Activation of glycoprotein VI (GPVI) and C-type lectin-like receptor-2 (CLEC-2) underlies platelet activation by diesel exhaust particles and other charged/hydrophobic ligands

Biochemical Journal

Volumn 468, Issue 3, 2015, Pages 459-473

  Alshehri, Osama M ^a   Montague, Samantha ^a   Watson, Stephanie ^a   Carter, Paul ^a   Sarker, Najiat ^a   Manne, Bhanu K ^b   Miller, Jeanette L C ^c   Herr, Andrew B ^c   Pollitt, Alice Y ^a   O'Callaghan, Chris A ^d   Kunapuli, Satya ^b   Arman, Monica ^a   Hughes, Craig E ^a   Watson, Steve P ^a  

^a Medical School   (United Kingdom)

^b TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^d UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

C type lectin like receptor 2 (clec 2); Glycoprotein vi (gpvi); Histones; Src; Syk; Tyrosine kinase

Indexed keywords

C TYPE LECTIN LIKE RECEPTOR 2; DEXTRAN SULFATE; FUCOIDIN; GLYCOPROTEIN VI; LECTIN RECEPTOR; PROTEIN KINASE SYK; UNCLASSIFIED DRUG; AIR POLLUTANT; ANTITHROMBOCYTIC AGENT; CD36 ANTIGEN; CLEC-2 PROTEIN, MOUSE; CLEC2B PROTEIN, HUMAN; COAGULATING AGENT; EXHAUST GAS; LECTIN; LIGAND; MEMBRANE PROTEIN; PEPTIDE; RECOMBINANT PROTEIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; EXHAUST GAS; HUMAN; HUMAN CELL; LIGAND BINDING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; THROMBOCYTE MEMBRANE; AGONISTS; AIR POLLUTANT; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL LINE; CHEMICAL PHENOMENA; CHEMISTRY; CHICKEN; COMPARATIVE STUDY; CONFORMATION; CROSS BREEDING; DRUG EFFECTS; GENETICS; JURKAT CELL LINE; METABOLISM; PHOSPHORYLATION; PROTEIN ENGINEERING; PROTEIN PROCESSING; REPORTER GENE; TOXICITY; TRANSGENIC MOUSE;

MUS;

AIR POLLUTANTS; ANIMALS; ANTIGENS, CD36; CELL LINE; CHICKENS; COAGULANTS; CROSSES, GENETIC; GENES, REPORTER; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; JURKAT CELLS; LECTINS, C-TYPE; LIGANDS; MEMBRANE GLYCOPROTEINS; MICE, TRANSGENIC; MOLECULAR CONFORMATION; PEPTIDES; PHOSPHORYLATION; PLATELET ACTIVATION; PLATELET AGGREGATION INHIBITORS; PROTEIN ENGINEERING; PROTEIN PROCESSING, POST-TRANSLATIONAL; RECOMBINANT PROTEINS; VEHICLE EMISSIONS;

EID: 84935025237     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20150192     Document Type: Article

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