Proteasomal degradation of the KLF5 transcription factor through a ubiquitin-independent pathway

FEBS Letters

Volumn 581, Issue 6, 2007, Pages 1124-1130

  Chen, Ceshi ^a   Zhou, Zhongmei ^a   Guo, Peng ^b   Dong, Jin Tang ^b  

^a ALBANY MEDICAL COLLEGE   (United States)

^b EMORY UNIVERSITY   (United States)

Author keywords

KLF5; Proteasome; Protein degradation; Ubiquitination

Indexed keywords

AMINO ACID; KRUPPEL LIKE FACTOR; MUTANT PROTEIN; PROTEASOME; TRANSCRIPTION FACTOR KLF5; UBIQUITIN; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

ACETYLATION; AMINO TERMINAL SEQUENCE; ANGIOGENESIS; APOPTOSIS; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL CYCLE; CELL PROLIFERATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; UBIQUITINATION;

AMINO ACID SEQUENCE; CELL LINE, TUMOR; HUMANS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MUTATION; PEPTIDE FRAGMENTS; PEPTIDES; PROTEASOME ENDOPEPTIDASE COMPLEX; TRANSFECTION; UBIQUITIN; UBIQUITIN-PROTEIN LIGASES;

EID: 33947124663     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2007.02.018     Document Type: Article

References (34)

