60-Day chronic exposure to low concentrations of hgcl2 impairs sperm quality: Hormonal imbalance and oxidative stress as potential routes for reproductive dysfunction in rats

PLoS ONE

Volumn 9, Issue 11, 2014, Pages

  Martinez, Caroline S ^a   Torres, João Guilherme D ^a   Peçanha, Franck M ^a   Anselmo Franci, Janete A ^b   Vassallo, Dalton V ^c   Salaices, Mercedes ^d   Alonso, María J ^e   Wiggers, Giulia A ^a  

^a UNIVERSIDADE FEDERAL DO PAMPA   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

^c FEDERAL UNIVERSITY OF ESPÍRITO SANTO   (Brazil)

^d UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^e UNIVERSIDAD REY JUAN CARLOS   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CATALASE; LUTEINIZING HORMONE; MERCURY CHLORIDE; SUPEROXIDE DISMUTASE; MERCURIC CHLORIDE; TESTOSTERONE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; EPIDIDYMIS; LIPID PEROXIDATION; MALE; NONHUMAN; OXIDATIVE STRESS; PROSTATE; RAT; REPRODUCTIVE TOXICITY; SPERM QUALITY; SPERMATOGENESIS; SPERMATOZOON COUNT; SPERMATOZOON HEAD; SPERMATOZOON MOTILITY; SPERMATOZOON TAIL; TESTIS; VAS DEFERENS; ANIMAL; BODY WEIGHT; DRUG EFFECTS; IMMUNOASSAY; METABOLISM; PHYSIOLOGY; SPERMATOZOON; TIME; WISTAR RAT;

ANIMALS; BODY WEIGHT; CATALASE; IMMUNOASSAY; LIPID PEROXIDATION; LUTEINIZING HORMONE; MALE; MERCURIC CHLORIDE; OXIDATIVE STRESS; RATS; RATS, WISTAR; SPERM COUNT; SPERM MOTILITY; SPERMATOZOA; SUPEROXIDE DISMUTASE; TESTOSTERONE; TIME FACTORS;

EID: 84934312126     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0111202     Document Type: Article

References (49)

