-
1
-
-
77955635233
-
Cancer statistics, 2010
-
Jemal, A., Siegel, R., Xu, J. & Ward, E. Cancer statistics, 2010. CA Cancer J Clin 60, 277-300 (2010).
-
(2010)
CA Cancer J Clin
, vol.60
, pp. 277-300
-
-
Jemal, A.1
Siegel, R.2
Xu, J.3
Ward, E.4
-
3
-
-
2942738959
-
Amplification of Mdmx (or Mdm4) directly contributes to tumor formation by inhibiting p53 tumor suppressor activity
-
Danovi, D. et al. Amplification of Mdmx (or Mdm4) directly contributes to tumor formation by inhibiting p53 tumor suppressor activity. Mol Cell Biol 24, 5835-5843 (2004).
-
(2004)
Mol Cell Biol
, vol.24
, pp. 5835-5843
-
-
Danovi, D.1
-
4
-
-
84864677524
-
MDM4 is a key therapeutic target in cutaneous melanoma
-
Gembarska, A. et al. MDM4 is a key therapeutic target in cutaneous melanoma. Nat Med 18, 1239-1247 (2012).
-
(2012)
Nat Med
, vol.18
, pp. 1239-1247
-
-
Gembarska, A.1
-
5
-
-
33750590095
-
Inactivation of the p53 pathway in retinoblastoma
-
Laurie, N. A. et al. Inactivation of the p53 pathway in retinoblastoma. Nature 444, 61-66 (2006).
-
(2006)
Nature
, vol.444
, pp. 61-66
-
-
Laurie, N.A.1
-
6
-
-
34548692296
-
High levels of the p53 inhibitor MDM4 in head and neck squamous carcinomas
-
Valentin-Vega, Y. A., Barboza, J. A., Chau, G. P., El-Naggar, A. K. & Lozano, G. High levels of the p53 inhibitor MDM4 in head and neck squamous carcinomas. Hum Pathol 38, 1553-1562 (2007).
-
(2007)
Hum Pathol
, vol.38
, pp. 1553-1562
-
-
Valentin-Vega, Y.A.1
Barboza, J.A.2
Chau, G.P.3
El-Naggar, A.K.4
Lozano, G.5
-
7
-
-
26444599546
-
Significance of HDMX-S (or MDM4) mRNA splice variant overexpression and HDMX gene amplification on primary soft tissue sarcoma prognosis
-
Bartel, F. et al. Significance of HDMX-S (or MDM4) mRNA splice variant overexpression and HDMX gene amplification on primary soft tissue sarcoma prognosis. Int J Cancer 117, 469-475 (2005).
-
(2005)
Int J Cancer
, vol.117
, pp. 469-475
-
-
Bartel, F.1
-
8
-
-
79551715546
-
Comprehensive mapping of p53 pathway alterations reveals an apparent role for both SNP309 and MDM2 amplification in sarcomagenesis
-
Ito, M. et al. Comprehensive mapping of p53 pathway alterations reveals an apparent role for both SNP309 and MDM2 amplification in sarcomagenesis. Clin Cancer Res 17, 416-426 (2011).
-
(2011)
Clin Cancer Res
, vol.17
, pp. 416-426
-
-
Ito, M.1
-
9
-
-
84355166531
-
Frequency of mouse double minute 2 (MDM2) and mouse double minute 4 (MDM4) amplification in parosteal and conventional osteosarcoma subtypes
-
Duhamel, L. A. et al. Frequency of Mouse Double Minute 2 (MDM2) and Mouse Double Minute 4 (MDM4) amplification in parosteal and conventional osteosarcoma subtypes. Histopathology 60, 357-359 (2012).
-
(2012)
Histopathology
, vol.60
, pp. 357-359
-
-
Duhamel, L.A.1
-
10
-
-
0142123127
-
HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53
-
Linares, L. K., Hengstermann, A., Ciechanover, A., Muller, S. & Scheffner, M. HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53. Proc Natl Acad Sci USA 100, 12009-12014 (2003).
