메뉴 건너뛰기




Volumn 942, Issue , 2013, Pages 179-191

Strategies for designing and validating immunostimulatory siRNAs

(1)  Gantier, Michael P a  

a NONE

Author keywords

Bifunctional siRNA; Innate immunity; RIG I; RNA interference; SiRNA; TLR7; TLR8; TLR9

Indexed keywords

DNA; LIPID; RETINOIC ACID INDUCIBLE PROTEIN I; SMALL INTERFERING RNA; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 8; TOLL LIKE RECEPTOR 9; TUMOR NECROSIS FACTOR ALPHA;

EID: 84934441252     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-62703-119-6_10     Document Type: Article
Times cited : (5)

References (33)
  • 2
    • 22344454846 scopus 로고    scopus 로고
    • Sequencedependent stimulation of the mammalian innate immune response by synthetic siRNA
    • Judge AD, Sood V, Shaw JR, Fang D, McClintock K, MacLachlan I (2005) Sequencedependent stimulation of the mammalian innate immune response by synthetic siRNA. Nat Biotechnol 23:457-462
    • (2005) Nat Biotechnol , vol.23 , pp. 457-462
    • Judge, A.D.1    Sood, V.2    Shaw, S.R.3    Fang, D.4    McClintock, K.5    Maclachlan, I.6
  • 4
    • 34548129595 scopus 로고    scopus 로고
    • The response of mammalian cells to double-stranded RNA
    • Gantier MP, Williams BR (2007) The response of mammalian cells to double-stranded RNA. Cytokine Growth Factor Rev 18:363-371
    • (2007) Cytokine Growth Factor Rev , vol.18 , pp. 363-371
    • Gantier, M.P.1    Williams, B.R.2
  • 5
    • 32944454941 scopus 로고    scopus 로고
    • Design of nonin flammatory synthetic siRNA mediating potent gene silencing in vivo
    • Judge AD, Bola G, Lee AC, MacLachlan I (2006) Design of nonin flammatory synthetic siRNA mediating potent gene silencing in vivo. Mol Ther 13:494-505
    • (2006) Mol Ther , vol.13 , pp. 494-505
    • Judge, A.D.1    Bola, G.2    Lee, A.C.3    Maclachlan, I.4
  • 9
    • 79959788938 scopus 로고    scopus 로고
    • Immunostimulatory motifs enhance antiviral siRNAs targeting highly pathogenic avian in fluenza H5N1
    • Stewart CR, Karpala AJ, Lowther S, Lowenthal JW, Bean AG (2011) Immunostimulatory motifs enhance antiviral siRNAs targeting highly pathogenic avian in fluenza H5N1. PLoS One 6:e21552
    • (2011) PLoS One , vol.6
    • Stewart, C.R.1    Karpala, A.J.2    Lowther, S.3    Lowenthal, J.W.4    Bean, A.G.5
  • 10
    • 80053330165 scopus 로고    scopus 로고
    • Reverse of HBV-induced immune tolerance by an immunostimulatory 3p-HBx-siRNA in a retinoic acid inducible gene i (RIG-I) -dependent manner
    • Han Q, Zhang C, Zhang J, Tian Z (2011) Reverse of HBV-induced immune tolerance by an immunostimulatory 3p-HBx-siRNA in a retinoic acid inducible gene I (RIG-I) -dependent manner. Hepatology 54(4):1179-1189
    • (2011) Hepatology , vol.54 , Issue.4 , pp. 1179-1189
    • Han, Q.1    Zhang, C.2    Zhang, J.3    Tian, Z.4
  • 11
    • 80051526424 scopus 로고    scopus 로고
    • 5′Triphosphorylated small interfering RNAs control replication of hepatitis B virus and induce an interferon response in human liver cells and mice
    • Ebert G, Poeck H, Lucifora J, Baschuk N, Esser K, Esposito I, Hartmann G, Protzer U (2011) 5′Triphosphorylated small interfering RNAs control replication of hepatitis B virus and induce an interferon response in human liver cells and mice. Gastroenterology 141(2):696-706