1. Zhang Y, Gao D, Bolivar VJ, Lawrence DA (2011) Induction of autoimmunity to brain antigens by developmental mercury exposure. Toxicol Sci 119: 270- 280.
2. Nyland JF, Fairweather D, Shirley DL, Davis SE, Rose NR, et al. (2012) Low dose inorganic mercury increases severity and frequency of chronic coxsackievirus- induced autoimmune myocarditis in mice. Toxicol Sci 125: 134-143.
3. Laks DR (2009) Assessment of chronic mercury exposure within the U.S. population, National Health and Nutrition Examination Survey, 1999-2006. Biometals 6: 1103-1114.
4. Corvelo TCO, Oliveira EA, de Parijó s AM, de Oliveira CS, de Loiola RSP, et al. (2014) Monitoring mercury exposure in reproductive aged women inhabiting the tapajós river basin, Amazon. Bull Environ Contam Toxicol 1: 42-6.
5. Rice DC (2004) The US EPA reference dose for methylmercury: sources of uncertainty. Environ Res 95: 406-413.
6. National Academy of Sciences (2000) Toxicological effects of methylmercury. National Research Council, Washington, DC, USA.
7. Carmignani M, Boscolo P, Artese L, Del Rosso G, Porcinelli G, et al. (1992) Renal mechanisms in the cardiovascular effects of chronic exposure to inorganic mercury rats. Br J Indust Med 49: 226-232.
8. Perottoni J, Rodrigues OED, Paixão MW, Zeni G, Lobato LP, et al. (2004) Renal and hepatic ALA-D activity and selected oxidative stress parameters of rats exposed to inorganic mercury and organoselenium compounds. Food Chem Toxicol 42: 17-28.
9. Zemolin APP, Meinerz DF, de Paula MT, Mariano DOC, Rocha JBT, et al. (2012) Evidences for a role of glutathione peroxidase 4 (GPx4) in methylmercury induced neurotoxicity in vivo. Toxicology 302: 60-67.
10. Ghaffari MA, Motlagh B (2011) In vitro effect of lead, silver, tin, mercury, indium and bismuth on human sperm creatine kinase activity: A presumable mechanism for men infertility. Iran Biomed J 15, 1-2: 38-43.
11. Khan AT, Atkinson A, Graham TC, Thompson SJ, Ali S, et al. (2004) Effects of inorganic mercury on reproductive performance of mice. Food Chem Toxicol 42: 571-577.
12. Keck C, Bergman M, Ernst E, Muller C, Kliensch S, et al. (1993) Autometallographic detection of mercury in testicular tissue of an infertile man exposed to mercury vapour. Reprod Toxicol 7: 469-475.
13. El-Desoky GE, Bashandy SA, Alhazza IM, Al-Othman ZA, Aboul-Soud MAM, et al. (2013) Improvement of Mercuric Chloride-Induced Testis Injuries and Sperm Quality Deteriorations by Spirulina platensis in Rats. PLoS ONE 8(3): e59177. doi:10.1371/journal.pone.0059177.
14. Kalender S, Uzun FG, Demir F, Uzunhisarcikli M, Aslanturk A (2013) Mercuric chloride-induced testicular toxicity in rats and the protective role of sodium selenite and vitamin E. Food Chem Toxicol 55: 456-462.
15. Mohamed MK, Barbacher TM, Mottet NK (1987) Effects of methylmercury on testicular functions in macaca fascicularis monkeys. Pharmacol Toxicol 60: 29- 36.
16. Buck Louis GM (2014) Persistent environmental pollutants and couple fecundity: An overview. Reproduction 4: R97-R104.
17. Popescu HI (1978) Poisoning with alkylmercuric compounds. Br Med J 1: 23- 47.
18. Choy CM, Lam CW, Cheung LT, Briton-Jones CM, Cheung LP, et al. (2002) Infertility, blood mercury concentrations and dietary seafood consumption: A case control study. BJOG 109: 1121-1125.
19. Mocevic E, Specht IO, Marott JL, Giwercman A, Jönsson BA, et al. (2013) Environmental mercury exposure, semen quality and reproductive hormones in Greenlandic Inuit and European men: A cross-sectional study. Asian J Androl 1: 97-104.
20. Erfurth EM, Schü tz A, Nilsson A, Barrega°rd L, Skerfving S (1990) Normal pituitary hormone response to thyrotrophin and gonadotrophin releasing hormones in subjects exposed to elemental mercury vapour. Br J Ind Med 9: 639-44.
21. Rana SV (2014) Perspectives in Endocrine Toxicity of Heavy Metals-A Review. Biol Trace Elem Res 1: 1-14.
22. Ramalingam V, Vimaladevi V, Rajeswary S, Suryavathi V (2003) Effect of mercuric chloride on circulating hormones in adult albino rats. J Environ Biol 24: 401-414.
23. Boujbiha MA, Hamdena K, Guermazib F, Bouslamac A, Omezzinec A, et al. (2009) Testicular toxicity in mercuric chloride treated rats: Association with oxidative stress. Reprod Toxicol 28: 81-89.
24. Carvalho CM, Chew EH, Hashemy SI, Lu J, Holmgren A (2008) Inhibition of the human thioredoxin system. A molecular mechanism of mercury toxicity. J Biol Chem 283: 11913-23.
