메뉴 건너뛰기




Volumn 18, Issue 1, 2013, Pages 60-69

Iptakalim ameliorates monocrotaline-induced pulmonary arterial hypertension in rats

Author keywords

ATP sensitive potassium channel opener; iptakalim; monocrotaline; pulmonary arterial hypertension

Indexed keywords

ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; BRAIN NATRIURETIC PEPTIDE; ENDOTHELIN 1; IPTAKALIM; MONOCROTALINE; NITRIC OXIDE; SODIUM CHLORIDE; TUMOR NECROSIS FACTOR ALPHA;

EID: 84871556857     PISSN: 10742484     EISSN: 19404034     Source Type: Journal    
DOI: 10.1177/1074248412458154     Document Type: Article
Times cited : (13)

References (44)
  • 1
  • 2
    • 70049112901 scopus 로고    scopus 로고
    • Guidelines for the diagnosis and treatment of pulmonary hypertension: The Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS), endorsed by the International Society of Heart and Lung Transplantation (ISHLT)
    • Galiè N, Hoeper MM, Humbert M, et al. Guidelines for the diagnosis and treatment of pulmonary hypertension: the Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS), endorsed by the International Society of Heart and Lung Transplantation (ISHLT). Eur Heart J. 2009 ; 30 (20). 2493-2537
    • (2009) Eur Heart J , vol.30 , Issue.20 , pp. 2493-2537
    • Galiè, N.1    Hoeper, M.M.2    Humbert, M.3
  • 3
  • 4
    • 75149192272 scopus 로고    scopus 로고
    • Nitric oxide, oxidative stress and inflammation in pulmonary arterial hypertension
    • Crosswhite P, Sun Z. Nitric oxide, oxidative stress and inflammation in pulmonary arterial hypertension. J Hypertens. 2010 ; 28 (2). 201-212
    • (2010) J Hypertens , vol.28 , Issue.2 , pp. 201-212
    • Crosswhite, P.1    Sun, Z.2
  • 5
    • 34548415037 scopus 로고    scopus 로고
    • The importance of endothelin-1 for vascular dysfunction in cardiovascular disease
    • Böhm F, Pernow J. The importance of endothelin-1 for vascular dysfunction in cardiovascular disease. Cardiovasc Res. 2007 ; 76 (1). 8-18
    • (2007) Cardiovasc Res , vol.76 , Issue.1 , pp. 8-18
    • Böhm, F.1    Pernow, J.2
  • 6
    • 70349260424 scopus 로고    scopus 로고
    • Resveratrol prevents monocrotaline-induced pulmonary hypertension in rats
    • Csiszar A, Labinskyy N, Olson S, et al. Resveratrol prevents monocrotaline-induced pulmonary hypertension in rats. Hypertension. 2009 ; 54 (3). 668-675
    • (2009) Hypertension , vol.54 , Issue.3 , pp. 668-675
    • Csiszar, A.1    Labinskyy, N.2    Olson, S.3
  • 7
    • 10744220901 scopus 로고    scopus 로고
    • Serotonin receptor antagonist inhibits monocrotaline-induced pulmonary hypertension and prolongs survival in rats
    • Hironaka E, Hongo M, Sakai A, et al. Serotonin receptor antagonist inhibits monocrotaline-induced pulmonary hypertension and prolongs survival in rats. Cardiovasc Res. 2003 ; 60 (3). 692-699
    • (2003) Cardiovasc Res , vol.60 , Issue.3 , pp. 692-699
    • Hironaka, E.1    Hongo, M.2    Sakai, A.3
  • 8
    • 77952192354 scopus 로고    scopus 로고
    • Idiopathic pulmonary arterial hypertension
    • Firth AL, Mandel J, Yuan JX. Idiopathic pulmonary arterial hypertension. Dis Model Mech. 2010 ; 3 (5-6). 268-273
    • (2010) Dis Model Mech , vol.3 , Issue.56 , pp. 268-273
    • Firth, A.L.1    Mandel, J.2    Yuan, J.X.3
  • 9
    • 33846013945 scopus 로고    scopus 로고
    • ATP-sensitive potassium channel openers and 2,3-dimethyl-2-butylamine derivatives
