메뉴 건너뛰기




Volumn 65, Issue 6, 2015, Pages 640-648

Effects of Single Drug and Combined Short-term Administration of Sildenafil, Pimobendan, and Nicorandil on Right Ventricular Function in Rats with Monocrotaline-induced Pulmonary Hypertension

Author keywords

ATP sensitive potassium channel; cardiac function; phosphodiesterase inhibitors

Indexed keywords

MONOCROTALINE; NICORANDIL; PIMOBENDAN; SILDENAFIL; SODIUM CHLORIDE; PHOSPHODIESTERASE III INHIBITOR; PHOSPHODIESTERASE V INHIBITOR; PYRIDAZINE DERIVATIVE; VASODILATOR AGENT;

EID: 84934965965     PISSN: 01602446     EISSN: 15334023     Source Type: Journal    
DOI: 10.1097/FJC.0000000000000236     Document Type: Article
Times cited : (10)

References (79)
  • 1
    • 10044258461 scopus 로고    scopus 로고
    • Guidelines on diagnosis and treatment of pulmonary arterial hypertension
    • Task Force The Task Force on Diagnosis and Treatment of Pulmonary Arterial Hypertension of the European Society of Cardiology
    • Galiè N, Torbicki A, Barst R, et al Task Force. Guidelines on diagnosis and treatment of pulmonary arterial hypertension. The Task Force on Diagnosis and Treatment of Pulmonary Arterial Hypertension of the European Society of Cardiology. Eur Heart J. 2004;25:2243-2278.
    • (2004) Eur Heart J. , vol.25 , pp. 2243-2278
    • Galiè, N.1    Torbicki, A.2    Barst, R.3
  • 2
    • 67649613565 scopus 로고    scopus 로고
    • Diagnosis, assessment, and treatment of non-pulmonary arterial hypertension pulmonary hypertension
    • Hoeper MM, Barberà JA, Channick RN, et al. Diagnosis, assessment, and treatment of non-pulmonary arterial hypertension pulmonary hypertension. J Am Coll Cardiol. 2009;54:S85-S96.
    • (2009) J Am Coll Cardiol. , vol.54 , pp. S85-S96
    • Hoeper, M.M.1    Barberà, J.A.2    Channick, R.N.3
  • 3
    • 82555181672 scopus 로고    scopus 로고
    • The value of tools to assess pulmonary arterial hypertension
    • Gupta H, Ghimire G, Naeije R. The value of tools to assess pulmonary arterial hypertension. Eur Respir Rev. 2011;20:222-235.
    • (2011) Eur Respir Rev. , vol.20 , pp. 222-235
    • Gupta, H.1    Ghimire, G.2    Naeije, R.3
  • 4
    • 34249276035 scopus 로고    scopus 로고
    • Echocardiographic assessment of right heart hemodynamic parameters
    • Lee KS, Abbas AE, Khandheria BK, et al. Echocardiographic assessment of right heart hemodynamic parameters. J Am Soc Echocardiogr. 2007;20:773-782.
    • (2007) J Am Soc Echocardiogr. , vol.20 , pp. 773-782
    • Lee, K.S.1    Abbas, A.E.2    Khandheria, B.K.3
  • 5
    • 82555183025 scopus 로고    scopus 로고
    • The role of the right ventricle in pulmonary arterial hypertension
    • Vonk Noordegraaf A, Galiè N. The role of the right ventricle in pulmonary arterial hypertension. Eur Respir Rev. 2011;20:243-253.
    • (2011) Eur Respir Rev. , vol.20 , pp. 243-253
    • Vonk Noordegraaf, A.1    Galiè, N.2
  • 6
    • 77955467749 scopus 로고    scopus 로고
    • New echocardiographic prognostic factors for mortality in pulmonary arterial hypertension
    • Brierre G, Blot-Souletie N, Degano B, et al. New echocardiographic prognostic factors for mortality in pulmonary arterial hypertension. Eur J Echocardiogr. 2010;11:516-522.
    • (2010) Eur J Echocardiogr. , vol.11 , pp. 516-522
    • Brierre, G.1    Blot-Souletie, N.2    Degano, B.3
  • 7
    • 33750560212 scopus 로고    scopus 로고
    • Right ventricular function and failure: Report of a National Heart, Lung, and Blood Institute working group on cellular and molecular mechanisms of right heart failure
    • Voelkel NF, Quaife RA, Leinwand LA, et al. Right ventricular function and failure: report of a National Heart, Lung, and Blood Institute working group on cellular and molecular mechanisms of right heart failure. Circulation. 2006;114:1883-1891.
    • (2006) Circulation. , vol.114 , pp. 1883-1891
    • Voelkel, N.F.1    Quaife, R.A.2    Leinwand, L.A.3
  • 8
    • 62149104001 scopus 로고    scopus 로고
    • The right ventricle under pressure. Cellular and molecular mechanisms of right-heart failure in pulmonary hypertension
    • Bogaard HJ, Abe K, Noordegraaf AV, et al. The right ventricle under pressure. Cellular and molecular mechanisms of right-heart failure in pulmonary hypertension. Chest. 2009;135:794-804.
    • (2009) Chest. , vol.135 , pp. 794-804
    • Bogaard, H.J.1    Abe, K.2    Noordegraaf, A.V.3
  • 9
    • 84914138634 scopus 로고    scopus 로고
    • RV-pulmonary arterial coupling predicts outcome in patients referred for pulmonary hypertension
    • pii: heartjnl-2014-306142
    • Vanderpool RR, Pinsky MR, Naeije R, et al. RV-pulmonary arterial coupling predicts outcome in patients referred for pulmonary hypertension. Heart. 2014; pii: heartjnl-2014-306142.
