The heptapeptide LSARLAF mediates platelet activation through phospholipase Cγ2 independently of glycoprotein IIb-IIIa

Biochemical Journal

Volumn 378, Issue 1, 2004, Pages 193-199

  Pearce, Andrew C ^a   Wonerow, Peter ^a   Marshall, Stuart J ^a   Frampton, Jon ^b   Gartner, T Kent ^c   Watson, Steve P ^a,b  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b Medical School   (United Kingdom)

^c UNIVERSITY OF MEMPHIS   (United States)

Author keywords

Fc receptor chain; Glycoprotein VI; Integrin IIb 3; LSARLAF; Phospholipase C 2; Platelet

Indexed keywords

AGGLOMERATION; AMINO ACIDS; BLOOD; LIPIDS; PROTEINS;

INTRACELLULAR SIGNALLING; PHOSPHORYLATION; PLATELET ACTIVATION;

BIOCHEMISTRY;

BETA METHYL CYCLODEXTRIN; CALCIUM; CD36 ANTIGEN; CYCLODEXTRIN DERIVATIVE; FC RECEPTOR; FIBRINOGEN RECEPTOR; GLYCOPROTEIN IB; GLYCOPROTEIN IIB; HEPTAPEPTIDE; HYPOCHOLESTEROLEMIC AGENT; INTEGRIN; LEUCYLSERYLALANYLARGINYLLEUCYLALANYLPHENYLALANINE; LIPID; PEPTIDE; PHOSPHOLIPASE C; PHOSPHOLIPASE C GAMMA2; PHOSPHOPROTEIN; PROTEIN; PROTEIN KINASE SYK; PROTEIN SH2; PROTEIN TYROSINE KINASE; REAGENT; TYROSINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CELL ACTIVATION; CELL LINE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; HUMAN; HUMAN CELL; INTRACELLULAR SPACE; MEMBRANE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN DEFECT; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RAT; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; STIMULATION; T LYMPHOCYTE ACTIVATION; THROMBOCYTE; THROMBOCYTE ACTIVATION;

ANIMALS; BLOOD PLATELETS; CALCIUM; CELL LINE; HUMANS; MICE; MICE, KNOCKOUT; OLIGOPEPTIDES; PHOSPHOLIPASE C; PHOSPHOLIPASE C GAMMA; PHOSPHORYLATION; PLATELET AGGREGATION; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; PLATELET MEMBRANE GLYCOPROTEINS; SIGNAL TRANSDUCTION; SRC-FAMILY KINASES; TYROSINE;

ANIMALIA; MURINAE;

EID: 1542284643     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20031298     Document Type: Article

References (38)