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 12009-12014
-
-
Linares, L.K.1
Hengstermann, A.2
Ciechanover, A.3
Muller, S.4
Scheffner, M.5
-
11
-
-
0036510399
-
Hdmx recruitment into the nucleus by Hdm2 is essential for its ability to regulate p53 stability and transactivation
-
Migliorini, D. et al. Hdmx recruitment into the nucleus by Hdm2 is essential for its ability to regulate p53 stability and transactivation. J Biol Chem 277, 7318-7323 (2002).
-
(2002)
J Biol Chem
, vol.277
, pp. 7318-7323
-
-
Migliorini, D.1
-
12
-
-
77951224332
-
Identification and characterization of the first small molecule inhibitor of MDMX
-
Reed, D. et al. Identification and characterization of the first small molecule inhibitor of MDMX. J Biol Chem 285, 10786-10796 (2010).
-
(2010)
J Biol Chem
, vol.285
, pp. 10786-10796
-
-
Reed, D.1
-
13
-
-
84861873122
-
On the mechanism of action of SJ-172550 in inhibiting the interaction of MDM4 and p53
-
Bista, M. et al. On the mechanism of action of SJ-172550 in inhibiting the interaction of MDM4 and p53. PLoS One 7, e37518 (2012).
-
(2012)
PLoS One
, vol.7
, pp. e37518
-
-
Bista, M.1
-
14
-
-
78249268240
-
A stapled p53 helix overcomes HDMX-mediated suppression of p53
-
Bernal, F. et al. A stapled p53 helix overcomes HDMX-mediated suppression of p53. Cancer Cell 18, 411-422 (2010).
-
(2010)
Cancer Cell
, vol.18
, pp. 411-422
-
-
Bernal, F.1
-
15
-
-
84855584802
-
Stapled peptides for intracellular drug targets
-
Verdine, G. L. & Hilinski, G. J. Stapled peptides for intracellular drug targets. Methods Enzymol 503, 3-33 (2012).
-
(2012)
Methods Enzymol
, vol.503
, pp. 3-33
-
-
Verdine, G.L.1
Hilinski, G.J.2
-
16
-
-
84873055344
-
MDM2, MDMX and p53 in oncogenesis and cancer therapy
-
Wade, M., Li, Y. C. & Wahl, G. M. MDM2, MDMX and p53 in oncogenesis and cancer therapy. Nat Rev Cancer 13, 83-96 (2013).
-
(2013)
Nat Rev Cancer
, vol.13
, pp. 83-96
-
-
Wade, M.1
Li, Y.C.2
Wahl, G.M.3
-
17
-
-
40349083970
-
Regulation of MDMX expression by mitogenic signaling
-
Gilkes, D. M. et al. Regulation of MDMX expression by mitogenic signaling. Mol Cell Biol 28, 1999-2010 (2008).
-
(2008)
Mol Cell Biol
, vol.28
, pp. 1999-2010
-
-
Gilkes, D.M.1
-
18
-
-
78751533820
-
A small-molecule inhibitor of MDMX activates p53 and induces apoptosis
-
Wang, H., Ma, X., Ren, S., Buolamwini, J. K. & Yan, C. A small-molecule inhibitor of MDMX activates p53 and induces apoptosis. Mol Cancer Ther 10, 69-79 (2011).
-
(2011)
Mol Cancer Ther
, vol.10
, pp. 69-79
-
-
Wang, H.1
Ma, X.2
Ren, S.3
Buolamwini, J.K.4
Yan, C.5
-
19
-
-
84893837391
-
Nutlin-3a efficacy in sarcoma predicted by transcriptomic and epigenetic profiling
-
Pishas, K. I. et al. Nutlin-3a efficacy in sarcoma predicted by transcriptomic and epigenetic profiling. Cancer Res 74, 921-31 (2014).
-
(2014)
Cancer Res
, vol.74
, pp. 921-931
-
-
Pishas, K.I.1
-
20
-
-
78649965834
-
An illegitimate microRNA target site within the 3' UTR of MDM4 affects ovarian cancer progression and chemosensitivity
-
Wynendaele, J. et al. An illegitimate microRNA target site within the 3' UTR of MDM4 affects ovarian cancer progression and chemosensitivity. Cancer Res 70, 9641-9649 (2010).
