Dextran sulphate induces fibrinogen receptor activation through a novel Syk-independent PI-3 kinase-mediated tyrosine kinase pathway in platelets

Thrombosis and Haemostasis

Volumn 109, Issue 6, 2013, Pages 1131-1140

  Getz, Todd M ^a   Kanth Manne, Bhanu ^a   Buitrago, Lorena ^a   Mao, Yingying ^a   Kunapuli, Satya P ^a  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Dextran sulfate; PI 3 kinase; Platelets; Signalling; Src family kinases; Syk kinase

Indexed keywords

12 (2 CYANOETHYL) 6, 7, 12, 13 TETRAHYDRO 13 METHYL 5 OXOINDOLO [2, 3 A] PYRROLO [3, 4 C] CARBAZOLE; 2 MORPHOLINO 8 PHENYLCHROMONE; 4 AMINO 7 TERT BUTYL 5 (4 CHLOROPHENYL) PYRAZOLO [3, 4 D] PYRIMIDINE; DEXTRAN SULFATE; FIBRINOGEN RECEPTOR; FIBRINOGEN RECEPTOR ANTAGONIST; GLYCOPROTEIN VI; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE SYK; PROTEIN TYROSINE KINASE; PROTEINASE ACTIVATED RECEPTOR 3; PROTEINASE ACTIVATED RECEPTOR 4; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CONTROLLED STUDY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; THROMBOCYTE; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; THROMBOCYTE RICH PLASMA; WESTERN BLOTTING;

ANIMALS; BLOOD PLATELETS; CALCIUM; DEXTRAN SULFATE; FEMALE; FLOW CYTOMETRY; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MICE; PEPTIDES, CYCLIC; PHOSPHATIDYLINOSITOL 3-KINASES; PLATELET MEMBRANE GLYCOPROTEINS; PROTEIN BINDING; PROTEIN-TYROSINE KINASES; RECEPTORS, THROMBIN; SIGNAL TRANSDUCTION; TYROSINE;

EID: 84878644733     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH12-09-0645     Document Type: Article

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