    • (2014) Heart
    • Vanderpool, R.R.1    Pinsky, M.R.2    Naeije, R.3
  • 10
    • 70349776690 scopus 로고    scopus 로고
    • Comprehensive invasive and noninvasive approach to the right ventricle-pulmonary circulation unit: State of the art and clinical and research implications
    • Champion HC, Michelakis ED, Hassoun PM. Comprehensive invasive and noninvasive approach to the right ventricle-pulmonary circulation unit: state of the art and clinical and research implications. Circulation. 2009;120:992-1007.
    • (2009) Circulation. , vol.120 , pp. 992-1007
    • Champion, H.C.1    Michelakis, E.D.2    Hassoun, P.M.3
  • 11
    • 82455203954 scopus 로고    scopus 로고
    • Progressive right ventricular dysfunction patients with pulmonary arterial hypertension responding to therapy
    • Van de Veerdonk MC, Kind T, Marcus JT, et al. Progressive right ventricular dysfunction patients with pulmonary arterial hypertension responding to therapy. J Am Coll Cardiol. 2011;58:2511-2519.
    • (2011) J Am Coll Cardiol. , vol.58 , pp. 2511-2519
    • Van De Veerdonk, M.C.1    Kind, T.2    Marcus, J.T.3
  • 12
    • 0030733082 scopus 로고    scopus 로고
    • Phosphodiesterase isoforms in the pulmonary arterial circulation of the rat: Changes in pulmonary hypertension
    • Maclean MR, Johnston ED, McCulloch KM, et al. Phosphodiesterase isoforms in the pulmonary arterial circulation of the rat: changes in pulmonary hypertension. J Pharmacol Exp Ther. 1997;283:619-624.
    • (1997) J Pharmacol Exp Ther. , vol.283 , pp. 619-624
    • Maclean, M.R.1    Johnston, E.D.2    McCulloch, K.M.3
  • 13
    • 12244282450 scopus 로고    scopus 로고
    • Increased expression of the cGMP-inhibited cAMP-specific (PDE3) and cGMP binding cGMP-specific (PDE5) phosphodiesterases in models of pulmonary hypertension
    • Murray F, MacLean MR, Pyne NJ. Increased expression of the cGMP-inhibited cAMP-specific (PDE3) and cGMP binding cGMP-specific (PDE5) phosphodiesterases in models of pulmonary hypertension. Br J Pharmacol. 2002;137:1187-1194.
    • (2002) Br J Pharmacol. , vol.137 , pp. 1187-1194
    • Murray, F.1    MacLean, M.R.2    Pyne, N.J.3
  • 14
    • 0031875353 scopus 로고    scopus 로고
    • Phosphodiesterase III and V inhibitors on pulmonary artery from pulmonary hypertensive rats: Differences between early and established pulmonary hypertension
    • Jeffery TK, Wanstall JC. Phosphodiesterase III and V inhibitors on pulmonary artery from pulmonary hypertensive rats: differences between early and established pulmonary hypertension. J Cardiovasc Pharmacol. 1998;32:213-219.
    • (1998) J Cardiovasc Pharmacol. , vol.32 , pp. 213-219
    • Jeffery, T.K.1    Wanstall, J.C.2
  • 15
    • 1242284323 scopus 로고    scopus 로고
    • Pulmonary responses to selective phosphodiesterase-5 and phosphodiesterase-3 inhibitors
    • Matot I, Gozal Y. Pulmonary responses to selective phosphodiesterase-5 and phosphodiesterase-3 inhibitors. Chest. 2004;125:644-651.
    • (2004) Chest. , vol.125 , pp. 644-651
    • Matot, I.1    Gozal, Y.2
  • 16
    • 33244478540 scopus 로고    scopus 로고
    • Treatment with phosphodiesterase inhibitors type III and V: Milrinone and sildenafil is an effective combination during thromboxane-induced acute pulmonary hypertension
    • Lobato EB, Beaver T, Muehjschlegel J, et al. Treatment with phosphodiesterase inhibitors type III and V: milrinone and sildenafil is an effective combination during thromboxane-induced acute pulmonary hypertension. Br J Anaesth. 2006;96:317-322.
    • (2006) Br J Anaesth. , vol.96 , pp. 317-322
    • Lobato, E.B.1    Beaver, T.2    Muehjschlegel, J.3
  • 17
    • 0028365921 scopus 로고
    • Identification of PDE isozymes in human pulmonary artery and effect of selective PDE inhibitors
    • Rabe KF, Tenor H, Dent G, et al. Identification of PDE isozymes in human pulmonary artery and effect of selective PDE inhibitors. Am J Physiol. 1994;266:L536-L543.
    • (1994) Am J Physiol. , vol.266 , pp. L536-L543
    • Rabe, K.F.1    Tenor, H.2    Dent, G.3
  • 18
    • 70350422573 scopus 로고    scopus 로고
    • Evaluation of pimobendan and N-terminal probrain natriuretic peptide in the treatment of pulmonary hypertension secondary to degenerative mitral valve disease in dogs
    • Atkinson KJ, Fine DM, Thombs LA, et al. Evaluation of pimobendan and N-terminal probrain natriuretic peptide in the treatment of pulmonary hypertension secondary to degenerative mitral valve disease in dogs. J Vet Intern Med. 2009;23:1190-1196.