25. Martinez CS, Escobar AG, Torres JGD, Brum DS, Santos FW, et al. (2014) Chronic exposure to low doses of mercury impairs sperm quality and induces oxidative stress in rats. J Toxicol Environ Health, Part A 77: 143-154.
26. Wiggers GA, Peçanha FM, Briones AM, Pérez-Girón JV, Miguel M, et al. (2008) Low mercury concentrations cause oxidative stress and endothelial dysfunction in conductance and resistance arteries. Am J Physiol Heart Circ Physiol 295: 1033-104.
27. Filler R (1993) Methods for evaluation of rats epididymal sperm morphology. In Male reproductive toxicology. Chapin RE, Heindel JH Eds. California: Academic Press. 334-343p.
28. Robb GW, Amman RP, Killian GJ (1978) Daily sperm production and epididymal sperm reserves of puberal and adult rats. J Reprod Fertil 54: 103- 107.
29. Ohkawa H, Ohishi N, Yagi K (1979) Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95: 351-358.
30. Ellman GL (1959) Tissue sulfhydryl groups. Arch Biochem 82: 70-77.
31. Misra HP, Fridovich I (1972) The role of superoxide anion in the autoxidation of epinephrine and simple assay for superoxide dismutase. J Biol Chem 247: 3170- 3175.
32. Aebi H (1984) Catalase in vitro. Methods Enzymol 105: 121-126.
33. Birch RJ, Bigler J, Rogers JW, Zhuang Y, Clickner RP (2014) Trends in blood mercury concentrations and fish consumption among U.S. women of reproductive age, NHANES, 1999-2010. Environ Res 14: 00021-8.
34. McKelvey W, Gwynn RC, Jeffery N, Kass D, Thorpe LE, et al. (2007) A biomonitoring study of lead, cadmium, and mercury in the blood of New York city adults. Environ Health Perspect 115: 1435-1441.
35. Waye A, Trudeau VL (2011) Neuroendocrine disruption: more than hormones are upset. J Toxicol Environ Health, Part B 14: 270-291.
36. Vahter ME, Mottet NK, Friberg LT, Lind SB, Charleston JS, et al. (1995) Demethylation of methyl mercury in different brain sites of Macaca fascicularis monkeys during long-term subclinical methyl mercury exposure. Toxicol Appl Pharmacol 134: 273-84.
37. Cornett CR, Ehmann WD, Wekstein DR, Markesbery WR (1998) Trace elements in Alzheimer's disease pituitary glands. Biol Trace Elem Res 62: 107- 14.
38. Mello-Carpes PB, Barros W, Borges S, Alves N, Rizzetti D, et al. (2013) Chronic exposure to low mercury chloride concentration induces object recognition and aversive memories deficits in rats. Int J Devl Neuroscience 31: 468-472.
39. Homma-Takeda S, Kugenuma Y, Iwamuro T, Kumagai Y, Shimojo N (2001) Impairment of spermatogenesis in rats by methylmercury: involvement of stageand- cell specific germ cell apoptosis. Toxicology 169: 25-35.
40. Boujbiha MA, Hamden K, Guermazi F, Bouslama A, Omezzine A, et al. (2011) Impairment of spermatogenesis in rats by mercuric chloride: involvement of low 17b-estradiol level in induction of acute oxidative stress. Biol Trace Elem Res 3: 598-610.
41. Omura M, Tanaka A, Hirata M, Zhao M, Makita Y, et al. (1996) Testicular toxicity of galliumarsenide, indium arsenide and arsenic oxide in rats by repetitive intratracheal instillation. Fundam Appl Toxicol 32: 72-78.
42. Goyer RA, Liu J, Waalkes MP (2004) Cadmium and cancer of prostate and testis. Biometals 17: 555-558.
43. Kumar BA, Reddy AG, Kumar PR, Reddy YR, Rao TM, et al. (2013) Protective role of N-Acetyl L-Cysteine against reproductive toxicity due to interaction of lead and cadmium in male Wistar rats. J Nat Sci Biol Med 4: 414- 9.
44. Santos FW, Zen G, Rocha JB, Weiss S, Fachineto JM, et al. (2005) Diphenyl diselenide reverses cadmium-induced oxidative damage on mice tissues. Chem Biol Interact 151: 159-165.
45. Aitken RJ (1995) Free radicals, lipid peroxidation and sperm function. Reprod Fertil Dev 7: 659-668.
46. Rao MV, Gangadharan B (2008) Antioxidative potential of melatonin against mercury induce intoxication in spermatozoa in vitro. Toxicol In Vitro 22: 935- 42.
47. Farina M, Brandão R, de Lara FS, Pagliosa LB, Soares FA, et al. (2003) Profile of nonprotein thiols, lipid peroxidation and delta-aminolevulinate dehydratase activity in mouse kidney and liver in response to acute exposure to mercuric chloride and sodium selenite. Toxicol 184, 2-3: 179-87.
48. Bando I, Reus MIS, Andrés D, Cascales M (2005) Endogenous antioxidant defence system in rat liver following mercury chloride oral intoxication. J Biochem Mol Toxicol 19: 154-161.
49. Sharma AK, Kapadia AG, Fransis P, Rao MV (1996) Reversible effects of mercuric chloride on reproductive organs of the male mouse. Reprod Toxicol 10: 153-9.