The Toll-like receptor 2/1 (TLR2/1) complex initiates human platelet activation via the src/Syk/LAT/PLCγ2 signalling cascade

Cellular Signalling

Volumn 26, Issue 2, 2014, Pages 279-286

  Fälker, Knut ^a,b   Klarström Engström, Kristin ^b   Bengtsson, Torbjörn ^b   Lindahl, Tomas L ^a   Grenegård, Magnus ^b  

^a LINKÖPING UNIVERSITY   (Sweden)

^b ÖREBRO UNIVERSITY   (Sweden)

Author keywords

Human platelets; LAT; Pam3CSK4; PLC 2; Syk; TLR2

Indexed keywords

BETA3 INTEGRIN; CALCIUM ION; COLLAGEN; CONVULXIN; GLYCOPROTEIN VI; LAT PROTEIN; N PALMITOYL [2,3 BIS(PALMITOYLOXY)PROPYL]CYSTEINYLSERYLLYSYLYSYLLYSINE; PHOSPHOLIPASE C GAMMA2; PROTEIN KINASE SYK; PROTEINASE ACTIVATED RECEPTOR; THROMBIN; THROMBOXANE A2; TOLL LIKE RECEPTOR 1; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR AGONIST; UNCLASSIFIED DRUG;

ARTICLE; CALCIUM MOBILIZATION; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME ACTIVATION; GLANZMANN DISEASE; HUMAN; HUMAN CELL; IMMUNOCOMPETENT CELL; INTRACELLULAR SIGNALING; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION;

HUMAN PLATELETS; LAT; PAM3CSK4; PLCΓ2; SYK; TLR2;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; BLOOD PLATELETS; CALCIUM; CROTALID VENOMS; HUMANS; INTEGRINS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LECTINS, C-TYPE; LIPOPEPTIDES; MEMBRANE PROTEINS; NIACINAMIDE; PHOSPHOLIPASE C GAMMA; PHOSPHORYLATION; PLATELET ACTIVATION; PLATELET AGGREGATION; PLATELET MEMBRANE GLYCOPROTEINS; PROTEIN-TYROSINE KINASES; PYRIMIDINES; RECEPTORS, THROMBOXANE A2, PROSTAGLANDIN H2; SIGNAL TRANSDUCTION; SRC-FAMILY KINASES; THROMBASTHENIA; TOLL-LIKE RECEPTOR 1; TOLL-LIKE RECEPTOR 2;

EID: 84889605890     PISSN: 08986568     EISSN: 18733913     Source Type: Journal    
DOI: 10.1016/j.cellsig.2013.11.011     Document Type: Article

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