    • (2009) J Vet Intern Med. , vol.23 , pp. 1190-1196
    • Atkinson, K.J.1    Fine, D.M.2    Thombs, L.A.3
  • 19
    • 0025982134 scopus 로고
    • Contribution of cAMP-phosphodiesterase inhibition and sensitization of the contractile proteins for calcium to the inotropic effect of pimobendan in the failing human myocardium
    • Böhm M, Morano I, Pieske B, et al. Contribution of cAMP-phosphodiesterase inhibition and sensitization of the contractile proteins for calcium to the inotropic effect of pimobendan in the failing human myocardium. Circ Res. 1991;68:689-701.
    • (1991) Circ Res. , vol.68 , pp. 689-701
    • Böhm, M.1    Morano, I.2    Pieske, B.3
  • 20
    • 0025799802 scopus 로고
    • Mechanism underlying the reduced positive inotropic effects of the phosphodiesterase III inhibitors pimobendan, adibendan and saterinone in failing as compared to nonfailing human cardiac muscle preparations
    • Von Der Leyen H, Mende U, Meyer W, et al. Mechanism underlying the reduced positive inotropic effects of the phosphodiesterase III inhibitors pimobendan, adibendan and saterinone in failing as compared to nonfailing human cardiac muscle preparations. Naunyn Schmiedebergs Arch Pharmacol. 1991;344:90-100.
    • (1991) Naunyn Schmiedebergs Arch Pharmacol. , vol.344 , pp. 90-100
    • Von Der Leyen, H.1    Mende, U.2    Meyer, W.3
  • 21
    • 52749099087 scopus 로고    scopus 로고
    • Phosphodiesterase inhibitors for the treatment of pulmonary hypertension
    • Wilkins MR, Wharton J, Grimminger F, et al. Phosphodiesterase inhibitors for the treatment of pulmonary hypertension. Eur Respir J. 2008;32:198-209.
    • (2008) Eur Respir J. , vol.32 , pp. 198-209
    • Wilkins, M.R.1    Wharton, J.2    Grimminger, F.3
  • 22
    • 34547611337 scopus 로고    scopus 로고
    • Phosphodiesterase type 5 is highly expressed in the hypertrophied human right ventricle, and acute inhibition of phosphodiesterase type 5 improves contractility
    • Nagendran J, Archer SL, Soliman D, et al. Phosphodiesterase type 5 is highly expressed in the hypertrophied human right ventricle, and acute inhibition of phosphodiesterase type 5 improves contractility. Circulation. 2007;116:238-248.
    • (2007) Circulation. , vol.116 , pp. 238-248
    • Nagendran, J.1    Archer, S.L.2    Soliman, D.3
  • 23
    • 20044363270 scopus 로고    scopus 로고
    • Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy
    • Takimoto E, Champion HC, Li M, et al. Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy. Nat Med. 2005;11:214-222.
    • (2005) Nat Med. , vol.11 , pp. 214-222
    • Takimoto, E.1    Champion, H.C.2    Li, M.3
  • 24
    • 17144405644 scopus 로고    scopus 로고
    • Phosphodiesterase-5 inhibition with sildenafil attenuates cardiomyocyte apoptosis and left ventricular dysfunction in a chronic model of doxorubicin cardiotoxicity
    • Fisher PW, Salloum F, Das A, et al. Phosphodiesterase-5 inhibition with sildenafil attenuates cardiomyocyte apoptosis and left ventricular dysfunction in a chronic model of doxorubicin cardiotoxicity. Circulation. 2005;111:1601-1610.
    • (2005) Circulation. , vol.111 , pp. 1601-1610
    • Fisher, P.W.1    Salloum, F.2    Das, A.3
  • 25
    • 0023485276 scopus 로고
    • Similarity and dissimilarity in the mode and mechanism of action between nicorandil and classical nitrates: An overview
    • Taira N. Similarity and dissimilarity in the mode and mechanism of action between nicorandil and classical nitrates: an overview. J Cardiovasc Pharmacol. 1987;10:S1-S9.
    • (1987) J Cardiovasc Pharmacol. , vol.10 , pp. S1-S9
    • Taira, N.1
  • 26
    • 0344851838 scopus 로고    scopus 로고
    • Pulmonary arterial hypertension: Pathophysiology and anesthetic approach
    • Blaise G, Langleben D, Hubert B. Pulmonary arterial hypertension: pathophysiology and anesthetic approach. Anesthesiology. 2003;99:1415-1432.
    • (2003) Anesthesiology. , vol.99 , pp. 1415-1432
    • Blaise, G.1    Langleben, D.2    Hubert, B.3
  • 27
    • 84871556857 scopus 로고    scopus 로고
    • Iptakalim ameliorates monocrotaline-induced pulmonary arterial hypertension in rats
    • Li J, Long C, Cui W, et al. Iptakalim ameliorates monocrotaline-induced pulmonary arterial hypertension in rats. J Cardiovasc Pharmacol Ther. 2013;18:60-69.
    • (2013) J Cardiovasc Pharmacol Ther. , vol.18 , pp. 60-69
    • Li, J.1    Long, C.2    Cui, W.3
  • 28
    • 26044480636 scopus 로고    scopus 로고
    • Effects of nicorandil on monocrotaline-induced pulmonary arterial hypertension in rats
    • Hongo M, Mawatari E, Sakai A, et al. Effects of nicorandil on monocrotaline-induced pulmonary arterial hypertension in rats. J Cardiovasc Pharmacol. 2005;46:452-458.
    • (2005) J Cardiovasc Pharmacol. , vol.46 , pp. 452-458
    • Hongo, M.1    Mawatari, E.2    Sakai, A.3
  • 29
    • 84859131438 scopus 로고    scopus 로고
    • Nicorandil attenuates monocrotaline-induced vascular endothelial damage and pulmonary arterial hypertension
    • Sahara M, Sata M, Morita T, et al. Nicorandil attenuates monocrotaline-induced vascular endothelial damage and pulmonary arterial hypertension. PLoS One. 2012;7:e33367.
