The Lys-Specific Molecular Tweezer, CLR01, Modulates Aggregation of the Mutant p53 DNA Binding Domain and Inhibits Its Toxicity

Biochemistry

Volumn 54, Issue 24, 2015, Pages 3729-3738

  Herzog, Gal ^a   Shmueli, Merav D ^a   Levy, Limor ^a   Engel, Liat ^a   Gazit, Ehud ^a   Klärner, Frank Gerrit ^b   Schrader, Thomas ^b   Bitan, Gal ^c   Segal, Daniel ^a  

^a TEL AVIV UNIVERSITY   (Israel)

^b UNIVERSITY OF DUISBURG ESSEN   (Germany)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CELL CULTURE; CELL PROLIFERATION; CYTOTOXICITY; MODULATORS; PROTEINS;

ANTI-CANCER THERAPEUTICS; APOPTOTIC PATHWAYS; DNA BINDING DOMAIN; HIGH MOLECULAR WEIGHT; MOLECULAR TWEEZERS; PHYSIOLOGICAL TEMPERATURE; PROTEIN MISFOLDING; TUMOR SUPPRESSORS;

AGGREGATES;

CLR01; LYSINE; PROTEIN INHIBITOR; PROTEIN P53; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; BRIDGED COMPOUND; CLR01 COMPOUND; ORGANOPHOSPHATE; PROTEIN AGGREGATE; RECOMBINANT PROTEIN; TP53 PROTEIN, HUMAN;

ARTICLE; BETA SHEET; CARCINOMA CELL; CELL CULTURE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CYTOTOXICITY; DNA BINDING; HUMAN; HUMAN CELL; IN VITRO STUDY; LUNG CARCINOMA; MUTANT; NON SMALL CELL LUNG CANCER; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN ASSEMBLY; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FOLDING; THERMOSTABILITY; TRANSCRIPTION REGULATION; TRANSMISSION ELECTRON MICROSCOPY; AMINO ACID SUBSTITUTION; ANTAGONISTS AND INHIBITORS; BINDING SITE; CARCINOMA, NON-SMALL-CELL LUNG; CELL SURVIVAL; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; GENETICS; LUNG NEOPLASMS; METABOLISM; MUTATION; PATHOLOGY; PROTEIN AGGREGATION, PATHOLOGICAL; PROTEIN STABILITY; PROTEIN UNFOLDING; PROTEOSTASIS DEFICIENCIES; SITE DIRECTED MUTAGENESIS; TUMOR CELL LINE; ULTRASTRUCTURE;

AMINO ACID SUBSTITUTION; ANTINEOPLASTIC AGENTS; BINDING SITES; BRIDGED COMPOUNDS; CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE, TUMOR; CELL SURVIVAL; HUMANS; LUNG NEOPLASMS; MICROSCOPY, ELECTRON, TRANSMISSION; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; MUTATION; ORGANOPHOSPHATES; PROTEIN AGGREGATES; PROTEIN AGGREGATION, PATHOLOGICAL; PROTEIN STABILITY; PROTEIN UNFOLDING; PROTEOSTASIS DEFICIENCIES; RECOMBINANT PROTEINS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84934966270     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi501092p     Document Type: Article

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