Development of anti-coxsackievirus agents targeting 3C protease

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 22, 2012, Pages 6952-6956

  Kim, Bo Kyoung ^a   Kim, Jeong Hyun ^a   Kim, Na Ri ^a   Lee, Won Gil ^a   Lee, So Deok ^a   Yun, Soo Hyeon ^b   Jeon, Eun Seok ^b   Kim, Yong Chul ^a  

^a Gwangju Institute of Science and Technology (GIST)   (South Korea)

^b Sungkyunkwan University   (South Korea)

Author keywords

3C protease; Coxsackievirus B3; Enzyme inhibitors

Indexed keywords

5 YL BENZIMIDAZOLE; 5 YL INDAZOL; 6 YL INDAZOL; ALPHA BETA UNSATURATED ESTER; ANTIVIRUS AGENT; BENZIMIDAZOLE DERIVATIVE; CHLOROBENZIMIDAZOLE; CHLOROIMIDAZOLE; CYSTEINE; ENZYME INHIBITOR; ESTER; INDAZOLE DERIVATIVE; ISOQUINOLINE DERIVATIVE; METHYLIMIDAZO PYRIDINE DERIVATIVE; OXADIAZOLO PYRIDINE DERIVATIVE; PEPTIDOMIMETIC AGENT; PROTEINASE; PROTEINASE CVB3; PYRIDINE DERIVATIVE; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CHEMICAL INTERACTION; CONTROLLED STUDY; COXSACKIE VIRUS B3; CYTOTOXICITY; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME ASSAY; ENZYME BINDING; ENZYME INHIBITION; HUMAN; HUMAN CELL; HYDROGEN BOND; IC 50; MOLECULAR DOCKING; STRUCTURE ACTIVITY RELATION;

ANTIVIRAL AGENTS; BINDING SITES; CATALYTIC DOMAIN; CELL SURVIVAL; CYSTEINE ENDOPEPTIDASES; ENTEROVIRUS; HELA CELLS; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; HYDROGEN BONDING; MOLECULAR DOCKING SIMULATION; OLIGOPEPTIDES; PROTEASE INHIBITORS; QUINOLINES; VIRAL PROTEINS;

COXSACKIEVIRUS;

EID: 84867883161     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.08.120     Document Type: Article

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