    • (2011) Gastroenterology , vol.141 , Issue.2 , pp. 696-706
    • Ebert, G.1    Poeck, H.2    Lucifora, J.3    Baschuk, N.4    Esser, K.5    Esposito, I.6    Hartmann, G.7    Protzer, U.8
  • 14
    • 0344926320 scopus 로고    scopus 로고
    • Cationic liposome- mediated delivery of siRNAs in adult mice
    • Sioud M, Sorensen DR (2003) Cationic liposome- mediated delivery of siRNAs in adult mice. Biochem Biophys Res Commun 312:1220-1225
    • (2003) Biochem Biophys Res Commun , vol.312 , pp. 1220-1225
    • Sioud, M.1    Sorensen, D.R.2
  • 15
    • 33748069824 scopus 로고    scopus 로고
    • SiRNA and isRNA: Two edges of one sword
    • Schlee M, Hornung V, Hartmann G (2006) siRNA and isRNA: two edges of one sword. Mol Ther 14:463-470
    • (2006) Mol Ther , vol.14 , pp. 463-470
    • Schlee, M.1    Hornung, V.2    Hartmann, G.3
  • 16
  • 21
    • 33646544416 scopus 로고    scopus 로고
    • Single-stranded small interfering RNA are more immunostimulatory than their double-stranded counterparts: A central role for 2′-hydroxyl uridines in immune responses
    • Sioud M (2006) Single-stranded small interfering RNA are more immunostimulatory than their double-stranded counterparts: a central role for 2′-hydroxyl uridines in immune responses. Eur J Immunol 36:1222-1230
    • (2006) Eur J Immunol , vol.36 , pp. 1222-1230
    • Sioud, M.1
  • 24
    • 0036811055 scopus 로고    scopus 로고
    • Effects on RNA interference in gene expression (RNAi) in cultured mammalian cells of mismatches and the introduction of chemical modifications at the 3′-ends of siRNAs
    • Hamada M, Ohtsuka T, Kawaida R, Koizumi M, Morita K, Furukawa H, Imanishi T, Miyagishi M, Taira K (2002) Effects on RNA interference in gene expression (RNAi) in cultured mammalian cells of mismatches and the introduction of chemical modifications at the 3′-ends of siRNAs. Antisense Nucleic Acid Drug Dev 12:301-309
    • (2002) Antisense Nucleic Acid Drug Dev , vol.12 , pp. 301-309
    • Hamada, M.1    Ohtsuka, T.2    Kawaida, R.3    Koizumi, M.4    Morita, K.5    Furukawa, H.6    Imanishi, T.7    Miyagishi, M.8    Taira, K.9
  • 28
    • 77954242369 scopus 로고    scopus 로고
    • The chase for the RIG-I ligand - Recent advances
    • Schlee M, Hartmann G (2010) The chase for the RIG-I ligand - recent advances. Mol Ther 18:1254-1262
    • (2010) Mol Ther , vol.18 , pp. 1254-1262
    • Schlee, M.1    Hartmann, G.2
  • 32
    • 0036570169 scopus 로고    scopus 로고
    • Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides
    • Hornung V, Rothenfusser S, Britsch S, Krug A, Jahrsdorfer B, Giese T, Endres S, Hartmann G (2002) Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides. J Immunol 168:4531-4537
    • (2002) J Immunol , vol.168 , pp. 4531-4537
    • Hornung, V.1    Rothenfusser, S.2    Britsch, S.3    Krug, A.4    Jahrsdorfer, B.5    Giese, T.6    Endres, S.7    Hartmann, G.8
  • 33
    • 77952305853 scopus 로고    scopus 로고
    • Monitoring innate immune recruitment by siRNAs in mammalian cells
    • Gantier MP, Williams BR (2010) Monitoring innate immune recruitment by siRNAs in mammalian cells. Methods Mol Biol 623:21-33
    • (2010) Methods Mol Biol , vol.623 , pp. 21-33
    • Gantier, M.P.1    Williams, B.R.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.