Mutants of the tumour suppressor p53 L1 loop as second-site suppressors for restoring DNA binding to oncogenic p53 mutations: Structural and biochemical insights

Biochemical Journal

Volumn 427, Issue 2, 2010, Pages 225-236

  Merabet, Assia ^a   Houlleberghs, Hellen ^a   Maclagan, Kate ^a   Akanho, Ester ^a   Bui, Tam T T ^a   Pagano, Bruno ^b,c   Drake, Alex F ^a   Fraternali, Franca ^b   Nikolova, Penka V ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF SALERNO   (Italy)

Author keywords

Cancer; DNA binding; Molecular dynamics simulation (MD simulation); p53 mutant; Protein folding; Thermal stability

Indexed keywords

DNA BINDING; MD SIMULATION; MOLECULAR DYNAMICS SIMULATIONS; P53 MUTANTS; THERMAL STABILITY;

BINDING SITES; DNA; PROTEIN FOLDING; THERMODYNAMIC STABILITY; TUMORS;

GENES;

DNA; PROTEIN P53; TUMOR SUPPRESSOR PROTEIN; CELL CYCLE PROTEIN; GADD45A PROTEIN, HUMAN; NUCLEAR PROTEIN; ONCOPROTEIN;

ARTICLE; BIOCHEMISTRY; CANCER THERAPY; CELL CYCLE ARREST; CONTROLLED STUDY; DNA BINDING; GENE MUTATION; HUMAN; MOLECULAR DYNAMICS; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN CONFORMATION; SITE DIRECTED MUTAGENESIS; STRUCTURE ANALYSIS; THERMOSTABILITY; WILD TYPE; GENETICS; METABOLISM; MISSENSE MUTATION; NEOPLASM; PHYSIOLOGY; PROTEIN BINDING; PROTEIN STABILITY;

CELL CYCLE PROTEINS; DNA; HUMANS; MOLECULAR DYNAMICS SIMULATION; MUTAGENESIS, SITE-DIRECTED; MUTATION, MISSENSE; NEOPLASMS; NUCLEAR PROTEINS; ONCOGENE PROTEINS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STABILITY; TUMOR SUPPRESSOR PROTEIN P53;

EID: 77952755475     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20091888     Document Type: Article

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