Characterization of the conformational changes of acetohydroxy acid isomeroreductase induced by the binding of Mg2+ ions, NADPH, and a competitive inhibitor

Biochemistry

Volumn 38, Issue 19, 1999, Pages 6025-6034

  Halgand, Frédéric ^a   Dumas, Renaud ^b   Biou, Valérie ^a   Andrieu, Jean Pierre ^a   Thomazeau, Karine ^a   Gagnon, Jean ^a   Douce, Roland ^a   Forest, Eric ^a  

^a CEA GRENOBLE   (France)

^b SANOFI   (France)

Author keywords

[No Author keywords available]

Indexed keywords

KETOL ACID REDUCTOISOMERASE; MAGNESIUM ION; OXIDOREDUCTASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; UNCLASSIFIED DRUG;

ARTICLE; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; ENZYME ACTIVE SITE; ENZYME ANALYSIS; ENZYME BINDING; ENZYME CONFORMATION; ENZYME KINETICS; ENZYME MECHANISM; ENZYME SUBSTRATE COMPLEX; LIGAND BINDING; MASS SPECTROMETRY; PRIORITY JOURNAL; REACTION ANALYSIS; STRUCTURE ANALYSIS;

ALCOHOL OXIDOREDUCTASES; AMINO ACID SEQUENCE; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; KETOL-ACID REDUCTOISOMERASE; MAGNESIUM; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NADP; PEPTIDES; PROTEIN CONFORMATION; SPINACIA OLERACEA;

EID: 0033545907     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi982412e     Document Type: Article

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