Mercuric chloride-induced testicular toxicity in rats and the protective role of sodium selenite and vitamin E

Food and Chemical Toxicology

Volumn 55, Issue , 2013, Pages 456-462

  Kalender, Suna ^a   Uzun, Fatma Gokce ^a   Demir, Filiz ^a   Uzunhisarcikli, Meltem ^a   Aslanturk, Ayse ^a  

^a GAZI UNIVERSITY   (Turkey)

Author keywords

Histopathology; Mercuric chloride; Oxidative stress; Sodium selenite; Testicular toxicity; Vitamin E

Indexed keywords

ALPHA TOCOPHEROL; CATALASE; GLUTATHIONE PEROXIDASE; MERCURIC CHLORIDE; POLYUNSATURATED FATTY ACID; SODIUM SELENITE; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CATALYSIS; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME SYNTHESIS; GERM CELL; HISTOPATHOLOGY; LIPID PEROXIDATION; MALE; NONHUMAN; OXIDATION; OXIDATIVE STRESS; RAT; TESTIS DISEASE; TISSUE HOMOGENATE;

ANIMALS; CATALASE; GLUTATHIONE PEROXIDASE; MALE; MERCURIC CHLORIDE; RATS; RATS, WISTAR; SODIUM SELENITE; SUPEROXIDE DISMUTASE; TESTIS; THIOBARBITURIC ACID REACTIVE SUBSTANCES; VITAMIN E;

EID: 84874470858     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2013.01.024     Document Type: Article

References (70)