    • Wang H, Tang Y, Wang L, Long CL, Zhang YL. ATP-sensitive potassium channel openers and 2,3-dimethyl-2-butylamine derivatives. Curr Med Chem. 2007 ; 14 (2). 133-155
    • (2007) Curr Med Chem , vol.14 , Issue.2 , pp. 133-155
    • Wang, H.1    Tang, Y.2    Wang, L.3    Long, C.L.4    Zhang, Y.L.5
  • 10
    • 59849087929 scopus 로고    scopus 로고
    • Activation of ATP-sensitive potassium channels protects vascular endothelial cells from hypertension and renal injury induced by hyperuricemia
    • Long CL, Qin XC, Pan ZY, et al. Activation of ATP-sensitive potassium channels protects vascular endothelial cells from hypertension and renal injury induced by hyperuricemia. J Hypertens. 2008 ; 26 (12). 2326-2338
    • (2008) J Hypertens , vol.26 , Issue.12 , pp. 2326-2338
    • Long, C.L.1    Qin, X.C.2    Pan, Z.Y.3
  • 11
    • 77958498187 scopus 로고    scopus 로고
    • Activation of SUR2B/Kir6.1 subtype of adenosine triphosphate-sensitive potassium channel improves pressure overload induced cardiac remodeling via protecting endothelial function
    • Tang Y, Long CL, Wang RH, Cui W, Wang H. Activation of SUR2B/Kir6.1 subtype of adenosine triphosphate-sensitive potassium channel improves pressure overload induced cardiac remodeling via protecting endothelial function. J Cardiovasc Pharmacol. 2010 ; 56 (4). 345-353
    • (2010) J Cardiovasc Pharmacol , vol.56 , Issue.4 , pp. 345-353
    • Tang, Y.1    Long, C.L.2    Wang, R.H.3    Cui, W.4    Wang, H.5
  • 12
    • 14344259289 scopus 로고    scopus 로고
    • A new ATP-sensitive potassium channel opener reduces blood pressure and reverses cardiovascular remodeling in experimental hypertension
    • Wang H, Long CL, Zhang YL. A new ATP-sensitive potassium channel opener reduces blood pressure and reverses cardiovascular remodeling in experimental hypertension. J Pharmacol Exp Ther. 2005 ; 312 (3). 1326-1333
    • (2005) J Pharmacol Exp Ther , vol.312 , Issue.3 , pp. 1326-1333
    • Wang, H.1    Long, C.L.2    Zhang, Y.L.3
  • 13
    • 77957603729 scopus 로고    scopus 로고
    • Targeting hypertension with a new ATP sensitive potassium channel opener iptakalim
    • Pan Z, Huang J, Cui W, Long C, Zhang Y, Wang H. Targeting hypertension with a new ATP sensitive potassium channel opener iptakalim. J Cardiovasc Pharmacol. 2010 ; 56 (3). 215-228
    • (2010) J Cardiovasc Pharmacol , vol.56 , Issue.3 , pp. 215-228
    • Pan, Z.1    Huang, J.2    Cui, W.3    Long, C.4    Zhang, Y.5    Wang, H.6
  • 14
    • 0037282533 scopus 로고    scopus 로고
    • Pharmacological characteristics of the novel antihypertensive drug, iptakalim hydrochloride, and its molecular mechanisms
    • Pharmacological characteristics of the novel antihypertensive drug, iptakalim hydrochloride, and its molecular mechanisms. Drug Dev Res. 2003 ; 58: 65-68
    • (2003) Drug Dev Res , vol.58 , pp. 65-68
  • 15
    • 67651124964 scopus 로고    scopus 로고
    • KATP activation prevents progression of cardiac hypertrophy to failure induced by pressure overload via protecting endothelial function
    • Gao S, Long CL, Wang RH, Wang H. KATP activation prevents progression of cardiac hypertrophy to failure induced by pressure overload via protecting endothelial function. Cardiovasc Res. 2009 ; 83 (3). 444-456
    • (2009) Cardiovasc Res , vol.83 , Issue.3 , pp. 444-456
    • Gao, S.1    Long, C.L.2    Wang, R.H.3    Wang, H.4
  • 16