    • (2012) PLoS One. , vol.7
    • Sahara, M.1    Sata, M.2    Morita, T.3
  • 30
    • 84866129433 scopus 로고    scopus 로고
    • Nicorandil prevents right ventricular remodeling by inhibiting apoptosis and lowering pressure overload in rats with pulmonary arterial hypertension
    • Zuo XR, Wang Q, Cao Q, et al. Nicorandil prevents right ventricular remodeling by inhibiting apoptosis and lowering pressure overload in rats with pulmonary arterial hypertension. PLoS One. 2012;7:e44485.
    • (2012) PLoS One. , vol.7
    • Zuo, X.R.1    Wang, Q.2    Cao, Q.3
  • 31
    • 0034917137 scopus 로고    scopus 로고
    • Hypoxic vasoconstriction of rat main pulmonary artery: Role of endogenous nitric oxide, potassium channels, and phosphodiesterase inhibition
    • Bardou M, Goirand F, Marchand S, et al. Hypoxic vasoconstriction of rat main pulmonary artery: role of endogenous nitric oxide, potassium channels, and phosphodiesterase inhibition. J Cardiovasc Pharmacol. 2001;38:325-334.
    • (2001) J Cardiovasc Pharmacol. , vol.38 , pp. 325-334
    • Bardou, M.1    Goirand, F.2    Marchand, S.3
  • 32
    • 41649103553 scopus 로고    scopus 로고
    • Right ventricular function in cardiovascular disease, part I: Anatomy, physiology, aging, and functional assessment of the right ventricle
    • Haddad F, Hunt SA, Rosenthal DN, et al. Right ventricular function in cardiovascular disease, part I: anatomy, physiology, aging, and functional assessment of the right ventricle. Circulation. 2008;117:1436-1448.
    • (2008) Circulation. , vol.117 , pp. 1436-1448
    • Haddad, F.1    Hunt, S.A.2    Rosenthal, D.N.3
  • 33
    • 77953661132 scopus 로고    scopus 로고
    • Guidelines for the echocardiographic assessment of the right heart in adults: A report from the American Society of Echocardiography endorsed by the European Association of Echocardiography, a registered branch of the European Society of Cardiology, and the Canadian Society of Echocardiography
    • Rudski LG, Lai WW, Afilalo J, et al. Guidelines for the echocardiographic assessment of the right heart in adults: a report from the American Society of Echocardiography endorsed by the European Association of Echocardiography, a registered branch of the European Society of Cardiology, and the Canadian Society of Echocardiography. J Am Soc Echocardiogr. 2010;23:685-713.
    • (2010) J Am Soc Echocardiogr. , vol.23 , pp. 685-713
    • Rudski, L.G.1    Lai, W.W.2    Afilalo, J.3
  • 34
    • 0142008980 scopus 로고    scopus 로고
    • Recommendations for evaluation of the severity of native valvular regurgitation with two-dimensional and Doppler echocardiography
    • Zoghbi WA, Enriquez-Sarano M, Foster E, et al American Society of Echocardiography. Recommendations for evaluation of the severity of native valvular regurgitation with two-dimensional and Doppler echocardiography. J Am Soc Echocardiogr. 2003;16:777-802.
    • (2003) J Am Soc Echocardiogr. , vol.16 , pp. 777-802
    • American Society of Echocardiography1    Zoghbi, W.A.2    Enriquez-Sarano, M.3    Foster, E.4
  • 35
    • 43449131870 scopus 로고    scopus 로고
    • Echocardiography in the assessment of right heart function
    • Lindqvist P, Calcutteea A, Henein M. Echocardiography in the assessment of right heart function. Eur J Echocardiogr. 2008;9:225-234.
    • (2008) Eur J Echocardiogr. , vol.9 , pp. 225-234
    • Lindqvist, P.1    Calcutteea, A.2    Henein, M.3
  • 36
    • 0034526932 scopus 로고    scopus 로고
    • Triptolide attenuates pulmonary arterial hypertension and neointimal formation in rats
    • Faul JL, Nishimura T, Berry GJ, et al. Triptolide attenuates pulmonary arterial hypertension and neointimal formation in rats. Am J Respir Crit Care Med. 2000;162:2252-2258.
    • (2000) Am J Respir Crit Care Med. , vol.162 , pp. 2252-2258
    • Faul, J.L.1    Nishimura, T.2    Berry, G.J.3
  • 37
    • 1642285326 scopus 로고    scopus 로고
    • Right ventricular hypertrophy and apoptosis after pulmonary artery banding: Regulation of PKC isozymes
    • Braun MU, Szalai P, Strasser RH, et al. Right ventricular hypertrophy and apoptosis after pulmonary artery banding: regulation of PKC isozymes. Cardiovasc Res. 2003;59:658-667.
    • (2003) Cardiovasc Res. , vol.59 , pp. 658-667
    • Braun, M.U.1    Szalai, P.2    Strasser, R.H.3
  • 38
    • 33750041335 scopus 로고    scopus 로고
    • Protective role of protein C inhibitor in monocrotaline-induced pulmonary hypertension
    • Nishii Y, Gabazza EC, Fujimoto H, et al. Protective role of protein C inhibitor in monocrotaline-induced pulmonary hypertension. J Thromb Haemost. 2006;4:2331-2339.