1. Acharya U.R., Mishra M., Patro J., Panda M.K. Effect of vitamins C and E on spermatogenesis in mice exposed to cadmium. Reprod. Toxicol. 2008, 25:84-88.
2. Aebi H. Catalase in vitro. Methods Enzymol. 1984, 105:121-126.
3. Al-Attar A.M. Vitamin E attenuates liver injury induced by exposure to lead, mercury, cadmium and copper in albino mice. Saudi J. Biol. Sci. 2011, 18:395-401.
4. Al-Attar A.M. Antioxidant effect of vitamin E treatment on some heavy metals-induced renal and testicular injuries in male mice. Saudi J. Biol. Sci. 2011, 18:63-72.
5. Amara S., Abdelmelek H., Garrel C., Guiraud P., Douki T., Ravanat J.-L., Favier A., Sakly M., Rhouma K.B. Influence of static magnetic field on cadmium toxicity: study of oxidative stress and DNA damage in rat tissues. J. Trace Elem. Med. Biol. 2006, 20:263-269.
6. Aruldhas M.M., Subramanian S., Sekar P., Vengatesh G., Chandrahasan G., Govindarajulu P., Akbarsha M.A. Chronic chromium exposure-induced changes in testicular histoarchitecture are associated with oxidative stress: study in a non-human primate (Macaca radiata Geoffroy). Hum. Reprod. 2005, 20:2801-2813.
7. Atkinson A., Thompson S.J., Khan A.T., Graham T.C., Ali S., Shannon C., Clarke O., Upchurch L. Assessment of a two-generation reproductive and fertility study of mercuric chloride in rats. Food Chem. Toxicol. 2001, 39:73-84.
8. Bando I., Reus M.I.S., Andrés D., Cascales M. Endogenous antioxidant defence system in rat liver following mercury chloride oral intoxication. J. Biochem. Mol. Toxicol. 2005, 19:154-161.
9. Bansal A.K., Bansal M., Soni G., Bhatnagar D. Protective role of vitamin E pre-treatment on N-nitrosodiethylamine induced oxidative stress in rat liver. Chem-Biol. Interact. 2005, 156:101-111.
10. Bebe F.N., Panemangalore M. Exposure to low doses of endosulfan and chlorpyrifos modifies endogenous in tissues of rats. J. Environ. Sci. Health B 2003, 38:349-363.
11. Boujbiha M.A., Hamden K., Guermazi F., Bouslama A., Omezzine A., Kammoun A., El Feki A. Testicular toxicity in mercuric chloride treated rats: association with oxidative stress. Reprod. Toxicol. 2009, 28:81-89.
12. Boujbiha M.A.M., Hamden K., Guermazi F., Bouslama A., Omezzine A., El Feki A. Impairment of spermatogenesis in rats by mercuric chloride: Involvement of low 17β-estradiol level in induction of acute oxidative stress. Biol. Trace Elem. Res. 2011, 142:598-610.
13. Celik I., Suzek H. Effects of subacute exposure of dichlorvos at sublethal dosages on erythrocyte and tissue antioxidant defense systems and lipid peroxidation in rats. Ecotoxicol. Environ. Saf. 2009, 72:905-908.
14. de Freitas A.S., Funck V.R., Rotta M.S., Bohrer D., Mörschbächer V., Puntel R.L., Nogueira C.W., Farina M., Aschner M., Rocha J.B.T. Diphenyl diselenide, a simple organoselenium compound, decreases methylmercury-induced cerebral, hepatic and renal oxidative stress and mercury deposition in adult mice. Brain Res. Bull. 2009, 79:77-84.
15. Demir F., Uzun F.G., Durak D., Kalender Y. Subacute chlorpyrifos-induced oxidative stress in rat erythrocytes and the protective effects of catechin and quercetin. Pestic. Biochem. Phys. 2011, 99:77-81.
16. Durak D., Kalender S., Uzun F.G., Demir F., Kalender Y. Mercury chloride-induced oxidative stress and the protective effect of vitamins C and E in human erythrocytes in vitro. Afr. J. Biotechnol. 2010, 9(4):488-495.
17. El-Demerdash F.M. Lipid peroxidation, oxidative stress and acetylcholinesterase in rat brain exposed to organophosphate and pyrethroid insecticides. Food Chem. Toxicol. 2011, 49:1346-1352.
18. El-Demerdash F.M., Yousef M.I., Kedwany F.S., Baghdadi H.H. Cadmium-induced changes in lipid peroxidation, blood hematology, biochemical parameters and semen quality of male rats: protective role of vitamin E and β-carotene. Food Chem. Toxicol. 2004, 42:1563-1571.
19. Eraslan G., Saygi S., Essiz D., Aksoy A., Gul H., Macit E. Evaluation of aspect of some oxidative stress parameters using vitamin E, proanthocyanidin and N-acetylcysteine against exposure to cyfluthrin in mice. Pestic. Biochem. Phys. 2007, 88:43-49.
20. Fahmy M.A., Hassan N.H.A., Farghaly A.A., Hassan E.E.S. Studies on the genotoxic effect of beryllium chloride and the possible protective role of selenium/vitamins A, C and E. Mutat. Res. 2008, 652:103-111.
21. Franco J.L., Braga H.C., Nunes A.K.C., Ribas C.M., Stringari J., Silva A.P., Pomblum S.C.G., Moro Â.M., Bohrer D., Santos A.R.S., Dafre A.L., Farina M. Lactational exposure to inorganic mercury: evidence of neurotoxic effects. Neurotoxicol. Teratol. 2007, 29:360-367.
