Genotoxicity of nanomaterials: Refining strategies and tests for hazard identification

Environmental and Molecular Mutagenesis

Volumn 54, Issue 4, 2013, Pages 229-239

  Pfuhler, Stefan ^a   Elespuru, Rosalie ^b   Aardema, Marilyn J ^c   Doak, Shareen H ^d   Maria Donner, E ^e   Honma, Masamitsu ^f   Kirsch Volders, Micheline ^g   Landsiedel, Robert ^h   Manjanatha, Mugimane ^b   Singer, Tim ⁱ   Kim, James H ^j  

^a PROCTER AND GAMBLE COMPANY   (United States)

^b CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^c Marilyn Aardema Consulting LLC   (United States)

^d SWANSEA UNIVERSITY   (United Kingdom)

^e DUPONT COMPANY   (United States)

^f NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

^g VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

^h BASF SE   (Germany)

ⁱ HEALTH CANADA   (Canada)

^j ILSI HEALTH AND ENVIRONMENTAL SCIENCES INSTITUTE   (United States)

more..

Author keywords

Genotoxicity; Nanomaterials; Workshop

Indexed keywords

CARBON NANOTUBE; CYTOCHALASIN B; FULLERENE; NANOMATERIAL; REACTIVE OXYGEN METABOLITE; SILICON DIOXIDE; TITANIUM DIOXIDE;

ANEUPLOIDY; ASSAY; CARCINOGENICITY; CELL MEMBRANE; CELL TYPE; CHROMOSOME DAMAGE; DNA STRAND BREAKAGE; DOSE RESPONSE; GENE MUTATION; GENOTOXICITY; HUMAN; IN VIVO STUDY; MAMMAL CELL; MICRONUCLEUS TEST; MITOCHONDRION; MITOSIS; NONHUMAN; NOTE; SALMONELLA TYPHIMURIUM; TISSUE INJURY; ULTRAVIOLET RADIATION;

ANIMALS; CONGRESSES AS TOPIC; DNA DAMAGE; HAZARDOUS SUBSTANCES; HUMANS; MUTAGENICITY TESTS; NANOSTRUCTURES; RISK ASSESSMENT;

BACTERIA (MICROORGANISMS); MAMMALIA;

EID: 84875928467     PISSN: 08936692     EISSN: 10982280     Source Type: Journal    
DOI: 10.1002/em.21770     Document Type: Note

References (26)