    • 4243059647 scopus 로고    scopus 로고
    • Effects of iptakalim hydrochloride, a novel KATP channel opener, on pulmonary vascular remodeling in hypoxic rats
    • Xie WP, Wang H, Wang H, Hu G. Effects of iptakalim hydrochloride, a novel KATP channel opener, on pulmonary vascular remodeling in hypoxic rats. Life Sci. 2004 ; 75 (17). 2065-2076
    • (2004) Life Sci , vol.75 , Issue.17 , pp. 2065-2076
    • Xie, W.P.1    Wang, H.2    Wang, H.3    Hu, G.4
  • 17
    • 15744397784 scopus 로고    scopus 로고
    • Anti-proliferating effect of iptakalim, a novel KATP channel opener, in cultured rabbit pulmonary arterial smooth muscle cells
    • Xie W, Wang H, Ding J, Wang H, Hu G.. Anti-proliferating effect of iptakalim, a novel KATP channel opener, in cultured rabbit pulmonary arterial smooth muscle cells. Eur J Pharmacol. 2005 ; 511 (2-3). 81-87
    • (2005) Eur J Pharmacol , vol.511 , Issue.23 , pp. 81-87
    • Xie, W.1    Wang, H.2    Ding, J.3    Wang, H.4    Hu, G.5
  • 18
    • 40149089375 scopus 로고    scopus 로고
    • Iptakalim inhibited endothelin-1-induced proliferation of human pulmonary arterial smooth muscle cells through the activation of KATP channel
    • Zhu Y, Zhang S, Xie W, Li Q, Zhou Y, Wang H. Iptakalim inhibited endothelin-1-induced proliferation of human pulmonary arterial smooth muscle cells through the activation of KATP channel. Vasc Pharmacol. 2008 ; 48 (2-3). 92-99
    • (2008) Vasc Pharmacol , vol.48 , Issue.23 , pp. 92-99
    • Zhu, Y.1    Zhang, S.2    Xie, W.3    Li, Q.4    Zhou, Y.5    Wang, H.6
  • 19
    • 71949129187 scopus 로고    scopus 로고
    • Animal models of pulmonary arterial hypertension: The hope for etiological discovery and pharmacological cure
    • Stenmark KR, Meyrick B, Galie N, Mooi WJ, McMurtry IF. Animal models of pulmonary arterial hypertension: the hope for etiological discovery and pharmacological cure. Am J Physiol Lung Cell Mol Physiol. 2009 ; 297 (6). L1013 - L1032
    • (2009) Am J Physiol Lung Cell Mol Physiol , vol.297 , Issue.6
    • Stenmark, K.R.1    Meyrick, B.2    Galie, N.3    Mooi, W.J.4    McMurtry, I.F.5
  • 20
    • 34247899006 scopus 로고    scopus 로고
    • Animal models of pulmonary arterial hypertension
    • Naeije R, Dewachter L. Animal models of pulmonary arterial hypertension. Rev Mal Respir. 2007 ; 24 (4 pt 1). 481-496
    • (2007) Rev Mal Respir , vol.24 , Issue.4 PART 1 , pp. 481-496
    • Naeije, R.1    Dewachter, L.2
  • 22
    • 0032474287 scopus 로고    scopus 로고
    • Endothelin A receptor blockade improves nitric oxide-mediated vasodilation in monocrotaline-induced pulmonary hypertension
    • Prié S, Stewart DJ, Dupuis J. Endothelin A receptor blockade improves nitric oxide-mediated vasodilation in monocrotaline-induced pulmonary hypertension. Circulation. 1998 ; 97 (21). 2169-2174
    • (1998) Circulation , vol.97 , Issue.21 , pp. 2169-2174
    • Prié, S.1    Stewart, D.J.2    Dupuis, J.3
  • 23
    • 33644541826 scopus 로고    scopus 로고
    • Genistein, a phytoestrogen, attenuates monocrotaline-induced pulmonary hypertension
    • Homma N, Morio Y, Takahashi H, et al. Genistein, a phytoestrogen, attenuates monocrotaline-induced pulmonary hypertension. Respiration. 2006 ; 73 (1). 105-112
    • (2006) Respiration , vol.73 , Issue.1 , pp. 105-112
    • Homma, N.1    Morio, Y.2    Takahashi, H.3
  • 24
    • 73349135641 scopus 로고    scopus 로고
