Protective role of N-Acetyl L-Cysteine against reproductive toxicity due to interaction of lead and cadmium in male Wistar rats

Journal of Natural Science, Biology and Medicine

Volumn 4, Issue 2, 2013, Pages 414-419

  Kumar, Banothu Anil ^a   Reddy, Alla Gopala ^a   Kumar, Pentela Ravi ^b   Reddy, Yerradoddi Ramana ^a   Rao, Thirtham Madava ^a   Haritha, Chiluka ^a  

^a Uttar Pradesh Pandit Deen Dayal Upadhayay Pashu Chikitsa Vigyan Vishwavidyalay Evum Go Anusandhan Sansthan   (India)

^b NTR College of Veterinary Science   (India)

Author keywords

Cadmium; Glutathione; GST; Lead; Male Wistar rats; TBARS and protein carbonyl; Testis

Indexed keywords

EID: 84884255566     PISSN: 09769668     EISSN: 22297707     Source Type: Journal    
DOI: 10.4103/0976-9668.117021     Document Type: Article

References (34)

1. Obianime AW, Roberts II. Antioxidants, cadmium-induced toxicity, serum biochemical and the histological abnormalities of the kidney and testes of the male Wistar rats. Niger J Physiol Sci 2009;2:177-85.
2. Wang L, Xun P, Zhao Y, Wang X, Qian L, Chen F. Effects of lead exposure on sperm concentrations and testes weight in male rats: A meta-regression analysis. J Toxicol Environ Health A 2008;7:454-63.
3. Meeker JD, Rossano MG, Protas B, Diamond MP, Puscheck E, Daly D, et al. Cadmium, lead and other metals in relation to semen quality: Human evidence for Molybdenum as a male reproductive toxicant. Environ Health Perspect 2008;116:1473-9.
4. Telisman S, Colak B, Pizent A, Jurasovic J, Cvitkovic P. Reproductive toxicity of low-level lead exposure in men. Environ Res 2007;105:256-66.
5. Stohs SJ, Bagchi D, Hassoun E, Bagchi M. Oxidative mechanisms in the toxicity of chromium and cadmium ions. J Environ Pathol Toxicol Oncol 2001;20:77-88.
6. Massanyi P, Lukac N, Slivkova J, Kovacik J, Makarevich AV, Chrenek P, et al. Mercury-induced alterations in rat kidneys and testes in vivo. J Environ Sci Health A Tox Hazard Subst Environ Eng 2007;7:865-70.
7. Smith DM, Mielke HW, Heneghan JB. Sub chronic lead feeding study in male rats. Arch Environ Contam Toxicol 2008;3:518-28.
8. Valko M, Rhodes CJ, Moncol J, Izakovic M, Mazur M. Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chem Biol Interact 2006;160:1-40.
9. Whittaker MH, Wang G, Chen XQ, Lipsky M, Smith D, Gwiazda R, et al. Exposure to Pb Cd, and As mixtures potentates the production of oxidative stress precursors: 30-day, 90-day and 180-day drinking water studies in rats. Toxicol Appl Pharmacol 2010;23:1-13.
10. Blanusa M, Varnai VD, Piasek M, Kostial K. Chelators as antidotes of metal toxicity: Therapeutic and experimental aspects. Curr Med Chem 2005;12:2271-794.
11. Clement SL, Hellier BC, Elberson LR, Staska RT, Evans AA. Flies (Diptera: Muscidae: Calliphoridae) are efficient pollinators of Allium ampeloprasum L. (Alliaceae) in field cages. J Econ Entomol 2007;100:131-5.
12. Balasubramanian KA, Manohar M, Mathan VI. An unidentified inhibitor of lipid peroxidation in intestinal mucosa. Biochim Biophys Acta 1988;962:51-8.
13. Moron MS, Depierre JW, Mannervik B. Levels of glutathione, glutathione reductase and glutathione S transferase in rat lung and liver. Biochim Biophys Acta 1979;582:67-8.
14. Habig WH, Pabst MJ, Jakoby WB. Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. J Biol Chem 1974;249:7130-9.