1. Derrick, J. M., Taylor, D. B., Loudon, R. G. and Gartner, T. K. (1997) The peptide LSARLAF causes platelet secretion and aggregation by directly activating the integrin αIIbβ3. Biochem. J. 325, 309-313
2. Derrick, J. M., Loudon, R. G. and Gartner, T. K. (1998) Peptide LSARLAF activates αIIbβ3 on resting platelets and causes resting platelet aggregate formation without platelet shape change. Thromb. Res. 89, 31-40
3. Cho, M. J., Liu, J., Pestina, T. I., Steward, S. A., Jackson, C. W. and Gartner, T. K. (2003) αIIbβ3-mediated outside-in signaling induced by the agonist peptide LSARLAF utilizes ADP and thromboxane A2 receptors to cause alpha-granule secretion by platelets. J. Thromb. Haemostasis. 1, 363-373
4. Derrick, J. M., Shattil, S. J., Poncz, M., Gruppo, R. A. and Gartner, T. K. (2001) Distinct domains of αIIbβ3 support different aspects of outside-in signal transduction and platelet activation induced by LSARLAF, an αIIbβ3 interacting peptide. Thromb. Haemostasis 86, 894-901
5. Cho, M. J., Takayama, H., Pestina, T. I., Wang, D., Jackson, C. W. and Gartner, T. K. (2001) Thromb. Haemostasis, ISTH Abstract Supplement, abstract number P1161
6. Miranti, C. K., Leng, L., Maschberger, P., Brugge, J. S. and Shattil, S. J. (1998) Identification of a novel integrin signaling pathway involving the kinase Syk and the guanine nucleotide exchange factor Vav1. Curr. Biol. 8, 1289-1299
7. Obergfell, A., Eto, K., Mocsai, A., Buensuceso, C., Moores, S. L., Brugge, J. S., Lowell, C. A. and Shattil, S. J. (2002) Coordinate interactions of Csk, Src, and Syk kinases with αIIbβ3 initiate integrin signaling to the cytoskeleton. J. Cell Biol. 157, 265-275
8. Woodside, D. G., Obergfell, A., Leng, L., Wilsbacher, J. L., Miranti, C. K., Brugge, J. S., Shattil, S. J. and Ginsberg, M. H. (2001) Activation of Syk protein tyrosine kinase through interaction with integrin β cytoplasmic domains. Curr. Biol. 11, 1799-1804
9. Phillips, D. R., Nannizzi-Alaimo, L. and Prasad, K. S. (2001) Beta3 tyrosine phosphorylatlon in alphaIIbbeta3 (platelet membrane GP IIb-IIIa) outside-in integrin signaling. Thromb. Haemostasis 86, 246-258
10. Musci, M. A., Hendricks-Taylor, L. R., Motto, D. G., Paskind, M., Kamens, J., Turck, C. W. and Koretzky, G. A. (1997) Molecular cloning of SLAP-130, an SLP-76-associated substrate of the T cell antigen receptor-stimulated protein tyrosine kinases. J. Biol. Chem. 272, 11674-11677
11. Obergfell, A., Judd, B. A., del Pozo, M. A., Schwartz, M. A., Koretzky, G. A. and Shattil, S. J. (2001) The molecular adapter SLP-76 relays signals from platelet integrin αIIbβ3 to the actin cytoskeleton. J. Biol. Chem. 276, 5916-5923
12. da Silva, A. J., Li, Z., de Vera, C., Canto, E., Findell, P. and Rudd, C. E. (1997) Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain-containing leukocyte protein 76 and modulates interleukin 2 production. Proc. Natl. Acad. Sci. U.S.A. 94, 7493-7498
13. Griffiths, E. K. and Penninger, J. M. (2002) Communication between the TCR and integrins: role of the molecular adapter ADAP/Fyb/Slap. Curr. Opin. Immunol. 14, 317-322
14. Payrastre, B., Missy, K., Trumel, C., Bodin, S., Plantavid, M. and Chap, H. (2000) The integrin αIIbβ3 in human platelet signal transduction. Biochem. Pharmacol. 60, 1069-1074
15. Shattil, S. J. (1999) Signaling through platelet integrin αIIbβ3: inside-out, outside-in, and sideways. Thromb. Haemostasis 82, 318-325
16. Wonerow, P., Pearce, A. C., Vaux, D. J. and Watson, S. P. (2003) A critical role for phospholipase Cγ2 in αIIβ3-mediated platelet spreading. J. Biol. Chem. 278, 37520-37529
17. Poole, A., Gibbins, J. M., Turner, M., van Vugt, M. J., van de Winkel, J. G., Saito, T., Tybulewicz, V. L. and Watson, S. P. (1997) The Fc receptor γ-chain and the tyrosine kinase Syk are essential for activation of mouse platelets by collagen. EMBO J. 16, 2333-2341
18. Gibbins, J. M., Okuma, M., Farndale, R., Barnes, M. and Watson, S. P. (1997) Glycoprotein VI is the collagen receptor in platelets which underlies tyrosine phosphorylation of the Fc receptor γ-chain. FEBS Lett. 413, 255-259
19. lyn in collagen receptor signalling in human platelets. Biochem. J. 338, 203-209
20. Ezumi, Y., Shindoh, K., Tsuji, M. and Takayama, H. (1998) Physical and functional association of the Src family kinases Fyn and Lyn with the collagen receptor glycoprotein VI-Fc receptor γ-chain complex on human platelets. J. Exp. Med. 188, 267-276
21. Quek, L. S., Pasquet, J. M., Hers, I., Cornall, R., Knight, G., Barnes, M., Hibbs, M. L., Dunn, A. R., Lowell, C. A. and Watson, S. P. (2000) Fyn and Lyn phosphorylate the Fc receptor γ-chain downstream of glycoprotein VI in murine platelets, and Lyn regulates a novel feedback pathway. Blood 96, 4246-4253