    • (2006) J Thromb Haemost. , vol.4 , pp. 2331-2339
    • Nishii, Y.1    Gabazza, E.C.2    Fujimoto, H.3
  • 39
    • 65249161113 scopus 로고    scopus 로고
    • Accuracy of Doppler echocardiography in the hemodynamic assessment of pulmonary hypertension
    • Fisher MR, Forfia PR, Chamera E, et al. Accuracy of Doppler echocardiography in the hemodynamic assessment of pulmonary hypertension. Am J Respir Crit Care Med. 2009;179:615-621.
    • (2009) Am J Respir Crit Care Med. , vol.179 , pp. 615-621
    • Fisher, M.R.1    Forfia, P.R.2    Chamera, E.3
  • 40
    • 0036306437 scopus 로고    scopus 로고
    • Serial noninvasive assessment of progressive pulmonary hypertension in a rat model
    • Jones JE, Mendes L, Rudd MA, et al. Serial noninvasive assessment of progressive pulmonary hypertension in a rat model. Am J Physiol Heart Circ Physiol. 2002;283:H364-H371.
    • (2002) Am J Physiol Heart Circ Physiol. , vol.283 , pp. H364-H371
    • Jones, J.E.1    Mendes, L.2    Rudd, M.A.3
  • 41
    • 71949129187 scopus 로고    scopus 로고
    • Animal models of pulmonary arterial hypertension: The hope for etiological discovery and pharmacological cure
    • Stenmark KR, Meyrick B, Galie N, et al. Animal models of pulmonary arterial hypertension: the hope for etiological discovery and pharmacological cure. Am J Physiol Lung Cell Mol Physiol. 2009;297:L1013-L1032.
    • (2009) Am J Physiol Lung Cell Mol Physiol. , vol.297 , pp. L1013-L1032
    • Stenmark, K.R.1    Meyrick, B.2    Galie, N.3
  • 43
    • 0031882223 scopus 로고    scopus 로고
    • Right ventricular diastolic performance: Compliance characteristics with focus on pulmonary hypertension, right ventricular hypertrophy, and calcium channel blockade
    • Ferlinz J. Right ventricular diastolic performance: compliance characteristics with focus on pulmonary hypertension, right ventricular hypertrophy, and calcium channel blockade. Cathet Cardiovasc Diagn. 1998;43:206-243.
    • (1998) Cathet Cardiovasc Diagn. , vol.43 , pp. 206-243
    • Ferlinz, J.1
  • 44
    • 41649100266 scopus 로고    scopus 로고
    • Right ventricular function in cardiovascular disease, part II: Pathophysiology, clinical importance, and management of right ventricular failure
    • Haddad F, Doyle R, Murphy DJ, et al. Right ventricular function in cardiovascular disease, part II: pathophysiology, clinical importance, and management of right ventricular failure. Circulation. 2008;117:1717-1731.
    • (2008) Circulation. , vol.117 , pp. 1717-1731
    • Haddad, F.1    Doyle, R.2    Murphy, D.J.3
  • 45
    • 28144434008 scopus 로고    scopus 로고
    • Doppler tissue imaging in assessment of pulmonary hypertension-induced right ventricle dysfunction
    • Boissiere J, Gautier M, Machet MC, et al. Doppler tissue imaging in assessment of pulmonary hypertension-induced right ventricle dysfunction. Am J Physiol Heart Circ Physiol. 2005;289:H2450-H2455.
    • (2005) Am J Physiol Heart Circ Physiol. , vol.289 , pp. H2450-H2455
    • Boissiere, J.1    Gautier, M.2    Machet, M.C.3
  • 46
    • 33748748913 scopus 로고    scopus 로고
    • Sequence of echocardiographic changes during development of right ventricular failure in rat
    • Hardziyenka M, Campian ME, de Bruin-Bon HA, et al. Sequence of echocardiographic changes during development of right ventricular failure in rat. J Am Soc Echocardiogr. 2006;19:1272-1279.
    • (2006) J Am Soc Echocardiogr. , vol.19 , pp. 1272-1279
    • Hardziyenka, M.1    Campian, M.E.2    De Bruin-Bon, H.A.3
  • 47
    • 77955492061 scopus 로고    scopus 로고
    • A comparison of echocardiography to invasive measurement in the evaluation of pulmonary arterial hypertension in a rat model
    • Koskenvuo JW, Mirsky R, Zhang Y, et al. A comparison of echocardiography to invasive measurement in the evaluation of pulmonary arterial hypertension in a rat model. Int J Cardiovasc Imaging. 2010;26:509-518.
    • (2010) Int J Cardiovasc Imaging. , vol.26 , pp. 509-518
    • Koskenvuo, J.W.1    Mirsky, R.2    Zhang, Y.3
  • 48
    • 84875833534 scopus 로고    scopus 로고
    • The right ventricle: Biologic insights and response to disease: Updated
    • Walker LA, Buttrick PM. The right ventricle: biologic insights and response to disease: updated. Curr Cardiol Rev. 2013;9:73-81.
    • (2013) Curr Cardiol Rev. , vol.9 , pp. 73-81
    • Walker, L.A.1    Buttrick, P.M.2
  • 49
    • 16844382827 scopus 로고    scopus 로고
    • Phosphodiesterase-5 inhibitor sildenafil preconditions adult cardiac myocytes against necrosis and apoptosis
    • Das A, Xi L, Kukreja RC. Phosphodiesterase-5 inhibitor sildenafil preconditions adult cardiac myocytes against necrosis and apoptosis. J Biol Chem. 2005;280:12944-12955.
    • (2005) J Biol Chem. , vol.280 , pp. 12944-12955
    • Das, A.1    Xi, L.2    Kukreja, R.C.3
  • 50
    • 84859628031 scopus 로고    scopus 로고
    • Differential expression of PDE5 in failing and nonfailing human myocardium
    • Shan X, Quaile MP, Monk JK, et al. Differential expression of PDE5 in failing and nonfailing human myocardium. Circ Heart Fail. 2012;5:79-86.