15. Levine RL, Garland D, Oliver CN, Amici A, Climent I, Lenz AG, et al. Determination of carbonyl content in oxidatively modified proteins. Methods Enzymol 1990;186:464-78.
16. Belsey MA, Moshissi KS, Eliasson R, Paulsen CA, Callegos AJ, Prasad MR. Laboratory manual for the examination of human semen and Semen Cervical Mucus Interaction 1980; Press concern.
17. Sawhney SK, Singh R. Analysis of plant tissues introductory practical biochemistry. Vol. 2. Narosh Publishing House Private Limited; 2007. p. 141-3.
18. Szkoda J, Zmudzki J. Determination of lead and cadmium in biological material by graphite furnace atomic absorption spectrometry method. http://www.piwet.pulawy.pl/bulletin/images/stories/pdf/20051/20051089092.pdf. Bull Vet Inst Pulawy 2005;49:89-92.
19. Lowry OH, Rosenbrough MJ, Farr AL, Rawdell RA. Protein measurement with the Folin phenol reagent. J Biol Chem 1951;193:265-75.
20. nd ed. Hyderabad, India: Premier Publishing House; 1997.
21. Maybauer DM, Maybauer MO, Traber LD, Westphal M, Nakano YY, Enkhbaatar P, et al. Effects of severe smoke inhalation injury and septic shock on global hemodynamics and microvascular blood flow in sheep. Shock 2006;26:489-95.
22. Gupta SR, Gupta SE, Dhakal BK, Thakur AR, Ahnn J. Vitamin C and vitamin E protect the rat testes from cadmium-induced reactive oxygen species. Mol Cells 2004;17:132-9.
23. Valko M, Morris H, Cronin MT. Metals, toxicity and oxidative stress. Curr Med Chem 2005;12:1161-208.
24. Beyersmann D, Hartwig A. Carcinogenic metal compounds: Recent insight into molecular and cellular mechanisms. Arch Toxicol 2008;82:493-512.
25. Hamadouche AN, Slimani M, Merad-Boudia B, Zaoui C. Reproductive toxicity of lead acetate in adult male rats. American Journal of Scientific Research 2009;3:38-50.
26. Xu HH, Chen ZP, Shen Y, Wu X, He F. Meta analysis for effect of lead on male productive function. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2006;10:634-6.
27. Tohami EM, Nattat EW. Effect of antioxidants on lead induced oxidative damage on reproductive dysfunction in male rabbits. J Anim Sci 2010;6:14-7.
28. +-ATPase in liver tissue of rat. J Environ Biol 2009;30:895-8.
29. Sokol RZ, Wang S, Wan YJ, Stanczyk FZ, Gentzschein E, Chapin RE. Long-term, low-dose lead exposure alters the gonadotropin-releasing hormone system in the male rat. Environ Health Perspect 2002;110:871-4.
30. Lopez AM, Montana PF, Miranda M, Castillo C, Hernandez J, Benedito LJ. Interactions between toxic (As, Cd, Hg and Pb) and nutritional essential (Ca, Co, Cr, Cu, Fe, Mn, Mo, Ni, Se, Zn) elements in the tissues of cattle from NW Spain. Biometals 2004;17:389-97.
31. Skoczynska A, Smolik R, Milian A. The effect of combined exposure to lead and cadmium on the concentration of zinc and copper in rat tissues. Int J Occup Med Environ Health 1994;7:41-9.
32. Bizoska MM, Monuszko JJ, Jurczuk M, Galazyn SM, Bogalska J. The effect of zinc supply on cadmium influenced changes in the tibia of rats. Food Chem Toxicol 2001;39:729-37.
33. Qu W, Diwan BA, Liu J, Goyer RA, Dawson T, Horton JL, et al. The metallothionein-null phenotype is associated with heightened sensitivity to lead toxicity and an inability to form inclusion bodies. Am J Pathol 2002;160:1047-56.
34. Goyer RA, Clarkson TW. Toxic effects of metals. In: Klaassen CD, Watkins JB III, editors. Casarett and Doull's essentials of TOXICOLOGY. New York: McGraw-Hill Company; 2003. p. 348-59.