Crystal Structure of Antagonist Bound Human Lysophosphatidic Acid Receptor 1

Cell

Volumn 161, Issue 7, 2015, Pages 1633-1643

  Chrencik, Jill E ^a,h   Roth, Christopher B ^a   Terakado, Masahiko ^b   Kurata, Haruto ^b   Omi, Rie ^b   Kihara, Yasuyuki ^e   Warshaviak, Dora ^c   Nakade, Shinji ^b   Asmar Rovira, Guillermo ^a   Mileni, Mauro ^a,g   Mizuno, Hirotaka ^b,e   Griffith, Mark T ^a   Rodgers, Caroline ^a   Han, Gye Won ^d   Velasquez, Jeffrey ^d   Chun, Jerold ^e   Stevens, Raymond C ^d,f   Hanson, Michael A ^a,i  

^a Receptos   (United States)

^b ONO PHARMACEUTICAL CO   (Japan)

^c SCHRÖDINGER INC   (United States)

^d UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^e SCRIPPS RESEARCH INSTITUTE   (United States)

^f SHANGHAITECH UNIVERSITY   (China)

^g Abilita Bio Inc   (United States)

^h PFIZER INC   (United States)

ⁱ GPCR Consortium   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOCANNABINOID; G PROTEIN COUPLED RECEPTOR; LYSOPHOSPHATIDIC ACID; LYSOPHOSPHATIDIC ACID RECEPTOR; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE 1 PHOSPHATE RECEPTOR; LIGAND; MOLECULAR LIBRARY;

ALPHA HELIX; ARTICLE; CALCIUM MOBILIZATION ASSAY; CELL MEMBRANE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; CRYSTALLIZATION; DISULFIDE BOND; EXTRACELLULAR SPACE; GLOBAL CHANGE; HUMAN; HYDROCEPHALUS; HYPOTHESIS; LIPOPHILICITY; METABOLIC STABILITY; MOLECULAR DYNAMICS; MOLECULAR RECOGNITION; POLYPHARMACOLOGY; PRIORITY JOURNAL; PROTEIN SECONDARY STRUCTURE; QUANTUM MECHANICS; ANTAGONISTS AND INHIBITORS; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; MOLECULAR LIBRARY; SIZE EXCLUSION CHROMATOGRAPHY; X RAY CRYSTALLOGRAPHY;

BINDING SITES; CHROMATOGRAPHY, GEL; CRYSTALLOGRAPHY, X-RAY; HUMANS; LIGANDS; MODELS, MOLECULAR; RECEPTORS, LYSOPHOSPHATIDIC ACID; RECEPTORS, LYSOSPHINGOLIPID; SMALL MOLECULE LIBRARIES;

EID: 84934965135     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2015.06.002     Document Type: Article

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