    • Tadalafil, a long-acting inhibitor of PDE5, improves pulmonary hemodynamics and survival rate of monocrotaline-induced pulmonary artery hypertension in rats
    • Sawamura F, Kato M, Fujita K, Nakazawa T, Beardsworth A. Tadalafil, a long-acting inhibitor of PDE5, improves pulmonary hemodynamics and survival rate of monocrotaline-induced pulmonary artery hypertension in rats. J Pharmacol Sci. 2009 ; 111 (3). 235-243
    • (2009) J Pharmacol Sci , vol.111 , Issue.3 , pp. 235-243
    • Sawamura, F.1    Kato, M.2    Fujita, K.3    Nakazawa, T.4    Beardsworth, A.5
  • 25
    • 33846117876 scopus 로고    scopus 로고
    • Protecting endothelial function: A novel therapeutic target of ATP-sensitive potassium channel openers
    • Minamino T, Hori M. Protecting endothelial function: a novel therapeutic target of ATP-sensitive potassium channel openers. Cardiovasc Res. 2007 ; 73 (3). 448-449
    • (2007) Cardiovasc Res , vol.73 , Issue.3 , pp. 448-449
    • Minamino, T.1    Hori, M.2
  • 26
    • 33846116157 scopus 로고    scopus 로고
    • A new ATP-sensitive potassium channel opener protects endothelial function in cultured aortic endothelial cells
    • Wang H, Long C, Duan Z, Shi C, Jia G, Zhang Y. A new ATP-sensitive potassium channel opener protects endothelial function in cultured aortic endothelial cells. Cardiovasc Res. 2007 ; 73 (3). 497-503
    • (2007) Cardiovasc Res , vol.73 , Issue.3 , pp. 497-503
    • Wang, H.1    Long, C.2    Duan, Z.3    Shi, C.4    Jia, G.5    Zhang, Y.6
  • 28
    • 38149109703 scopus 로고    scopus 로고
    • Recent advances in natriuretic peptide research
    • Woodard Ge, Rosado JA.. Recent advances in natriuretic peptide research. J Cell Mol Med. 2007 ; 11 (6). 1263-1271
    • (2007) J Cell Mol Med , vol.11 , Issue.6 , pp. 1263-1271
    • Ge, W.1    Rosado, J.A.2
  • 29
    • 0345707647 scopus 로고    scopus 로고
    • Regulatory effects of iNOS on acute lung inflammatory responses in mice
    • Speyer CL, Neff TA, Warner RL, et al. Regulatory effects of iNOS on acute lung inflammatory responses in mice. Am J Pathol. 2003 ; 163 (6). 2319-2328
    • (2003) Am J Pathol , vol.163 , Issue.6 , pp. 2319-2328
    • Speyer, C.L.1    Neff, T.A.2    Warner, R.L.3
  • 30
    • 72749124664 scopus 로고    scopus 로고
    • Mediators released from LPS-challenged lungs induce inflammatory responses in liver vascular endothelial cells and neutrophilic leukocytes
    • Markovic N, McCaig LA, Stephen J, et al. Mediators released from LPS-challenged lungs induce inflammatory responses in liver vascular endothelial cells and neutrophilic leukocytes. Am J Physiol Gastrointest Liver Physiol. 2009 ; 297 (6). G1066 - G1076
    • (2009) Am J Physiol Gastrointest Liver Physiol , vol.297 , Issue.6
    • Markovic, N.1    McCaig, L.A.2    Stephen, J.3
  • 31
    • 20344365090 scopus 로고    scopus 로고
    • Serotonin transporter inhibition prevents and reverses monocrotaline-induced pulmonary hypertension in rats
    • Guignabert C, Raffestin B, Benferhat R, et al. Serotonin transporter inhibition prevents and reverses monocrotaline-induced pulmonary hypertension in rats. Circulation. 2005 ; 111 (21). 2812-2819
    • (2005) Circulation , vol.111 , Issue.21 , pp. 2812-2819
    • Guignabert, C.1    Raffestin, B.2    Benferhat, R.3
  • 32
    • 0033564747 scopus 로고    scopus 로고
    • Nitric oxide synthases in the failing human heart: A doubled-edged sword?
