Regulation of krüpple-like factor 5 by targeted protein degradation

Methods in Molecular Biology

Volumn 647, Issue , 2010, Pages 267-277

  Chen, Ceshi ^a  

^a ALBANY MEDICAL COLLEGE   (United States)

Author keywords

Degradation; KLF5; Proteasome; Ubiquitination; WWP1

Indexed keywords

EID: 84934437793     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-60761-738-9_16     Document Type: Article

References (25)

1. Kaiser P, Tagwerker C (2005) Is this protein ubiquitinated? Methods Enzymol 399: 243-248 (Pubitemid 41772733)
2. Bloom J, Pagano M (2005) Experimental tests to definitively determine ubiquitylation of a substrate. Methods Enzymol 399: 249-266 (Pubitemid 41772734)
3. Chen C, Seth AK, Aplin AE (2006) Genetic and expression aberrations of e3 ubiquitin ligases in human breast cancer. Mol Cancer Res 4:695-707 (Pubitemid 44683310)
4. Black AR, Black JD, Azizkhan-Clifford J (2001) Sp1 and Kruppel-like factor family of transcription factors in cell growth regulation and cancer. J Cell Physiol 188:143-160 (Pubitemid 32622905)
5. Kojima S, Kobayashi A, Gotoh O, Ohkuma Y, Fujii-Kuriyama Y, Sogawa K (1997) J Biochem (Tokyo) 121:389-396
6. Zhang Z, Teng CT (2003) Phosphorylation of Kruppel-like factor 5 (KLF5/IKLF) at the CBP interaction region enhances its transactivation function. Nucleic Acids Res 31: 2196-2208 (Pubitemid 37442086)
7. Matsumura T, Suzuki T, Aizawa K, Munemasa Y, Muto S, Horikoshi M, Nagai R (2005) The deacetylase HDAC1 negatively regulates the cardiovascular transcription factor Kruppel-like factor 5 through direct interaction. J Biol Chem 280:12123-12129
8. Oishi Y, Manabe I, Tobe K, Ohsugi M, Kubota T, Fujiu K, Maemura K, Kubota N, Kadowaki T, Nagai R (2008) SUMOylation of Kruppel-like transcription factor 5 acts as a molecular switch in transcriptional programs of lipid metabolism involving PPAR-delta. Nat Med 14:656-666 (Pubitemid 351809542)
9. Chen C, Sun X, Ran Q, Wilkinson KD, Murphy TJ, Simons JW, Dong JT (2005) Ubiquitin-proteasome degradation of KLF5 transcription factor in cancer and untransformed epithelial cells. Oncogene 24: 3319-3327 (Pubitemid 40695113)
10. Chen C, Sun X, Guo P, Dong XY, Sethi P, Cheng X, Zhou J, Ling J, Simons JW, Lingrel JB, Dong JT (2005) Human Kruppel-like factor 5 is a target of the E3 ubiquitin ligase WWP1 for proteolysis in epithelial cells. J Biol Chem 280:41553-41561 (Pubitemid 41832217)
11. Shindo T, Manabe I, Fukushima Y, Tobe K, Aizawa K, Miyamoto S, Kawai-Kowase K, Moriyama N, Imai Y, Kawakami H, Nishimatsu H, Ishikawa T, Suzuki T, Morita H, Maemura K, Sata M, Hirata Y, Komukai M, Kagechika H, Kadowaki T, Kurabayashi M, Nagai R (2002) Kruppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling. Nat Med 8:856-863
12. Sur I, Unden AB, Toftgard R (2002) Human Kruppel-like factor5/KLF5: Synergy with NF-kappaB/Rel factors and expression in human skin and hair follicles. Eur J Cell Biol 81:323-334 (Pubitemid 34692943)
13. Aizawa K, Suzuki T, Kada N, Ishihara A, Kawai-Kowase K, Matsumura T, Sasaki K, Munemasa Y, Manabe I, Kurabayashi M, Collins T, Nagai R (2004) Regulation of platelet-derived growth factor-A chain by Kruppel-like factor 5: New pathway of cooperative activation with nuclear factor-kappaB. J Biol Chem 279:70-76 (Pubitemid 38044800)
14. Bateman NW, Tan D, Pestell RG, Black JD, Black AR (2004) Intestinal tumor progression is associated with altered function of KLF5. J Biol Chem 279:12093-12101 (Pubitemid 38445773)
15. Yang Y, Goldstein BG, Nakagawa H, Katz JP (2007) Kruppel-like factor 5 activates MEK/ERK signaling via EGFR in primary squamous epithelial cells. FASEB J 21(2):543-550 (Pubitemid 46213501)
16. Oishi Y, Manabe I, Tobe K, Tsushima K, Shindo T, Fujiu K, Nishimura G, Maemura K, Yamauchi T, Kubota N, Suzuki R, Kitamura T, Akira S, Kadowaki T, Nagai R (2005) Kruppel-like transcription factor KLF5 is a key regulator of adipocyte differentiation. Cell Metab 1:27-39 (Pubitemid 43960584)
17. Jiang J, Chan YS, Loh YH, Cai J, Tong GQ, Lim CA, Robson P, Zhong S, Ng HH (2008) A core Klf circuitry regulates self-renewal of embryonic stem cells. Nat Cell Biol 10:353-360 (Pubitemid 351331023)
18. Chen C, Matesic LE (2007) The Nedd4-like family of E3 ubiquitin ligases and cancer. Cancer Metastasis Rev 26:587-604 (Pubitemid 350119775)
19. Komuro A, Imamura T, Saitoh M, Yoshida Y, Yamori T, Miyazono K, Miyazawa K (2004) Negative regulation of transforming growth factor-beta (TGF-beta) signaling by WW domain-containing protein 1 (WWP1). Oncogene 23:6914-6923 (Pubitemid 39279992)
20. Seo SR, Lallemand F, Ferrand N, Pessah M, L'Hoste S, Camonis J, Atfi A (2004) The novel E3 ubiquitin ligase Tiul1 associates with TGIF to target Smad2 for degradation. Embo J 23:3780-3792 (Pubitemid 39389709)
21. Moren A, Imamura T, Miyazono K, Heldin CH, Moustakas A (2005) Degradation of the tumor suppressor Smad4 by WW and HECT domain ubiquitin ligases. J Biol Chem 280:22115-22123 (Pubitemid 40827867)
22. Laine A, Ronai Z (2007) Regulation of p53 localization and transcription by the HECT domain E3 ligase WWP1. Oncogene 26:1477-1483 (Pubitemid 46340811)
23. Li Y, Zhou Z, Chen C (2008) WW domaincontaining E3 ubiquitin protein ligase 1 targets p63 transcription factor for ubiquitinmediated proteasomal degradation and regulates apoptosis. Cell Death Differ 15(12): 1941-1951
24. Chen C, Zhou Z, Guo P, Dong JT (2007) Proteasomal degradation of the KLF5 transcription factor through a ubiquitin-independent pathway. FEBS Lett 581:1124-1130 (Pubitemid 46394549)
25. Newton K, Matsumoto ML, Wertz IE, Kirkpatrick DS, Lill JR, Tan J, Dugger D, Gordon N, Sidhu SS, Fellouse FA, Komuves L, French DM, Ferrando RE, Lam C, Compaan D, Yu C, Bosanac I, Hymowitz SG, Kelley RF, Dixit VM (2008) Ubiquitin chain editing revealed by polyubiquitin linkage-specific antibodies. Cell 134:668-678