Hypotensive interaction of sildenafil and nicorandil in rats through the cGMP pathway but not by K(ATP) channel activation

Japanese Journal of Pharmacology

Volumn 84, Issue 3, 2000, Pages 316-324

  Ishizuka, N ^a   Saito, K ^a   Akima, M ^a   Matsubara, S ^a   Saito, M ^a  

^a CHUGAI PHARMACEUTICAL CO LTD   (Japan)

Author keywords

cGMP; K(ATP) channel; Nicorandil; Sildenafil

Indexed keywords

1H 1,2,4 OXADIAZOLO[4,3 A]QUINOXALIN 1 ONE; CYCLIC GMP; GLIBENCLAMIDE; GLYCERYL TRINITRATE; NICORANDIL; NITRIC OXIDE; PINACIDIL; POTASSIUM CHANNEL; SILDENAFIL;

ANIMAL CELL; ANIMAL TISSUE; AORTA; AORTA CONSTRICTION; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG POTENTIATION; HYPOTENSION; IN VITRO STUDY; IN VIVO STUDY; MALE; NONHUMAN; RAT; SMOOTH MUSCLE FIBER; SMOOTH MUSCLE RELAXATION; VASCULAR ENDOTHELIUM; VASODILATATION;

EID: 0034537343     PISSN: 00215198     EISSN: None     Source Type: Journal    
DOI: 10.1254/jjp.84.316     Document Type: Article

References (35)

1. Sildenafil, a novel effective oral therapy for male erectile dysfunction
2. Nitric oxide in the penis: Physiology and pathology
3. Viagra leads as rivals are moving up
4. Tissue distribution of phosphodiesterase families and the effects of sildenafil on tissue cyclic nucleotides, platelet function, and the contractile responses of trabeculae carneae and aortic rings in vitro
5. Cyclic nucleotide phosphodiesterases: Functional implications of multiple isoforms
6. Effects of sildenafil on the relaxation of human corpus cavernosum tissue in vitro and on the activities of cyclic nucleotide phosphodiesterase isozymes
7. Use of sildenafil (Viagra) in patients with cardiovascular disease. Technology and Practice Executive Committee
8. Role of nitric oxide in the physiology of erection
9. Cardiovascular effects of sildenafil citrate and recommendation for its use
10. Nicorandil as a hybrid between nitrates and potassium channel activators
11. Effects of nicorandil on human isolated corpus cavernosum and cavernous artery
12. 86Rb efflux and isometric vasorelaxation studies in vascular smooth muscle
13. + channels and cyclic GMP as components of vasodilation by nicorandil
14. Vascular levels and cGMP-increasing effects of nicorandil administered orally to rats
15. + channels responsible for adenosine A2 receptor-mediated vaso-depression does not involve a pertussis toxin-sensitive G protein
16. Sildenafil: Study of a novel oral treatment for erectile dysfunction in diabetic men
17. Efficacy and safety of oral sildenafil (Viagra) in men with erectile dysfunction caused by spinal cord injury
18. cGMP mediates the vascular and platelet actions of nitric oxide: Confirmation using an inhibitor of the soluble guanylyl cyclase
19. Nitric oxide in the regulation of blood flow and arterial pressure
20. Sildenafil: An orally active type 5 cyclic GMP-specific phosphodiesterase inhibitor for the treatment of penile erectile dysfunction
21. Sildenafil citrate and blood-pressure-lowering drugs: Results of drug interaction studies with an organic nitrate and a calcium antagonist
22. Nitric oxide: Physiology, pathophysiology and pharmacology
23. Nitric oxide directly activates calcium-dependent potassium channels in vascular smooth muscle
24. Nitroglycerin-mediated vasorelaxation is modulated by endothelial calcium-activated potassium channels
25. ++ stores
26. ANF elicits phosphorylation of the cGMP phosphodiesterase in vascular smooth muscle cells
27. Expression of cyclic GMP-inhibited phosphodiesterases 3A and 3B (PDE3A and PDE3B) in rat tissues: Differential subcellular localization and regulated expression by cyclic AMP
28. Expression of inducible nitric oxide synthase in human coronary atherosclerotic plaque
29. Potentiating effect of nicorandil, an antianginal agent, on relaxation induced by isoproterenol in isolated rat aorta: Involvement of cyclic GMP-inhibitable cyclic AMP phosphodiesterase
30. + currents in rabbit arterial smooth muscle via protein kinase
31. Effects of 2-nicotinamid-ethyl nitrate (SG-75), a new antianginal drug, on the cyclic AMP phosphodiesterase activity
32. Comparison of nicorandil-induced relaxation, elevations of cyclic guanosine monophosphate and stimulation of guanylate cyclase with organic nitrate esters
33. + -channel openers, and nicorandil on large and small coronary arteries in conscious dogs
34. Mechanism of the vasodilatory action of nicorandil on coronary circulation in dogs