    • (2012) Circ Heart Fail. , vol.5 , pp. 79-86
    • Shan, X.1    Quaile, M.P.2    Monk, J.K.3
  • 51
    • 79551580284 scopus 로고    scopus 로고
    • PDE5 inhibition with sildenafil improves left ventricular diastolic function, cardiac geometry, and clinical status in patients with stable systolic heart failure: Results of a 1-year, prospective, randomized, placebo-controlled study
    • Guazzi M, Vicenzi M, Arena R, et al. PDE5 inhibition with sildenafil improves left ventricular diastolic function, cardiac geometry, and clinical status in patients with stable systolic heart failure: results of a 1-year, prospective, randomized, placebo-controlled study. Circ Heart Fail. 2011;4:8-17.
    • (2011) Circ Heart Fail. , vol.4 , pp. 8-17
    • Guazzi, M.1    Vicenzi, M.2    Arena, R.3
  • 52
    • 0026517517 scopus 로고
    • Reversal of left ventricular hypertrophy in hypertensive patients. A meta-analysis of 109 treatment studies
    • Dahlöf B, Pennert K, Hansson L. Reversal of left ventricular hypertrophy in hypertensive patients. A meta-analysis of 109 treatment studies. Am J Hypertens. 1992;5:95-110.
    • (1992) Am J Hypertens. , vol.5 , pp. 95-110
    • Dahlöf, B.1    Pennert, K.2    Hansson, L.3
  • 53
    • 0032588934 scopus 로고    scopus 로고
    • The use of milrinone in pre-transplant assessment of patients with congestive heart failure and pulmonary hypertension
    • Pamboukian SV, Carere RG, Webb JG, et al. The use of milrinone in pre-transplant assessment of patients with congestive heart failure and pulmonary hypertension. J Heart Lung Transplant. 1999;18:367-371.
    • (1999) J Heart Lung Transplant. , vol.18 , pp. 367-371
    • Pamboukian, S.V.1    Carere, R.G.2    Webb, J.G.3
  • 54
    • 0023797004 scopus 로고
    • Sensitization of dog and guinea pig heart myofilaments to Ca2+ activation and the inotropic effect of pimobendan: Comparison with milrinone
    • Fujino K, Sperelakis N, Solaro RJ. Sensitization of dog and guinea pig heart myofilaments to Ca2+ activation and the inotropic effect of pimobendan: comparison with milrinone. Circ Res. 1988;63:911-922.
    • (1988) Circ Res. , vol.63 , pp. 911-922
    • Fujino, K.1    Sperelakis, N.2    Solaro, R.J.3
  • 55
    • 0029788449 scopus 로고    scopus 로고
    • Influence of levosimendan, pimobendan, and milrinone on the regional distribution of cardiac output in anaesthetized dogs
    • Pagel PS, Hettrick DA, Warltier DC. Influence of levosimendan, pimobendan, and milrinone on the regional distribution of cardiac output in anaesthetized dogs. Br J Pharmacol. 1996;119:609-615.
    • (1996) Br J Pharmacol. , vol.119 , pp. 609-615
    • Pagel, P.S.1    Hettrick, D.A.2    Warltier, D.C.3
  • 56
    • 84898925443 scopus 로고    scopus 로고
    • Pimobendan improves right ventricular myocardial contraction and attenuates pulmonary arterial hypertension in rats with monocrotaline-induced pulmonary arterial hypertension
    • Yoshiyuki R, Nakata TM, Fukayama T, et al. Pimobendan improves right ventricular myocardial contraction and attenuates pulmonary arterial hypertension in rats with monocrotaline-induced pulmonary arterial hypertension. J Med Ultrason. 2014;14:173-180.
    • (2014) J Med Ultrason. , vol.14 , pp. 173-180
    • Yoshiyuki, R.1    Nakata, T.M.2    Fukayama, T.3
  • 57
    • 18544380923 scopus 로고    scopus 로고
    • Increased mitral valve regurgitation and myocardial hypertrophy in two dogs with long-term pimobendan therapy
    • Tissier R, Chetboul V, Moraillon R, et al. Increased mitral valve regurgitation and myocardial hypertrophy in two dogs with long-term pimobendan therapy. Cardiovasc Toxicol. 2005;5:43-51.
    • (2005) Cardiovasc Toxicol. , vol.5 , pp. 43-51
    • Tissier, R.1    Chetboul, V.2    Moraillon, R.3
  • 58
    • 29644447197 scopus 로고    scopus 로고
    • Relative toxicity of cardiotonic agents: Some induce more cardiac and skeletal myocyte apoptosis and necrosis in vivo than others
    • Burniston JG, Ellison GM, Clark WA, et al. Relative toxicity of cardiotonic agents: some induce more cardiac and skeletal myocyte apoptosis and necrosis in vivo than others. Cardiovasc Toxicol. 2005;5:355-364.
    • (2005) Cardiovasc Toxicol. , vol.5 , pp. 355-364
    • Burniston, J.G.1    Ellison, G.M.2    Clark, W.A.3
  • 59
    • 34547800235 scopus 로고    scopus 로고
    • Comparative adverse cardiac effects of pimobendan and benazepril monotherapy in dogs with mild degenerative mitral valve disease: A prospective, controlled, blinded, and randomized study
    • Chetboul V, Lefebvre HP, Sampedrano CC, et al. Comparative adverse cardiac effects of pimobendan and benazepril monotherapy in dogs with mild degenerative mitral valve disease: a prospective, controlled, blinded, and randomized study. J Vet Intern Med. 2007;21:742-753.