    • Drexler H. Nitric oxide synthases in the failing human heart: a doubled-edged sword?. Circulation. 1999 ; 99 (23). 2972-2975
    • (1999) Circulation , vol.99 , Issue.23 , pp. 2972-2975
    • Drexler, H.1
  • 33
    • 0027418514 scopus 로고
    • Porcine ventricular endocardial cells in culture express the inducible form of nitric oxide synthase
    • Smith JA, Radomski MW, Schulz R, Moncada S, Lewis MJ. Porcine ventricular endocardial cells in culture express the inducible form of nitric oxide synthase. Br J Pharmacol. 1993 ; 108 (4). 1107-1110
    • (1993) Br J Pharmacol , vol.108 , Issue.4 , pp. 1107-1110
    • Smith, J.A.1    Radomski, M.W.2    Schulz, R.3    Moncada, S.4    Lewis, M.J.5
  • 34
    • 0030754628 scopus 로고    scopus 로고
    • Inhibition of constitutive nitric oxide synthase (NOS) by nitric oxide generated by inducible NOS after lipopolysaccharide administration provokes renal dysfunction in rats
    • Schwartz D, Mendonca M, Schwartz I, et al. Inhibition of constitutive nitric oxide synthase (NOS) by nitric oxide generated by inducible NOS after lipopolysaccharide administration provokes renal dysfunction in rats. J Clin Invest. 1997 ; 100 (2). 439-448
    • (1997) J Clin Invest , vol.100 , Issue.2 , pp. 439-448
    • Schwartz, D.1    Mendonca, M.2    Schwartz, I.3
  • 35
    • 68249150556 scopus 로고    scopus 로고
    • Serial noninvasive assessment of apoptosis during right ventricular disease progression in rats
    • Campian ME, Verberne HJ, Hardziyenka M, et al. Serial noninvasive assessment of apoptosis during right ventricular disease progression in rats. J Nucl Med. 2009 ; 50 (8). 1371-1377
    • (2009) J Nucl Med , vol.50 , Issue.8 , pp. 1371-1377
    • Campian, M.E.1    Verberne, H.J.2    Hardziyenka, M.3
  • 36
    • 0033593596 scopus 로고    scopus 로고
    • Modulation of cytokine-induced cardiac myocyte apoptosis by nitric oxide, Bak, and Bcl-x
    • Ing DJ, Zang J, Dzau VJ, Webster KA, Bishopric NH. Modulation of cytokine-induced cardiac myocyte apoptosis by nitric oxide, Bak, and Bcl-x. Circ Res. 1999 ; 84 (1). 21-33
    • (1999) Circ Res , vol.84 , Issue.1 , pp. 21-33
    • Ing, D.J.1    Zang, J.2    Dzau, V.J.3    Webster, K.A.4    Bishopric, N.H.5
  • 37
    • 63849121398 scopus 로고    scopus 로고
    • Role of oxidative and nitrosative stress biomarkers in chronic heart failure
    • Eleuteri E, Magno F, Gnemmi I, et al. Role of oxidative and nitrosative stress biomarkers in chronic heart failure. Front Biosci. 2009 ; 14: 2230-2237
    • (2009) Front Biosci , vol.14 , pp. 2230-2237
    • Eleuteri, E.1    Magno, F.2    Gnemmi, I.3
  • 38
    • 77649337086 scopus 로고    scopus 로고
    • Role of apoptosis in pulmonary hypertension: From experimental models to clinical trials
    • Jurasz P, Courtman D, Babaie S, Stewart DJ. Role of apoptosis in pulmonary hypertension: from experimental models to clinical trials. Pharmacol Ther. 2010 ; 126 (1). 1-8
    • (2010) Pharmacol Ther , vol.126 , Issue.1 , pp. 1-8
    • Jurasz, P.1    Courtman, D.2    Babaie, S.3    Stewart, D.J.4
  • 39
    • 67649844313 scopus 로고    scopus 로고
    • Inflammation, growth factors, and pulmonary vascular remodeling
    • Hassoun PM, Mouthon L, Barberà JA, et al. Inflammation, growth factors, and pulmonary vascular remodeling. J Am Coll Cardiol. 2009 ; 54 (1 suppl). S10 - S19
    • (2009) J Am Coll Cardiol , vol.54 , Issue.1 SUPPL.