-
(2010)
Cancer Res
, vol.70
, pp. 9641-9649
-
-
Wynendaele, J.1
-
21
-
-
79551713220
-
Nutlin-3a is a potential therapeutic for ewing sarcoma
-
Pishas, K. I. et al. Nutlin-3a is a potential therapeutic for ewing sarcoma. Clin Cancer Res 17, 494-504 (2011).
-
(2011)
Clin Cancer Res
, vol.17
, pp. 494-504
-
-
Pishas, K.I.1
-
22
-
-
0032508504
-
Enhanced phosphorylation of p53 by ATM in response to DNA damage
-
Banin, S. et al. Enhanced phosphorylation of p53 by ATM in response to DNA damage. Science 281, 1674-1677 (1998).
-
(1998)
Science
, vol.281
, pp. 1674-1677
-
-
Banin, S.1
-
23
-
-
78650631094
-
Cross-species chemogenomic profiling reveals evolutionarily conserved drug mode of action
-
Kapitzky, L. et al. Cross-species chemogenomic profiling reveals evolutionarily conserved drug mode of action. Molecular systems biology 6, 451 (2010).
-
(2010)
Molecular Systems Biology
, vol.6
, pp. 451
-
-
Kapitzky, L.1
-
24
-
-
0032489520
-
DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139
-
Rogakou, E. P., Pilch, D. R., Orr, A. H., Ivanova, V. S. & Bonner, W. M. DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J Biol Chem 273, 5858-5868 (1998).
-
(1998)
J Biol Chem
, vol.273
, pp. 5858-5868
-
-
Rogakou, E.P.1
Pilch, D.R.2
Orr, A.H.3
Ivanova, V.S.4
Bonner, W.M.5
-
25
-
-
27144444111
-
ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage
-
Chen, L., Gilkes, D. M., Pan, Y., Lane, W. S. & Chen, J. ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage. Embo J 24, 3411-3422 (2005).
-
(2005)
Embo J
, vol.24
, pp. 3411-3422
-
-
Chen, L.1
Gilkes, D.M.2
Pan, Y.3
Lane, W.S.4
Chen, J.5
-
26
-
-
62149139782
-
Phosphorylation of Ewing's sarcoma protein (EWS) and EWS-Fli1 in response to DNA damage
-
Klevernic, I. V., Morton, S., Davis, R. J. & Cohen, P. Phosphorylation of Ewing's sarcoma protein (EWS) and EWS-Fli1 in response to DNA damage. Biochem J 418, 625-634 (2009).
-
(2009)
Biochem J
, vol.418
, pp. 625-634
-
-
Klevernic, I.V.1
Morton, S.2
Davis, R.J.3
Cohen, P.4
-
27
-
-
84859391984
-
PARP-1 inhibition as a targeted strategy to treat Ewing's sarcoma
-
Brenner, J. C. et al. PARP-1 inhibition as a targeted strategy to treat Ewing's sarcoma. Cancer Res 72, 1608-1613 (2012).
-
(2012)
Cancer Res
, vol.72
, pp. 1608-1613
-
-
Brenner, J.C.1
-
28
-
-
69849097500
-
PARP is activated at stalled forks to mediate Mre11-dependent replication restart and recombination
-
Bryant, H. E. et al. PARP is activated at stalled forks to mediate Mre11-dependent replication restart and recombination. Embo J 28, 2601-2615 (2009).
-
(2009)
Embo J
, vol.28
, pp. 2601-2615
-
-
Bryant, H.E.1
-
29
-
-
0041885206
-
Phosphorylation of mitotic kinesin-like protein 2 by polo-like kinase 1 is required for cytokinesis
-
Neef, R. et al. Phosphorylation of mitotic kinesin-like protein 2 by polo-like kinase 1 is required for cytokinesis. The Journal of cell biology 162, 863-875 (2003).