22. 1. Braz. Arch. Biol. Technol. 2005, 48:905-910.
23. Giadinis N., Koptopoulus G., Roubies N., Siarkou V., Papasteriades A. Selenium and vitamin E effect on antibody production of sheep vaccinated against enzootic abortion (Chlamydia psittaci). Comp. Immunol. Microbiol. Infect. Dis. 2000, 23:129-137.
24. Goering P.L., Morgan D.L., Ali S.F. Effects of mercury vapor inhalation on reactive oxygen species and antioxidant enzymes in rat brain and kidney are minimal. J. Appl. Toxicol. 2002, 22:167-172.
25. Gupta S., Gupta H.K., Soni J. Effect of vitamin E and selenium supplementation on concentrations of plasma cortisol and erythrocyte lipid peroxides and the incidence of retinal fetal membranes in crossbred dairy cattle. Theriogenology 2005, 64:1273-1286.
26. Jadhav S.H., Sarkar S.N., Aggarwal M., Tripathi H.C. Induction of oxidative stress in erythrocytes of male rats subchronically exposed to a mixture of eight metals found as groundwater contaminants in different parts of India. Arch. Environ. Contam. Toxicol. 2007, 52:145-151.
27. Jihen E.H., Imed M., Fatima H., Abdelhamid K. Protective effects of selenium (Se) and zinc (Zn) on cadmium (Cd) toxicity in the liver of the rat: effects on the oxidative stress. Ecotoxicol. Environ. Saf. 2009, 72:1559-1564.
28. Kalender S., Uzun F.G., Durak D., Demir F., Kalender Y. Malathion-induced hepatotoxicity in rats: the effects of vitamins C and E. Food Chem. Toxicol. 2010, 48:633-638.
29. Kanbur M., Eraslan G., Silici S. Antioxidant effect of propolis against exposure to propetamphos in rats. Ecotoxicol. Environ. Saf. 2009, 72:909-915.
30. Kołodziej A., Jacyno E. Effect of selenium and vitamin E supplementation on reproductive performance of young boars. Arch. Tiez. 2005, 48:68-75.
31. Koyuturk M., Yanardag R., Bolkent S., Tunal S. Influence of combined antioxidants against cadmium induced testicular damage. Environ. Toxicol. Pharmacol. 2006, 21:235-240.
32. Koyuturk M., Yanardag R., Bolkent S., Tunal S. The potential role of combined antioxidants against cadmium toxicity on liver of rats. Toxicol. Ind. Health 2007, 23:393-401.
33. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 1951, 19:265.
34. Mahboob M., Shireen K.F., Atkinson A., Khan A.T. Lipid peroxidation and antioxidant enzyme activity in different organs of mice exposed to low level of mercury. J. Environ. Sci. Health B 2001, 36:687-697.
35. Mansour S.A., Mossa A.T.H. Lipid peroxidation and oxidative stress in rat erythrocytes induced by chlorpyrifos and protective effect of zinc. Pestic. Biochem. Phys. 2009, 93:34-39.
36. Marin-Guzman J., Mahan D.C., Whitmoyer R. Effect of dietary selenium and vitamin E on the ultrastructure and ATP concentration of boar spermatozoa, and the efficacy of added sodium selenite in extended semen on sperm motility. J. Anim. Sci. 2000, 78:1544-1550.
37. Marklund S., Marklund G. Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur. J. Biochem. 1974, 47:469-474.
38. Méndez-Armenta M., Nava-Ruiz C., Fernández-Valverde F., Sánchez-García A., Rios C. Histochemical changes in muscle of rats exposed subchronically to low doses of heavy metals. Environ. Toxicol. Pharmacol. 2011, 32:107-112.
39. Mohamed M.K., Lee W.I., Mottet N.K., Burbacher T.M. Laser light scattering study of the toxic effects of methyl mercury on sperm motility. J. Androl. 1986, 7:11-15.
40. Nordberg G.F., Fowler B.A., Nordberg M., Friberg L. Handbook on the toxicology of metals. Reproductive and Developmental Toxicity of Metals 2007, 213-249. Academic press, (Chapter 12). third ed. P. Apostoi, S. Telisman, P.R. Sager (Eds.).
41. Ohkawa H., Ohishi N., Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal. Biochem. 1979, 95:351-358.
42. 10 and Vitamin E. Reprod. Toxicol. 2010, 29:191-197.
43. Orisakwe O.E., Afonne O.J., Nwobodo E., Asomungha L., Dioka C.E. Low-dose mercury induces testicular damage protected by zinc in mice. Eur. J. Obstet. Gynecol. Reprod. Biol. 2001, 95:92-96.
44. Özyurt H., Söĝüt S., Yi{dotless}ldi{dotless}ri{dotless}m Z., Kart L., Iraz M., Armutçu F., Ismail T., Özen S., Uzun A., Akyol Ö. Inhibitory effect of caffeic acid phenethyl ester on bleomycine-induced lung fibrosis in rats. Clin. Chim. Acta 2004, 339:65-75.
45. Paglia D.E., Valentine W.N. Studies on the quantitative and qualitative characterization of erythrocytes glutathione peroxidase. J. Lab. Clin. Med. 1967, 70:158-165.
46. Patra R.C., Swarup D., Dwiedi S.K. Antioxidant effects of α-tocopherol, ascorbic acid and L-methionine on lead induced oxidative stress to the liver, kidney and brain in rats. Toxicology 2001, 162:81-88.