1. Shindo T., et al. Kruppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling. Nat. Med. 8 (2002) 856-863
2. Chen C., Bhalala H.V., Qiao H., and Dong J.T. A possible tumor suppressor role of the KLF5 transcription factor in human breast cancer. Oncogene 21 (2002) 6567-6572
3. Chen C., Bhalala H.V., Vessella R.L., and Dong J.T. KLF5 is frequently deleted and down-regulated but rarely mutated in prostate cancer. Prostate 55 (2003) 81-88
4. Chen C., et al. KLF5 promotes cell proliferation and tumorigenesis through gene regulation in the TSU-Pr1 human bladder cancer cell line. Int. J. Cancer 118 (2006) 1346-1355
5. Sur I., Rozell B., Jaks V., Bergstrom A., and Toftgard R. Epidermal and craniofacial defects in mice overexpressing Klf5 in the basal layer of the epidermis. J. Cell Sci. 119 (2006) 3593-3601
6. Sun R., Chen X., and Yang V.W. Intestinal-enriched Kruppel-like factor (Kruppel-like factor 5) is a positive regulator of cellular proliferation. J. Biol. Chem. 276 (2001) 6897-6900
7. Adam P.J., Regan C.P., Hautmann M.B., and Owens G.K. Positive- and negative-acting Kruppel-like transcription factors bind a transforming growth factor beta control element required for expression of the smooth muscle cell differentiation marker SM22alpha in vivo. J. Biol. Chem. 275 (2000) 37798-37806
8. Oishi Y., et al. Kruppel-like transcription factor KLF5 is a key regulator of adipocyte differentiation. Cell Metab. 1 (2005) 27-39
9. Yang Y., Goldstein B.G., Chao H.H., and Katz J.P. KLF4 and KLF5 regulate proliferation, apoptosis and invasion in esophageal cancer cells. Cancer Biol. Ther. 4 (2005) 1216-1221
10. Aizawa K., et al. Regulation of platelet-derived growth factor-A chain by Kruppel-like factor 5: new pathway of cooperative activation with nuclear factor-kappaB. J. Biol. Chem. 279 (2004) 70-76
11. Chanchevalap S., Nandan M.O., McConnell B.B., Charrier L., Merlin D., Katz J.P., and Yang V.W. Kruppel-like factor 5 is an important mediator for lipopolysaccharide-induced proinflammatory response in intestinal epithelial cells. Nucleic Acids Res. 34 (2006) 1216-1223
12. Bateman N.W., Tan D., Pestell R.G., Black J.D., and Black A.R. Intestinal tumor progression is associated with altered function of KLF5. J. Biol. Chem. 279 (2004) 12093-12101
13. Chen C., Zhou Y., Zhou Z., Sun X., Otto K.B., Uht R.M., and Dong J.T. Regulation of KLF5 involves the Sp1 transcription factor in human epithelial cells. Gene 330 (2004) 133-142
14. Gao D., Niu X., Ning N., and Hao G. Regulation of angiotensin II-Induced Kruppel-like factor 5 expression in vascular smooth muscle cells. Biol. Pharm. Bull. 29 (2006) 2004-2008
15. Miyamoto S., et al. Positive and negative regulation of the cardiovascular transcription factor KLF5 by p300 and the oncogenic regulator SET through interaction and acetylation on the DNA-binding domain. Mol. Cell. Biol. 23 (2003) 8528-8541
16. Zhang Z., and Teng C.T. Phosphorylation of Kruppel-like factor 5 (KLF5/IKLF) at the CBP interaction region enhances its transactivation function. Nucleic Acids Res. 31 (2003) 2196-2208
17. Chen C., Sun X., Ran Q., Wilkinson K.D., Murphy T.J., Simons J.W., and Dong J.T. Ubiquitin-proteasome degradation of KLF5 transcription factor in cancer and untransformed epithelial cells. Oncogene 24 (2005) 3319-3327
18. Chen C., et al. Human Kruppel-like factor 5 is a target of the E3 ubiquitin ligase WWP1 for proteolysis in epithelial cells. J. Biol. Chem. 280 (2005) 41553-41561
19. Salghetti S.E., Kim S.Y., and Tansey W.P. Destruction of Myc by ubiquitin-mediated proteolysis: cancer-associated and transforming mutations stabilize Myc. EMBO J. 18 (1999) 717-726
20. Herbst A., Salghetti S.E., Kim S.Y., and Tansey W.P. Multiple cell-type-specific elements regulate Myc protein stability. Oncogene 23 (2004) 3863-3871
21. Chen H., MacDonald A., and Coffino P. Structural elements of antizymes 1 and 2 are required for proteasomal degradation of ornithine decarboxylase. J. Biol. Chem. 277 (2002) 45957-45961
22. Li X., et al. The SRC-3/AIB1 coactivator is degraded in a ubiquitin- and ATP-independent manner by the REGgamma proteasome. Cell 124 (2006) 381-392
23. Sdek P., Ying H., Chang D.L., Qiu W., Zheng H., Touitou R., Allday M.J., and Xiao Z.X. MDM2 promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma protein. Mol. Cell 20 (2005) 699-708
24. Breitschopf K., Bengal E., Ziv T., Admon A., and Ciechanover A. A novel site for ubiquitination: the N-terminal residue, and not internal lysines of MyoD, is essential for conjugation and degradation of the protein. EMBO J. 17 (1998) 5964-5973
25. Fajerman I., Schwartz A.L., and Ciechanover A. Degradation of the Id2 developmental regulator: targeting via N-terminal ubiquitination. Biochem. Biophys. Res. Commun. 314 (2004) 505-512
26. Bloom J., Amador V., Bartolini F., DeMartino G., and Pagano M. Proteasome-mediated degradation of p21 via N-terminal ubiquitinylation. Cell 115 (2003) 71-82
27. Ju D., and Xie Y. Proteasomal degradation of RPN4 via two distinct mechanisms, ubiquitin-dependent and -independent. J. Biol. Chem. 279 (2004) 23851-23854
28. Ciechanover A., and Ben-Saadon R. N-terminal ubiquitination: more protein substrates join in. Trends Cell Biol. 14 (2004) 103-106
29. Medintz I., Wang X., Hradek T., and Michels C.A. A PEST-like sequence in the N-terminal cytoplasmic domain of Saccharomyces maltose permease is required for glucose-induced proteolysis and rapid inactivation of transport activity. Biochemistry 39 (2000) 4518-4526
30. Reverte C.G., Ahearn M.D., and Hake L.E. CPEB degradation during Xenopus oocyte maturation requires a PEST domain and the 26S proteasome. Dev. Biol. 231 (2001) 447-458
31. Spencer M.L., Theodosiou M., and Noonan D.J. NPDC-1, a novel regulator of neuronal proliferation, is degraded by the ubiquitin/proteasome system through a PEST degradation motif. J. Biol. Chem. 279 (2004) 37069-37078
32. Coulombe P., Rodier G., Bonneil E., Thibault P., and Meloche S. N-terminal ubiquitination of extracellular signal-regulated kinase 3 and p21 directs their degradation by the proteasome. Mol. Cell. Biol. 24 (2004) 6140-6150
33. Jariel-Encontre I., Pariat M., Martin F., Carillo S., Salvat C., and Piechaczyk M. Ubiquitinylation is not an absolute requirement for degradation of c-Jun protein by the 26 S proteasome. J. Biol. Chem. 270 (1995) 11623-11627
34. Asher G., Lotem J., Sachs L., Kahana C., and Shaul Y. Mdm-2 and ubiquitin-independent p53 proteasomal degradation regulated by NQO1. Proc. Natl. Acad. Sci. USA 99 (2002) 13125-13130