Cofactor specificity motifs and the induced fit mechanism in class I ketol-acid reductoisomerases

Biochemical Journal

Volumn 468, Issue 3, 2015, Pages 475-484

  Cahn, Jackson K B ^a   Brinkmann Chen, Sabine ^a   Spatzal, Thomas ^a,b,c   Wiig, Jared A ^d   Buller, Andrew R ^a   Einsle, Oliver ^c,d   Hu, Yilin ^c   Ribbe, Markus W ^c,d   Arnold, Frances H ^a  

^a California Institute of Technology   (United States)

^b CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

^c UNIVERSITY OF FREIBURG   (Germany)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Acetohydroxyacid isomeroreductase (AHAIR); Cofactor binding; Conformational change; Crystal structure; Ketol acid reductoisomerase (KARI)

Indexed keywords

CLASS I KETOL ACID REDUCTOISOMERASE; KETOL ACID REDUCTOISOMERASE; NICOTINAMIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; UNCLASSIFIED DRUG; ADENOSINE DIPHOSPHATE RIBOSE; BACTERIAL PROTEIN; COENZYME; MAGNESIUM; MUTANT PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; RECOMBINANT PROTEIN;

ARTICLE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; DRUG BINDING SITE; ENZYME SPECIFICITY; ENZYME STRUCTURE; ESCHERICHIA COLI; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; RICE; SPINACH; ALICYCLOBACILLUS; AMINO ACID SEQUENCE; ANALOGS AND DERIVATIVES; AZOTOBACTER VINELANDII; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; COENZYME; COMPARATIVE STUDY; CONFORMATION; DESULFUROCOCCACEAE; ENZYME ACTIVE SITE; ENZYMOLOGY; GENETICS; METABOLISM; MOLECULAR GENETICS; PHOSPHORYLATION; PROTEIN FOLDING; SEQUENCE ALIGNMENT; X RAY CRYSTALLOGRAPHY;

ESCHERICHIA COLI; SPINACIA OLERACEA;

ADENOSINE DIPHOSPHATE RIBOSE; ALICYCLOBACILLUS; AMINO ACID SEQUENCE; AZOTOBACTER VINELANDII; BACTERIAL PROTEINS; BINDING SITES; CATALYTIC DOMAIN; COENZYMES; CRYSTALLOGRAPHY, X-RAY; DESULFUROCOCCACEAE; KETOL-ACID REDUCTOISOMERASE; MAGNESIUM; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR SEQUENCE DATA; MUTANT PROTEINS; NAD; NADP; PHOSPHORYLATION; PROTEIN FOLDING; RECOMBINANT PROTEINS; SEQUENCE ALIGNMENT;

EID: 84935015129     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20150183     Document Type: Article

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