47. Perettoni J., Rodrigues O.E.D., Paixão M.W., Zeni G., Lobato L.P., Braga A.L., Rocha J.B.T., Emanuelli T. Renal and hepatic ALA-D activity and selected oxidative stress parameters of rats exposed to inorganic mercury and organoselenium compounds. Food Chem. Toxicol. 2004, 42:17-28.
48. Qiao D., Seidler F.J., Slotkin T.A. Oxidative mechanisms contributing to the developmental neurotoxicity of nicotine and chlorpyrifos. Toxicol. Appl. Pharmacol. 2005, 206:17-26.
49. Ramalingam V., Vimaladevi V. Effect of mercuric chloride on membrane-bound enzymes in rat testis. Asian J. Androl. 2002, 4:309-311.
50. Rao M.V. Histophysiological changes of organs in methyl mercury intoxicated mice. Endocrinol. Exp. 1989, 23:60-65.
51. Rao M.V., Sharma P.S.N. Protective effect of vitamin E against mercuric chloride reproductive toxicity in male mice. Reprod. Toxicol. 2001, 15:705-712.
52. Rao M.V., Gangadharan B. Antioxidative potential of melatonin against mercury induced intoxication in spermatozoa in vitro. Toxicol. in Vitro 2008, 22:935-942.
53. Rao M.V., Chhunchha B. Protective role of melatonin against the mercury induced oxidative stress in rat thyroid. Food Chem. Toxicol. 2010, 48:7-10.
54. Rozgaj R., Kašuba V., Blanuša M. Mercury chloride genotoxicity in rats following oral exposure, evaluated by comet assay and micronucleus test. Arh. Hig. Rada. Toksikol. 2005, 56:9-15.
55. Sakr S.A.R., Mahran H.A., Nofal A.E. Effect of selenium on carbimazole-induced testicular damage and oxidative stress in albino rats. J. Trace Elem. Med. Biol. 2011, 25:59-66.
56. Sharma A.K., Kapadia A.G., Francis P., Rao M.V. Reversible effects of mercuric chloride on reproductive organs of the male mice. Reprod. Toxicol. 1996, 10:153-159.
57. Sharma M.K., Sharma A., Kumar A., Kumar M. Evaluation of protective efficacy of Spirulina fusiformis against mercury induced nephrotoxicity in Swiss albino mice. Food Chem. Toxicol. 2007, 45:879-887.
58. Sharma M.K., Sharma A., Kumar A., Kumar M. Spirulina fusiformis provides protection against mercuric chloride induced oxidative stress in Swiss albino mice. Food Chem. Toxicol. 2007, 45:2412-2419.
59. Shen H., Ong C. Detection of oxidative DNA damage in human sperm and its association with sperm function and male infertility. Free Radical Biol. Med. 2000, 28:529-536.
60. Shilo S., Aronis A., Komarnitsky R., Tirosh O. Selenite sensitizes mitochondrial permeability transition pore opening in vitro and in vivo: a possible mechanism for chemo-protection. Biochem. J. 2003, 370:283-290.
61. Su L., Wabg M., Yin S.-T., Wang H.-L., Chen L., Sun L.-G., Ruan D.-Y. The interaction of selenium and mercury in the accumulations and oxidative stress of rat tissues. Ecotoxicol. Environ. Saf. 2008, 70:483-489.
62. şener G., şehirli A.Ö., Ayanoĝlu-Dülger G. Melatonin protects against mercury (II)-induced oxidative tissue damage in rats. Pharmacol. Toxicol. 2003, 93:290-296.
63. Tiwary A.K., Stegelmeier B.L., Panter K.E., James L.F., Hall J.O. Comparative toxicosis of sodium selenite and selenomethionine in lambs. J. Vet. Diagn. Invest. 2006, 18:61-70.
64. Thompson J., Bannigan J. Cadmium: toxic effects on the reproductive system and the embriyo. Reprod. Toxicol. 2008, 25:304-315.
65. Uzun F.G., Kalender S., Durak D., Demir F., Kalender Y. Malathion-induced testicular toxicity in male rats and the protective effect of vitamins C and E. Food Chem. Toxicol. 2009, 47:1903-1908.
66. Uzun F.G., Demir F., Kalender S., Bas H., Kalender Y. Protective effect of catechin and quercetin on chlorpyrifos-induced lung toxicity in male rats. Food Chem. Toxicol. 2010, 48:1714-1720.
67. Uzunhisarcikli M., Kalender Y., Dirican K., Kalender S., Ogutcu A., Buyukkomurcu F. Acute, subacute and subchronic administration of methyl parathion-induced testicular damage in male rats and protective role of vitamins C and E. Pestic. Biochem. Phys. 2007, 87(2):115-122.
68. Uzunhisarcikli M., Kalender Y. Protective effects of vitamins C and E against hepatotoxicity induced by methyl parathion in rats. Ecotoxicol. Environ. Saf. 2011, 74:2112-2118.
69. Wafa T., Amel N., Issam C., Imed C., Abdelhedi M., Mohamed H. Subacute effects of 2,4-dichlorophenoxyacetic herbicide on antioxidant defense system and lipid peroxidation in rat erythrocytes. Pestic. Biochem. Phys. 2011, 99:256-264.
70. Yang J.-M., Arnush M., Chen Q.-Y., Wu X.-D., Pang B., Jian X.-Z. Cadmium-induced damage to primary cultures of rat Leydig cells. Reprod. Toxicol. 2003, 17:553-560.