xueyun ^b   Cao, Dan ^a   Zou, Zhou ^a   Zhang, Lijuan ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b HUBEI UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

Bone marrow mesenchymal stem cells; Inflammatory bowel diseases; Regulatory T cells

Indexed keywords

GREEN FLUORESCENT PROTEIN; LENTIVIRUS VECTOR; MESSENGER RNA; PHOSPHATE BUFFERED SALINE; TRANSCRIPTION FACTOR FOXP3; TRINITROBENZENESULFONIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW TRANSPLANTATION; CD4+ CD25+ T LYMPHOCYTE; CELL INTERACTION; CELL ISOLATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DISEASE SEVERITY; EXPERIMENTAL COLITIS; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION; HISTOPATHOLOGY; IMMUNOMODULATION; IN VIVO GENE TRANSFER; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; NONHUMAN; PRIORITY JOURNAL; RAT; REGULATORY T LYMPHOCYTE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSCRIPTION REGULATION;

ANIMALS; ANTIGENS, SURFACE; BLOTTING, WESTERN; BONE MARROW CELLS; CELL COMMUNICATION; COLITIS; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION REGULATION; GREEN FLUORESCENT PROTEINS; INTESTINAL MUCOSA; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMAL CELLS; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; T-LYMPHOCYTES, REGULATORY;

EID: 84892183497     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2013.1529     Document Type: Article

References (40)