1. Balasubramanyam A, Sailaja N, Mahboob M, Rahman MF, Hussain SM, Grover P. 2009. In vivo genotoxicity assessment of aluminium oxide nanomaterials in rat peripheral blood cells using the comet assay and micronucleus test. Mutagenesis 24:245-251.
2. Balasubramanyam A, Sailaja N, Mahboob M, Rahman MF, Hussain SM, Grover P. 2010. In vitro mutagenicity assessment of aluminium oxide nanomaterials using the salmonella/microsome assay. Toxicol in vitro 24:1871-1876.
3. Bhabra G, Sood A, Fisher B, Cartwright L, Saunders M, Evans WH, Surprenant A, Lopez-Castejon G, Mann S, Davis SA, Hails LA, Ingham E, Verkade P, Lane J, Heesom K, Newson R, Case CP. 2009. Nanoparticles can cause DNA damage across a cellular barrier. Nature Nanotech 4:876-883.
4. Collins AR. Investigating oxidative DNA damage and its repair using the comet assay. 2009. Mutat Res 681:24-32.
5. Di Virgilio AL, Reigosa M, Arnal PM, de Mele MFL. 2010. Comparative study of the cytotoxic and genotoxic effects of titanium oxide and aluminium oxide nanoparticles in Chinese hamster ovary (CHO-K1) cells. J Hazardous Mater 177:711-718.
6. Doak SH, Johnson G, Quick E, Jenkins GJS, Parry JM. 2007. Mechanistic influences for mutation induction curves after exposure to DNA-reactive carcinogens. Cancer Res 67:3904-3911.
7. Doak SH, Griffiths SM, Manshian B, Singh N, Williams PM, Brown AP, Jenkins GJS. 2009. Confounding experimental considerations in nanogenotoxicology. Mutagenesis 24:285-293.
8. Doak SH, Manshian B, Jenkins GJS, Singh N. 2012. In vitro genotoxicity testing strategy for nanomaterials and the adaptation of current OECD guidelines. Mutat Res 745:104-111.
9. Downs TR, Crosby ME, Hu T, Kumar S, Sullivan A, Sarlo K, Reeder B, Lynch M, Wagner M, Mills T, Pfuhler S. 2012. Silica nanoparticles administered at the maximum tolerated dose induce genotoxic effects through an inflammatory reaction while gold nanoparticles do not. Mutat Res 14;745:38-50.
10. Driscoll KE, Deyo LC, Carter JM, Howard BW, Hassenbein DG, Bertram TA. 1997. Effects of particle exposure and particle elicited inflammatory cells on mutation in rat alveolar epithelial cells. Carcinogenesis 18:423-430.
11. Elhajouji A, Van Hummelen P, Kirsch-Volders M. 1995. Indications for a threshold of chemically induced aneuploidy in vitro in human lymphocytes. Environ Mol Mutagen 26:292-304.
12. Gonzalez L, Lison D, Kirsch-Volders M. 2008. Genotoxicity of engineered nanomaterials: A critical review. Nanotoxicol 2:252-273.
13. Gonzalez L, Decordier I, Kirsch-Volders M. 2010. Induction of chromosome malsegregation by nanomaterials. Biochem Soc Trans. 38:1691-1697.
14. Gonzalez L, Sanderson BJS, Kirsch-Volders M. 2011. Adaptations of the in vitro MN assay for the genotoxicity assessment of nanomaterials. Mutagenesis 26:185-191.
15. Greim H, Norppa H. 2010. Genotoxicity testing of nanomaterials - Conclusions. Nanotoxicol 4:421-424.
16. Landsiedel R, Kapp MD, Schulz M, Wiench K, Oesch F. 2009. Gentoxicity investigations on nanomaterials: methods, preparation and characterization of test material, potential artifacts and limitations-Many questions, some answers. Mutat Res 681:241-258.
17. Landsiedel R, Ma-Hock L, van Ravenzwaay B, Schulz M, Wiench K, Champ S, Schulte S, Wohlleben W, Oesch F. 2010a. Gene toxicity studies on titanium dioxide and zinc oxide nanomaterials used for UV-protection in cosmetic formulations. Nanotoxicol 4:364-381.
18. Landsiedel R, Ma-Hock L, Kroll A, Hahn D, Schnekenburger J, Wiench K, Wohlleben W. 2010b. Testing metal-oxide nanomaterials for human safety. Adv mater 22:2601-2627.
19. Lindberg HK, Falck GCM, Suhonen S, Vippola M, Vanhala E, Catalan J, Savolainen K, Norppa H. 2009. Genotoxicity of nanomaterials: DNA damage and micronuclei induced by carbon nanotubes and graphite nanofibres in human bronchial epithelial cells in vitro. Toxicol Lett 186:166-173.
20. Maenosono S, Suzuki T, Saita S. 2007. Mutagenicity of water-soluble FePt nanoparticles in Ames test. J Toxicol Sci 32:575-579.
21. Sargent LM, Shvedova AA, Hubbs AF, Salisbury JL, Benkovic SA, Kashon ML, Lowry DT, Murray AR, Kisin ER, Friend S, McKinstry KT, Battelli L, Reynolds SH. 2009. Induction of aneuploidy by single-walled carbon nanotubes. Env Mol Mutagen 50:708-717.
22. Schulze C, Kroll A, Lehr CM, Schäfer UF, Becker K, Schnekenburger J, Schulze-Isfort C, Landsiedel R, Wohlleben W. 2008. Not ready to use-Overcoming pitfalls when dispersing nanoparticles in physiological media. Nanotoxicology 2:51-61.
23. Schulz M, Wiench K, Chodakowski K, Hartwig A, Brill S, Ma-Hock L, van Ravenzwaay B, Landsiedel R. 2011. Genotoxic effects of nanomaterials in lung tissue in vitro and in vivo. The Toxicologist 120:315-316.
24. Scientific Committee on Consumer Products. Opinion on safety of nanomaterials in cosmetic products. European Commission, 2007. SCCP 1147/07.
25. Singh N, Manshian B, Jenkins GJS, Griffiths SM, Williams PM, Maffeis TGG, Wright CJ, Doak SH. 2009. NanoGenotoxicology: The DNA damaging potential of nanomaterials. Biomaterials 30:3891-3914.
26. Shinohara N, Matsumoto K, Endoh S, Maru J, Nakanishi J. 2010. In vitro and in vivo genotoxicity tests on fullerene C-60 nanoparticles. Toxicol Lett 191:289-296.