    • (2007) J Vet Intern Med. , vol.21 , pp. 742-753
    • Chetboul, V.1    Lefebvre, H.P.2    Sampedrano, C.C.3
  • 60
    • 0023944395 scopus 로고
    • Pimobendane (UD-CG 115 BS) in the treatment of severe congestive heart failure. An acute haemodynamic cross-over and double-blind study with two different doses
    • Walter M, Liebens I, Goethals H, et al. Pimobendane (UD-CG 115 BS) in the treatment of severe congestive heart failure. An acute haemodynamic cross-over and double-blind study with two different doses. Br J Clin Pharmacol. 1988;25:323-329.
    • (1988) Br J Clin Pharmacol. , vol.25 , pp. 323-329
    • Walter, M.1    Liebens, I.2    Goethals, H.3
  • 61
    • 0036234691 scopus 로고    scopus 로고
    • Effects of pimobendan on adverse cardiac events and physical activities in patients with mild to moderate chronic heart failure: The effects of pimobendan on chronic heart failure study (EPOCH study)
    • Effects of Pimobendan on Chronic Heart Failure Study (EPOCH Study)
    • Effects of Pimobendan on Chronic Heart Failure Study (EPOCH Study). Effects of pimobendan on adverse cardiac events and physical activities in patients with mild to moderate chronic heart failure: the effects of pimobendan on chronic heart failure study (EPOCH study). Circ J. 2002;66:149-157.
    • (2002) Circ J. , vol.66 , pp. 149-157
  • 62
    • 0345059760 scopus 로고    scopus 로고
    • Low-dose systemic phosphodiesterase III inhibitor pimobendan combined with prostacyclin therapy in a patient with severe primary pulmonary hypertension
    • Watanabe E, Shiga T, Matsuda N, et al. Low-dose systemic phosphodiesterase III inhibitor pimobendan combined with prostacyclin therapy in a patient with severe primary pulmonary hypertension. Cardiovasc Drugs Ther. 2003;17:375-379.
    • (2003) Cardiovasc Drugs Ther. , vol.17 , pp. 375-379
    • Watanabe, E.1    Shiga, T.2    Matsuda, N.3
  • 63
    • 33845677584 scopus 로고    scopus 로고
    • New insights in the treatment strategy for pulmonary arterial hypertension
    • Sahara M, Takahashi T, Imai Y, et al. New insights in the treatment strategy for pulmonary arterial hypertension. Cardiovasc Drugs Ther. 2006;20:377-386.
    • (2006) Cardiovasc Drugs Ther. , vol.20 , pp. 377-386
    • Sahara, M.1    Takahashi, T.2    Imai, Y.3
  • 64
    • 0030281648 scopus 로고    scopus 로고
    • Doppler echocardiographic index for assessment of global right ventricular function
    • Tei C, Dujardin KS, Hodge DO, et al. Doppler echocardiographic index for assessment of global right ventricular function. J Am Soc Echocardiogr. 1996;9:838-847.
    • (1996) J Am Soc Echocardiogr. , vol.9 , pp. 838-847
    • Tei, C.1    Dujardin, K.S.2    Hodge, D.O.3
  • 65
    • 0032076759 scopus 로고    scopus 로고
    • Value of a Doppler-derived index combining systolic and diastolic time intervals in predicting outcome in primary pulmonary hypertension
    • Yeo TC, Dujardin KS, Tei C, et al. Value of a Doppler-derived index combining systolic and diastolic time intervals in predicting outcome in primary pulmonary hypertension. Am J Cardiol. 1998;81:1157-1161.
    • (1998) Am J Cardiol. , vol.81 , pp. 1157-1161
    • Yeo, T.C.1    Dujardin, K.S.2    Tei, C.3
  • 66
    • 0020628151 scopus 로고
    • Cyclic GMP as possible mediator of coronary arterial relaxation by nicorandil (SG-75)
    • Holzmann S. Cyclic GMP as possible mediator of coronary arterial relaxation by nicorandil (SG-75). J Cardiovasc Pharmacol. 1983;5:364-370.
    • (1983) J Cardiovasc Pharmacol. , vol.5 , pp. 364-370
    • Holzmann, S.1
  • 67
    • 13844256288 scopus 로고    scopus 로고
    • Sildenafil prevents endothelial dysfunction induced by ischemia and reperfusion via opening of adenosine triphosphate-sensitive potassium channels: A human in vivo study
    • Gori T, Sicuro S, Dragoni S, et al. Sildenafil prevents endothelial dysfunction induced by ischemia and reperfusion via opening of adenosine triphosphate-sensitive potassium channels: a human in vivo study. Circulation. 2005;111:742-746.
    • (2005) Circulation. , vol.111 , pp. 742-746
    • Gori, T.1    Sicuro, S.2    Dragoni, S.3
  • 68
    • 19844361803 scopus 로고    scopus 로고
    • Hemodynamic effects of sildenafil in patients with congestive heart failure and pulmonary hypertension: Combined administration with inhaled nitric oxide
    • Lepore JJ, Maroo A, Bigatello LM, et al. Hemodynamic effects of sildenafil in patients with congestive heart failure and pulmonary hypertension: combined administration with inhaled nitric oxide. Chest. 2005;127:1647-1653.
    • (2005) Chest. , vol.127 , pp. 1647-1653
    • Lepore, J.J.1    Maroo, A.2    Bigatello, L.M.3
  • 69
    • 0034537343 scopus 로고    scopus 로고
    • Hypotensive interaction of sildenafil and nicorandil in rats through the cGMP pathway but not by K(ATP) channel activation
    • Ishizuka N, Saito K, Akima M, et al. Hypotensive interaction of sildenafil and nicorandil in rats through the cGMP pathway but not by K(ATP) channel activation. Jpn J Pharmacol. 2000;84:316-324.
