Frequency of Mouse Double Minute 2 (MDM2) and Mouse Double Minute 4 (MDM4) amplification in parosteal and conventional osteosarcoma subtypes

Histopathology

Volumn 60, Issue 2, 2012, Pages 357-359

  Duhamel, Laure A E ^a   Ye, Hongtao ^b   Halai, Dina ^a,b   Idowu, Bernadine D ^b   Presneau, Nadège ^a   Tirabosco, Roberto ^b   Flanagan, Adrienne M ^a,b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b ROYAL NATIONAL ORTHOPAEDIC HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

NUTLIN 3; PROTEIN MDM2; PROTEIN MDMX; PROTEIN P53;

ANEUPLOIDY; APOPTOSIS; CANCER CELL CULTURE; CANCER CHEMOTHERAPY; CELL CYCLE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE AMPLIFICATION; GENE FREQUENCY; GENE MUTATION; IN VITRO STUDY; INOPERABLE CANCER; LETTER; OSTEOSARCOMA; PRIORITY JOURNAL; TISSUE MICROARRAY;

APOPTOSIS; BONE NEOPLASMS; GENE AMPLIFICATION; GENE DOSAGE; HUMANS; IMIDAZOLES; MUTATION; NUCLEAR PROTEINS; OSTEOSARCOMA; PIPERAZINES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-MDM2; RETROSPECTIVE STUDIES; TUMOR MARKERS, BIOLOGICAL; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84355166531     PISSN: 03090167     EISSN: 13652559     Source Type: Journal    
DOI: 10.1111/j.1365-2559.2011.04023.x     Document Type: Letter

References (5)

1. Tovar C, Rosinski J, Filipovic Z et al. Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy. Proc. Natl Acad. Sci. USA 2006; 103; 1888-1893.
2. Yoshida A, Ushiku T, Motoi T et al. Immunohistochemical analysis of MDM2 and CDK4 distinguishes low-grade osteosarcoma from benign mimics. Mod. Pathol. 2010; 23; 1279-1288.
3. Gamberi G, Ragazzini P, Benassi MS et al. Analysis of 12q13-15 genes in parosteal osteosarcoma. Clin. Orthop. Relat. Res. 2000; 377; 195-204.
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5. Mejia-Guerrero S, Quejada M, Gokgoz N et al. Characterization of the 12q15 MDM2 and 12q13-14 CDK4 amplicons and clinical correlations in osteosarcoma. Genes Chromosom. Cancer 2010; 49; 518-525.