-
(2003)
The Journal of Cell Biology
, vol.162
, pp. 863-875
-
-
Neef, R.1
-
31
-
-
79957575681
-
PARP-1 and PARP-2: New players in tumour development
-
Yelamos, J., Farres, J., Llacuna, L., Ampurdanes, C. & Martin-Caballero, J. PARP-1 and PARP-2: New players in tumour development. American journal of cancer research 1, 328-346 (2011).
-
(2011)
American Journal of Cancer Research
, vol.1
, pp. 328-346
-
-
Yelamos, J.1
Farres, J.2
Llacuna, L.3
Ampurdanes, C.4
Martin-Caballero, J.5
-
32
-
-
0025058865
-
Enhanced poly(adenosine diphosphate ribose) polymerase activity and gene expression in Ewing's sarcoma cells
-
Prasad, S. C., Thraves, P. J., Bhatia, K. G., Smulson, M. E. & Dritschilo, A. Enhanced poly(adenosine diphosphate ribose) polymerase activity and gene expression in Ewing's sarcoma cells. Cancer Res 50, 38-43 (1990).
-
(1990)
Cancer Res
, vol.50
, pp. 38-43
-
-
Prasad, S.C.1
Thraves, P.J.2
Bhatia, K.G.3
Smulson, M.E.4
Dritschilo, A.5
-
33
-
-
84859187259
-
Systematic identification of genomic markers of drug sensitivity in cancer cells
-
Garnett, M. J. et al. Systematic identification of genomic markers of drug sensitivity in cancer cells. Nature 483, 570-575 (2012).
-
(2012)
Nature
, vol.483
, pp. 570-575
-
-
Garnett, M.J.1
-
34
-
-
67650471685
-
Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers
-
Fong, P. C. et al. Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers. N Engl J Med 361, 123-134 (2009).
-
(2009)
N Engl J Med
, vol.361
, pp. 123-134
-
-
Fong, P.C.1
-
35
-
-
84891301320
-
Causes and consequences of replication stress
-
Zeman, M. K. & Cimprich, K. A. Causes and consequences of replication stress. Nat Cell Biol 16, 2-9 (2014).
-
(2014)
Nat Cell Biol
, vol.16
, pp. 2-9
-
-
Zeman, M.K.1
Cimprich, K.A.2
-
36
-
-
78951474460
-
The MRE11 complex: Starting from the ends
-
Stracker, T. H. & Petrini, J. H. The MRE11 complex: starting from the ends. Nat Rev Mol Cell Biol 12, 90-103 (2011).
-
(2011)
Nat Rev Mol Cell Biol
, vol.12
, pp. 90-103
-
-
Stracker, T.H.1
Petrini, J.H.2
-
37
-
-
84866559001
-
Cross-platform pathway-based analysis identifies markers of response to the PARP inhibitor olaparib
-
Daemen, A. et al. Cross-platform pathway-based analysis identifies markers of response to the PARP inhibitor olaparib. Breast Cancer Res Treat 135, 505-517 (2012).
-
(2012)
Breast Cancer Res Treat
, vol.135
, pp. 505-517
-
-
Daemen, A.1
-
38
-
-
84891834093
-
Poly (ADP-ribose) polymerase inhibitor LT-626: Sensitivity correlates with MRE11 mutations and synergizes with platinums and irinotecan in colorectal cancer cells
-
McPherson, L. A., Shen, Y. & Ford, J. M. Poly (ADP-ribose) polymerase inhibitor LT-626: Sensitivity correlates with MRE11 mutations and synergizes with platinums and irinotecan in colorectal cancer cells. Cancer Lett 343, 217-223 (2014).
-
(2014)
Cancer Lett
, vol.343
, pp. 217-223
-
-
McPherson, L.A.1
Shen, Y.2
Ford, J.M.3
-
39
-
-
79953313615
-
MRE11 deficiency increases sensitivity to poly(ADP-ribose) polymerase inhibition in microsatellite unstable colorectal cancers
-
Vilar, E. et al. MRE11 deficiency increases sensitivity to poly(ADP-ribose) polymerase inhibition in microsatellite unstable colorectal cancers. Cancer Res 71, 2632-2642 (2011).