    • (2000) Jpn J Pharmacol. , vol.84 , pp. 316-324
    • Ishizuka, N.1    Saito, K.2    Akima, M.3
  • 70
    • 0028788150 scopus 로고
    • Neurohormonal activation in patients with right ventricular failure from pulmonary hypertension: Relation to hemodynamic variables and endothelin levels
    • Nootens M, Kaufmann E, Rector T, et al. Neurohormonal activation in patients with right ventricular failure from pulmonary hypertension: relation to hemodynamic variables and endothelin levels. J Am Coll Cardiol. 1995;26:1581-1585.
    • (1995) J Am Coll Cardiol. , vol.26 , pp. 1581-1585
    • Nootens, M.1    Kaufmann, E.2    Rector, T.3
  • 71
    • 0031024065 scopus 로고    scopus 로고
    • Haemodynamic and endocrine effects of type 1 angiotensin II receptor blockade in patients with hypoxaemic cor pulmonale
    • Kiely DG, Cargill RI, Wheeldon NM, et al. Haemodynamic and endocrine effects of type 1 angiotensin II receptor blockade in patients with hypoxaemic cor pulmonale. Cardiovasc Res. 1997;33:201-208.
    • (1997) Cardiovasc Res. , vol.33 , pp. 201-208
    • Kiely, D.G.1    Cargill, R.I.2    Wheeldon, N.M.3
  • 72
    • 0033584460 scopus 로고    scopus 로고
    • Hormones and hemodynamics in heart failure
    • Schrier RW, Abraham WT. Hormones and hemodynamics in heart failure. N Engl J Med. 1999;341:577-585.
    • (1999) N Engl J Med. , vol.341 , pp. 577-585
    • Schrier, R.W.1    Abraham, W.T.2
  • 73
    • 0023277525 scopus 로고
    • Alterations in cardiac beta-adrenoceptor responsiveness and adenylate cyclase system by congestive heart failure in dogs
    • Fan TH, Liang CS, Kawashima S, et al. Alterations in cardiac beta-adrenoceptor responsiveness and adenylate cyclase system by congestive heart failure in dogs. Eur J Pharmacol. 1987;140:123-132.
    • (1987) Eur J Pharmacol. , vol.140 , pp. 123-132
    • Fan, T.H.1    Liang, C.S.2    Kawashima, S.3
  • 74
    • 0026547854 scopus 로고
    • Beta-adrenergic neuroeffector abnormalities in the failing human heart are produced by local rather than systemic mechanisms
    • Bristow MR, Minobe W, Rasmussen R, et al. Beta-adrenergic neuroeffector abnormalities in the failing human heart are produced by local rather than systemic mechanisms. J Clin Invest. 1992;89:803-815.
    • (1992) J Clin Invest. , vol.89 , pp. 803-815
    • Bristow, M.R.1    Minobe, W.2    Rasmussen, R.3
  • 75
    • 33749346055 scopus 로고    scopus 로고
    • Contrasting inotropic responses to alpha1-adrenergic receptor stimulation in left versus right ventricular myocardium
    • Wang GY, McCloskey DT, Turcato S, et al. Contrasting inotropic responses to alpha1-adrenergic receptor stimulation in left versus right ventricular myocardium. Am J Physiol Heart Circ Physiol. 2006;291:H2013-H2017.
    • (2006) Am J Physiol Heart Circ Physiol. , vol.291 , pp. H2013-H2017
    • Wang, G.Y.1    McCloskey, D.T.2    Turcato, S.3
  • 76
    • 84855958098 scopus 로고    scopus 로고
    • Right ventricular dysfunction compromises accuracy of echocardiographic diagnosis of pulmonary hypertension in heart failure
    • McClanahan A, Guglin M. Right ventricular dysfunction compromises accuracy of echocardiographic diagnosis of pulmonary hypertension in heart failure. J Card Fail. 2011;17:1023-1027.
    • (2011) J Card Fail. , vol.17 , pp. 1023-1027
    • McClanahan, A.1    Guglin, M.2
  • 77
    • 0037364372 scopus 로고    scopus 로고
    • Echocardiographic assessment of pulmonary hypertension in patients with advanced lung disease
    • Arcasoy SM, Christie JD, Ferrari VA, et al. Echocardiographic assessment of pulmonary hypertension in patients with advanced lung disease. Am J Respir Crit Care Med. 2003;167:735-740.
    • (2003) Am J Respir Crit Care Med. , vol.167 , pp. 735-740
    • Arcasoy, S.M.1    Christie, J.D.2    Ferrari, V.A.3
  • 78
    • 0021917699 scopus 로고
    • Magnitude and implications of spontaneous hemodynamic variability in primary pulmonary hypertension
    • Rich S, D'Alonzo GE, Dantzker DR, et al. Magnitude and implications of spontaneous hemodynamic variability in primary pulmonary hypertension. Am J Cardiol. 1985;55:159-163.
    • (1985) Am J Cardiol. , vol.55 , pp. 159-163
    • Rich, S.1    D'Alonzo, G.E.2    Dantzker, D.R.3
  • 79
    • 84927765472 scopus 로고    scopus 로고
    • Pericardial effusion in pulmonary arterial hypertension
    • Sahay S, Tonelli AR. Pericardial effusion in pulmonary arterial hypertension. Pulm Circ. 2013;3:467-477.
    • (2013) Pulm Circ. , vol.3 , pp. 467-477
    • Sahay, S.1    Tonelli, A.R.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.