1. Baumgart DC and Carding SR: Inflammatory bowel disease: cause and immunobiology. Lancet 369: 1627-1640, 2007.
2. Bouma G and Strober W: The immunological and genetic basis of inflammatory bowel disease. Nat Rev Immunol 3: 521-533, 2003.
3. Xavier RJ and Podolsky DK: Unravelling the pathogenesis of inflammatory bowel disease. Nature 448: 427-434, 2007.
4. Baumgart DC and Sandborn WJ: Inflammatory bowel disease: clinical aspects and established and evolving therapies. Lancet 369: 1641-1657, 2007.
5. Himmel ME, Hardenberg G, Piccirillo CA, et al: The role of T-regulatory cells and Toll-like receptors in the pathogenesis of human inflammatory bowel disease. Immunology 125: 145-153, 2008.
6. Fiocchi C: Towards a 'cure' for IBD. Dig Dis 30: 428-433, 2012.
7. + T regulatory cell-mediated suppression. Immunity 30: 636-645, 2009.
8. Wing K and Sakaguchi S: Regulatory T cells exert checks and balances on self tolerance and autoimmunity. Nat Immunol 11: 7-13, 2010.
9. Bacchetta R, Passerini L, Gambineri E, et al: Defective regulatory and effector T cell functions in patients with FOXP3 mutations. J Clin Invest 116: 1713-1722, 2006.
10. McMurchy AN, Di Nunzio S, Roncarolo MG, et al: Molecular regulation of cellular immunity by FOXP3. Adv Exp Med Biol 665: 30-46, 2009.
11. + regulatory T cells. Nat Immunol 4: 330-336, 2003.
12. + regulatory T cells. J Immunol 170: 3939-3943, 2003.
13. Yi T and Song SU: Immunomodulatory properties of mesenchymal stem cells and their therapeutic applications. Arch Pharm Res 35: 213-221, 2012.
14. Potian JA, Aviv H, Ponzio NM, et al: Veto-like activity of mesenchymal stem cells: functional discrimination between cellular responses to alloantigens and recall antigens. J Immunol 171: 3426-3434, 2003.
15. Le Blanc K, Tammik C, Rosendahl K, et al: HLA expression and immunologic properties of differentiated and undifferentiated mesenchymal stem cells. Exp Hematol 31: 890-896, 2003.
16. Engela AU, Baan CC, Dor FJ, et al: On the interactions between mesenchymal stem cells and regulatory T cells for immunomodulation in transplantation. Front Immunol 3: 126, 2012.
17. Le Blanc K, Frassoni F, Ball L, et al: Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: a phase II study. Lancet 371: 1579-1586, 2008.
18. Dalal J, Gandy K and Domen J: Role of mesenchymal stem cell therapy in Crohn's disease. Pediatr Res 71: 445-451, 2012.
19. Sun S, Guo Z, Xiao X, et al: Isolation of mouse marrow mesenchymal progenitors by a novel and reliable method. Stem Cells 21: 527-535, 2003.
20. Morris GP, Beck PL, Herridge MS, et al: Hapten-induced model of chronic inflammation and ulceration in the rat colon. Gastroenterology 96: 795-803, 1989.
21. Vowinkel T, Kalogeris TJ, Mori M, et a1: Impact of dextran sulfate sodium load on the severity of inflammation in experimental colitis. Dig Dis Sci 49: 556-564, 2004.
22. González R, Rodríguez S, Romay C, et al: Anti-inflammatory activity of phycocyanin extract in acetic acid-induced colitis in rats. Parmacol Res 39: 55-59, 1999.
23. Powrie F, Correaoliveira R, Mauze S, et al: Regulatory interactions between Cd45Rb(high) and Cd45Rb(low) Cd4(+) T-cells are important for the balance between protective and pathogenic cell-mediated immunity. J Exp Med 179: 589-600, 1994.
24. Read S, Malmstrom V and Powrie F: Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation. J Exp Med 192: 295-302, 2000.
25. Strober W: Animal models of inflammatory bowel disease - an overview. Dig Dis Sci 30: 3S-10S, 1985.
26. Neuman MG. Signaling for inflammation and repair in inflammatory bowel disease. Rom J Gastroenterol 13: 309-316, 2004.
27. Reiff C and Kelly D: Inflammatory bowel disease, gut bacteria and probiotic therapy. Int J Med Microbiol 300: 25-33, 2010.
28. Cho JH: The genetics and immunopathogenesis of inflammatory bowel disease. Nat Rev Immunol 8: 458-466, 2008.
29. Chaperon EA, Selner JC and Claman HN: Migration of antibody-forming cells and antigen-sensitive precursors between spleen, thymus and bone marrow. Immunology 14: 553-561, 1968.
30. Sakaguchi S, Sakaguchi N, Asano M, et al: Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol 155: 1151-1164, 1995.
31. + naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state. Int Immunol 10: 1969-1980, 1998.
32. d'Hennezel E, Bin Dhuban K, Torgerson T, et al: The immunogenetics of immune dysregulation, polyendocrinopathy, enteropathy, X linked (IPEX) syndrome. J Med Genet 49: 291-302, 2012.
33. + T-cell subsets. Methods Mol Biol 380: 327-335, 2007.
34. Eri R, McGuckin MA and Wadley R: T cell transfer model of colitis : a great tool to assess the contribution of T cells in chronic intestinal inflammation. Methods Mol Biol 844: 261-275, 2012.
35. Tolar, J, Le Blanc K, Keating A and Blazar BR: Concise review: hitting the right spot with mesenchymal stromal cells. Stem Cells 28: 1446-1455, 2010.
36. Casiraghi F, Azzollini N, Cassis P, et al: Pretransplant infusion of mesenchymal stem cells prolongs the survival of a semiallogeneic heart transplant through the generation of regulatory T cells. J Immunol 181: 3933-3946, 2008.
37. Ge W, Jiang J, Arp J, et al: Regulatory T-cell generation and kidney allograft tolerance induced by mesenchymal stem cells associated with indoleamine 2,3-dioxygenase expression. Transplantation 90: 1312-1320, 2010.
38. Li Z, Arijs I, De Hertogh G, et al: Reciprocal changes of Foxp3 expression in blood and intestinal mucosa in IBD patients responding to infliximab. Inflamm Bowel Dis 16: 1299-1310, 2010.
39. Djouad F, Plence P, Bony C, et al: Immunosuppressive effect of mesenchymal stem cells favors tumor growth in allogeneic animals. Blood 102: 3837-3844, 2003.
40. Karp JM and Leng Teo GS: Mesenchymal stem cell homing: the devil is in the details. Cell Stem Cell 4: 206-216, 2009.