-
(2011)
Cancer Res
, vol.71
, pp. 2632-2642
-
-
Vilar, E.1
-
40
-
-
84902817327
-
Effect of MRE11 loss on PARP-inhibitor sensitivity in endometrial cancer in vitro
-
Koppensteiner, R. et al. Effect of MRE11 loss on PARP-inhibitor sensitivity in endometrial cancer in vitro. PLoS One 9, e100041 (2014).
-
(2014)
PLoS One
, vol.9
, pp. e100041
-
-
Koppensteiner, R.1
-
41
-
-
84880326910
-
Microsatellite instability induced mutations in DNA repair genes CtIP and MRE11 confer hypersensitivity to poly (ADP-ribose) polymerase inhibitors in myeloid malignancies
-
Gaymes, T. J. et al. Microsatellite instability induced mutations in DNA repair genes CtIP and MRE11 confer hypersensitivity to poly (ADP-ribose) polymerase inhibitors in myeloid malignancies. Haematologica 98, 1397-1406 (2013).
-
(2013)
Haematologica
, vol.98
, pp. 1397-1406
-
-
Gaymes, T.J.1
-
42
-
-
45349094984
-
Mitochondrial dynamics and apoptosis
-
Suen, D. F., Norris, K. L. & Youle, R. J. Mitochondrial dynamics and apoptosis. Genes Dev 22, 1577-1590 (2008).
-
(2008)
Genes Dev
, vol.22
, pp. 1577-1590
-
-
Suen, D.F.1
Norris, K.L.2
Youle, R.J.3
-
43
-
-
0035487808
-
The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosis
-
Frank, S. et al. The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosis. Developmental cell 1, 515-525 (2001).
-
(2001)
Developmental Cell
, vol.1
, pp. 515-525
-
-
Frank, S.1
-
44
-
-
0037164813
-
Spatial and temporal association of Bax with mitochondrial fission sites, Drp1, and Mfn2 during apoptosis
-
Karbowski, M. et al. Spatial and temporal association of Bax with mitochondrial fission sites, Drp1, and Mfn2 during apoptosis. The Journal of cell biology 159, 931-938 (2002).
-
(2002)
The Journal of Cell Biology
, vol.159
, pp. 931-938
-
-
Karbowski, M.1
-
45
-
-
27144543784
-
Scaffolding microdomains and beyond: The function of reggie/flotillin proteins
-
Langhorst, M. F., Reuter, A. & Stuermer, C. A. Scaffolding microdomains and beyond: the function of reggie/flotillin proteins. Cell Mol Life Sci 62, 2228-2240 (2005).
-
(2005)
Cell Mol Life Sci
, vol.62
, pp. 2228-2240
-
-
Langhorst, M.F.1
Reuter, A.2
Stuermer, C.A.3
-
46
-
-
79956033520
-
Knockdown of FLOT1 impairs cell proliferation and tumorigenicity in breast cancer through upregulation of FOXO3a
-
Lin, C. et al. Knockdown of FLOT1 impairs cell proliferation and tumorigenicity in breast cancer through upregulation of FOXO3a. Clin Cancer Res 17, 3089-3099 (2011).
-
(2011)
Clin Cancer Res
, vol.17
, pp. 3089-3099
-
-
Lin, C.1
-
47
-
-
84866660323
-
Flotillin-1 promotes tumor necrosis factor-alpha receptor signaling and activation of NF-kappaB in esophageal squamous cell carcinoma cells
-
e1012
-
Song, L. et al. Flotillin-1 promotes tumor necrosis factor-alpha receptor signaling and activation of NF-kappaB in esophageal squamous cell carcinoma cells. Gastroenterology 143, 995-1005 e1012 (2012).
-
(2012)
Gastroenterology
, vol.143
, pp. 995-1005
-
-
Song, L.1
-
48
-
-
79958724988
-
Kinesins and protein kinases: Key players in the regulation of microtubule dynamics and organization
-
Daire, V. & Pous, C. Kinesins and protein kinases: key players in the regulation of microtubule dynamics and organization. Arch Biochem Biophys 510, 83-92 (2011).