22. Asselin, J., Gibbins, J. M., Achison, M., Lee, Y. H., Morton, L. F., Farndale, R. W., Barnes, M. J. and Watson, S. P. (1997) A collagen-like peptide stimulates tyrosine phosphorylation of syk and phospholipase Cγ2 in platelets independent of the integrin α2β1. Blood 89, 1235-1242
23. Pasquet, J. M., Bobe, R., Gross, B., Gratacap, M. P., Tomlinson, M. G., Payrastre, B. and Watson, S. P. (1999) A collagen-related peptide regulates phospholipase Cγ2 via phosphatidylinositol 3-kinase in human platelets. Biochem. J. 342, 171-177
24. Gross, B. S., Lee, J. R., Clements, J. L., Turner, M., Tybulewicz, V. L., Findell, P. R., Koretzky, G. A. and Watson, S. P. (1999) Tyrosine phosphorylation of SLP-76 is downstream of Syk following stimulation of the collagen receptor in platelets. J. Biol. Chem. 274, 5963-5971
25. Mangin, P., Yuan, Y., Goncalves, I., Eckly, A., Freund, M., Cazenave, J. P., Gachet, C., Jackson, S. P. and Lanza, F. (2003) Signaling role for phospholipase Cγ2 in platelet glycoprotein Ibα calcium flux and cytoskeletal reorganization. Involvement of a pathway distinct from FcR γ-chain and Fc γRIIA. J. Biol. Chem. 278, 32880-32891
26. Pasquet, J. M., Gross, B., Quek, L., Asazuma, N., Zhang, W., Sommers, C. L., Schweighoffer, E., Tybulewicz, V., Judd, B., Lee, J. R. et al. (1999) LAT is required for tyrosine phosphorylation of phospholipase Cγ2 and platelet activation by the collagen receptor GPVI. Mol. Cell. Biol. 19, 8326-8334
27. Wonerow, P., Obergfell, A., Wilde, J. I., Bobe, R., Asazuma, N., Brdicka, T., Leo, A., Schraven, B., Horejsi, V., Shattil, S. J. and Watson, S. P. (2002) Differential role of glycolipid-enriched membrane domains in glycoprotein VI- and integrin-mediated phospholipase Cγ2 regulation in platelets. Biochem. J. 364, 755-765
28. Marshall, S. J., Asazuma, N., Best, D., Wonerow, P., Salmon, G., Andrews, R. K. and Watson, S. P. (2002) Glycoprotein IIb-IIIa-dependent aggregation by glycoprotein Ibalpha is reinforced by a Src family kinase inhibitor (PP1)-sensitive signalling pathway. Biochem. J. 361, 297-305
29. Shrimpton, C. N., Borthakur, G., Larrucea, S., Cruz, M. A., Dong, J. F. and Lopez, J. A. (2002) Localization of the adhesion receptor glycoprotein Ib-IX-V complex to lipid rafts is required for platelet adhesion and activation. J. Exp. Med. 196, 1057-1066
30. Bennett, J. S., Shattil, S. J., Power, J. W. and Gartner, T. K. (1988) Interaction of fibrinogen with its platelet receptor. Differential effects of α and γ chain fibrinogen peptides on the glycoprotein IIb-IIIa complex. J. Biol. Chem. 263, 12948-12953
31. Park, S. Y., Arase, H., Wakizaka, K., Hirayama, N., Masaki, S., Sato, S., Ravetch, J. V. and Saito, T. (1995) Differential contribution of the FcR γ-chain to the surface expression of the T cell receptor among T cells localized in epithelia: analysis of FcR γ-deficient mice. Eur. J. Immunol. 25, 2107-2110
32. Wang, D., Feng, J., Wen, R., Marine, J. C., Sangster, M. Y., Parganas, E., Hoffmeyer, A., Jackson, C. W., Cleveland, J. L., Murray, P. J. and Ihle, J. N. (2000) Phospholipase Cγ2 is essential in the functions of B cell and several Fc receptors. Immunity 13, 25-35
33. Zhang, W., Irvin, B. J., Trible, R. P., Abraham, R. T. and Samelson, L. E. (1999) Functional analysis of LAT in TCR-mediated signaling pathways using a LAT-deficient Jurkat cell line. Int. Immunol. 11, 943-950
34. Emambokus, N. R. and Frampton, J. (2003) The glycoprotein IIb molecule is expressed on early murine hematopoietic progenitors and regulates their numbers in sites of hematopoiesis. Immunity 19, 33-45
35. Essex, D. W. and Li, M. (2003) Redox control of platelet aggregation. Biochemistry 42, 129-136
36. Tulasne, D., Judd, B. A., Johansen, M., Asazuma, N., Best, D., Brown, E. J., Kahn, M., Koretzky, G. A. and Watson, S. P. (2001) C-terminal peptide of thrombospondin-1 induces platelet aggregation through the Fc receptor γ-chain-associated signaling pathway and by agglutination. Blood 98, 3346-3352
37. Suzuki-Inoue, K., Ozaki, Y., Kainoh, M., Shin, Y., Wu, Y., Yatomi, Y., Ohmori, T., Tanaka, T., Satoh, K. and Morita, T. (2001) Rhodocytin induces platelet aggregation by interacting with glycoprotein Ia/IIa (GPIa/IIa, integrin α2β1). Involvement of GPIa/IIa-associated src and protein tyrosine phosphorylation. J. Biol. Chem. 276, 1643-1652
38. Bergmeier, W., Bouvard, D., Eble, J. A., Mokhtari-Nejad, R., Schulte, V., Zirngibl, H., Brakebusch, C., Fassler, R. and Nieswandt, B. (2001) Rhodocytin (aggretin) activates platelets lacking α2β1 integrin, glycoprotein VI, and the ligand-binding domain of glycoprotein Ibα. J. Biol. Chem. 276, 25121-25126