Benserazide, the first allosteric inhibitor of Coxsackievirus B3 3C protease

FEBS Letters

Volumn 589, Issue 15, 2015, Pages 1795-1801

  Kim, Bo Kyoung ^a   Cho, Joong Heui ^b   Jeong, Pyeonghwa ^a   Lee, Youngjin ^a   Lim, Jia Jia ^a   Park, Kyoung Ryoung ^a   Eom, Soo Hyun ^a   Kim, Yong Chul ^a  

^a Gwangju Institute of Science and Technology (GIST)   (South Korea)

^b Daegu Gyeongbuk Medical Innovation Foundation   (South Korea)

Author keywords

3C protease; Allosteric binding site; Benserazide; Coxsackievirus B3; Enzyme kinetics; Non competitive inhibitor

Indexed keywords

AROMATIC LEVO AMINO ACID DECARBOXYLASE; BENSERAZIDE; COXSACKIEVIRUS 3C PROTEASE; HYDRAZONE DERIVATIVE; PROTEINASE; PROTEINASE INHIBITOR; UNCLASSIFIED DRUG; 3C PROTEASES; CYSTEINE PROTEINASE; VIRUS PROTEIN;

ARTICLE; CONTROLLED STUDY; COXSACKIEVIRUS B3; DRUG BINDING; DRUG BINDING SITE; DRUG SCREENING; DRUG STRUCTURE; ENZYME INHIBITION; ENZYME KINETICS; FLUORESCENCE RESONANCE ENERGY TRANSFER; MOLECULAR DOCKING; NONHUMAN; PHARMACOPHORE; PRIORITY JOURNAL; ANTAGONISTS AND INHIBITORS; BINDING SITE; ENTEROVIRUS B; ENZYMOLOGY; GENETICS;

COXSACKIEVIRUS;

ALLOSTERIC SITE; BENSERAZIDE; CYSTEINE ENDOPEPTIDASES; ENTEROVIRUS B, HUMAN; FLUORESCENCE RESONANCE ENERGY TRANSFER; MOLECULAR DOCKING SIMULATION; PROTEASE INHIBITORS; VIRAL PROTEINS;

EID: 84934438222     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2015.05.027     Document Type: Article

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