-
(2011)
Arch Biochem Biophys
, vol.510
, pp. 83-92
-
-
Daire, V.1
Pous, C.2
-
49
-
-
84883213373
-
Automated tracking of mitotic spindle pole positions shows that LGN is required for spindle rotation but not orientation maintenance
-
Corrigan, A. M. et al. Automated tracking of mitotic spindle pole positions shows that LGN is required for spindle rotation but not orientation maintenance. Cell Cycle 12, 2643-2655 (2013).
-
(2013)
Cell Cycle
, vol.12
, pp. 2643-2655
-
-
Corrigan, A.M.1
-
50
-
-
0034331310
-
The Rab6-binding kinesin, Rab6-KIFL, is required for cytokinesis
-
Hill, E., Clarke, M. & Barr, F. A. The Rab6-binding kinesin, Rab6-KIFL, is required for cytokinesis. Embo J 19, 5711-5719 (2000).
-
(2000)
Embo J
, vol.19
, pp. 5711-5719
-
-
Hill, E.1
Clarke, M.2
Barr, F.A.3
-
51
-
-
11244284210
-
Down-regulation of RAB6KIFL/KIF20A, a kinesin involved with membrane trafficking of discs large homologue 5, can attenuate growth of pancreatic cancer cell
-
Taniuchi, K. et al. Down-regulation of RAB6KIFL/KIF20A, a kinesin involved with membrane trafficking of discs large homologue 5, can attenuate growth of pancreatic cancer cell. Cancer Res 65, 105-112 (2005).
-
(2005)
Cancer Res
, vol.65
, pp. 105-112
-
-
Taniuchi, K.1
-
52
-
-
84864556009
-
Genistein-induced mitotic arrest of gastric cancer cells by downregulating KIF20A, a proteomics study
-
Yan, G. R. et al. Genistein-induced mitotic arrest of gastric cancer cells by downregulating KIF20A, a proteomics study. Proteomics 12, 2391-2399 (2012).
-
(2012)
Proteomics
, vol.12
, pp. 2391-2399
-
-
Yan, G.R.1
-
53
-
-
0030008570
-
Interaction of vinca alkaloids with tubulin: A comparison of vinblastine, vincristine, and vinorelbine
-
Lobert, S., Vulevic, B. & Correia, J. J. Interaction of vinca alkaloids with tubulin: a comparison of vinblastine, vincristine, and vinorelbine. Biochemistry 35, 6806-6814 (1996).
-
(1996)
Biochemistry
, vol.35
, pp. 6806-6814
-
-
Lobert, S.1
Vulevic, B.2
Correia, J.J.3
-
54
-
-
84889982509
-
An observational study on the expression levels of MDM2 and MDMX proteins, and associated effects on P53 in a series of human liposarcomas
-
Touqan, N. et al. An observational study on the expression levels of MDM2 and MDMX proteins, and associated effects on P53 in a series of human liposarcomas. BMC clinical pathology 13, 32 (2013).
-
(2013)
BMC Clinical Pathology
, vol.13
, pp. 32
-
-
Touqan, N.1
-
55
-
-
84865187027
-
Analysis of MDM2 and MDM4 single nucleotide polymorphisms, mRNA splicing and protein expression in retinoblastoma
-
McEvoy, J. et al. Analysis of MDM2 and MDM4 single nucleotide polymorphisms, mRNA splicing and protein expression in retinoblastoma. PLoS One 7, e42739 (2012).
-
(2012)
PLoS One
, vol.7
, pp. e42739
-
-
McEvoy, J.1
-
56
-
-
9744254768
-
Evaluation of combination chemotherapy: Integration of nonlinear regression, curve shift, isobologram, and combination index analyses
-
Zhao, L., Wientjes, M. G. & Au, J. L. Evaluation of combination chemotherapy: integration of nonlinear regression, curve shift, isobologram, and combination index analyses. Clin Cancer Res 10, 7994-8004 (2004).
-
(2004)
Clin Cancer Res
, vol.10
, pp. 7994-8004
-
-
Zhao, L.1
Wientjes, M.G.2
Au, J.L.3
|