Simvastatin Reduces Burn Injury-induced Splenic Apoptosis via Downregulation of the TNF-α/NF-κB Pathway

Annals of Surgery

Volumn 261, Issue 5, 2015, Pages 1006-1012

  Zhao, Gaofeng ^a   Yu, Yong Ming ^a   Kaneki, Masao ^a   Bonab, Ali A ^a   Tompkins, Ronald G ^a   Fischman, Alan J ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

apoptosis; burn; NF B; simvastatin; TNF

Indexed keywords

ANTIINFLAMMATORY AGENT; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; SIMVASTATIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL; APOPTOSIS; BLOOD; BURNS; DOWN REGULATION; DRUG EFFECTS; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY; SPLEEN;

ANIMALS; ANTI-INFLAMMATORY AGENTS; APOPTOSIS; BURNS; CYTOKINES; DOWN-REGULATION; MICE, KNOCKOUT; NF-KAPPA B; SIMVASTATIN; SPLEEN; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84934302256     PISSN: 00034932     EISSN: 15281140     Source Type: Journal    
DOI: 10.1097/SLA.0000000000000764     Document Type: Article

References (25)

1. Leseva M, Arguirova M, Nashev D, Nosocomial infections in burn patients: etiology, antimicrobial resistance, means to control. Ann Burns Fire Disasters. 2013; 26: 5-11.
2. D'Elia M, Patenaude J, Dupras C, T cells from burn-injured mice demonstrate a loss of sensitivity to glucocorticoids. Am J Physiol Endocrinol Metab. 2010; 299: 299-307.
3. Jeschke MG, Boehning DF, Finnerty CC, Effect of insulin on the inflammatory and acute phase response after burn injury. Crit Care Med. 2007; 35: 519-523.
4. Valenti L, Mathieu J, Chancerelle Y, Nitric oxide inhibits spleen cell proliferative response after burn injury by inducing cytostasis, apoptosis, and necrosis of activated T lymphocytes: role of the guanylate cyclase. Cell Immunol. 2003; 221: 50-63.
5. Fouad AA, Albuali WH, Jresat I,. Simvastatin treatment ameliorates injury of rat testes induced by cadmium toxicity. Biol Trace Elem Res. 2013; 153: 269-278.
6. Melo AC, Valença SS, Gitirana LB, Redox markers and inflammation are differentially affected by atorvastatin, pravastatin or simvastatin administered before endotoxin-induced acute lung injury. Int Immunopharmacol. 2013; 17: 57-64.
7. Leite CF, Marangoni FA, Camargo EA, Simvastatin attenuates neutrophil recruitment in one-lung ventilation model in rats. Acta Cir Bras. 2013; 28: 245-250.
8. Du X, He S, Jiang Y, Wei L, Adiponectin prevents islet ischemia-reperfusion injury through the COX2-TNFα-NF-κB-dependent signal transduction pathway in mice. J Endocrinol. 2013; 218: 75-84.
9. Sevimli A, Bülbül T, Bülbül A, Chicken amyloid arthropathy: serum amyloid A, interleukin-1beta, interleukin-6, tumour necrosis factor-alpha and nitric oxide profile in acute phase (12th hour). Pol J Vet Sci. 2013; 16: 241-247.
10. Hunter I, Nixon GF,. Spatial compartmentalization of tumor necrosis factor (TNF) receptor 1-dependent signaling pathways in human airway smooth muscle cells. Lipid rafts are essential for TNF-alpha-mediated activation of RhoA but dispensable for the activation of the NF-kappaB and MAPK pathways. J Biol Chem. 2006; 281: 34705-34715.
11. Takeda K, Kermani P, Anastasia A, BDNF protects human vascular endothelial cells from TNFα-induced apoptosis. Biochem Cell Biol. 2013; 91: 341-349.
12. Li D, Zhong Y, Zhou Y, Autocrine TNF-α-mediated NF-κB activation is a determinant for evasion of CD40-induced cytotoxicity in cancer cells. Biochem Biophys Res Commun. 2013; 436: 467-472.
13. + T cells. Toxicol Appl Pharmacol. 2013; 269: 270-279.
14. Filip GA, Postescu ID, Bolfa P, Inhibition of UVB-induced skin phototoxicity by a grape seed extract as modulator of nitrosative stress, ERK/NF-kB signaling pathway and apoptosis, in SKH-1 mice. Food Chem Toxicol. 2013; 57: 296-306.
15. Koppula S, Kim WJ, Jiang J, Carpesium macrocephalum attenuates lipopolysaccharide-induced inflammation in macrophages by regulating the NF-κB/IκB-α Akt, and STAT signaling pathways. Am J Chin Med. 2013; 41: 927-943.
16. Pinto M, Zehavi-Willner T,. Thermal injury-induced non-specific resistance to fatal Pseudomonas aeruginosa burn-infection in mice. Jpn J Exp Med. 1989; 59: 189-196.
17. Leng XF, Wang DC, Zhang Q, Expression of tumor necrosis factor related apoptosis inducing ligand and its receptor in thymus during early post-burn stage in rat with severe burns. Zhonghua Shao Shang Za Zhi. 2007; 23: 184-187.
18. Krampera M, Sartoris S, Liotta F, Immune regulation by mesenchymal stem cells derived from adult spleen and thymus. Stem Cells Dev. 2007; 16: 797-810.
19. Chen MM, Bird MD, Zahs A, Deburghgraeve C, Posnik B, Davis CS, Kovacs EJ,. Pulmonary inflammation after ethanol exposure and burn injury is attenuated in the absence of IL-6. Alcohol. 2013; 47: 223-229.
20. Jeschke MG, Herndon DN, Vita R, IGF-I/BP-3 administration preserves hepatic homeostasis after thermal injury which is associated with increases in no and hepatic NF-kappa B. Shock. 2001; 16: 373-379.
21. Wang Y, Li de L, Zhang XB, Increase of TNFα-stimulated osteoarthritic chondrocytes apoptosis and decrease of matrix metalloproteinases 9 by NF-κB inhibition. Biomed Environ Sci. 2013; 26: 277-283.
22. Wu YL, Wan Y, Jin XJ, 25-OCH3-PPD induces the apoptosis of activated t-HSC/Cl-6 cells via c-FLIP-mediated NF-κB activation. Chem Biol Interact. 2011; 194: 106-112.
23. Bouchier-Hayes L, Conroy H, Egan H, CARDINAL, a novel caspase recruitment domain protein, is an inhibitor of multiple NF-kappa B activation pathways. J Biol Chem. 2001; 276: 44069-44077.
24. Kast RE,. Aspirin, TNF-alpha, NFkB, and survival in multiple myeloma: the importance of measuring TNF-alpha. Inflammopharmacology. 2006; 14: 256-259.
25. Ahn KS, Sethi G, Aggarwal BB,. Simvastatin potentiates TNF-alpha-induced apoptosis through the down-regulation of NF-kappaB-dependent antiapoptotic gene products: role of IkappaB alpha kinase and TGF-beta-activated kinase-1. J Immunol. 2007; 178: 2507-2516.