Structural definitions of Jumonji family demethylase selectivity

Drug Discovery Today

Volumn 20, Issue 6, 2015, Pages 743-749

  Pilka, Ewa S ^a   James, Tim ^a   Lisztwan, Joanna Hergovich ^a  

^a EVOTEC UK LTD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE; HISTONE DEMETHYLASE; METHYL GROUP; ENZYME INHIBITOR; PROTEIN BINDING;

ARTICLE; DIMERIZATION; ENZYME ACTIVE SITE; ENZYME MECHANISM; ENZYME STRUCTURE; EPIGENETICS; HUMAN; MOLECULAR RECOGNITION; PROTEIN DOMAIN; PROTEIN METHYLATION; ANIMAL; ANTAGONISTS AND INHIBITORS; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG DESIGN; ENZYME SPECIFICITY; GENETIC EPIGENESIS; METABOLISM; PROTEIN TERTIARY STRUCTURE; STRUCTURE ACTIVITY RELATION;

ANIMALS; BINDING SITES; CATALYTIC DOMAIN; DRUG DESIGN; ENZYME INHIBITORS; EPIGENESIS, GENETIC; HUMANS; JUMONJI DOMAIN-CONTAINING HISTONE DEMETHYLASES; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 84934940832     PISSN: 13596446     EISSN: 18785832     Source Type: Journal    
DOI: 10.1016/j.drudis.2014.12.013     Document Type: Review

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