    • Hassoun, P.M.1    Mouthon, L.2    Barberà, J.A.3
  • 40
    • 77951742414 scopus 로고    scopus 로고
    • L-arginine enhances nitrative stress and exacerbates tumor necrosis factor-alpha toxicity to human endothelial cells in culture: Prevention by propofol
    • Xia Z, Luo T, Liu HM, et al. L-arginine enhances nitrative stress and exacerbates tumor necrosis factor-alpha toxicity to human endothelial cells in culture: prevention by propofol. J Cardiovasc Pharmacol. 2010 ; 55 (4). 358-367
    • (2010) J Cardiovasc Pharmacol , vol.55 , Issue.4 , pp. 358-367
    • Xia, Z.1    Luo, T.2    Liu, H.M.3
  • 41
    • 77957125679 scopus 로고    scopus 로고
    • Peroxynitrite mediates right-ventricular dysfunction in nitric oxide-exposed juvenile rats
    • Jankov RP, Lewis P, Kantores C, et al. Peroxynitrite mediates right-ventricular dysfunction in nitric oxide-exposed juvenile rats. Free Radic Biol Med. 2010 ; 49 (9). 1453-1467
    • (2010) Free Radic Biol Med , vol.49 , Issue.9 , pp. 1453-1467
    • Jankov, R.P.1    Lewis, P.2    Kantores, C.3
  • 42
    • 8644277006 scopus 로고    scopus 로고
    • Reactive oxygen species in vascular biology: Implications in hypertension
    • Touyz RM, Schiffrin EL. Reactive oxygen species in vascular biology: implications in hypertension. Histochem Cell Biol. 2004 ; 122 (4). 339-352
    • (2004) Histochem Cell Biol , vol.122 , Issue.4 , pp. 339-352
    • Touyz, R.M.1    Schiffrin, E.L.2
  • 43
    • 25144453937 scopus 로고    scopus 로고
    • NADPH oxidase and endothelial cell function
    • Ray R, Shah AM. NADPH oxidase and endothelial cell function. Clin Sci (Lond). 2005 ; 109 (3). 217-226
    • (2005) Clin Sci (Lond) , vol.109 , Issue.3 , pp. 217-226
    • Ray, R.1    Shah, A.M.2
  • 44
    • 34547828784 scopus 로고    scopus 로고
    • Right-ventricular failure is associated with increased mitochondrial complex II activity and production of reactive oxygen species
    • Redout EM, Wagner MJ, Zuidwijk MJ, et al. Right-ventricular failure is associated with increased mitochondrial complex II activity and production of reactive oxygen species. Cardiovasc Res. 2007 ; 75 (4). 770-781
    • (2007) Cardiovasc Res , vol.75 , Issue.4 , pp. 770-781
    • Redout, E.M.1    Wagner, M.J.2    Zuidwijk, M.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.